<\/p>\n
Colospa<\/strong> \u0441\u044a\u0434\u044a\u0440\u0436\u0430 mebeverine hydrochloride<\/strong> (135 mg), a gut-selective musculotropic antispasmodic<\/strong> \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430 \u0441\u0435 \u0437\u0430 irritable bowel syndrome (IBS) and functional bowel disorders<\/strong> — abdominal cramps, pain, spasm, bloating, and altered bowel habit. Mebeverine works directly on the smooth muscle of the gut wall<\/strong>, relaxing spasm without blocking normal peristalsis — unlike anticholinergic antispasmodics (hyoscine, dicyclomine), mebeverine does \u043d\u0435<\/strong> cause dry mouth, urinary retention, blurred vision, or tachycardia. Standard dose: 135 mg three times daily, 20 minutes before meals. Onset 30–60 minutes; effect lasts 4–6 hours. Safe for long-term daily use. Effective for cramping\/pain; less useful for bloating or constipation-dominant symptoms. First-line pharmacological option for IBS pain in NICE and BSG guidelines.<\/p>\n<\/div>\n \ud83d\udce6 \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u043a\u0440\u0438\u0442\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 \u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/strong><\/a> \u2014 \u0430\u043a\u043e \u0432\u0430\u0448\u0430\u0442\u0430 \u043f\u0440\u0430\u0442\u043a\u0430 \u043d\u0435 \u043f\u0440\u0438\u0441\u0442\u0438\u0433\u043d\u0435 \u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 20 \u0440\u0430\u0431\u043e\u0442\u043d\u0438 \u0434\u043d\u0438, \u043d\u0438\u0435 \u044f \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043c\u0435 \u043e\u0442\u043d\u043e\u0432\u043e.<\/p>\n \u041d\u0430\u0448\u0438\u0442\u0435 \u0433\u0435\u043d\u0435\u0440\u0438\u0447\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0441\u0435 \u0434\u043e\u0441\u0442\u0430\u0432\u044f\u0442 \u043e\u0442 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b\u0438, \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d\u0438 \u043e\u0442 WHO-GMP, \u0438 \u0441\u0435 \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u0442 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442 \u0432 \u0434\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430, \u043e\u0431\u0438\u043a\u043d\u043e\u0432\u0435\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u2014 \u0431\u0435\u0437 \u0438\u043c\u0435 \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e\u0442\u043e \u0432\u044a\u043d\u0448\u043d\u043e \u043d\u0430 \u043f\u0440\u0430\u0442\u043a\u0430\u0442\u0430. \u041f\u043b\u0430\u0449\u0430\u043d\u0438\u044f\u0442\u0430 \u0441 \u043a\u0430\u0440\u0442\u0430 \u0441\u0435 \u043e\u0431\u0440\u0430\u0431\u043e\u0442\u0432\u0430\u0442 \u0447\u0440\u0435\u0437 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430\u043d \u043f\u0440\u043e\u0446\u0435\u0441\u043e\u0440 (\u043e\u043f\u0438\u0441\u0430\u043d\u0438\u0435\u0442\u043e \u043d\u0430 \u0438\u0437\u0432\u043b\u0435\u0447\u0435\u043d\u0438\u0435\u0442\u043e \u0432\u043a\u043b\u044e\u0447\u0432\u0430 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430\u043d \u043f\u0440\u043e\u0446\u0435\u0441\u043e\u0440 \u0437\u0430 \u043f\u043b\u0430\u0449\u0430\u043d\u0435 \u0441 \u043a\u0430\u0440\u0442\u0430 \u2014 \u043d\u0438\u043a\u043e\u0433\u0430 \u201cMedsBase\u201d \u0438\u043b\u0438 \u0438\u043c\u0435 \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e). \u041f\u0440\u0438\u0435\u043c\u0430\u0442 \u0441\u0435 \u0441\u044a\u0449\u043e \u043a\u0440\u0438\u043f\u0442\u043e\u0432\u0430\u043b\u0443\u0442\u0438 \u0438 \u0431\u0430\u043d\u043a\u043e\u0432 \u043f\u0440\u0435\u0432\u043e\u0434 SEPA. \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u0434\u043a\u0440\u0435\u043f\u0435\u043d\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 \u043f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u0433\u0430\u0440\u0430\u043d\u0442\u0438\u0440\u0430\u043d\u043e \u043f\u0440\u0435\u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043d\u0435.<\/p>\n Colospa is an oral antispasmodic containing mebeverine hydrochloride<\/strong> (135 mg), manufactured by Abbott India. Supplied in packs of 30, 60, 90 or 180 tablets. Originator brand: Colofac<\/strong> (Abbott \/ Mylan \/ Viatris). In clinical use since the 1960s and one of the most widely prescribed drugs for IBS globally.<\/p>\n Unlike older antispasmodics (hyoscine butylbromide, dicyclomine, propantheline) that work by blocking muscarinic acetylcholine receptors and cause dry mouth, blurred vision, urinary retention, and palpitations, mebeverine is a musculotropic antispasmodic<\/strong> — it acts directly on smooth muscle cells without engaging the autonomic nervous system. This means essentially no anticholinergic side effects at standard doses.<\/p>\n Mebeverine treats the spasm and pain<\/em> component of IBS. It does not address bloating, gas, constipation, or the psychological component — these may need additional strategies (peppermint oil, dietary FODMAP modification, psyllium, PEG laxatives, central modulators like low-dose amitriptyline).<\/p>\n The precise molecular mechanism of mebeverine is still debated, but the best-characterised actions include:<\/p>\n Mebeverine is highly metabolised on first-pass through the liver. Plasma concentrations of the parent drug are very low; activity is largely from the metabolite veratric acid<\/em> and direct smooth-muscle action during first intestinal passage.<\/p>\n \u0424\u0430\u0440\u043c\u0430\u043a\u043e\u043a\u0438\u043d\u0435\u0442\u0438\u043a\u0430:<\/strong> onset 30–60 minutes. Peak 1–3 hours. Duration of effect 4–6 hours. No meaningful accumulation; no dose adjustment needed for renal impairment.<\/p>\n Adults and children aged 10+:<\/strong> 135 mg three times daily, approximately 20 minutes before each main meal.<\/strong> Modified-release 200 mg capsules (twice daily) are available in some markets but are an alternative to the three-times-daily standard tablet.<\/p>\n Once symptoms are controlled, the dose may be reduced gradually or taken only as needed for flare-ups.<\/p>\n Mebeverine is one of the best-tolerated IBS medicines because it avoids anticholinergic effects.<\/p>\n \u0427\u0435\u0441\u0442\u0438:<\/strong><\/p>\n \u041d\u0435\u0447\u0435\u0441\u0442\u043e \u0441\u0440\u0435\u0449\u0430\u043d\u0438:<\/strong><\/p>\n Mebeverine does not cause drowsiness and does not impair driving.<\/p>\n Mebeverine has few clinically significant interactions. It is metabolised by esterases rather than CYP enzymes, so it is relatively interaction-free.<\/p>\n Store Colospa below 30°C in a dry place, in the original blister. Keep out of reach of children.<\/p>\n Yes — Colospa contains the same active ingredient (mebeverine hydrochloride) at the same strength as Colofac (Abbott \/ Viatris). Bioequivalence to the originator is required by regulatory authorities, so clinical effect is the same at the same dose.<\/p>\n Onset of smooth-muscle relaxation is 30–60 minutes after a dose; noticeable reduction in cramps usually within the first day or two. Full effect on symptom frequency often takes 1–2 weeks of regular dosing. If there is no improvement after 4 weeks at full dose, reconsider the diagnosis or add a second IBS strategy (dietary FODMAP, peppermint oil, central modulator).<\/p>\n No — mebeverine is not sedating and does not have anticholinergic effects at therapeutic doses. This is the main reason it is preferred over hyoscine or dicyclomine for long-term IBS management, especially in drivers, older adults, or patients on other medications.<\/p>\n Yes — long-term daily use of mebeverine is safe and commonly continued for months or years in chronic IBS. Many patients use it daily during symptomatic periods and pause when symptoms settle.<\/p>\n Yes — the combination is a sensible stacking strategy for IBS pain. Peppermint oil has a different mechanism (calcium-channel blockade in smooth muscle) and adds modest benefit. Take enteric-coated peppermint oil before meals, ideally at the same time as mebeverine.<\/p>\n Mebeverine’s strength is cramping and pain. It has little direct effect on bloating or constipation. For bloating, consider dietary FODMAP restriction and simethicone; for IBS-C (constipation-predominant), consider fibre modulation, PEG laxatives, or linaclotide.<\/p>\n Yes, moderate alcohol is fine with mebeverine. Be aware that alcohol is a common IBS trigger and may worsen symptoms independent of the medicine.<\/p>\n You can order Colospa (135 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide with discreet packaging and genuine WHO-GMP certified manufacturer stock.<\/p>\n <\/p>\n \u0414\u0440\u0443\u0433\u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0438 \u0432 \u0425\u0440\u043e\u043d\u0438\u0447\u043d\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f<\/strong> \u043a\u043e\u0438\u0442\u043e \u043a\u043b\u0438\u0435\u043d\u0442\u0438\u0442\u0435 \u0441\u044a\u0449\u043e \u0440\u0430\u0437\u0433\u043b\u0435\u0436\u0434\u0430\u0442:<\/p>\n \u2705 \u041e\u0431\u043b\u0435\u043a\u0447\u0430\u0432\u0430 \u043a\u043e\u0440\u0435\u043c\u043d\u0430\u0442\u0430 \u0431\u043e\u043b\u043a\u0430 Colospa contains Mebeverine.<\/p>","protected":false},"featured_media":58701,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3565],"product_tag":[4546,4547],"class_list":{"0":"post-58700","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-irritable-bowel-syndrome-ibs-treatment","9":"product_tag-colospa","10":"product_tag-mebeverine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product\/58700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/comments?post=58700"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media\/58701"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media?parent=58700"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_brand?post=58700"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_cat?post=58700"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_tag?post=58700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\u0417\u0430\u0449\u043e \u0434\u0430 \u043f\u043e\u0440\u044a\u0447\u0432\u0430\u0442\u0435 \u043e\u0442 MedsBase<\/h3>\n
What Is Colospa?<\/h2>\n
What Is Colospa Used For?<\/h2>\n
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How Does Colospa Work?<\/h2>\n
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\u0414\u043e\u0437\u0438\u0440\u0430\u043d\u0435 \u0438 \u043f\u0440\u0438\u043b\u0430\u0433\u0430\u043d\u0435<\/h2>\n
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\u0421\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438<\/h2>\n
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\u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u0438 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f<\/h2>\n
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Who Should Not Take Colospa?<\/h2>\n
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\u0421\u044a\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435<\/h2>\n
\u0427\u0435\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u043d\u0438 \u0432\u044a\u043f\u0440\u043e\u0441\u0438<\/h2>\n
Is Colospa the same as Colofac?<\/h3>\n
How long does it take Colospa to work?<\/h3>\n
Does Colospa cause drowsiness or dry mouth?<\/h3>\n
Can I take Colospa every day long-term?<\/h3>\n
Can I take Colospa with peppermint oil capsules?<\/h3>\n
Does Colospa help with bloating or constipation?<\/h3>\n
Can I drink alcohol while taking Colospa?<\/h3>\n
Where can I buy Colospa online?<\/h3>\n
\u0421\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0437\u0430 \u0421\u0420\u041a \u0438 \u0412\u0417\u0412<\/h2>\n
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\u0421\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u0430\u043b\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u0438<\/h3>\n
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\n\u2705 Treats irritable bowel syndrome
\n\u2705 Reduces gastrointestinal spasms
\n\u2705 Improves bowel movements
\n\u2705 Minimizes digestive discomfort<\/p>\n