{"id":59954,"date":"2024-02-28T06:25:37","date_gmt":"2024-02-28T06:25:37","guid":{"rendered":"https:\/\/medsname.com\/palip-xr\/"},"modified":"2026-04-30T10:23:52","modified_gmt":"2026-04-30T10:23:52","slug":"palip-xr","status":"publish","type":"product","link":"https:\/\/medsbase.com\/bg\/product\/palip-xr\/","title":{"rendered":"Palip XR"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8d6;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u26a1 \u0411\u044a\u0440\u0437 \u043e\u0442\u0433\u043e\u0432\u043e\u0440<\/h3>\n<p style=\"margin-bottom:0;\">Palip XR (Paliperidone 3 \/ 6 \/ 9 mg XR, extended-release) is an atypical antipsychotic for schizophrenia and schizoaffective disorder. Active metabolite of risperidone, dosed once daily via OROS osmotic-pump tablet. Largely renally cleared \u2014 dose-adjust in renal impairment.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u041a\u0430\u043a\u0432\u043e \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u0442\u0435 \u0441 MedsBase:<\/strong> \u041f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b, \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u043e\u0442 WHO-GMP \u00b7 \u0414\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u00b7 \u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442 \u00b7 \u041d\u0430\u0434 1400 \u043f\u043e\u0442\u0432\u044a\u0440\u0434\u0435\u043d\u0438 <a href=\"https:\/\/medsbase.com\/bg\/reviews\/\">\u043e\u0442\u0437\u0438\u0432\u0430 \u043e\u0442 \u043a\u043b\u0438\u0435\u043d\u0442\u0438<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u043a\u0440\u0438\u0442\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 <a href=\"https:\/\/medsbase.com\/bg\/medsbase-re-shipment-assurance-policy\/\"><strong>\u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/strong><\/a> \u2014 \u0430\u043a\u043e \u0432\u0430\u0448\u0430\u0442\u0430 \u043f\u0440\u0430\u0442\u043a\u0430 \u043d\u0435 \u043f\u0440\u0438\u0441\u0442\u0438\u0433\u043d\u0435 \u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 20 \u0440\u0430\u0431\u043e\u0442\u043d\u0438 \u0434\u043d\u0438, \u043d\u0438\u0435 \u044f \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043c\u0435 \u043e\u0442\u043d\u043e\u0432\u043e.<\/p>\n<h3>\u0417\u0430\u0449\u043e \u0434\u0430 \u043f\u043e\u0440\u044a\u0447\u0432\u0430\u0442\u0435 \u043e\u0442 MedsBase<\/h3>\n<p>Palip XR at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our <a href=\"https:\/\/medsbase.com\/bg\/medsbase-re-shipment-assurance-policy\/\">\u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/a> \u2014 20-\u0440\u0430\u0431\u043e\u0442\u043d\u043e\u0434\u043d\u0435\u0432\u0435\u043d \u0441\u0440\u043e\u043a \u0437\u0430 \u0434\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u0438\u043b\u0438 \u0431\u0435\u0437\u043f\u043b\u0430\u0442\u043d\u043e \u043f\u0440\u0435\u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043d\u0435 \u2014 \u0438 \u0434\u0430\u0432\u0430 \u043f\u0440\u0430\u0432\u043e \u043d\u0430 \u0443\u0447\u0430\u0441\u0442\u0438\u0435 \u0432 \u043d\u0430\u0448\u0430\u0442\u0430 <a href=\"https:\/\/medsbase.com\/bg\/loyalty-points\/\">\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u0430 \u0437\u0430 \u043b\u043e\u044f\u043b\u043d\u043e\u0441\u0442<\/a>. \u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430\u0442\u0430 \u0435 \u043d\u0430\u043b\u0438\u0447\u043d\u0430 \u0432 \u043f\u043e\u0432\u0435\u0447\u0435\u0442\u043e \u0434\u044a\u0440\u0436\u0430\u0432\u0438 \u043f\u043e \u0441\u0432\u0435\u0442\u0430.<\/p>\n<h2>What Palip XR is and how it works<\/h2>\n<p>Palip XR is a paliperidone extended-release tablet supplied by Sun Pharma. Available strengths: <strong>3 \/ 6 \/ 9 mg XR<\/strong>. Paliperidone is the major active metabolite of risperidone (9-hydroxyrisperidone). Pharmacologically very similar \u2014 strong D2 and 5-HT2A antagonism, prolactin elevation, EPS at higher doses \u2014 but with two practical differences: (1) the OROS extended-release formulation produces a flat 24-hour plasma curve (smoother tolerability than risperidone IR), and (2) paliperidone is largely renally cleared (75%) rather than hepatically metabolised, so it is unaffected by CYP-altering drugs but requires dose adjustment in renal impairment.<\/p>\n<h2>\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f \u0438 \u0434\u043e\u0437\u0438\u0440\u0430\u043d\u0435<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u0435<\/th>\n<th>\u041d\u0430\u0447\u0430\u043b\u043d\u0430 \u0434\u043e\u0437\u0430<\/th>\n<th>\u0426\u0435\u043b\u0435\u0432\u0430 \u0434\u043e\u0437\u0430<\/th>\n<th>\u041c\u0430\u043a\u0441\u0438\u043c\u0430\u043b\u043d\u0430 \u0434\u043e\u0437\u0430<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u0428\u0438\u0437\u043e\u0444\u0440\u0435\u043d\u0438\u044f (\u0432\u044a\u0437\u0440\u0430\u0441\u0442\u043d\u0438)<\/td>\n<td>6 mg OD morning<\/td>\n<td>3\u201312 mg OD<\/td>\n<td>12 mg<\/td>\n<\/tr>\n<tr>\n<td>Schizophrenia (adolescent \u2265 12 y, \u2265 51 kg)<\/td>\n<td>3 mg OD<\/td>\n<td>3\u201312 mg OD<\/td>\n<td>12 mg<\/td>\n<\/tr>\n<tr>\n<td>Schizoaffective disorder<\/td>\n<td>6 mg OD<\/td>\n<td>3\u201312 mg OD<\/td>\n<td>12 mg<\/td>\n<\/tr>\n<tr>\n<td>Renal impairment (CrCl 50\u201380)<\/td>\n<td>3 mg OD<\/td>\n<td>up to 6 mg<\/td>\n<td>6 mg<\/td>\n<\/tr>\n<tr>\n<td>Renal impairment (CrCl 10\u201350)<\/td>\n<td>1.5 mg OD<\/td>\n<td>up to 3 mg<\/td>\n<td>3 mg<\/td>\n<\/tr>\n<tr>\n<td>\u0411\u044a\u0431\u0440\u0435\u0447\u043d\u0430 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u044a\u0447\u043d\u043e\u0441\u0442 (CrCl &lt; 10)<\/td>\n<td>\u043d\u0435 \u0441\u0435 \u043f\u0440\u0435\u043f\u043e\u0440\u044a\u0447\u0432\u0430<\/td>\n<td>\u2014<\/td>\n<td>\u2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Take whole \u2014 do not crush, chew, or split. The OROS osmotic pump shell will pass intact in stool \u2014 this is normal and expected.<\/p>\n<h2>\u0412\u0430\u0436\u043d\u0438 \u043c\u0435\u0440\u043a\u0438 \u0437\u0430 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>FDA \u0447\u0435\u0440\u043d\u0430 \u043a\u0443\u0442\u0438\u044f \u2014 \u0434\u0435\u043c\u0435\u043d\u0446\u0438\u044f-\u0441\u0432\u044a\u0440\u0437\u0430\u043d\u0430 \u043f\u0441\u0438\u0445\u043e\u0437\u0430<\/strong><\/p>\n<p style=\"margin-bottom:0;\">\u0412\u0441\u0438\u0447\u043a\u0438 \u0430\u0442\u0438\u043f\u0438\u0447\u043d\u0438 \u0430\u043d\u0442\u0438\u043f\u0441\u0438\u0445\u043e\u0442\u0438\u0446\u0438 \u043d\u043e\u0441\u044f\u0442 FDA \u0447\u0435\u0440\u043d\u043e\u043a\u0443\u0442\u0438\u0439\u043d\u043e \u043f\u0440\u0435\u0434\u0443\u043f\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u0437\u0430 \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u0430 \u0441\u043c\u044a\u0440\u0442\u043d\u043e\u0441\u0442 (\u043f\u0440\u0435\u0434\u0438\u043c\u043d\u043e \u0441\u044a\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u044a\u0434\u043e\u0432\u0430 \u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u0437\u043d\u0430) \u043f\u0440\u0438 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u0437\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u043d\u0430 \u043f\u043e\u0432\u0435\u0434\u0435\u043d\u0447\u0435\u0441\u043a\u0438 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u043f\u0440\u0438 \u0432\u044a\u0437\u0440\u0430\u0441\u0442\u043d\u0438 \u0441 \u0434\u0435\u043c\u0435\u043d\u0446\u0438\u044f. <strong>\u0410\u0442\u0438\u043f\u0438\u0447\u043d\u0438\u0442\u0435 \u0430\u043d\u0442\u0438\u043f\u0441\u0438\u0445\u043e\u0442\u0438\u0446\u0438 \u043d\u0435 \u0441\u0430 \u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0438 \u0437\u0430 \u0434\u0435\u043c\u0435\u043d\u0446\u0438\u044f-\u0441\u0432\u044a\u0440\u0437\u0430\u043d\u0430 \u043f\u0441\u0438\u0445\u043e\u0437\u0430 \u0438\u043b\u0438 \u0432\u044a\u0437\u0431\u0443\u0434\u0430.<\/strong>. \u0423\u043f\u043e\u0442\u0440\u0435\u0431\u0430\u0442\u0430 \u043f\u0440\u0438 \u0442\u0430\u0437\u0438 \u043f\u043e\u043f\u0443\u043b\u0430\u0446\u0438\u044f \u0435 \u0438\u0437\u0432\u044a\u043d \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u0442\u0430, \u043f\u043e\u0441\u043b\u0435\u0434\u043d\u0430 \u043c\u044f\u0440\u043a\u0430, \u043e\u0433\u0440\u0430\u043d\u0438\u0447\u0435\u043d\u0430 \u0432\u044a\u0432 \u0432\u0440\u0435\u043c\u0435\u0442\u043e \u0438 \u0438\u0437\u0438\u0441\u043a\u0432\u0430 \u0438\u0437\u0440\u0438\u0447\u0435\u043d \u0440\u0430\u0437\u0433\u043e\u0432\u043e\u0440 \u0437\u0430 \u0440\u0438\u0441\u043a\u043e\u0432\u0435 \u0438 \u043f\u043e\u043b\u0437\u0438.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Hyperprolactinaemia (similar to risperidone)<\/strong><\/p>\n<p style=\"margin-bottom:0;\">As an active risperidone metabolite, paliperidone produces the same prolactin elevation: amenorrhoea, galactorrhoea, sexual dysfunction, and long-term bone-density loss. Monitor as for risperidone; switch to a prolactin-sparing atypical (aripiprazole, quetiapine) if symptomatic.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>EPS \/ dose-dependent<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Above 6 mg\/day, EPS and akathisia rise in frequency. Dose-dependent.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>GI obstruction caveat<\/strong><\/p>\n<p style=\"margin-bottom:0;\">The non-deformable OROS tablet is theoretically problematic in pre-existing severe GI narrowing (severe Crohn&rsquo;s strictures, oesophageal stricture, prior bowel resection). Rare clinically, but worth noting.<\/p>\n<\/div>\n<h2>\u0427\u0435\u0441\u0442\u043e \u0441\u0440\u0435\u0449\u0430\u043d\u0438 \u0441\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438<\/h2>\n<ul>\n<li><strong>\u0425\u0438\u043f\u0435\u0440\u043f\u0440\u043e\u043b\u0430\u043a\u0442\u0438\u043d\u0435\u043c\u0438\u044f \u0438 \u043f\u043e\u0441\u043b\u0435\u0434\u0432\u0430\u0449\u0438 \u0435\u0444\u0435\u043a\u0442\u0438<\/strong> \u2014 same profile as risperidone.<\/li>\n<li><strong>Akathisia, EPS<\/strong> \u2014 \u0437\u0430\u0432\u0438\u0441\u0438\u043c\u0438 \u043e\u0442 \u0434\u043e\u0437\u0430\u0442\u0430.<\/li>\n<li><strong>Somnolence, sedation<\/strong> \u2014 \u0443\u043c\u0435\u0440\u0435\u043d\u043e.<\/li>\n<li><strong>\u041d\u0430\u043f\u044a\u043b\u043d\u044f\u0432\u0430\u043d\u0435<\/strong> \u2014 moderate (2\u20134 kg \/ 6 months).<\/li>\n<li><strong>\u041e\u0440\u0442\u043e\u0441\u0442\u0430\u0442\u043d\u0430 \u0445\u0438\u043f\u043e\u0442\u0435\u043d\u0437\u0438\u044f<\/strong> \u2014 \u0447\u0435\u0441\u0442\u043e \u0432 \u043d\u0430\u0447\u0430\u043b\u043e\u0442\u043e.<\/li>\n<li><strong>\u0423\u0434\u044a\u043b\u0436\u0430\u0432\u0430\u043d\u0435 \u043d\u0430 QT \u0438\u043d\u0442\u0435\u0440\u0432\u0430\u043b\u0430<\/strong> \u2014 modest dose-dependent.<\/li>\n<\/ul>\n<h2>\u0412\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f \u0441 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430<\/h2>\n<ul>\n<li><strong>Less affected by CYP inhibitors\/inducers<\/strong> than risperidone (75% renal clearance).<\/li>\n<li><strong>\u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430, \u0443\u0434\u044a\u043b\u0436\u0430\u0432\u0430\u0449\u0438 QT \u0438\u043d\u0442\u0435\u0440\u0432\u0430\u043b\u0430<\/strong> \u2014 additive risk.<\/li>\n<li><strong>Antihypertensives, CNS depressants, anticholinergics<\/strong> \u2014 additive class effects.<\/li>\n<li><strong>\u0421\u0438\u043b\u043d\u0438 \u0438\u043d\u0434\u0443\u0446\u0438\u0440\u0430\u0449\u0438 \u0432\u0435\u0449\u0435\u0441\u0442\u0432\u0430 \u043d\u0430 CYP3A4 + P-gp<\/strong> (carbamazepine, rifampicin, phenytoin) \u2014 meaningful reduction in paliperidone levels.<\/li>\n<\/ul>\n<h2>\u0411\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442, \u043a\u044a\u0440\u043c\u0435\u043d\u0435, \u043f\u0435\u0434\u0438\u0430\u0442\u0440\u0438\u0447\u043d\u0438<\/h2>\n<p>Pregnancy: limited data; late-pregnancy exposure can produce neonatal EPS. Breastfeeding: passes into milk; usually requires monitoring. Paediatric: licensed from 12 (schizophrenia, \u2265 51 kg).<\/p>\n<h2>\u0421\u044a\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435<\/h2>\n<p>\u0421\u044a\u0445\u0440\u0430\u043d\u044f\u0432\u0430\u0439\u0442\u0435 \u043f\u0440\u0438 15\u201330 \u00b0C \u0432 \u043e\u0440\u0438\u0433\u0438\u043d\u0430\u043b\u043d\u0430\u0442\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430.<\/p>\n<h2 id=\"faqs\">\u0427\u0435\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u043d\u0438 \u0432\u044a\u043f\u0440\u043e\u0441\u0438<\/h2>\n<h3>How is Palip XR different from risperidone?<\/h3>\n<p>Paliperidone is risperidone&rsquo;s major active metabolite \u2014 they are pharmacologically similar. The two practical differences: (1) once-daily OROS dosing produces flatter plasma levels and smoother tolerability than BID risperidone IR; (2) paliperidone is largely renally cleared, so it is unaffected by CYP-interacting drugs but requires renal dose adjustment.<\/p>\n<h3>Why does the empty tablet shell appear in my stool?<\/h3>\n<p>The OROS (osmotic-controlled-release oral delivery system) tablet is a non-deformable shell containing the drug in a semipermeable membrane. Water enters slowly, pushing drug out through a laser-drilled pore. The empty shell passes intact \u2014 this is the design, not a problem. Do not stop the medication because of this.<\/p>\n<h3>Is the once-daily LAI different from the oral tablet?<\/h3>\n<p>Paliperidone palmitate (Invega Sustenna monthly, Trinza three-monthly, Hafyera six-monthly) is the depot injectable LAI. The oral tablet is for initiation, titration, and patients who prefer oral therapy. The LAI is a separate product with separate dosing.<\/p>\n<h3>Will Palip XR affect my fertility?<\/h3>\n<p>Paliperidone&rsquo;s prolactin elevation can suppress fertility in both men and women. Most effects are reversible on discontinuation. If pregnancy is desired, discuss switching to aripiprazole or quetiapine.<\/p>\n<h3>How long until Palip XR works?<\/h3>\n<p>Acute effect on agitation within days. Antipsychotic effect on positive symptoms 1\u20132 weeks; full effect at 4\u20136 weeks.<\/p>\n<h3>\u041c\u043e\u0433\u0430 \u043b\u0438 \u0434\u0430 \u0440\u0430\u0437\u0434\u0435\u043b\u044f \u0438\u043b\u0438 \u0441\u0447\u0443\u043f\u044f \u0442\u0430\u0431\u043b\u0435\u0442\u043a\u0430\u0442\u0430?<\/h3>\n<p>No \u2014 never. The OROS osmotic-pump formulation depends on the tablet remaining intact. Crushing or splitting destroys the controlled release and produces an immediate-release dose-dump.<\/p>\n<h3>What about driving on Palip XR?<\/h3>\n<p>Sedation is moderate and concentrated in the first 1\u20132 weeks. Most patients on stable doses drive normally. Avoid alcohol when driving.<\/p>\n<h3>Will Palip XR make me gain weight?<\/h3>\n<p>Yes \u2014 typically 2\u20134 kg over 6 months. Less than olanzapine or quetiapine; similar to risperidone.<\/p>\n<h3>Can Palip XR be stopped abruptly?<\/h3>\n<p>Taper over 2\u20134 weeks. Relapse risk in schizophrenia and schizoaffective disorder is the main concern.<\/p>\n<h3>Why is Palip XR better in liver disease than risperidone?<\/h3>\n<p>Paliperidone is largely renally cleared (75%) rather than hepatically metabolised \u2014 so it is less affected by hepatic impairment and by CYP-interacting drugs. The trade-off: it requires renal dose adjustment, where risperidone does not.<\/p>\n<h2>\u0414\u0440\u0443\u0433\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0437\u0430 \u043f\u0441\u0438\u0445\u0438\u0447\u043d\u043e \u0437\u0434\u0440\u0430\u0432\u0435<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/bg\/aripicon\/\">Aripicon (\u0410\u0440\u0438\u043f\u0438\u043f\u0440\u0430\u0437\u043e\u043b \u2014 \u0447\u0430\u0441\u0442\u0438\u0447\u0435\u043d \u0430\u0433\u043e\u043d\u0438\u0441\u0442 \u043d\u0430 D2 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0438)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/olanzap\/\">\u041e\u043b\u0430\u043d\u0437\u0430\u043f (\u041e\u043b\u0430\u043d\u0437\u0430\u043f\u0438\u043d \u2014 \u043c\u043e\u0449\u0435\u043d \u0430\u043d\u0442\u0438\u043f\u0441\u0438\u0445\u043e\u0442\u0438\u043a)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/risdone\/\">\u0420\u0438\u0437\u0434\u043e\u043d (\u0420\u0438\u0441\u043f\u0435\u0440\u0438\u0434\u043e\u043d)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/seroquit\/\">\u0421\u0435\u0440\u043e\u043a\u0432\u0438\u0442 (\u041a\u0432\u0435\u0442\u0438\u0430\u043f\u0438\u043d \u2014 \u0431\u0438\u043f\u043e\u043b\u044f\u0440\u043d\u0430 \u0434\u0435\u043f\u0440\u0435\u0441\u0438\u044f)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/atlura\/\">\u0410\u0442\u043b\u0443\u0440\u0430 (\u041b\u0443\u0440\u0430\u0437\u0438\u0434\u043e\u043d \u2014 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u043d\u043e \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u0435\u043d)<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:0.9em;\">\n<strong>\u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430 \u0434\u0435\u043a\u043b\u0430\u0440\u0430\u0446\u0438\u044f.<\/strong> \u0422\u0430\u0437\u0438 \u0441\u0442\u0440\u0430\u043d\u0438\u0446\u0430 \u0435 \u0441 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u0442\u0435\u043b\u043d\u0430 \u0446\u0435\u043b \u0438 \u043d\u0435 \u0437\u0430\u043c\u0435\u0441\u0442\u0432\u0430 \u0438\u043d\u0434\u0438\u0432\u0438\u0434\u0443\u0430\u043b\u043d\u0438\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438 \u0441\u044a\u0432\u0435\u0442. \u0424\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f\u0442\u0430 \u043d\u0430 \u043f\u0441\u0438\u0445\u0438\u0447\u043d\u043e\u0442\u043e \u0437\u0434\u0440\u0430\u0432\u0435 \u0442\u0440\u044f\u0431\u0432\u0430 \u0434\u0430 \u0441\u0435 \u0438\u043d\u0438\u0446\u0438\u0438\u0440\u0430, \u0441\u043b\u0435\u0434\u0438 \u0438 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430 \u043e\u0442 \u043a\u0432\u0430\u043b\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u043a\u043b\u0438\u043d\u0438\u0446\u0438\u0441\u0442. \u0410\u043a\u043e \u0432\u0438\u0435 \u0438\u043b\u0438 \u043d\u044f\u043a\u043e\u0439, \u043a\u043e\u0433\u043e\u0442\u043e \u043f\u043e\u0437\u043d\u0430\u0432\u0430\u0442\u0435, \u0435 \u0432 \u0441\u0443\u0438\u0446\u0438\u0434\u0430\u043b\u043d\u0430 \u043a\u0440\u0438\u0437\u0430, \u0441\u0432\u044a\u0440\u0436\u0435\u0442\u0435 \u0441\u0435 \u043d\u0435\u0437\u0430\u0431\u0430\u0432\u043d\u043e \u0441 \u043c\u0435\u0441\u0442\u043d\u0438\u0442\u0435 \u0441\u043f\u0435\u0448\u043d\u0438 \u0441\u043b\u0443\u0436\u0431\u0438 \u0438\u043b\u0438 \u0441\u0435 \u043e\u0431\u0430\u0434\u0435\u0442\u0435 \u043d\u0430 \u0442\u0435\u043b\u0435\u0444\u043e\u043d\u043d\u0430\u0442\u0430 \u043b\u0438\u043d\u0438\u044f \u0437\u0430 \u043f\u0440\u0435\u0432\u0435\u043d\u0446\u0438\u044f \u043d\u0430 \u0441\u0430\u043c\u043e\u0443\u0431\u0438\u0439\u0441\u0442\u0432\u0430 \u0432\u044a\u0432 \u0432\u0430\u0448\u0430\u0442\u0430 \u0434\u044a\u0440\u0436\u0430\u0432\u0430 (\u0421\u0410\u0429\/\u041a\u0430\u043d\u0430\u0434\u0430: 988; \u041e\u0431\u0435\u0434\u0438\u043d\u0435\u043d\u043e\u0442\u043e \u043a\u0440\u0430\u043b\u0441\u0442\u0432\u043e: Samaritans 116 123; \u043c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u0435\u043d \u0441\u043f\u0438\u0441\u044a\u043a: <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Palip XR (Paliperidone 3\/6\/9 mg XR) \u2014 OROS extended-release atypical for schizophrenia and schizoaffective disorder. once-daily, renally cleared \u2014 unaffected by CYP-altering drugs.<\/p>","protected":false},"featured_media":59955,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4774,4775],"class_list":{"0":"post-59954","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-palip-xr","10":"product_tag-paliperidone","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product\/59954","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/comments?post=59954"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media\/59955"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media?parent=59954"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_brand?post=59954"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_cat?post=59954"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_tag?post=59954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}