{"id":59061,"date":"2024-02-28T05:40:05","date_gmt":"2024-02-28T05:40:05","guid":{"rendered":"https:\/\/medsname.com\/seroquit\/"},"modified":"2026-04-30T10:24:04","modified_gmt":"2026-04-30T10:24:04","slug":"seroquit","status":"publish","type":"product","link":"https:\/\/medsbase.com\/bg\/product\/seroquit\/","title":{"rendered":"Seroquit"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8d6;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u26a1 \u0411\u044a\u0440\u0437 \u043e\u0442\u0433\u043e\u0432\u043e\u0440<\/h3>\n<p style=\"margin-bottom:0;\">Seroquit (Quetiapine 25 \/ 50 \/ 100 \/ 200 \/ 300 mg, immediate-release) is an atypical antipsychotic for schizophrenia, bipolar mania, bipolar depression, MDD adjunct, and GAD adjunct. Strongly sedating and metabolically heavy \u2014 but uniquely effective for bipolar depression. Often misused as a &ldquo;sleeping pill&rdquo; \u2014 discouraged because of metabolic burden.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u041a\u0430\u043a\u0432\u043e \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u0442\u0435 \u0441 MedsBase:<\/strong> \u041f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b, \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u043e\u0442 WHO-GMP \u00b7 \u0414\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u00b7 \u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442 \u00b7 \u041d\u0430\u0434 1400 \u043f\u043e\u0442\u0432\u044a\u0440\u0434\u0435\u043d\u0438 <a href=\"https:\/\/medsbase.com\/bg\/reviews\/\">\u043e\u0442\u0437\u0438\u0432\u0430 \u043e\u0442 \u043a\u043b\u0438\u0435\u043d\u0442\u0438<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u043a\u0440\u0438\u0442\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 <a href=\"https:\/\/medsbase.com\/bg\/medsbase-re-shipment-assurance-policy\/\"><strong>\u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/strong><\/a> \u2014 \u0430\u043a\u043e \u0432\u0430\u0448\u0430\u0442\u0430 \u043f\u0440\u0430\u0442\u043a\u0430 \u043d\u0435 \u043f\u0440\u0438\u0441\u0442\u0438\u0433\u043d\u0435 \u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 20 \u0440\u0430\u0431\u043e\u0442\u043d\u0438 \u0434\u043d\u0438, \u043d\u0438\u0435 \u044f \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043c\u0435 \u043e\u0442\u043d\u043e\u0432\u043e.<\/p>\n<h3>\u0417\u0430\u0449\u043e \u0434\u0430 \u043f\u043e\u0440\u044a\u0447\u0432\u0430\u0442\u0435 \u043e\u0442 MedsBase<\/h3>\n<p>Seroquit at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our <a href=\"https:\/\/medsbase.com\/bg\/medsbase-re-shipment-assurance-policy\/\">\u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/a> \u2014 20-\u0440\u0430\u0431\u043e\u0442\u043d\u043e\u0434\u043d\u0435\u0432\u0435\u043d \u0441\u0440\u043e\u043a \u0437\u0430 \u0434\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u0438\u043b\u0438 \u0431\u0435\u0437\u043f\u043b\u0430\u0442\u043d\u043e \u043f\u0440\u0435\u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043d\u0435 \u2014 \u0438 \u0434\u0430\u0432\u0430 \u043f\u0440\u0430\u0432\u043e \u043d\u0430 \u0443\u0447\u0430\u0441\u0442\u0438\u0435 \u0432 \u043d\u0430\u0448\u0430\u0442\u0430 <a href=\"https:\/\/medsbase.com\/bg\/loyalty-points\/\">\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u0430 \u0437\u0430 \u043b\u043e\u044f\u043b\u043d\u043e\u0441\u0442<\/a>. \u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430\u0442\u0430 \u0435 \u043d\u0430\u043b\u0438\u0447\u043d\u0430 \u0432 \u043f\u043e\u0432\u0435\u0447\u0435\u0442\u043e \u0434\u044a\u0440\u0436\u0430\u0432\u0438 \u043f\u043e \u0441\u0432\u0435\u0442\u0430.<\/p>\n<h2>What Seroquit is and how it works<\/h2>\n<p>Seroquit is a quetiapine immediate-release tablet supplied by Cipla. Available strengths: <strong>25 \/ 50 \/ 100 \/ 200 \/ 300 mg<\/strong>. Quetiapine has loose D2 binding (rapid dissociation explains low EPS), strong 5-HT2A antagonism, very strong H1 antihistamine action (sedation, weight gain), \u03b11-adrenergic antagonism (orthostasis), and \u03b12 antagonism. Its active metabolite, norquetiapine, has noradrenaline transporter inhibition \u2014 the basis for the antidepressant effect in bipolar depression.<\/p>\n<p>IR is dosed BID or TID. The strong sedation peaks 1\u20132 hours after each dose.<\/p>\n<h2>\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f \u0438 \u0434\u043e\u0437\u0438\u0440\u0430\u043d\u0435<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u0435<\/th>\n<th>\u041d\u0430\u0447\u0430\u043b\u043d\u0430 \u0434\u043e\u0437\u0430<\/th>\n<th>\u0426\u0435\u043b\u0435\u0432\u0430 \u0434\u043e\u0437\u0430<\/th>\n<th>\u041c\u0430\u043a\u0441\u0438\u043c\u0430\u043b\u043d\u0430 \u0434\u043e\u0437\u0430<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Schizophrenia (IR)<\/td>\n<td>50 mg HS<\/td>\n<td>400\u2013800 mg\/\u0434\u0435\u043d<\/td>\n<td>800 mg<\/td>\n<\/tr>\n<tr>\n<td>Bipolar mania<\/td>\n<td>50 mg BID (IR) or 300 mg HS (SR)<\/td>\n<td>400\u2013800 mg\/\u0434\u0435\u043d<\/td>\n<td>800 mg<\/td>\n<\/tr>\n<tr>\n<td>Bipolar depression<\/td>\n<td>50 mg HS<\/td>\n<td>300 mg \u043f\u0440\u0435\u0434\u0438 \u0441\u044a\u043d<\/td>\n<td>600 mg<\/td>\n<\/tr>\n<tr>\n<td>MDD adjunct (SR)<\/td>\n<td>50 mg HS<\/td>\n<td>150\u2013300 mg HS<\/td>\n<td>300 mg<\/td>\n<\/tr>\n<tr>\n<td>GAD adjunct (off-label)<\/td>\n<td>50 mg HS<\/td>\n<td>50\u2013150 mg HS<\/td>\n<td>\u2014<\/td>\n<\/tr>\n<tr>\n<td>\u0412\u044a\u0437\u0440\u0430\u0441\u0442\u043d\u0438 \u0445\u043e\u0440\u0430<\/td>\n<td>25 mg HS<\/td>\n<td>50\u2013200 mg\/\u0434\u0435\u043d<\/td>\n<td>\u043f\u043e \u0442\u043e\u043b\u0435\u0440\u0430\u043d\u0442\u043d\u043e\u0441\u0442<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>\u0412\u0430\u0436\u043d\u0438 \u043c\u0435\u0440\u043a\u0438 \u0437\u0430 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>FDA \u0447\u0435\u0440\u043d\u0430 \u043a\u0443\u0442\u0438\u044f \u2014 \u0434\u0435\u043c\u0435\u043d\u0446\u0438\u044f-\u0441\u0432\u044a\u0440\u0437\u0430\u043d\u0430 \u043f\u0441\u0438\u0445\u043e\u0437\u0430<\/strong><\/p>\n<p style=\"margin-bottom:0;\">\u0412\u0441\u0438\u0447\u043a\u0438 \u0430\u0442\u0438\u043f\u0438\u0447\u043d\u0438 \u0430\u043d\u0442\u0438\u043f\u0441\u0438\u0445\u043e\u0442\u0438\u0446\u0438 \u043d\u043e\u0441\u044f\u0442 FDA \u0447\u0435\u0440\u043d\u043e\u043a\u0443\u0442\u0438\u0439\u043d\u043e \u043f\u0440\u0435\u0434\u0443\u043f\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u0437\u0430 \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u0430 \u0441\u043c\u044a\u0440\u0442\u043d\u043e\u0441\u0442 (\u043f\u0440\u0435\u0434\u0438\u043c\u043d\u043e \u0441\u044a\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u044a\u0434\u043e\u0432\u0430 \u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u0437\u043d\u0430) \u043f\u0440\u0438 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u0437\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u043d\u0430 \u043f\u043e\u0432\u0435\u0434\u0435\u043d\u0447\u0435\u0441\u043a\u0438 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u043f\u0440\u0438 \u0432\u044a\u0437\u0440\u0430\u0441\u0442\u043d\u0438 \u0441 \u0434\u0435\u043c\u0435\u043d\u0446\u0438\u044f. <strong>\u0410\u0442\u0438\u043f\u0438\u0447\u043d\u0438\u0442\u0435 \u0430\u043d\u0442\u0438\u043f\u0441\u0438\u0445\u043e\u0442\u0438\u0446\u0438 \u043d\u0435 \u0441\u0430 \u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0438 \u0437\u0430 \u0434\u0435\u043c\u0435\u043d\u0446\u0438\u044f-\u0441\u0432\u044a\u0440\u0437\u0430\u043d\u0430 \u043f\u0441\u0438\u0445\u043e\u0437\u0430 \u0438\u043b\u0438 \u0432\u044a\u0437\u0431\u0443\u0434\u0430.<\/strong>. \u0423\u043f\u043e\u0442\u0440\u0435\u0431\u0430\u0442\u0430 \u043f\u0440\u0438 \u0442\u0430\u0437\u0438 \u043f\u043e\u043f\u0443\u043b\u0430\u0446\u0438\u044f \u0435 \u0438\u0437\u0432\u044a\u043d \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u0442\u0430, \u043f\u043e\u0441\u043b\u0435\u0434\u043d\u0430 \u043c\u044f\u0440\u043a\u0430, \u043e\u0433\u0440\u0430\u043d\u0438\u0447\u0435\u043d\u0430 \u0432\u044a\u0432 \u0432\u0440\u0435\u043c\u0435\u0442\u043e \u0438 \u0438\u0437\u0438\u0441\u043a\u0432\u0430 \u0438\u0437\u0440\u0438\u0447\u0435\u043d \u0440\u0430\u0437\u0433\u043e\u0432\u043e\u0440 \u0437\u0430 \u0440\u0438\u0441\u043a\u043e\u0432\u0435 \u0438 \u043f\u043e\u043b\u0437\u0438.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>\u0422\u0435\u0436\u043a\u043e \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u043e \u043d\u0430\u0442\u043e\u0432\u0430\u0440\u0432\u0430\u043d\u0435<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Weight gain, insulin resistance, dyslipidaemia \u2014 second only to olanzapine and clozapine among atypicals. Mandatory monitoring at baseline, 12 weeks, then 6-monthly: weight, fasting glucose \/ HbA1c, fasting lipids, BP. Counsel about diet\/exercise from initiation.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>\u041e\u0440\u0442\u043e\u0441\u0442\u0430\u0442\u043d\u0430 \u0445\u0438\u043f\u043e\u0442\u0435\u043d\u0437\u0438\u044f<\/strong><\/p>\n<p style=\"margin-bottom:0;\">\u03b11 antagonism produces orthostatic hypotension, particularly in older adults and at initiation. Titrate slowly. Check sitting and standing BP at follow-up.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>&#8220;Off-label sleep aid&#8221; \u2014 discouraged<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Low-dose quetiapine (25\u201350 mg HS) is widely used off-label as a hypnotic. The metabolic burden is the same regardless of indication \u2014 patients on quetiapine for sleep gain weight and develop insulin resistance just as much as patients on quetiapine for psychosis. Dedicated hypnotics (Z-drugs, low-dose doxepin, melatonin agonists, behavioural sleep therapy) are usually safer choices for primary insomnia.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Suicidality (under-25, MDD adjunct use)<\/strong><\/p>\n<p style=\"margin-bottom:0;\">\u041f\u0440\u0438 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430\u043d\u0435 \u043a\u0430\u0442\u043e \u0434\u043e\u043f\u044a\u043b\u043d\u0435\u043d\u0438\u0435 \u043a\u044a\u043c \u0430\u043d\u0442\u0438\u0434\u0435\u043f\u0440\u0435\u0441\u0430\u043d\u0442\u0438\u0442\u0435, \u043f\u0440\u0435\u0434\u0443\u043f\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435\u0442\u043e \u0437\u0430 \u0441\u0443\u0438\u0446\u0438\u0434\u0430\u043b\u043d\u043e\u0441\u0442 \u043f\u0440\u0438 \u043b\u0438\u0446\u0430 \u043f\u043e\u0434 25 \u0433\u043e\u0434\u0438\u043d\u0438 \u0435 \u0432 \u0441\u0438\u043b\u0430.<\/p>\n<\/div>\n<h2>\u0427\u0435\u0441\u0442\u043e \u0441\u0440\u0435\u0449\u0430\u043d\u0438 \u0441\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438<\/h2>\n<ul>\n<li><strong>\u0421\u0435\u0434\u0430\u0446\u0438\u044f<\/strong> \u2014 universal; harness as bedtime benefit.<\/li>\n<li><strong>\u041d\u0430\u0442\u0440\u0443\u043f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0442\u0435\u0433\u043b\u043e \u0438 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u0435\u043d \u0441\u0438\u043d\u0434\u0440\u043e\u043c<\/strong> \u2014 \u0442\u0435\u0436\u043a\u043e.<\/li>\n<li><strong>\u041e\u0440\u0442\u043e\u0441\u0442\u0430\u0442\u0438\u0447\u043d\u0430 \u0445\u0438\u043f\u043e\u0442\u0435\u043d\u0437\u0438\u044f \u0438 \u0437\u0430\u043c\u0430\u044f\u043d\u043e\u0441\u0442<\/strong> \u2014 \u0447\u0435\u0441\u0442\u043e \u0432 \u043d\u0430\u0447\u0430\u043b\u043e\u0442\u043e.<\/li>\n<li><strong>Dry mouth, constipation<\/strong> \u2014 moderate anticholinergic effect.<\/li>\n<li><strong>\u0422\u0430\u0445\u0438\u043a\u0430\u0440\u0434\u0438\u044f<\/strong> \u2014 often noticed.<\/li>\n<li><strong>\u0415\u043a\u0441\u0442\u0440\u0430\u043f\u0438\u0440\u0430\u043c\u0438\u0434\u0430\u043b\u043d\u0438 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u0438 \/ \u0430\u043a\u0430\u0442\u0438\u0437\u0438\u044f<\/strong> \u2014 less common than risperidone or olanzapine.<\/li>\n<li><strong>\u041f\u0440\u043e\u043b\u0430\u043a\u0442\u0438\u043d<\/strong> \u2014 usually normal or low.<\/li>\n<li><strong>QT<\/strong> \u2014 modest dose-dependent prolongation.<\/li>\n<\/ul>\n<h2>\u0412\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f \u0441 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430<\/h2>\n<ul>\n<li><strong>\u0421\u0438\u043b\u043d\u0438 CYP3A4 \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440\u0438<\/strong> (azoles, clarithromycin, ritonavir, grapefruit juice) \u2014 raise quetiapine levels several-fold; reduce dose or avoid.<\/li>\n<li><strong>\u0421\u0438\u043b\u043d\u0438 CYP3A4 \u0438\u043d\u0434\u0443\u043a\u0442\u043e\u0440\u0438<\/strong> (rifampicin, carbamazepine, phenytoin, St John&rsquo;s wort) \u2014 reduce levels; may need higher doses or switch.<\/li>\n<li><strong>\u0414\u0440\u0443\u0433\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430, \u0443\u0434\u044a\u043b\u0436\u0430\u0432\u0430\u0449\u0438 QT \u0438\u043d\u0442\u0435\u0440\u0432\u0430\u043b\u0430<\/strong> \u2014 additive risk.<\/li>\n<li><strong>\u0414\u0435\u043f\u0440\u0435\u0441\u0430\u043d\u0442\u0438 \u043d\u0430 \u0426\u041d\u0421<\/strong> \u2014 strong additive sedation.<\/li>\n<li><strong>\u0410\u043d\u0442\u0438\u0445\u0438\u043f\u0435\u0440\u0442\u0435\u043d\u0437\u0438\u0432\u0438<\/strong> \u2014 additive orthostasis.<\/li>\n<\/ul>\n<h2>\u0411\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442, \u043a\u044a\u0440\u043c\u0435\u043d\u0435, \u043f\u0435\u0434\u0438\u0430\u0442\u0440\u0438\u0447\u043d\u0438<\/h2>\n<p>Pregnancy: limited data; late-pregnancy exposure can produce neonatal EPS. Breastfeeding: passes into milk in small amounts; usually compatible with monitoring. Paediatric: licensed from 13 (schizophrenia), 10 (bipolar mania).<\/p>\n<h2>\u0421\u044a\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435<\/h2>\n<p>\u0421\u044a\u0445\u0440\u0430\u043d\u044f\u0432\u0430\u0439\u0442\u0435 \u043f\u0440\u0438 15\u201330 \u00b0C \u0432 \u043e\u0440\u0438\u0433\u0438\u043d\u0430\u043b\u043d\u0430\u0442\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430.<\/p>\n<h2 id=\"faqs\">\u0427\u0435\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u043d\u0438 \u0432\u044a\u043f\u0440\u043e\u0441\u0438<\/h2>\n<h3>Why is Seroquit so sedating?<\/h3>\n<p>Strong H1 antihistamine action plus \u03b11-adrenergic blockade \u2014 this is the dominant pharmacology at low doses. The antipsychotic dopamine-D2 effect dominates only at higher doses. The clinical translation: 25\u2013100 mg is mostly a sleeping pill; 200\u2013400 mg starts to have antipsychotic effect; 600\u2013800 mg is the antipsychotic dose range.<\/p>\n<h3>Is using Seroquit for sleep a good idea?<\/h3>\n<p>Probably not. The metabolic burden of quetiapine is identical at 25 mg and at 800 mg \u2014 patients on low-dose quetiapine for insomnia gain weight, develop insulin resistance, and accumulate cardiometabolic risk just as much as patients on full antipsychotic doses. Z-drugs, low-dose doxepin, melatonin agonists, and CBT-I are usually safer for primary insomnia.<\/p>\n<h3>Why is Seroquit effective in bipolar depression?<\/h3>\n<p>The norquetiapine metabolite inhibits the noradrenaline transporter \u2014 adding an antidepressant component to the sedating-stabilising profile of the parent drug. Quetiapine and lurasidone are the two main atypicals with FDA approval for bipolar depression; quetiapine is more sedating, lurasidone is metabolically cleaner.<\/p>\n<h3>Will Seroquit make me gain weight?<\/h3>\n<p>Yes \u2014 typically 3\u20137 kg over 6 months, sometimes more. Dose-related but real at all doses. Plot weight at every visit and counsel about diet\/exercise from week 1.<\/p>\n<h3>How long until Seroquit works?<\/h3>\n<p>Sleep effect: same night. Mood\/anxiety effect: 1\u20132 weeks. Antipsychotic effect: 2\u20136 weeks at adequate dose. Bipolar depression effect: 2\u20136 weeks.<\/p>\n<h3>What is the difference between IR and SR quetiapine?<\/h3>\n<p>Both have the same molecule and the same active metabolite. SR\/XR delivers it more slowly, producing a flatter sedation peak \u2014 better for daytime function and easier once-daily dosing. IR has stronger immediate sedation, useful when bedtime sedation is desired.<\/p>\n<h3>Can Seroquit be stopped abruptly?<\/h3>\n<p>Taper over 2\u20134 weeks. Abrupt cessation can produce cholinergic rebound (nausea, sweating, insomnia) and antipsychotic relapse. Never stop without prescriber agreement.<\/p>\n<h3>What about driving on Seroquit?<\/h3>\n<p>Avoid driving for at least the first 1\u20132 weeks of any new dose. Many patients on stable bedtime doses drive normally during the day; some patients on higher daytime doses or split BID dosing remain too sedated to drive safely.<\/p>\n<h3>Can Seroquit be combined with an SSRI?<\/h3>\n<p>Yes \u2014 quetiapine SR is FDA-approved as an adjunct to SSRI\/SNRI in MDD at low doses (50\u2013300 mg HS). Sometimes used in treatment-resistant anxiety as well.<\/p>\n<h3>\u0417\u0430\u0449\u043e \u0434\u0430 \u0438\u0437\u0431\u044f\u0433\u0432\u0430\u043c\u0435 \u0433\u0440\u0435\u0439\u043f\u0444\u0440\u0443\u0442\u043e\u0432 \u0441\u043e\u043a?<\/h3>\n<p>Grapefruit juice strongly inhibits intestinal CYP3A4. Quetiapine is a CYP3A4 substrate; grapefruit raises levels markedly, increasing sedation, orthostasis, and metabolic burden. Avoid grapefruit and grapefruit juice during Seroquit therapy.<\/p>\n<h2>\u0414\u0440\u0443\u0433\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0437\u0430 \u043f\u0441\u0438\u0445\u0438\u0447\u043d\u043e \u0437\u0434\u0440\u0430\u0432\u0435<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/bg\/aripicon\/\">Aripicon (\u0410\u0440\u0438\u043f\u0438\u043f\u0440\u0430\u0437\u043e\u043b \u2014 \u0447\u0430\u0441\u0442\u0438\u0447\u0435\u043d \u0430\u0433\u043e\u043d\u0438\u0441\u0442 \u043d\u0430 D2 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0438)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/olanzap\/\">\u041e\u043b\u0430\u043d\u0437\u0430\u043f (\u041e\u043b\u0430\u043d\u0437\u0430\u043f\u0438\u043d \u2014 \u043c\u043e\u0449\u0435\u043d \u0430\u043d\u0442\u0438\u043f\u0441\u0438\u0445\u043e\u0442\u0438\u043a)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/risdone\/\">\u0420\u0438\u0437\u0434\u043e\u043d (\u0420\u0438\u0441\u043f\u0435\u0440\u0438\u0434\u043e\u043d)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/seroquit\/\">\u0421\u0435\u0440\u043e\u043a\u0432\u0438\u0442 (\u041a\u0432\u0435\u0442\u0438\u0430\u043f\u0438\u043d \u2014 \u0431\u0438\u043f\u043e\u043b\u044f\u0440\u043d\u0430 \u0434\u0435\u043f\u0440\u0435\u0441\u0438\u044f)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/atlura\/\">\u0410\u0442\u043b\u0443\u0440\u0430 (\u041b\u0443\u0440\u0430\u0437\u0438\u0434\u043e\u043d \u2014 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u043d\u043e \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u0435\u043d)<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:0.9em;\">\n<strong>\u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430 \u0434\u0435\u043a\u043b\u0430\u0440\u0430\u0446\u0438\u044f.<\/strong> \u0422\u0430\u0437\u0438 \u0441\u0442\u0440\u0430\u043d\u0438\u0446\u0430 \u0435 \u0441 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u0442\u0435\u043b\u043d\u0430 \u0446\u0435\u043b \u0438 \u043d\u0435 \u0437\u0430\u043c\u0435\u0441\u0442\u0432\u0430 \u0438\u043d\u0434\u0438\u0432\u0438\u0434\u0443\u0430\u043b\u043d\u0438\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438 \u0441\u044a\u0432\u0435\u0442. \u0424\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f\u0442\u0430 \u043d\u0430 \u043f\u0441\u0438\u0445\u0438\u0447\u043d\u043e\u0442\u043e \u0437\u0434\u0440\u0430\u0432\u0435 \u0442\u0440\u044f\u0431\u0432\u0430 \u0434\u0430 \u0441\u0435 \u0438\u043d\u0438\u0446\u0438\u0438\u0440\u0430, \u0441\u043b\u0435\u0434\u0438 \u0438 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430 \u043e\u0442 \u043a\u0432\u0430\u043b\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u043a\u043b\u0438\u043d\u0438\u0446\u0438\u0441\u0442. \u0410\u043a\u043e \u0432\u0438\u0435 \u0438\u043b\u0438 \u043d\u044f\u043a\u043e\u0439, \u043a\u043e\u0433\u043e\u0442\u043e \u043f\u043e\u0437\u043d\u0430\u0432\u0430\u0442\u0435, \u0435 \u0432 \u0441\u0443\u0438\u0446\u0438\u0434\u0430\u043b\u043d\u0430 \u043a\u0440\u0438\u0437\u0430, \u0441\u0432\u044a\u0440\u0436\u0435\u0442\u0435 \u0441\u0435 \u043d\u0435\u0437\u0430\u0431\u0430\u0432\u043d\u043e \u0441 \u043c\u0435\u0441\u0442\u043d\u0438\u0442\u0435 \u0441\u043f\u0435\u0448\u043d\u0438 \u0441\u043b\u0443\u0436\u0431\u0438 \u0438\u043b\u0438 \u0441\u0435 \u043e\u0431\u0430\u0434\u0435\u0442\u0435 \u043d\u0430 \u0442\u0435\u043b\u0435\u0444\u043e\u043d\u043d\u0430\u0442\u0430 \u043b\u0438\u043d\u0438\u044f \u0437\u0430 \u043f\u0440\u0435\u0432\u0435\u043d\u0446\u0438\u044f \u043d\u0430 \u0441\u0430\u043c\u043e\u0443\u0431\u0438\u0439\u0441\u0442\u0432\u0430 \u0432\u044a\u0432 \u0432\u0430\u0448\u0430\u0442\u0430 \u0434\u044a\u0440\u0436\u0430\u0432\u0430 (\u0421\u0410\u0429\/\u041a\u0430\u043d\u0430\u0434\u0430: 988; \u041e\u0431\u0435\u0434\u0438\u043d\u0435\u043d\u043e\u0442\u043e \u043a\u0440\u0430\u043b\u0441\u0442\u0432\u043e: Samaritans 116 123; \u043c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u0435\u043d \u0441\u043f\u0438\u0441\u044a\u043a: <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Seroquit (Quetiapine 25\u2013300 mg) \u2014 IR atypical antipsychotic for schizophrenia, bipolar mania, bipolar depression, MDD adjunct. dose-dependent receptor profile across 25\u2013800 mg range.<\/p>","protected":false},"featured_media":59062,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4619,4621],"class_list":{"0":"post-59061","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-quetiapine","10":"product_tag-seroquit","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product\/59061","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/comments?post=59061"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media\/59062"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media?parent=59061"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_brand?post=59061"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_cat?post=59061"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_tag?post=59061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}