<\/p>\n
\u0413\u043b\u0438\u0437\u0435\u043d PM<\/strong> \u0435 triple-drug fixed-dose combination<\/strong> \u043e\u0442 glimepiride, pioglitazone and metformin<\/strong> (Glimepiride 1 mg (or 2 mg) + Pioglitazone 15 mg + Metformin 500 mg) used for \u0434\u0438\u0430\u0431\u0435\u0442 \u0442\u0438\u043f 2<\/strong> not controlled on dual therapy. It targets hyperglycaemia through three complementary mechanisms: glimepiride stimulates insulin release from the pancreas, pioglitazone reduces insulin resistance in muscle\/fat\/liver, and metformin reduces liver glucose output. Typical HbA1c reduction: 2.0–2.5 points<\/strong>. Usual dose: one tablet once daily with breakfast. Side-effect profile combines hypoglycaemia risk (from glimepiride), weight gain and oedema (from pioglitazone), and metformin GI upset. Avoid in heart failure, active bladder cancer, eGFR < 30, severe hepatic impairment, and sulfa allergy. This is typically a step before insulin initiation.<\/p>\n<\/div>\n \ud83d\udce6 \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u043a\u0440\u0438\u0442\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 \u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/strong><\/a> \u2014 \u0430\u043a\u043e \u0432\u0430\u0448\u0430\u0442\u0430 \u043f\u0440\u0430\u0442\u043a\u0430 \u043d\u0435 \u043f\u0440\u0438\u0441\u0442\u0438\u0433\u043d\u0435 \u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 20 \u0440\u0430\u0431\u043e\u0442\u043d\u0438 \u0434\u043d\u0438, \u043d\u0438\u0435 \u044f \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043c\u0435 \u043e\u0442\u043d\u043e\u0432\u043e.<\/p>\n \u041d\u0430\u0448\u0438\u0442\u0435 \u0433\u0435\u043d\u0435\u0440\u0438\u0447\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0441\u0435 \u0434\u043e\u0441\u0442\u0430\u0432\u044f\u0442 \u043e\u0442 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b\u0438, \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d\u0438 \u043e\u0442 WHO-GMP, \u0438 \u0441\u0435 \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u0442 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442 \u0432 \u0434\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430, \u043e\u0431\u0438\u043a\u043d\u043e\u0432\u0435\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u2014 \u0431\u0435\u0437 \u0438\u043c\u0435 \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e\u0442\u043e \u0432\u044a\u043d\u0448\u043d\u043e \u043d\u0430 \u043f\u0440\u0430\u0442\u043a\u0430\u0442\u0430. \u041f\u043b\u0430\u0449\u0430\u043d\u0438\u044f\u0442\u0430 \u0441 \u043a\u0430\u0440\u0442\u0430 \u0441\u0435 \u043e\u0431\u0440\u0430\u0431\u043e\u0442\u0432\u0430\u0442 \u0447\u0440\u0435\u0437 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430\u043d \u043f\u0440\u043e\u0446\u0435\u0441\u043e\u0440 (\u043e\u043f\u0438\u0441\u0430\u043d\u0438\u0435\u0442\u043e \u043d\u0430 \u0438\u0437\u0432\u043b\u0435\u0447\u0435\u043d\u0438\u0435\u0442\u043e \u0432\u043a\u043b\u044e\u0447\u0432\u0430 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430\u043d \u043f\u0440\u043e\u0446\u0435\u0441\u043e\u0440 \u0437\u0430 \u043f\u043b\u0430\u0449\u0430\u043d\u0435 \u0441 \u043a\u0430\u0440\u0442\u0430 \u2014 \u043d\u0438\u043a\u043e\u0433\u0430 \u201cMedsBase\u201d \u0438\u043b\u0438 \u0438\u043c\u0435 \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e). \u041f\u0440\u0438\u0435\u043c\u0430\u0442 \u0441\u0435 \u0441\u044a\u0449\u043e \u043a\u0440\u0438\u043f\u0442\u043e\u0432\u0430\u043b\u0443\u0442\u0438 \u0438 \u0431\u0430\u043d\u043a\u043e\u0432 \u043f\u0440\u0435\u0432\u043e\u0434 SEPA. \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u0434\u043a\u0440\u0435\u043f\u0435\u043d\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 \u043f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u0433\u0430\u0440\u0430\u043d\u0442\u0438\u0440\u0430\u043d\u043e \u043f\u0440\u0435\u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043d\u0435.<\/p>\n Glisen PM is an oral fixed-dose combination tablet containing three active antidiabetic ingredients: glimepiride, pioglitazone and metformin hydrochloride<\/strong> (Glimepiride 1 mg (or 2 mg) + Pioglitazone 15 mg + Metformin 500 mg). It is manufactured by WHO-GMP certified manufacturer and supplied in packs of 30, 60, 90 or 180 tablets.<\/p>\n Triple therapy in a single tablet is used when dual therapy (usually metformin + sulfonylurea or metformin + TZD) is not achieving glycaemic targets, and the clinician wants to intensify treatment without starting insulin yet.<\/p>\n The three components attack hyperglycaemia from three different directions:<\/p>\n Combined HbA1c reduction is typically 2.0–2.5 percentage points<\/strong> compared with dual therapy.<\/p>\n \u041e\u0431\u0438\u0447\u0430\u0439\u043d\u0430 \u0434\u043e\u0437\u0430:<\/strong> one tablet once daily, with or just before breakfast. Some prescribers use one tablet twice daily with larger meals if HbA1c is not controlled on once-daily dosing.<\/p>\n \u0427\u0435\u0441\u0442\u0438:<\/strong><\/p>\n \u041d\u0435\u0447\u0435\u0441\u0442\u0438, \u043d\u043e \u0441\u0435\u0440\u0438\u043e\u0437\u043d\u0438:<\/strong> severe hypoglycaemia (especially in older adults, renal impairment); heart failure decompensation; bladder cancer (long-term high-dose pioglitazone); macular oedema; bone fracture in women; lactic acidosis (very rare; acute kidney injury or hypoxia).<\/p>\n In older adults (> 65):<\/strong> triple therapy containing a sulfonylurea carries a high hypoglycaemia risk. Many clinicians prefer a DPP-4 inhibitor or SGLT-2 inhibitor instead of glimepiride in this group.<\/p>\n Store Glisen PM below 30°C in a dry place. Keep out of reach of children.<\/p>\n Usually when dual therapy (typically metformin + sulfonylurea, or metformin + TZD) is not achieving HbA1c targets, and the clinician wants to intensify oral therapy before starting insulin. It is also convenient for patients already taking these three medicines separately — one tablet instead of three improves adherence.<\/p>\n Clinically, yes — same molecules at the same doses. The fixed-dose combination improves adherence and typically costs less, but offers less flexibility if one component needs a dose change.<\/p>\n Yes — it contains glimepiride, a sulfonylurea. Skipping meals, unusual exercise, alcohol without food, and renal impairment all raise hypoglycaemia risk. Always take with food and carry glucose tablets.<\/p>\n Typically 2–4 kg over the first year — driven by pioglitazone (fluid and fat redistribution) and glimepiride (anabolic effect of more insulin). Metformin partially offsets this. Diet and exercise are the best counterweights.<\/p>\n That is a decision for you and your prescriber. Insulin gives more predictable glucose control and is essential once beta-cell reserve is exhausted, but it requires injections and has its own hypoglycaemia and weight-gain profile. Triple oral therapy is often tried first in motivated patients who want to avoid injections.<\/p>\n You can order Glisen PM (Glimepiride 1 mg (or 2 mg) + Pioglitazone 15 mg + Metformin 500 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide, with discreet packaging and genuine WHO-GMP certified manufacturer stock.<\/p>\n <\/p>\n \u0414\u0440\u0443\u0433\u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0438 \u0432 \u0425\u0440\u043e\u043d\u0438\u0447\u043d\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f<\/strong> \u043a\u043e\u0438\u0442\u043e \u043a\u043b\u0438\u0435\u043d\u0442\u0438\u0442\u0435 \u0441\u044a\u0449\u043e \u0440\u0430\u0437\u0433\u043b\u0435\u0436\u0434\u0430\u0442:<\/p>\n \u2705 \u041a\u043e\u043d\u0442\u0440\u043e\u043b\u0438\u0440\u0430 \u043a\u0440\u044a\u0432\u043d\u0430\u0442\u0430 \u0437\u0430\u0445\u0430\u0440 Glisen PM contains Glimepiride, Metformin, and Pioglitazone.<\/p>","protected":false},"featured_media":57403,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3230,3231],"product_tag":[3251,4296,3255,4297],"class_list":{"0":"post-57402","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-diabetes","9":"product_cat-diabetes-medication","10":"product_tag-glimepiride","11":"product_tag-glisen-pm","12":"product_tag-metformin","13":"product_tag-pioglitazone","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable","20":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product\/57402","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/comments?post=57402"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media\/57403"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media?parent=57402"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_brand?post=57402"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_cat?post=57402"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_tag?post=57402"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\u0417\u0430\u0449\u043e \u0434\u0430 \u043f\u043e\u0440\u044a\u0447\u0432\u0430\u0442\u0435 \u043e\u0442 MedsBase<\/h3>\n
What Is Glisen PM?<\/h2>\n
How Does Glisen PM Work?<\/h2>\n
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\u0414\u043e\u0437\u0438\u0440\u0430\u043d\u0435 \u0438 \u043f\u0440\u0438\u043b\u0430\u0433\u0430\u043d\u0435<\/h2>\n
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\u0421\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438<\/h2>\n
\n
\u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u0438 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f<\/h2>\n
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Who Should Not Take Glisen PM?<\/h2>\n
\n
\u0421\u044a\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435<\/h2>\n
\u0427\u0435\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u043d\u0438 \u0432\u044a\u043f\u0440\u043e\u0441\u0438<\/h2>\n
When is a triple-drug diabetes tablet like Glisen PM prescribed?<\/h3>\n
Is Glisen PM the same as taking the three drugs separately?<\/h3>\n
Will Glisen PM cause low blood sugar?<\/h3>\n
How much weight will I gain on Glisen PM?<\/h3>\n
Should I switch to insulin instead?<\/h3>\n
Where can I buy Glisen PM online?<\/h3>\n
\u0421\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0437\u0430 \u0434\u0438\u0430\u0431\u0435\u0442<\/h2>\n
\n
\u0421\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u0430\u043b\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u0438<\/h3>\n
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\n\u2705 Controls diabetes
\n\u2705 \u041f\u043e\u0434\u043e\u0431\u0440\u044f\u0432\u0430 \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u043e\u0432\u0430\u0442\u0430 \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u043d\u043e\u0441\u0442
\n\u2705 Reduces glucose levels
\n\u2705 \u041f\u043e\u0434\u043e\u0431\u0440\u044f\u0432\u0430 \u0433\u043b\u0438\u043a\u0435\u043c\u0438\u0447\u043d\u0438\u044f \u043a\u043e\u043d\u0442\u0440\u043e\u043b<\/p>\n