{"id":60437,"date":"2024-02-28T06:48:51","date_gmt":"2024-02-28T06:48:51","guid":{"rendered":"https:\/\/medsname.com\/rioci-1\/"},"modified":"2026-05-01T10:49:16","modified_gmt":"2026-05-01T10:49:16","slug":"rioci-1","status":"publish","type":"product","link":"https:\/\/medsbase.com\/bg\/product\/rioci-1\/","title":{"rendered":"Rioci 1"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Rioci 1?<\/h3>\n<p style=\"margin:0;\"><strong>Rioci 1<\/strong> is 1 mg riociguat tablets from a WHO-GMP certified manufacturer &mdash; a soluble guanylate cyclase (sGC) stimulator for <strong>\u043f\u0443\u043b\u043c\u043e\u043d\u0430\u043b\u043d\u0430 \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u043d\u0430 \u0445\u0438\u043f\u0435\u0440\u0442\u043e\u043d\u0438\u044f (PAH)<\/strong>. PAH \u0435 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e, \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0438\u0440\u0430\u0449\u043e \u0438 \u0440\u044f\u0434\u043a\u043e \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435 \u2014 <strong>\u043d\u0435 \u0435 \u0441\u044a\u0449\u043e\u0442\u043e \u043a\u0430\u0442\u043e \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u0430 \u0445\u0438\u043f\u0435\u0440\u0442\u043e\u043d\u0438\u044f<\/strong>. It raises pressure in the pulmonary arteries, not the systemic arteries, and requires dedicated specialist-directed therapy at an accredited PAH centre. Riociguat was introduced by Bayer in 2013 as <strong>Adempas<\/strong> &mdash; the first sGC stimulator approved for human use. FDA-approved for two specific forms of pulmonary hypertension: pulmonary arterial hypertension (PAH, WHO Group 1) and chronic thromboembolic pulmonary hypertension (CTEPH, WHO Group 4) &mdash; the only oral drug approved for inoperable CTEPH. directly activates soluble guanylate cyclase (the NO receptor) in pulmonary arterial smooth muscle, raising cGMP and producing pulmonary vasodilation. Unlike PDE5 inhibitors, riociguat stimulates sGC even in the absence of NO, giving activity in NO-deficient vascular beds characteristic of PAH and CTEPH. Dosing: Start 1 mg three times daily (8-hour intervals); titrate every 2 weeks by 0.5 mg increments based on systolic BP (must remain &gt;95 mmHg) and symptoms. Target dose 2.5 mg three times daily. PAH treatment is typically combination therapy initiated and monitored at a specialist centre; this is not a DIY disease.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u041a\u0430\u043a\u0432\u043e \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u0442\u0435 \u0441 MedsBase:<\/strong> \u041f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b, \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u043e\u0442 WHO-GMP \u00b7 \u0414\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u00b7 \u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442 \u00b7 \u041d\u0430\u0434 1400 \u043f\u043e\u0442\u0432\u044a\u0440\u0434\u0435\u043d\u0438 <a href=\"https:\/\/medsbase.com\/bg\/reviews\/\">\u043e\u0442\u0437\u0438\u0432\u0430 \u043e\u0442 \u043a\u043b\u0438\u0435\u043d\u0442\u0438<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u043a\u0440\u0438\u0442\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 <a href=\"https:\/\/medsbase.com\/bg\/medsbase-re-shipment-assurance-policy\/\"><strong>\u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/strong><\/a> \u2014 \u0430\u043a\u043e \u0432\u0430\u0448\u0430\u0442\u0430 \u043f\u0440\u0430\u0442\u043a\u0430 \u043d\u0435 \u043f\u0440\u0438\u0441\u0442\u0438\u0433\u043d\u0435 \u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 20 \u0440\u0430\u0431\u043e\u0442\u043d\u0438 \u0434\u043d\u0438, \u043d\u0438\u0435 \u044f \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043c\u0435 \u043e\u0442\u043d\u043e\u0432\u043e.<\/p>\n<h3>\u0417\u0430\u0449\u043e \u0434\u0430 \u043f\u043e\u0440\u044a\u0447\u0432\u0430\u0442\u0435 \u043e\u0442 MedsBase<\/h3>\n<p>\u041d\u0430\u0448\u0438\u0442\u0435 \u0433\u0435\u043d\u0435\u0440\u0438\u0447\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0441\u0435 \u0434\u043e\u0441\u0442\u0430\u0432\u044f\u0442 \u043e\u0442 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b\u0438, \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d\u0438 \u043e\u0442 WHO-GMP, \u0438 \u0441\u0435 \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u0442 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442 \u0432 \u0434\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430, \u043e\u0431\u0438\u043a\u043d\u043e\u0432\u0435\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u2014 \u0431\u0435\u0437 \u0438\u043c\u0435 \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e\u0442\u043e \u0432\u044a\u043d\u0448\u043d\u043e \u043d\u0430 \u043f\u0440\u0430\u0442\u043a\u0430\u0442\u0430. \u041f\u043b\u0430\u0449\u0430\u043d\u0438\u044f\u0442\u0430 \u0441 \u043a\u0430\u0440\u0442\u0430 \u0441\u0435 \u043e\u0431\u0440\u0430\u0431\u043e\u0442\u0432\u0430\u0442 \u0447\u0440\u0435\u0437 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430\u043d \u043f\u0440\u043e\u0446\u0435\u0441\u043e\u0440 (\u043e\u043f\u0438\u0441\u0430\u043d\u0438\u0435\u0442\u043e \u043d\u0430 \u0438\u0437\u0432\u043b\u0435\u0447\u0435\u043d\u0438\u0435\u0442\u043e \u0432\u043a\u043b\u044e\u0447\u0432\u0430 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430\u043d \u043f\u0440\u043e\u0446\u0435\u0441\u043e\u0440 \u0437\u0430 \u043f\u043b\u0430\u0449\u0430\u043d\u0435 \u0441 \u043a\u0430\u0440\u0442\u0430 \u2014 \u043d\u0438\u043a\u043e\u0433\u0430 \u201cMedsBase\u201d \u0438\u043b\u0438 \u0438\u043c\u0435 \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e). \u041f\u0440\u0438\u0435\u043c\u0430\u0442 \u0441\u0435 \u0441\u044a\u0449\u043e \u043a\u0440\u0438\u043f\u0442\u043e\u0432\u0430\u043b\u0443\u0442\u0438 \u0438 \u0431\u0430\u043d\u043a\u043e\u0432 \u043f\u0440\u0435\u0432\u043e\u0434 SEPA. \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u0434\u043a\u0440\u0435\u043f\u0435\u043d\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 \u043f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u0433\u0430\u0440\u0430\u043d\u0442\u0438\u0440\u0430\u043d\u043e \u043f\u0440\u0435\u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043d\u0435.<\/p>\n<h2 class=\"wp-block-heading\">What Is Rioci 1?<\/h2>\n<p>Rioci 1 is 1 mg riociguat tablets from a WHO-GMP certified manufacturer, supplied in 10-180 tablets. Riociguat was introduced by Bayer in 2013 as <strong>Adempas<\/strong> &mdash; the first sGC stimulator approved for human use. FDA-approved for two specific forms of pulmonary hypertension: pulmonary arterial hypertension (PAH, WHO Group 1) and chronic thromboembolic pulmonary hypertension (CTEPH, WHO Group 4) &mdash; the only oral drug approved for inoperable CTEPH.<\/p>\n<p><strong>\u041f\u0443\u043b\u043c\u043e\u043d\u0430\u043b\u043d\u0430\u0442\u0430 \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u043d\u0430 \u0445\u0438\u043f\u0435\u0440\u0442\u043e\u043d\u0438\u044f (PAH) \u043d\u0435 \u0435 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u0430 \u0445\u0438\u043f\u0435\u0440\u0442\u043e\u043d\u0438\u044f.<\/strong> PAH \u0441\u0435 \u043e\u0442\u043d\u0430\u0441\u044f \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e \u0434\u043e \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u043e \u043d\u0430\u043b\u044f\u0433\u0430\u043d\u0435 \u0432 \u043f\u0443\u043b\u043c\u043e\u043d\u0430\u043b\u043d\u0430\u0442\u0430 \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u043d\u0430 \u0446\u0438\u0440\u043a\u0443\u043b\u0430\u0446\u0438\u044f (\u226520 mmHg \u0441\u0440\u0435\u0434\u043d\u043e \u043f\u0443\u043b\u043c\u043e\u043d\u0430\u043b\u043d\u043e \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u043d\u043e \u043d\u0430\u043b\u044f\u0433\u0430\u043d\u0435 \u0441 \u043f\u0443\u043b\u043c\u043e\u043d\u0430\u0440\u043d\u043e \u0441\u044a\u0434\u043e\u0432\u043e \u0441\u044a\u043f\u0440\u043e\u0442\u0438\u0432\u043b\u0435\u043d\u0438\u0435 \u22652 Wood Units \u0441\u043f\u043e\u0440\u0435\u0434 \u0443\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u0442\u0430 \u043d\u0430 ESC\/ERS \u043e\u0442 2022). \u0422\u044f \u0435 \u0440\u044f\u0434\u043a\u0430 (\u043e\u0446\u0435\u043d\u0435\u043d\u0430 \u043d\u0430 15-50 \u043d\u0430 \u043c\u0438\u043b\u0438\u043e\u043d \u0432\u044a\u0437\u0440\u0430\u0441\u0442\u043d\u0438), \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0438\u0432\u043d\u0430 \u0438 \u0431\u0435\u0437 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0438\u043c\u0430 \u043b\u043e\u0448 \u043f\u0440\u043e\u0433\u043d\u043e\u0437 (\u0438\u0441\u0442\u043e\u0440\u0438\u0447\u0435\u0441\u043a\u043e 5-\u0433\u043e\u0434\u0438\u0448\u043d\u043e \u043e\u0446\u0435\u043b\u044f\u0432\u0430\u043d\u0435 \u223c30%). \u0421\u044a\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u0430\u0442\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044f, \u043d\u0430\u0441\u043e\u0447\u0435\u043d\u0430 \u043a\u044a\u043c PAH, \u0435 \u043f\u043e\u0434\u043e\u0431\u0440\u0438\u043b\u0430 5-\u0433\u043e\u0434\u0438\u0448\u043d\u043e\u0442\u043e \u043e\u0446\u0435\u043b\u044f\u0432\u0430\u043d\u0435 \u0434\u043e 60-70% \u0432 \u0435\u043a\u0441\u043f\u0435\u0440\u0442\u043d\u0438 \u0446\u0435\u043d\u0442\u0440\u043e\u0432\u0435.<\/p>\n<p>Candidates for Rioci 1 have been diagnosed at a PAH specialist centre via right heart catheterisation, with WHO\/NYHA functional class II-IV symptoms and confirmed PAH (WHO Group 1) or &mdash; for riociguat &mdash; inoperable or persistent CTEPH (WHO Group 4). This is not a drug for ordinary hypertension or for self-initiated therapy.<\/p>\n<h2 class=\"wp-block-heading\">How Riociguat Works<\/h2>\n<p>Directly activates soluble guanylate cyclase (the NO receptor) in pulmonary arterial smooth muscle, raising cGMP and producing pulmonary vasodilation. Unlike PDE5 inhibitors, riociguat stimulates sGC even in the absence of NO, giving activity in NO-deficient vascular beds characteristic of PAH and CTEPH.<\/p>\n<h2 class=\"wp-block-heading\">\u0414\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0441\u0442\u0432\u0430<\/h2>\n<p><strong>PATENT-1 (2013)<\/strong> &mdash; riociguat in 443 PAH patients; 6-minute walk distance improved by 30 m vs placebo, with better WHO functional class and delayed clinical worsening. <strong>CHEST-1 (2013)<\/strong> &mdash; riociguat in 261 inoperable or persistent CTEPH patients; 6-minute walk improved by 46 m vs placebo.<\/p>\n<h2 class=\"wp-block-heading\">\u0414\u043e\u0437\u0438\u0440\u0430\u043d\u0435 \u0438 \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433<\/h2>\n<p><strong>\u0414\u043e\u0437\u0438\u0440\u043e\u0432\u043a\u0430:<\/strong> Start 1 mg three times daily (8-hour intervals); titrate every 2 weeks by 0.5 mg increments based on systolic BP (must remain &gt;95 mmHg) and symptoms. Target dose 2.5 mg three times daily.<\/p>\n<p><strong>\u041c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433:<\/strong> \u043f\u0440\u0438 \u043f\u044a\u0440\u0432\u043e\u043d\u0430\u0447\u0430\u043b\u043d\u043e\u0442\u043e \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435 \u0438 \u043d\u0430 \u0432\u0441\u0435\u043a\u0438 3-6 \u043c\u0435\u0441\u0435\u0446\u0430 \u0441\u043b\u0435\u0434 \u0442\u043e\u0432\u0430 \u2014 \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u0435\u043d \u043a\u043b\u0430\u0441 \u043d\u0430 WHO, \u0440\u0430\u0437\u0441\u0442\u043e\u044f\u043d\u0438\u0435 \u043f\u0440\u0438 6-\u043c\u0438\u043d\u0443\u0442\u043d\u0430 \u0440\u0430\u0437\u0445\u043e\u0434\u043a\u0430, NT-proBNP, \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0435\u0445\u043e\u043a\u0430\u0440\u0434\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f \u0438 (\u043d\u0430 \u043f\u043e-\u0434\u044a\u043b\u0433\u0438 \u0438\u043d\u0442\u0435\u0440\u0432\u0430\u043b\u0438) \u043a\u0430\u0442\u0435\u0442\u0435\u0440\u0438\u0437\u0430\u0446\u0438\u044f \u043d\u0430 \u0434\u0435\u0441\u043d\u0438\u044f \u0441\u044a\u0440\u0434\u0435\u0447\u0435\u043d \u043e\u0442\u0434\u0435\u043b. \u0412\u0441\u0438\u0447\u043a\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f \u0441\u0435 \u0438\u0437\u0432\u044a\u0440\u0448\u0432\u0430\u0442 \u0432 \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0437\u0438\u0440\u0430\u043d \u0446\u0435\u043d\u0442\u044a\u0440 \u0437\u0430 \u041f\u0410\u0425.<\/p>\n<p><strong>BP monitoring:<\/strong> systolic BP must remain &gt;95 mmHg; uptitration paused or reversed on symptomatic hypotension.<\/p>\n<h2 class=\"wp-block-heading\">\u0421\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438<\/h2>\n<ul>\n<li><strong>\u0425\u0438\u043f\u043e\u0442\u0435\u043d\u0437\u0438\u044f<\/strong> &mdash; dose-limiting; titrate slowly.<\/li>\n<li><strong>Haemoptysis<\/strong> &mdash; increased risk, especially in CTEPH.<\/li>\n<li>Syncope<\/li>\n<li>\u0413\u043b\u0430\u0432\u043e\u0431\u043e\u043b\u0438\u0435, \u0437\u0430\u043c\u0430\u044f\u043d\u043e\u0441\u0442<\/li>\n<li>\u041f\u0435\u0440\u0438\u0444\u0435\u0440\u0435\u043d \u043e\u0442\u043e\u043a<\/li>\n<li>\u0410\u043d\u0435\u043c\u0438\u044f<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u041f\u0440\u043e\u0442\u0438\u0432\u043e\u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f<\/h2>\n<ul>\n<li><strong>Concurrent PDE5 inhibitors<\/strong> (sildenafil, tadalafil) &mdash; additive cGMP rise, severe hypotension. Contraindicated combination.<\/li>\n<li><strong>Concurrent nitrates or NO donors<\/strong> &mdash; same reason; contraindicated.<\/li>\n<li>Pregnancy &mdash; embryofetal toxicity (REMS programme in US: women must use contraception, monthly pregnancy test)<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u0427\u0435\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u043d\u0438 \u0432\u044a\u043f\u0440\u043e\u0441\u0438<\/h2>\n<h3 class=\"wp-block-heading\">\u0414\u0430\u043b\u0438 \u043f\u0443\u043b\u043c\u043e\u043d\u0430\u0440\u043d\u0430\u0442\u0430 \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u043d\u0430 \u0445\u0438\u043f\u0435\u0440\u0442\u043e\u043d\u0438\u044f \u0435 \u0441\u044a\u0449\u043e\u0442\u043e \u043a\u0430\u0442\u043e \u201c\u0432\u0438\u0441\u043e\u043a\u043e \u043a\u0440\u044a\u0432\u043d\u043e \u043d\u0430\u043b\u044f\u0433\u0430\u043d\u0435\u201d?<\/h3>\n<p>\u041d\u0435. \u0421\u0438\u0441\u0442\u0435\u043c\u043d\u0430\u0442\u0430 \u0445\u0438\u043f\u0435\u0440\u0442\u043e\u043d\u0438\u044f \u0435 \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u043e \u043d\u0430\u043b\u044f\u0433\u0430\u043d\u0435 \u0432 \u043e\u0431\u0449\u0430\u0442\u0430 \u043a\u0440\u044a\u0432\u043e\u043d\u043e\u0441\u043d\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u0430 \u0438 \u0435 \u043c\u043d\u043e\u0433\u043e \u0447\u0435\u0441\u0442\u043e \u0441\u0440\u0435\u0449\u0430\u043d\u0430; PAH \u0435 \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u043e \u043d\u0430\u043b\u044f\u0433\u0430\u043d\u0435 \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u043d\u043e \u0432 \u043f\u0443\u043b\u043c\u043e\u043d\u0430\u0440\u043d\u0430\u0442\u0430 \u043a\u0440\u044a\u0432\u043e\u043d\u043e\u0441\u043d\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u0430 \u0438 \u0435 \u0440\u044f\u0434\u043a\u043e. \u0422\u0435 \u0438\u043c\u0430\u0442 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u0438 \u043f\u0440\u0438\u0447\u0438\u043d\u0438, \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u0438 \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0441\u0442\u0438 (PAH \u0441\u0435 \u043b\u0435\u043a\u0443\u0432\u0430 \u043e\u0431\u0438\u043a\u043d\u043e\u0432\u0435\u043d\u043e \u043e\u0442 \u043f\u0443\u043b\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u043d\u0438\/\u043a\u0430\u0440\u0434\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u043d\u0438 \u0435\u043a\u0438\u043f\u0438 \u0432 \u0442\u0440\u0435\u0442\u0438\u0447\u043d\u0438 \u0446\u0435\u043d\u0442\u0440\u043e\u0432\u0435) \u0438 \u043c\u043d\u043e\u0433\u043e \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044f. \u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e, \u043a\u043e\u0435\u0442\u043e \u043f\u043e\u043d\u0438\u0436\u0430\u0432\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0442\u043e \u043a\u0440\u044a\u0432\u043d\u043e \u043d\u0430\u043b\u044f\u0433\u0430\u043d\u0435 (ACE \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440\u0438, ARB, CCB, \u0442\u0438\u0430\u0437\u0438\u0434\u0438), \u043e\u0431\u0438\u043a\u043d\u043e\u0432\u0435\u043d\u043e \u0438\u043c\u0430 \u043c\u0430\u043b\u044a\u043a \u0435\u0444\u0435\u043a\u0442 \u0432\u044a\u0440\u0445\u0443 PAH.<\/p>\n<h3 class=\"wp-block-heading\">Why does Rioci 1 require specialist monitoring?<\/h3>\n<p>PAH \u0435 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435, \u0443\u043f\u0440\u0430\u0432\u043b\u044f\u0432\u0430\u043d\u043e \u043e\u0442 \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0441\u0442\u0438, \u0441 \u0440\u0435\u0433\u0438\u0441\u0442\u044a\u0440-\u0431\u0430\u0437\u0438\u0440\u0430\u043d \u043c\u043e\u0434\u0435\u043b \u043d\u0430 \u043d\u0430\u0431\u043b\u044e\u0434\u0435\u043d\u0438\u0435 \u0432 \u043f\u043e\u0432\u0435\u0447\u0435\u0442\u043e \u0441\u0442\u0440\u0430\u043d\u0438. \u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430\u0442\u0430 \u0441\u0430 \u0441\u043a\u044a\u043f\u0438, \u0438\u043c\u0430\u0442 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u0438 \u0441\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 (\u043e\u0441\u043e\u0431\u0435\u043d\u043e \u0445\u0435\u043f\u0430\u0442\u043e\u0442\u043e\u043a\u0441\u0438\u0447\u043d\u043e\u0441\u0442 \u0437\u0430 ERA \u0438 \u0445\u0438\u043f\u043e\u0442\u0435\u043d\u0437\u0438\u044f \u0437\u0430 sGC \u0441\u0442\u0438\u043c\u0443\u043b\u0430\u0442\u043e\u0440\u0438), \u0438 \u0442\u0438\u0442\u0440\u0443\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0434\u043e\u0437\u0430\u0442\u0430 \u0437\u0430\u0432\u0438\u0441\u0438 \u043e\u0442 \u0441\u0435\u0440\u0438\u0439\u043d\u0438 \u043e\u0446\u0435\u043d\u043a\u0438 (6-\u043c\u0438\u043d\u0443\u0442\u043d\u0430 \u0440\u0430\u0437\u0445\u043e\u0434\u043a\u0430, \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u0435\u043d \u043a\u043b\u0430\u0441, NT-proBNP, \u0435\u0445\u043e\u043a\u0430\u0440\u0434\u0438\u043e\u0433\u0440\u0430\u0444\u0438\u044f). \u0421\u0430\u043c\u043e\u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0438\u0437\u0432\u044a\u043d \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u0442\u0430 \u043d\u043e\u0441\u0438 \u0432\u0438\u0441\u043e\u043a \u0440\u0438\u0441\u043a \u043e\u0442 \u043a\u043b\u0438\u043d\u0438\u0447\u043d\u043e \u0432\u043b\u043e\u0448\u0430\u0432\u0430\u043d\u0435.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Rioci 1 with erectile dysfunction drugs?<\/h3>\n<p><strong>\u041d\u0435 \u2014 \u0430\u0431\u0441\u043e\u043b\u044e\u0442\u043d\u043e \u043a\u043e\u043d\u0442\u0440\u0430\u0438\u043d\u0434\u0438\u0446\u0438\u0440\u0430\u043d.<\/strong> PDE5 inhibitors (sildenafil, tadalafil, vardenafil) combined with riociguat cause severe additive hypotension. If you need ED therapy, discuss alternatives with your PAH team; some PAH regimens use PDE5 inhibitors instead of riociguat as the pulmonary vasodilator.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Rioci 1 in pregnancy?<\/h3>\n<p><strong>\u041d\u0435.<\/strong> Embryofetal toxicity documented in animal studies; pregnancy testing and contraception required.<\/p>\n<h3 class=\"wp-block-heading\">Where can I buy Rioci 1 online?<\/h3>\n<p>You can buy Rioci 1 (riociguat 1 mg, 10-180 tablets) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n<h2 class=\"wp-block-heading\">\u0421\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0437\u0430 \u0441\u044a\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u044a\u0434\u043e\u0432\u0430\u0442\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u0430<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/bg\/cardace\/\">Cardace \u2014 \u0420\u0430\u043c\u0438\u043f\u0440\u0438\u043b (ACE \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/ecopril\/\">Ecopril \u2014 \u041a\u043b\u043e\u043f\u0438\u0434\u043e\u0433\u0440\u0435\u043b 75 mg (\u0430\u043d\u0442\u0438\u0430\u0433\u0440\u0435\u0433\u0430\u043d\u0442)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/ecosprin\/\">Ecosprin \u2014 \u0410\u0441\u043f\u0438\u0440\u0438\u043d 75\/150 mg (\u0430\u043d\u0442\u0438\u0430\u0433\u0440\u0435\u0433\u0430\u043d\u0442)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/lonitab\/\">Lonitab \u2014 \u041c\u0438\u043d\u043e\u043a\u0441\u0438\u0434\u0438\u043b 5 mg (\u043e\u0440\u0430\u043b\u0435\u043d \u0432\u0430\u0437\u043e\u0434\u0438\u043b\u0430\u0442\u0430\u0442\u043e\u0440)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/waf-5\/\">Waf-5 \u2014 \u0412\u0430\u0440\u0444\u0430\u0440\u0438\u043d 5 mg (VKA)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/xarelto-20\/\">Xarelto 20 \u2014 \u0420\u0438\u0432\u0430\u0440\u043e\u043a\u0441\u0430\u0431\u0430\u043d 20 mg (DOAC)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/high-blood-pressure-medication\/\"><strong>\u0420\u0430\u0437\u0433\u043b\u0435\u0434\u0430\u0439\u0442\u0435 \u0432\u0441\u0438\u0447\u043a\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0437\u0430 \u0432\u0438\u0441\u043e\u043a\u043e \u043a\u0440\u044a\u0432\u043d\u043e \u043d\u0430\u043b\u044f\u0433\u0430\u043d\u0435<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e \u0438\u0437\u0432\u0435\u0441\u0442\u0438\u0435.<\/strong> \u0422\u0430\u0437\u0438 \u0441\u0442\u0440\u0430\u043d\u0438\u0446\u0430 \u0435 \u0441\u0430\u043c\u043e \u0437\u0430 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u043e\u043d\u043d\u0438 \u0446\u0435\u043b\u0438 \u0438 \u043d\u0435 \u0437\u0430\u043c\u0435\u0441\u0442\u0432\u0430 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0442\u0435 \u0441\u044a\u0432\u0435\u0442\u0438 \u043d\u0430 \u043a\u0432\u0430\u043b\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u0437\u0434\u0440\u0430\u0432\u0435\u043d \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0441\u0442. \u0425\u0438\u043f\u0435\u0440\u0442\u043e\u043d\u0438\u044f\u0442\u0430, \u0441\u044a\u0440\u0434\u0435\u0447\u043d\u0430\u0442\u0430 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u044a\u0447\u043d\u043e\u0441\u0442 \u0438 \u0430\u0440\u0438\u0442\u043c\u0438\u0438\u0442\u0435 \u0438\u0437\u0438\u0441\u043a\u0432\u0430\u0442 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430, \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433 \u0438 \u0438\u043d\u0434\u0438\u0432\u0438\u0434\u0443\u0430\u043b\u0438\u0437\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u0434\u043e\u0437\u0430\u0442\u0430 \u043e\u0442 \u043b\u0435\u043a\u0430\u0440 \u2014 \u0432\u0438\u043d\u0430\u0433\u0438 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430\u0439\u0442\u0435 \u0431\u0435\u0442\u0430-\u0431\u043b\u043e\u043a\u0430\u0442\u043e\u0440\u0438 \u043f\u043e\u0434 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e \u0440\u044a\u043a\u043e\u0432\u043e\u0434\u0441\u0442\u0432\u043e.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u0421\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u0430\u043b\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u0438<\/h3>\n<p>\u0414\u0440\u0443\u0433\u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0438 \u0432 <strong>\u0425\u0440\u043e\u043d\u0438\u0447\u043d\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f<\/strong> \u043a\u043e\u0438\u0442\u043e \u043a\u043b\u0438\u0435\u043d\u0442\u0438\u0442\u0435 \u0441\u044a\u0449\u043e \u0440\u0430\u0437\u0433\u043b\u0435\u0436\u0434\u0430\u0442:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/bg\/seretra\/\">Seretra<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/proclid-5\/\">Proclid 5<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/tacroz-forte-ointment\/\">Tacroz Forte Ointment<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/syndopa\/\">Syndopa<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/caditam\/\">Caditam<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Rioci 1 is riociguat 1 mg tablets \u2014 the first soluble guanylate cyclase (sGC) stimulator, originally Bayer Adempas (2013). Approved for pulmonary arterial hypertension (PAH, WHO Group 1) and the only oral drug for inoperable chronic thromboembolic pulmonary hypertension (CTEPH, WHO Group 4). PATENT-1 and CHEST-1 trial evidence. Specialist-managed disease \u2014 not ordinary hypertension. Contraindicated with PDE5 inhibitors and nitrates.<\/p>","protected":false},"featured_media":60438,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260,3356],"product_tag":[4861,4862],"class_list":{"0":"post-60437","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_cat-high-blood-pressure-medication","10":"product_tag-rioci","11":"product_tag-riociguat","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product\/60437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/comments?post=60437"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media\/60438"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media?parent=60437"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_brand?post=60437"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_cat?post=60437"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_tag?post=60437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}