{"id":58445,"date":"2024-02-27T18:36:12","date_gmt":"2024-02-27T18:36:12","guid":{"rendered":"https:\/\/medsname.com\/lomoother\/"},"modified":"2026-04-30T10:24:13","modified_gmt":"2026-04-30T10:24:13","slug":"lomoother","status":"publish","type":"product","link":"https:\/\/medsbase.com\/bg\/product\/lomoother\/","title":{"rendered":"\u041b\u043e\u043c\u043e\u0442\u0435\u0440"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Lomoother?<\/h3>\n<p style=\"margin:0;\"><strong>\u041b\u043e\u043c\u043e\u0442\u0435\u0440<\/strong> is an oral capsule from Beacon Pharmaceuticals containing <strong>lomustine (CCNU) 40 mg<\/strong> &mdash; a nitrosourea alkylating agent that crosses the blood-brain barrier. Used for <strong>recurrent or refractory primary brain tumours<\/strong> (high-grade glioma, ependymoma) and as part of older Hodgkin lymphoma combination regimens. Standard adult monotherapy dose: <strong>100&ndash;130 mg\/m&sup2; orally as a single dose every 6 weeks<\/strong> &mdash; the 6-week interval is mandatory because nadir is delayed (4&ndash;6 weeks) and recovery slow. Mandatory: FBC at baseline, weekly between cycles, and on day 42 before next dose. <strong>Cumulative dose limit ~1,000 mg\/m&sup2;<\/strong> because of cumulative myelotoxicity and pulmonary fibrosis risk. Pregnancy contraindication; offer fertility preservation.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u041a\u0430\u043a\u0432\u043e \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u0442\u0435 \u0441 MedsBase:<\/strong> \u041f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b, \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u043e\u0442 WHO-GMP \u00b7 \u0414\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u00b7 \u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442 \u00b7 \u041d\u0430\u0434 1400 \u043f\u043e\u0442\u0432\u044a\u0440\u0434\u0435\u043d\u0438 <a href=\"https:\/\/medsbase.com\/bg\/reviews\/\">\u043e\u0442\u0437\u0438\u0432\u0430 \u043e\u0442 \u043a\u043b\u0438\u0435\u043d\u0442\u0438<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u043a\u0440\u0438\u0442\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 <a href=\"https:\/\/medsbase.com\/bg\/medsbase-re-shipment-assurance-policy\/\"><strong>\u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/strong><\/a> \u2014 \u0430\u043a\u043e \u0432\u0430\u0448\u0430\u0442\u0430 \u043f\u0440\u0430\u0442\u043a\u0430 \u043d\u0435 \u043f\u0440\u0438\u0441\u0442\u0438\u0433\u043d\u0435 \u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 20 \u0440\u0430\u0431\u043e\u0442\u043d\u0438 \u0434\u043d\u0438, \u043d\u0438\u0435 \u044f \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043c\u0435 \u043e\u0442\u043d\u043e\u0432\u043e.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 \u041d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c \u0435 \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0437\u0438\u0440\u0430\u043d \u043d\u0430\u0434\u0437\u043e\u0440.<\/strong> \u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430\u0442\u0430 \u043f\u0440\u043e\u0442\u0438\u0432 \u0440\u0430\u043a \u0442\u0440\u044f\u0431\u0432\u0430 \u0434\u0430 \u0431\u044a\u0434\u0430\u0442 \u043f\u0440\u0435\u0434\u043f\u0438\u0441\u0430\u043d\u0438 \u043e\u0442 \u043b\u0435\u043a\u0443\u0432\u0430\u0449 \u043e\u043d\u043a\u043e\u043b\u043e\u0433 \u0441 \u043f\u043e\u0442\u0432\u044a\u0440\u0434\u0435\u043d\u0430 \u0434\u0438\u0430\u0433\u043d\u043e\u0437\u0430, \u0431\u0430\u0437\u043e\u0432\u043e \u0441\u0442\u0430\u0434\u0438\u0440\u0430\u043d\u0435 \u0438 \u0434\u0435\u0444\u0438\u043d\u0438\u0440\u0430\u043d \u043f\u043b\u0430\u043d \u0437\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u0435. \u041d\u0438\u043a\u043e\u0433\u0430 \u043d\u0435 \u0437\u0430\u043f\u043e\u0447\u0432\u0430\u0439\u0442\u0435, \u043d\u0435 \u0441\u043f\u0438\u0440\u0430\u0439\u0442\u0435, \u043d\u0435 \u043f\u0440\u043e\u043c\u0435\u043d\u044f\u0439\u0442\u0435 \u0434\u043e\u0437\u0430\u0442\u0430 \u0438\u043b\u0438 \u043d\u0435 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430\u0439\u0442\u0435 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e \u043f\u0440\u043e\u0442\u0438\u0432 \u0440\u0430\u043a \u0438\u0437\u0432\u044a\u043d \u043f\u043b\u0430\u043d \u0437\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u0435, \u0432\u043e\u0434\u0435\u043d \u043e\u0442 \u043e\u043d\u043a\u043e\u043b\u043e\u0433. \u041f\u043e\u0432\u0435\u0447\u0435\u0442\u043e \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u043f\u0440\u043e\u0442\u0438\u0432 \u0440\u0430\u043a \u0438\u0437\u0438\u0441\u043a\u0432\u0430\u0442 \u0440\u0435\u0434\u043e\u0432\u0435\u043d \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433 \u0441 \u043a\u0440\u044a\u0432\u043d\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f (\u043f\u044a\u043b\u043d\u0430 \u043a\u0440\u044a\u0432\u043d\u0430 \u043a\u0430\u0440\u0442\u0438\u043d\u0430, \u0447\u0435\u0440\u043d\u043e\u0434\u0440\u043e\u0431\u043d\u0438 \u0435\u043d\u0437\u0438\u043c\u0438, \u0431\u044a\u0431\u0440\u0435\u0447\u043d\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u044f), \u0441\u0430 \u0430\u0431\u0441\u043e\u043b\u044e\u0442\u043d\u043e \u043a\u043e\u043d\u0442\u0440\u0430\u0438\u043d\u0434\u0438\u0446\u0438\u0440\u0430\u043d\u0438 \u043f\u0440\u0438 \u0431\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442 \u0438 \u0438\u043c\u0430\u0442 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u0438 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 \u0428\u0438\u0444\u0440\u043e\u0432\u0430\u043d\u043e \u043f\u043b\u0430\u0449\u0430\u043d\u0435<\/strong> \u00b7 <strong>\ud83d\udcb3 \u0412\u0435\u0440\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u043f\u0440\u043e\u0446\u0435\u0441\u043e\u0440<\/strong> \u00b7 <strong>\ud83d\ude9a \u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442<\/strong> \u00b7 <strong>\u2b50 4.9\/5 \u043e\u0442 1,400+ \u043a\u043b\u0438\u0435\u043d\u0442\u0438<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Lomoother?<\/h2>\n<p>Lomoother is an oral capsule from Beacon Pharmaceuticals containing <strong>lomustine (CCNU) 40 mg<\/strong>. Lomustine is a nitrosourea alkylating agent that crosses the blood-brain barrier (CSF concentration ~30&ndash;50% of plasma), making it one of the few oral cytotoxics with meaningful CNS penetration. Used in primary brain tumours, particularly recurrent high-grade glioma after temozolomide failure.<\/p>\n<h2 class=\"wp-block-heading\">\u0423\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u0438 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f<\/h2>\n<ul>\n<li><strong>Recurrent or refractory glioblastoma multiforme<\/strong> after temozolomide<\/li>\n<li><strong>Anaplastic astrocytoma, anaplastic oligodendroglioma<\/strong> (PCV regimen)<\/li>\n<li><strong>Hodgkin lymphoma<\/strong> (older CCNU-containing combinations)<\/li>\n<li><strong>Brain metastases (selected)<\/strong><\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0414\u043e\u0437\u0438\u0440\u0430\u043d\u0435 \u0438 \u043d\u0430\u0447\u0438\u043d \u043d\u0430 \u043f\u0440\u0438\u0435\u043c\u0430\u043d\u0435<\/h2>\n<ul>\n<li><strong>Standard:<\/strong> 100&ndash;130 mg\/m&sup2; PO as a SINGLE dose every 6 weeks<\/li>\n<li><strong>PCV regimen (oligodendroglioma):<\/strong> 110 mg\/m&sup2; day 1 + procarbazine + vincristine, every 6 weeks<\/li>\n<\/ul>\n<ol>\n<li>Take as a single oral dose at bedtime, on an empty stomach (no food 2 hours before or 2 hours after).<\/li>\n<li>Antiemetic (ondansetron 8 mg) 1 hour before dose.<\/li>\n<li>Swallow capsules whole with water. Do NOT open.<\/li>\n<li><strong>Mandatory 6-week interval between doses<\/strong> &mdash; nadir is delayed (typically week 4&ndash;6), recovery slow. Dosing more frequently than every 6 weeks risks cumulative pancytopenia.<\/li>\n<li><strong>\u0417\u0430\u0434\u044a\u043b\u0436\u0438\u0442\u0435\u043b\u043d\u043e \u043d\u0430\u0431\u043b\u044e\u0434\u0435\u043d\u0438\u0435:<\/strong> FBC at baseline, weekly throughout the cycle, and on day 42 before next dose. LFTs and renal function monthly. PFTs (DLCO) baseline and if dyspnoea.<\/li>\n<li><strong>Cumulative dose limit ~1,000 mg\/m&sup2;<\/strong> over the lifetime &mdash; cumulative myelotoxicity and pulmonary fibrosis become rate-limiting.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">\u0421\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438<\/h2>\n<p><strong>\u0427\u0435\u0441\u0442\u0438:<\/strong> nausea (significant), vomiting, anorexia.<\/p>\n<p><strong>\u0412\u0430\u0436\u043d\u043e:<\/strong><\/p>\n<ul>\n<li><strong>Delayed cumulative myelosuppression<\/strong> &mdash; thrombocytopenia and leucopenia at week 4&ndash;6, recovery slow<\/li>\n<li><strong>Pulmonary fibrosis<\/strong> at high cumulative dose &mdash; mandatory PFTs if dyspnoea<\/li>\n<li>\u0425\u0435\u043f\u0430\u0442\u043e\u0442\u043e\u043a\u0441\u0438\u0447\u043d\u043e\u0441\u0442<\/li>\n<li>\u0411\u044a\u0431\u0440\u0435\u0447\u043d\u0430 \u0442\u043e\u043a\u0441\u0438\u0447\u043d\u043e\u0441\u0442<\/li>\n<li>Secondary leukaemia (long-term, dose-related)<\/li>\n<li>\u041f\u0435\u0440\u043c\u0430\u043d\u0435\u043d\u0442\u043d\u0430 \u0431\u0435\u0437\u043f\u043b\u043e\u0434\u0438\u0435 (\u0433\u043e\u043d\u0430\u0434\u043e\u0442\u043e\u043a\u0441\u0438\u0447\u043d\u043e)<\/li>\n<li>Confusion, lethargy, ataxia (high doses)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u041f\u0440\u0435\u0434\u0443\u043f\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u044f<\/h2>\n<ul>\n<li><strong>\u0411\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442:<\/strong> teratogenic; strict contraception throughout + 6 months after.<\/li>\n<li><strong>\u041a\u044a\u0440\u043c\u0435\u043d\u0435:<\/strong> \u0438\u0437\u0431\u044f\u0433\u0432\u0430\u0439\u0442\u0435.<\/li>\n<li><strong>Pre-existing pulmonary disease:<\/strong> baseline DLCO; avoid in severe.<\/li>\n<li><strong>\u0422\u0435\u0436\u043a\u043e \u0447\u0435\u0440\u043d\u043e\u0434\u0440\u043e\u0431\u043d\u043e\/\u0431\u044a\u0431\u0440\u0435\u0447\u043d\u043e \u0443\u0432\u0440\u0435\u0436\u0434\u0430\u043d\u0435:<\/strong> \u043d\u0430\u043c\u0430\u043b\u0435\u0442\u0435 \u0434\u043e\u0437\u0430\u0442\u0430.<\/li>\n<li><strong>\u0416\u0438\u0432\u0438 \u0432\u0430\u043a\u0441\u0438\u043d\u0438:<\/strong> \u043a\u043e\u043d\u0442\u0440\u0430\u0438\u043d\u0434\u0438\u0446\u0438\u0440\u0430\u043d\u043e.<\/li>\n<li><strong>Cumulative dose tracking<\/strong> &mdash; specialist responsibility.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u0438 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">\u041a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u0430\u0439\u0442\u0435 \u0441<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">\u0415\u0444\u0435\u043a\u0442<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">\u041a\u0430\u043a\u0432\u043e \u0434\u0430 \u043f\u0440\u0430\u0432\u0438\u0442\u0435<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Other myelosuppressives<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive prolonged pancytopenia<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u041d\u0430\u0431\u043b\u044e\u0434\u0435\u043d\u0438\u0435 \u043e\u0442 \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0441\u0442.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0426\u0438\u043c\u0435\u0442\u0438\u0434\u0438\u043d<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Increases lomustine marrow toxicity<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Use ranitidine or famotidine instead.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0416\u0438\u0432\u0438 \u0432\u0430\u043a\u0441\u0438\u043d\u0438<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0420\u0430\u0437\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0430 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u041f\u0440\u043e\u0442\u0438\u0432\u043e\u043f\u043e\u043a\u0430\u0437\u0430\u043d\u043e.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">\u0421\u044a\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435<\/h2>\n<ul>\n<li>\u0421\u044a\u0445\u0440\u0430\u043d\u044f\u0432\u0430\u0439\u0442\u0435 \u0432 \u0445\u043b\u0430\u0434\u0438\u043b\u043d\u0438\u043a \u043f\u0440\u0438 <strong>2\u20138\u00b0C<\/strong>.<\/li>\n<li>\u0414\u0430\u043b\u0435\u0447 \u043e\u0442 \u0434\u0435\u0446\u0430, \u0436\u0435\u043d\u0438 \u0432 \u0434\u0435\u0442\u0435\u0440\u043e\u0434\u043d\u0430 \u0432\u044a\u0437\u0440\u0430\u0441\u0442, \u0434\u043e\u043c\u0430\u0448\u043d\u0438 \u043b\u044e\u0431\u0438\u043c\u0446\u0438.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0421\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u0430\u043b\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u0438 \u0432 MedsBase<\/h2>\n<p>\u0414\u0440\u0443\u0433\u0438 \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0447\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430, \u043d\u0430\u043b\u0438\u0447\u043d\u0438 \u0437\u0430\u0435\u0434\u043d\u043e \u0441 \u0442\u043e\u0437\u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0442:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/bg\/endoxan\/\"><strong>\u0415\u043d\u0434\u043e\u043a\u0441\u0430\u043d (\u0446\u0438\u043a\u043b\u043e\u0444\u043e\u0441\u0444\u0430\u043c\u0438\u0434 50 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/celkeran\/\"><strong>Celkeran (\u0445\u043b\u043e\u0440\u0430\u043c\u0431\u0443\u0446\u0438\u043b 2 \/ 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/temotero\/\"><strong>\u0422\u0435\u043c\u043e\u0442\u0435\u0440\u043e (\u0442\u0435\u043c\u043e\u0437\u043e\u043b\u043e\u043c\u0438\u0434 20\/100 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/temozol-20\/\"><strong>\u0422\u0435\u043c\u043e\u0437\u043e\u043b (\u0442\u0435\u043c\u043e\u0437\u043e\u043b\u043e\u043c\u0438\u0434 20 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/endace\/\"><strong>\u0415\u043d\u0434\u0430\u0446\u0435 (\u043c\u0435\u0433\u0435\u0441\u0442\u0440\u043e\u043b 40\/160 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/bg\/anti-cancer-medication\/\">\u0420\u0430\u0437\u0433\u043b\u0435\u0434\u0430\u0439\u0442\u0435 \u0432\u0441\u0438\u0447\u043a\u0438 \u0430\u043d\u0442\u0438\u0440\u0430\u043a\u043e\u0432\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u2192<\/a><\/p>\n<h2 id=\"faqs\">\u0427\u0435\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u043d\u0438 \u0432\u044a\u043f\u0440\u043e\u0441\u0438<\/h2>\n<h3 class=\"wp-block-heading\">Why must doses be 6 weeks apart?<\/h3>\n<p>Lomustine causes <strong>delayed cumulative myelosuppression<\/strong>. The blood count nadir typically occurs at <strong>week 4&ndash;6<\/strong> after a dose, with slow recovery thereafter. Dosing more frequently than every 6 weeks stacks the marrow toxicity and risks severe pancytopenia. The 6-week interval is rigid &mdash; even if you feel well, do not dose-advance without specialist instruction.<\/p>\n<h3 class=\"wp-block-heading\">Why is there a cumulative dose limit?<\/h3>\n<p>Cumulative pulmonary fibrosis and persistent thrombocytopenia become limiting at total exposure above ~1,000 mg\/m&sup2; (lifetime). Specialists track cumulative dose and stop or extend the interval as the limit is approached. Tell every doctor about every previous chemotherapy course.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Lomoother with food?<\/h3>\n<p>No &mdash; take on an empty stomach (no food for 2 hours before or 2 hours after). Most patients take the dose at bedtime &ge; 2 hours after dinner. Pre-medicate with ondansetron 8 mg about 1 hour before to prevent the significant nausea and vomiting characteristic of nitrosoureas.<\/p>\n<h3 class=\"wp-block-heading\">\u041a\u0430\u043a\u0432\u0438 \u043a\u0440\u044a\u0432\u043d\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f \u0441\u0430 \u043c\u0438 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0438?<\/h3>\n<p>FBC at baseline, weekly between cycles, and on day 42 before each next dose. LFTs and renal function monthly. PFTs (with DLCO) at baseline and any time you develop new dyspnoea or persistent dry cough.<\/p>\n<h3 class=\"wp-block-heading\">Will Lomoother work for my brain tumour?<\/h3>\n<p>Lomustine has a long history in primary brain tumours. In recurrent glioblastoma after temozolomide failure, lomustine produces modest disease-control benefit in some patients. In oligodendroglioma, the PCV regimen (procarbazine + lomustine + vincristine) has documented overall survival benefit when combined with radiotherapy in 1p\/19q co-deleted disease. Discuss expected benefit specific to your tumour with the neuro-oncologist.<\/p>\n<h3 class=\"wp-block-heading\">Why must Lomoother be refrigerated?<\/h3>\n<p>Lomustine is heat-sensitive and degrades at room temperature, especially in warmer climates. Refrigeration (2&ndash;8&deg;C) preserves potency. Keep in original blister.<\/p>\n<h3 class=\"wp-block-heading\">Caregivers handling Lomoother?<\/h3>\n<p>Wear gloves when handling capsules and patient body fluids in the first 48 hours after a dose. Wash hands afterwards. Pregnant caregivers should avoid handling.<\/p>\n<h3 class=\"wp-block-heading\">\u041c\u043e\u0433\u0430 \u043b\u0438 \u0434\u0430 \u043f\u043e\u043b\u0443\u0447\u0430 \u0436\u0438\u0432\u0438 \u0432\u0430\u043a\u0441\u0438\u043d\u0438?<\/h3>\n<p>No &mdash; contraindicated during lomustine and for at least 6 months after the last dose. Inactivated vaccines safe and recommended.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>\u0417\u0430\u0449\u043e \u0434\u0430 \u043f\u043e\u0440\u044a\u0447\u0432\u0430\u0442\u0435 \u043e\u0442 MedsBase<\/h3>\n<p>\u0412\u0441\u044f\u043a\u0430 \u043f\u0430\u0440\u0442\u0438\u0434\u0430 \u0435 \u0437\u0430\u043a\u0443\u043f\u0435\u043d\u0430 \u043e\u0442 <strong>\u0421\u0417\u041e-GMP \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b<\/strong>. \u041f\u043e\u0440\u044a\u0447\u043a\u0438\u0442\u0435 \u0441\u0435 \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u0442 \u0432 \u043e\u0431\u0438\u043a\u043d\u043e\u0432\u0435\u043d\u0438 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0438 \u0431\u0435\u0437 \u043c\u0430\u0440\u043a\u0438\u0440\u043e\u0432\u043a\u0430 \u043e\u0442 \u043d\u0430\u0448\u0438\u0442\u0435 \u043f\u0430\u0440\u0442\u043d\u044c\u043e\u0440\u0438 \u0437\u0430 \u0438\u0437\u043f\u044a\u043b\u043d\u0435\u043d\u0438\u0435 \u0438 \u0441\u0430 \u043f\u043e\u043a\u0440\u0438\u0442\u0438 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 <a href=\"\/bg\/medsbase-re-shipment-assurance-policy\/\">\u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/a>: \u0430\u043a\u043e \u043f\u0440\u0430\u0442\u043a\u0430\u0442\u0430 \u043d\u0435 \u043f\u0440\u0438\u0441\u0442\u0438\u0433\u043d\u0435 \u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 20 \u0440\u0430\u0431\u043e\u0442\u043d\u0438 \u0434\u043d\u0438, \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043c\u0435 \u0431\u0435\u0437\u043f\u043b\u0430\u0442\u043d\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u043f\u0440\u0430\u0442\u043a\u0430, \u0431\u0435\u0437 \u0434\u043e\u043f\u044a\u043b\u043d\u0438\u0442\u0435\u043b\u043d\u0438 \u0432\u044a\u043f\u0440\u043e\u0441\u0438.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u0421\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0440\u0430\u043a\u043e\u0432\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430<\/h3>\n<p>\u0414\u0440\u0443\u0433\u0438 \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0447\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430, \u043d\u0430\u043b\u0438\u0447\u043d\u0438 \u0437\u0430\u0435\u0434\u043d\u043e \u0441 \u0442\u043e\u0437\u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0442:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/bg\/endoxan\/\">\u0415\u043d\u0434\u043e\u043a\u0441\u0430\u043d (\u0446\u0438\u043a\u043b\u043e\u0444\u043e\u0441\u0444\u0430\u043c\u0438\u0434 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/celkeran\/\">Celkeran (\u0445\u043b\u043e\u0440\u0430\u043c\u0431\u0443\u0446\u0438\u043b 2 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/temozol-20\/\">Temozol 20 (temozolomide 20 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/temotero\/\">Temotero (temozolomide 100\/250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/hydrosar\/\">Hydrosar (\u0445\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u0443\u0440\u0435\u044f 500 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Brain tumor treatment<br \/>\n\u2705 Chemotherapy drug<br \/>\n\u2705 Slows tumor growth<br \/>\n\u2705 Alkylating agent<br \/>\n\u2705 \u041e\u0440\u0430\u043b\u043d\u043e \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e<\/p>\n<p>Lomoother contains Lomustine.<\/p>","protected":false},"featured_media":58446,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4493,4494],"class_list":{"0":"post-58445","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-lomoother","10":"product_tag-lomustine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product\/58445","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/comments?post=58445"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media\/58446"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media?parent=58445"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_brand?post=58445"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_cat?post=58445"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_tag?post=58445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}