{"id":58603,"date":"2024-02-27T18:46:43","date_gmt":"2024-02-27T18:46:43","guid":{"rendered":"https:\/\/medsname.com\/olanzoop\/"},"modified":"2026-04-30T10:24:11","modified_gmt":"2026-04-30T10:24:11","slug":"olanzoop","status":"publish","type":"product","link":"https:\/\/medsbase.com\/bg\/product\/olanzoop\/","title":{"rendered":"\u041e\u043b\u0430\u043d\u0437\u043e\u043e\u043f"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8d6;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u26a1 \u0411\u044a\u0440\u0437 \u043e\u0442\u0433\u043e\u0432\u043e\u0440<\/h3>\n<p style=\"margin-bottom:0;\">Olanzoop (Olanzapine 5 \/ 10 mg) is an atypical antipsychotic for schizophrenia, bipolar mania and maintenance, treatment-resistant depression (with fluoxetine), and acute agitation. The most robust antipsychotic effect of the atypicals \u2014 but the heaviest metabolic burden.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u041a\u0430\u043a\u0432\u043e \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u0442\u0435 \u0441 MedsBase:<\/strong> \u041f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b, \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u043e\u0442 WHO-GMP \u00b7 \u0414\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u00b7 \u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442 \u00b7 \u041d\u0430\u0434 1400 \u043f\u043e\u0442\u0432\u044a\u0440\u0434\u0435\u043d\u0438 <a href=\"https:\/\/medsbase.com\/bg\/reviews\/\">\u043e\u0442\u0437\u0438\u0432\u0430 \u043e\u0442 \u043a\u043b\u0438\u0435\u043d\u0442\u0438<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u043a\u0440\u0438\u0442\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 <a href=\"https:\/\/medsbase.com\/bg\/medsbase-re-shipment-assurance-policy\/\"><strong>\u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/strong><\/a> \u2014 \u0430\u043a\u043e \u0432\u0430\u0448\u0430\u0442\u0430 \u043f\u0440\u0430\u0442\u043a\u0430 \u043d\u0435 \u043f\u0440\u0438\u0441\u0442\u0438\u0433\u043d\u0435 \u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 20 \u0440\u0430\u0431\u043e\u0442\u043d\u0438 \u0434\u043d\u0438, \u043d\u0438\u0435 \u044f \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043c\u0435 \u043e\u0442\u043d\u043e\u0432\u043e.<\/p>\n<h3>\u0417\u0430\u0449\u043e \u0434\u0430 \u043f\u043e\u0440\u044a\u0447\u0432\u0430\u0442\u0435 \u043e\u0442 MedsBase<\/h3>\n<p>Olanzoop at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our <a href=\"https:\/\/medsbase.com\/bg\/medsbase-re-shipment-assurance-policy\/\">\u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/a> \u2014 20-\u0440\u0430\u0431\u043e\u0442\u043d\u043e\u0434\u043d\u0435\u0432\u0435\u043d \u0441\u0440\u043e\u043a \u0437\u0430 \u0434\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u0438\u043b\u0438 \u0431\u0435\u0437\u043f\u043b\u0430\u0442\u043d\u043e \u043f\u0440\u0435\u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043d\u0435 \u2014 \u0438 \u0434\u0430\u0432\u0430 \u043f\u0440\u0430\u0432\u043e \u043d\u0430 \u0443\u0447\u0430\u0441\u0442\u0438\u0435 \u0432 \u043d\u0430\u0448\u0430\u0442\u0430 <a href=\"https:\/\/medsbase.com\/bg\/loyalty-points\/\">\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u0430 \u0437\u0430 \u043b\u043e\u044f\u043b\u043d\u043e\u0441\u0442<\/a>. \u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430\u0442\u0430 \u0435 \u043d\u0430\u043b\u0438\u0447\u043d\u0430 \u0432 \u043f\u043e\u0432\u0435\u0447\u0435\u0442\u043e \u0434\u044a\u0440\u0436\u0430\u0432\u0438 \u043f\u043e \u0441\u0432\u0435\u0442\u0430.<\/p>\n<h2>What Olanzoop is and how it works<\/h2>\n<p>Olanzoop is an olanzapine tablet supplied by Cipla. Available strengths: <strong>5 \/ 10 mg<\/strong>. Olanzapine is a thienobenzodiazepine atypical antipsychotic with strong D2 antagonism, strong 5-HT2A antagonism, and substantial H1 (sedation, weight gain), M1 (anticholinergic), and \u03b11 (orthostasis) blockade. The H1+M1 receptor profile is responsible both for its calming\/sedative effect (useful in acute agitation) and for its metabolic burden.<\/p>\n<h2>\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f \u0438 \u0434\u043e\u0437\u0438\u0440\u0430\u043d\u0435<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u0435<\/th>\n<th>\u041d\u0430\u0447\u0430\u043b\u043d\u0430 \u0434\u043e\u0437\u0430<\/th>\n<th>\u0426\u0435\u043b\u0435\u0432\u0430 \u0434\u043e\u0437\u0430<\/th>\n<th>\u041c\u0430\u043a\u0441\u0438\u043c\u0430\u043b\u043d\u0430 \u0434\u043e\u0437\u0430<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u0428\u0438\u0437\u043e\u0444\u0440\u0435\u043d\u0438\u044f (\u0432\u044a\u0437\u0440\u0430\u0441\u0442\u043d\u0438)<\/td>\n<td>5\u201310 mg \u0432\u0435\u0434\u043d\u044a\u0436 \u0434\u043d\u0435\u0432\u043d\u043e<\/td>\n<td>10\u201320 mg \u0432\u0435\u0434\u043d\u044a\u0436 \u0434\u043d\u0435\u0432\u043d\u043e<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>\u0428\u0438\u0437\u043e\u0444\u0440\u0435\u043d\u0438\u044f (\u044e\u043d\u043e\u0448\u0438 \u2265 13 \u0433.)<\/td>\n<td>2.5\u20135 mg OD<\/td>\n<td>10 mg \u0432\u0435\u0434\u043d\u044a\u0436 \u0434\u043d\u0435\u0432\u043d\u043e<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>\u0411\u0438\u043f\u043e\u043b\u044f\u0440\u043d\u0430 \u043c\u0430\u043d\u0438\u044f (\u0432\u044a\u0437\u0440\u0430\u0441\u0442\u043d\u0438)<\/td>\n<td>10\u201315 mg \u0432\u0435\u0434\u043d\u044a\u0436 \u0434\u043d\u0435\u0432\u043d\u043e<\/td>\n<td>10\u201320 mg \u0432\u0435\u0434\u043d\u044a\u0436 \u0434\u043d\u0435\u0432\u043d\u043e<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Acute agitation (IM)<\/td>\n<td>10 mg IM<\/td>\n<td>\u2014<\/td>\n<td>3 \u0434\u043e\u0437\u0438\/24\u0447<\/td>\n<\/tr>\n<tr>\n<td>Treatment-resistant depression (with fluoxetine)<\/td>\n<td>5 mg + 20 mg fluoxetine<\/td>\n<td>5\u201318 mg<\/td>\n<td>18 mg<\/td>\n<\/tr>\n<tr>\n<td>\u0412\u044a\u0437\u0440\u0430\u0441\u0442\u043d\u0438 \u0445\u043e\u0440\u0430<\/td>\n<td>2.5\u20135 mg OD<\/td>\n<td>5\u201310 mg \u0432\u0435\u0434\u043d\u044a\u0436 \u0434\u043d\u0435\u0432\u043d\u043e<\/td>\n<td>\u043f\u043e \u0442\u043e\u043b\u0435\u0440\u0430\u043d\u0442\u043d\u043e\u0441\u0442<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>\u0412\u0430\u0436\u043d\u0438 \u043c\u0435\u0440\u043a\u0438 \u0437\u0430 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>FDA \u0447\u0435\u0440\u043d\u0430 \u043a\u0443\u0442\u0438\u044f \u2014 \u0434\u0435\u043c\u0435\u043d\u0446\u0438\u044f-\u0441\u0432\u044a\u0440\u0437\u0430\u043d\u0430 \u043f\u0441\u0438\u0445\u043e\u0437\u0430<\/strong><\/p>\n<p style=\"margin-bottom:0;\">\u0412\u0441\u0438\u0447\u043a\u0438 \u0430\u0442\u0438\u043f\u0438\u0447\u043d\u0438 \u0430\u043d\u0442\u0438\u043f\u0441\u0438\u0445\u043e\u0442\u0438\u0446\u0438 \u043d\u043e\u0441\u044f\u0442 FDA \u0447\u0435\u0440\u043d\u043e\u043a\u0443\u0442\u0438\u0439\u043d\u043e \u043f\u0440\u0435\u0434\u0443\u043f\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u0437\u0430 \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u0430 \u0441\u043c\u044a\u0440\u0442\u043d\u043e\u0441\u0442 (\u043f\u0440\u0435\u0434\u0438\u043c\u043d\u043e \u0441\u044a\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u044a\u0434\u043e\u0432\u0430 \u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u0437\u043d\u0430) \u043f\u0440\u0438 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u0437\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u043d\u0430 \u043f\u043e\u0432\u0435\u0434\u0435\u043d\u0447\u0435\u0441\u043a\u0438 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u043f\u0440\u0438 \u0432\u044a\u0437\u0440\u0430\u0441\u0442\u043d\u0438 \u0441 \u0434\u0435\u043c\u0435\u043d\u0446\u0438\u044f. <strong>\u0410\u0442\u0438\u043f\u0438\u0447\u043d\u0438\u0442\u0435 \u0430\u043d\u0442\u0438\u043f\u0441\u0438\u0445\u043e\u0442\u0438\u0446\u0438 \u043d\u0435 \u0441\u0430 \u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0438 \u0437\u0430 \u0434\u0435\u043c\u0435\u043d\u0446\u0438\u044f-\u0441\u0432\u044a\u0440\u0437\u0430\u043d\u0430 \u043f\u0441\u0438\u0445\u043e\u0437\u0430 \u0438\u043b\u0438 \u0432\u044a\u0437\u0431\u0443\u0434\u0430.<\/strong>. \u0423\u043f\u043e\u0442\u0440\u0435\u0431\u0430\u0442\u0430 \u043f\u0440\u0438 \u0442\u0430\u0437\u0438 \u043f\u043e\u043f\u0443\u043b\u0430\u0446\u0438\u044f \u0435 \u0438\u0437\u0432\u044a\u043d \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u0442\u0430, \u043f\u043e\u0441\u043b\u0435\u0434\u043d\u0430 \u043c\u044f\u0440\u043a\u0430, \u043e\u0433\u0440\u0430\u043d\u0438\u0447\u0435\u043d\u0430 \u0432\u044a\u0432 \u0432\u0440\u0435\u043c\u0435\u0442\u043e \u0438 \u0438\u0437\u0438\u0441\u043a\u0432\u0430 \u0438\u0437\u0440\u0438\u0447\u0435\u043d \u0440\u0430\u0437\u0433\u043e\u0432\u043e\u0440 \u0437\u0430 \u0440\u0438\u0441\u043a\u043e\u0432\u0435 \u0438 \u043f\u043e\u043b\u0437\u0438.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Heaviest metabolic burden of the atypicals<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Olanzapine produces the most weight gain (typically 4\u201310 kg in the first 6 months, sometimes far more), the most insulin resistance, and the most lipid disturbance of any commonly-used antipsychotic. Patients can develop type 2 diabetes within months of initiation. <strong>Mandatory monitoring: weight at every visit; fasting glucose \/ HbA1c and fasting lipids at baseline, 12 weeks, then 6-monthly.<\/strong> Counsel about diet and exercise from initiation.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Sedation and anticholinergic burden<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Strong sedation in the first 1\u20132 weeks. Anticholinergic effects (dry mouth, constipation, urinary hesitancy) are universal. Both lessen but do not disappear.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Olanzapine + benzodiazepine IM \u2014 caution<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Combining IM olanzapine with parenteral benzodiazepines has produced cases of severe hypotension, respiratory depression, and death. If both are clinically necessary in acute agitation, separate by \u2265 1 hour and monitor closely.<\/p>\n<\/div>\n<h2>\u0427\u0435\u0441\u0442\u043e \u0441\u0440\u0435\u0449\u0430\u043d\u0438 \u0441\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438<\/h2>\n<ul>\n<li><strong>\u041d\u0430\u0442\u0440\u0443\u043f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0442\u0435\u0433\u043b\u043e \u0438 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u0435\u043d \u0441\u0438\u043d\u0434\u0440\u043e\u043c<\/strong> \u2014 the dominant long-term concern.<\/li>\n<li><strong>\u0421\u0435\u0434\u0430\u0446\u0438\u044f<\/strong> \u2014 universal at initiation.<\/li>\n<li><strong>\u041e\u0440\u0442\u043e\u0441\u0442\u0430\u0442\u043d\u0430 \u0445\u0438\u043f\u043e\u0442\u0435\u043d\u0437\u0438\u044f<\/strong> \u2014 common at initiation; titrate slowly in older adults.<\/li>\n<li><strong>\u0410\u043d\u0442\u0438\u0445\u043e\u043b\u0438\u043d\u0435\u0440\u0433\u0438\u0447\u043d\u043e<\/strong> \u2014 dry mouth, constipation, urinary hesitancy.<\/li>\n<li><strong>Akathisia, EPS<\/strong> \u2014 less common than risperidone, more common than aripiprazole.<\/li>\n<li><strong>\u041f\u0440\u043e\u043b\u0430\u043a\u0442\u0438\u043d<\/strong> \u2014 modest rise; less than risperidone.<\/li>\n<li><strong>Hepatic<\/strong> \u2014 transient AST\/ALT rises common.<\/li>\n<\/ul>\n<h2>\u0412\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f \u0441 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430<\/h2>\n<ul>\n<li><strong>\u0418\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440\u0438 \u043d\u0430 CYP1A2<\/strong> (fluvoxamine, ciprofloxacin) \u2014 raise olanzapine levels markedly.<\/li>\n<li><strong>\u0422\u044e\u0442\u044e\u043d\u043e\u043f\u0443\u0448\u0435\u043d\u0435<\/strong> \u2014 induces CYP1A2; smokers have lower levels and need higher doses; smoking cessation can produce toxicity.<\/li>\n<li><strong>\u041a\u0430\u0440\u0431\u0430\u043c\u0430\u0437\u0435\u043f\u0438\u043d<\/strong> \u2014 strong CYP1A2 induction; raises olanzapine clearance.<\/li>\n<li><strong>\u0414\u0435\u043f\u0440\u0435\u0441\u0430\u043d\u0442\u0438 \u043d\u0430 \u0426\u041d\u0421<\/strong> \u2014 \u0434\u043e\u043f\u044a\u043b\u043d\u0438\u0442\u0435\u043b\u043d\u0430 \u0441\u0435\u0434\u0430\u0446\u0438\u044f.<\/li>\n<li><strong>\u0410\u043d\u0442\u0438\u0445\u043e\u043b\u0438\u043d\u0435\u0440\u0433\u0438\u0446\u0438<\/strong> \u2014 \u0434\u043e\u043f\u044a\u043b\u043d\u0438\u0442\u0435\u043b\u043d\u043e \u043d\u0430\u0442\u043e\u0432\u0430\u0440\u0432\u0430\u043d\u0435.<\/li>\n<\/ul>\n<h2>\u0411\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442, \u043a\u044a\u0440\u043c\u0435\u043d\u0435, \u043f\u0435\u0434\u0438\u0430\u0442\u0440\u0438\u0447\u043d\u0438<\/h2>\n<p>Pregnancy: limited data; weigh against untreated illness; late-pregnancy exposure can produce neonatal EPS or withdrawal. Breastfeeding: passes into milk; usually requires alternative or close monitoring. Paediatric: licensed from 13 (schizophrenia, bipolar).<\/p>\n<h2>\u0421\u044a\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435<\/h2>\n<p>\u0421\u044a\u0445\u0440\u0430\u043d\u044f\u0432\u0430\u0439\u0442\u0435 \u043f\u0440\u0438 15\u201330 \u00b0C \u0432 \u043e\u0440\u0438\u0433\u0438\u043d\u0430\u043b\u043d\u0430\u0442\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430.<\/p>\n<h2 id=\"faqs\">\u0427\u0435\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u043d\u0438 \u0432\u044a\u043f\u0440\u043e\u0441\u0438<\/h2>\n<h3>Why does Olanzoop cause so much weight gain?<\/h3>\n<p>Olanzapine&rsquo;s combined H1 antihistamine, 5-HT2C antagonism, and other receptor effects produce strong appetite stimulation, slowed satiety, and shifted carbohydrate preference. Weight gain is dose-related but real even at low doses. Counselling about diet and exercise from week 1, plus regular weight monitoring, is mandatory.<\/p>\n<h3>How is Olanzoop different from risperidone or aripiprazole?<\/h3>\n<p>Olanzapine has the strongest acute antipsychotic effect and the fastest calming action \u2014 useful in acute agitation. The trade-off is the heaviest metabolic burden. Risperidone is more efficacious for some positive symptoms but raises prolactin substantially. Aripiprazole is metabolically cleanest but produces more akathisia.<\/p>\n<h3>Should I monitor my blood sugar on Olanzoop?<\/h3>\n<p>Yes \u2014 fasting glucose or HbA1c at baseline, 12 weeks, and then 6-monthly. Olanzapine can produce diabetes within months of initiation, sometimes presenting with diabetic ketoacidosis. Don&rsquo;t skip the monitoring.<\/p>\n<h3>Can Olanzoop be used long-term?<\/h3>\n<p>Yes \u2014 particularly for schizophrenia maintenance where olanzapine often outperforms other atypicals on relapse rate. The metabolic burden is the main reason long-term use requires careful weight, glucose, and lipid monitoring, plus active management of cardiometabolic risk.<\/p>\n<h3>How long until Olanzoop works?<\/h3>\n<p>Calming effect within 1\u20132 hours of the first oral dose. Antipsychotic effect builds over 1\u20132 weeks; full antipsychotic and mood-stabilising effect at 4\u20136 weeks.<\/p>\n<h3>What about driving on Olanzoop?<\/h3>\n<p>Avoid driving in the first 1\u20132 weeks of titration. Most patients on stable doses drive normally, but the sedation can be persistent at higher doses.<\/p>\n<h3>Is the orodispersible form different?<\/h3>\n<p>Yes \u2014 orodispersible (ODT) versions of olanzapine exist (Zyprexa Zydis, Olimelt) and dissolve on the tongue without water. Bioequivalent to standard tablets but useful in adherence-uncertain or dysphagia patients.<\/p>\n<h3>Can Olanzoop be combined with fluoxetine?<\/h3>\n<p>Yes \u2014 the olanzapine-fluoxetine combination (OFC, Symbyax) is FDA-approved for treatment-resistant depression and bipolar depression. The fluoxetine partly addresses olanzapine&rsquo;s lack of antidepressant effect; olanzapine adds a strong mood-stabilising component.<\/p>\n<h3>Why does smoking matter?<\/h3>\n<p>Smoking strongly induces CYP1A2, which is olanzapine&rsquo;s main metabolic enzyme. Smokers metabolise olanzapine faster and need higher doses; abrupt cessation of smoking (e.g. hospital admission) can produce olanzapine toxicity if the dose isn&rsquo;t adjusted. Tell the prescriber if smoking status changes.<\/p>\n<h3>Can Olanzoop be stopped abruptly?<\/h3>\n<p>Generally not \u2014 taper over 2\u20134 weeks. Abrupt cessation can produce cholinergic rebound (nausea, sweating, insomnia) and an antipsychotic relapse. Never stop without prescriber agreement.<\/p>\n<h2>\u0414\u0440\u0443\u0433\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0437\u0430 \u043f\u0441\u0438\u0445\u0438\u0447\u043d\u043e \u0437\u0434\u0440\u0430\u0432\u0435<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/bg\/aripicon\/\">Aripicon (\u0410\u0440\u0438\u043f\u0438\u043f\u0440\u0430\u0437\u043e\u043b \u2014 \u0447\u0430\u0441\u0442\u0438\u0447\u0435\u043d \u0430\u0433\u043e\u043d\u0438\u0441\u0442 \u043d\u0430 D2 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0438)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/olanzap\/\">\u041e\u043b\u0430\u043d\u0437\u0430\u043f (\u041e\u043b\u0430\u043d\u0437\u0430\u043f\u0438\u043d \u2014 \u043c\u043e\u0449\u0435\u043d \u0430\u043d\u0442\u0438\u043f\u0441\u0438\u0445\u043e\u0442\u0438\u043a)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/risdone\/\">\u0420\u0438\u0437\u0434\u043e\u043d (\u0420\u0438\u0441\u043f\u0435\u0440\u0438\u0434\u043e\u043d)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/seroquit\/\">\u0421\u0435\u0440\u043e\u043a\u0432\u0438\u0442 (\u041a\u0432\u0435\u0442\u0438\u0430\u043f\u0438\u043d \u2014 \u0431\u0438\u043f\u043e\u043b\u044f\u0440\u043d\u0430 \u0434\u0435\u043f\u0440\u0435\u0441\u0438\u044f)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/atlura\/\">\u0410\u0442\u043b\u0443\u0440\u0430 (\u041b\u0443\u0440\u0430\u0437\u0438\u0434\u043e\u043d \u2014 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u043d\u043e \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u0435\u043d)<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:0.9em;\">\n<strong>\u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430 \u0434\u0435\u043a\u043b\u0430\u0440\u0430\u0446\u0438\u044f.<\/strong> \u0422\u0430\u0437\u0438 \u0441\u0442\u0440\u0430\u043d\u0438\u0446\u0430 \u0435 \u0441 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u0442\u0435\u043b\u043d\u0430 \u0446\u0435\u043b \u0438 \u043d\u0435 \u0437\u0430\u043c\u0435\u0441\u0442\u0432\u0430 \u0438\u043d\u0434\u0438\u0432\u0438\u0434\u0443\u0430\u043b\u043d\u0438\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438 \u0441\u044a\u0432\u0435\u0442. \u0424\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f\u0442\u0430 \u043d\u0430 \u043f\u0441\u0438\u0445\u0438\u0447\u043d\u043e\u0442\u043e \u0437\u0434\u0440\u0430\u0432\u0435 \u0442\u0440\u044f\u0431\u0432\u0430 \u0434\u0430 \u0441\u0435 \u0438\u043d\u0438\u0446\u0438\u0438\u0440\u0430, \u0441\u043b\u0435\u0434\u0438 \u0438 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430 \u043e\u0442 \u043a\u0432\u0430\u043b\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u043a\u043b\u0438\u043d\u0438\u0446\u0438\u0441\u0442. \u0410\u043a\u043e \u0432\u0438\u0435 \u0438\u043b\u0438 \u043d\u044f\u043a\u043e\u0439, \u043a\u043e\u0433\u043e\u0442\u043e \u043f\u043e\u0437\u043d\u0430\u0432\u0430\u0442\u0435, \u0435 \u0432 \u0441\u0443\u0438\u0446\u0438\u0434\u0430\u043b\u043d\u0430 \u043a\u0440\u0438\u0437\u0430, \u0441\u0432\u044a\u0440\u0436\u0435\u0442\u0435 \u0441\u0435 \u043d\u0435\u0437\u0430\u0431\u0430\u0432\u043d\u043e \u0441 \u043c\u0435\u0441\u0442\u043d\u0438\u0442\u0435 \u0441\u043f\u0435\u0448\u043d\u0438 \u0441\u043b\u0443\u0436\u0431\u0438 \u0438\u043b\u0438 \u0441\u0435 \u043e\u0431\u0430\u0434\u0435\u0442\u0435 \u043d\u0430 \u0442\u0435\u043b\u0435\u0444\u043e\u043d\u043d\u0430\u0442\u0430 \u043b\u0438\u043d\u0438\u044f \u0437\u0430 \u043f\u0440\u0435\u0432\u0435\u043d\u0446\u0438\u044f \u043d\u0430 \u0441\u0430\u043c\u043e\u0443\u0431\u0438\u0439\u0441\u0442\u0432\u0430 \u0432\u044a\u0432 \u0432\u0430\u0448\u0430\u0442\u0430 \u0434\u044a\u0440\u0436\u0430\u0432\u0430 (\u0421\u0410\u0429\/\u041a\u0430\u043d\u0430\u0434\u0430: 988; \u041e\u0431\u0435\u0434\u0438\u043d\u0435\u043d\u043e\u0442\u043e \u043a\u0440\u0430\u043b\u0441\u0442\u0432\u043e: Samaritans 116 123; \u043c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u0435\u043d \u0441\u043f\u0438\u0441\u044a\u043a: <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Olanzoop (Olanzapine 5\/10 mg) \u2014 thienobenzodiazepine atypical for schizophrenia and bipolar mania. mandatory weight, glucose and lipid monitoring.<\/p>","protected":false},"featured_media":58604,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4527,4528],"class_list":{"0":"post-58603","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-olanzapine","10":"product_tag-olanzoop","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product\/58603","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/comments?post=58603"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media\/58604"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media?parent=58603"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_brand?post=58603"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_cat?post=58603"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_tag?post=58603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}