{"id":60487,"date":"2024-02-28T06:51:06","date_gmt":"2024-02-28T06:51:06","guid":{"rendered":"https:\/\/medsname.com\/rofaday\/"},"modified":"2026-04-30T10:23:46","modified_gmt":"2026-04-30T10:23:46","slug":"rofaday","status":"publish","type":"product","link":"https:\/\/medsbase.com\/bg\/product\/rofaday\/","title":{"rendered":"Rofaday"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 Quick Answer \u2014 What is Rofaday?<\/h3>\n<p><strong>Rofaday<\/strong> \u0441\u044a\u0434\u044a\u0440\u0436\u0430 <strong>roflumilast 500 mcg<\/strong>, an <strong>oral selective phosphodiesterase-4 (PDE4) inhibitor<\/strong> taken once daily for <strong>severe chronic obstructive pulmonary disease (COPD) with chronic bronchitis phenotype and frequent exacerbations<\/strong>. Roflumilast is anti-inflammatory rather than bronchodilator \u2014 it suppresses neutrophil and macrophage activation in airways, reducing exacerbation frequency by ~17% in landmark trials (M2-124, M2-125, REACT). It is added on top of optimal LAMA + LABA (\u00b1 ICS) in patients with severe disease. Manufactured by <strong>Cipla<\/strong>.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u041a\u0430\u043a\u0432\u043e \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u0442\u0435 \u0441 MedsBase:<\/strong> \u041f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b, \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u043e\u0442 WHO-GMP \u00b7 \u0414\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u00b7 \u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442 \u00b7 \u041d\u0430\u0434 1400 \u043f\u043e\u0442\u0432\u044a\u0440\u0434\u0435\u043d\u0438 <a href=\"https:\/\/medsbase.com\/bg\/reviews\/\">\u043e\u0442\u0437\u0438\u0432\u0430 \u043e\u0442 \u043a\u043b\u0438\u0435\u043d\u0442\u0438<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u043a\u0440\u0438\u0442\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 <a href=\"https:\/\/medsbase.com\/bg\/medsbase-re-shipment-assurance-policy\/\"><strong>\u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/strong><\/a> \u2014 \u0430\u043a\u043e \u0432\u0430\u0448\u0430\u0442\u0430 \u043f\u0440\u0430\u0442\u043a\u0430 \u043d\u0435 \u043f\u0440\u0438\u0441\u0442\u0438\u0433\u043d\u0435 \u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 20 \u0440\u0430\u0431\u043e\u0442\u043d\u0438 \u0434\u043d\u0438, \u043d\u0438\u0435 \u044f \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043c\u0435 \u043e\u0442\u043d\u043e\u0432\u043e.<\/p>\n<h3>\u0417\u0430\u0449\u043e \u0434\u0430 \u043f\u043e\u0440\u044a\u0447\u0432\u0430\u0442\u0435 \u043e\u0442 MedsBase<\/h3>\n<p>\u041d\u0430\u0448\u0438\u0442\u0435 \u0433\u0435\u043d\u0435\u0440\u0438\u0447\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0441\u0435 \u0434\u043e\u0441\u0442\u0430\u0432\u044f\u0442 \u043e\u0442 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b\u0438, \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d\u0438 \u043e\u0442 WHO-GMP, \u0438 \u0441\u0435 \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u0442 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442 \u0432 \u0434\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430, \u043e\u0431\u0438\u043a\u043d\u043e\u0432\u0435\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u2014 \u0431\u0435\u0437 \u0438\u043c\u0435 \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e\u0442\u043e \u0432\u044a\u043d\u0448\u043d\u043e \u043d\u0430 \u043f\u0440\u0430\u0442\u043a\u0430\u0442\u0430. \u041f\u043b\u0430\u0449\u0430\u043d\u0438\u044f\u0442\u0430 \u0441 \u043a\u0430\u0440\u0442\u0430 \u0441\u0435 \u043e\u0431\u0440\u0430\u0431\u043e\u0442\u0432\u0430\u0442 \u0447\u0440\u0435\u0437 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430\u043d \u043f\u0440\u043e\u0446\u0435\u0441\u043e\u0440 (\u043e\u043f\u0438\u0441\u0430\u043d\u0438\u0435\u0442\u043e \u043d\u0430 \u0438\u0437\u0432\u043b\u0435\u0447\u0435\u043d\u0438\u0435\u0442\u043e \u0432\u043a\u043b\u044e\u0447\u0432\u0430 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430\u043d \u043f\u0440\u043e\u0446\u0435\u0441\u043e\u0440 \u0437\u0430 \u043f\u043b\u0430\u0449\u0430\u043d\u0435 \u0441 \u043a\u0430\u0440\u0442\u0430 \u2014 \u043d\u0438\u043a\u043e\u0433\u0430 \u201cMedsBase\u201d \u0438\u043b\u0438 \u0438\u043c\u0435 \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e). \u041f\u0440\u0438\u0435\u043c\u0430\u0442 \u0441\u0435 \u0441\u044a\u0449\u043e \u043a\u0440\u0438\u043f\u0442\u043e\u0432\u0430\u043b\u0443\u0442\u0438 \u0438 \u0431\u0430\u043d\u043a\u043e\u0432 \u043f\u0440\u0435\u0432\u043e\u0434 SEPA. \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u0434\u043a\u0440\u0435\u043f\u0435\u043d\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 \u043f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u0433\u0430\u0440\u0430\u043d\u0442\u0438\u0440\u0430\u043d\u043e \u043f\u0440\u0435\u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043d\u0435.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 \u041a\u0440\u0438\u043f\u0442\u0438\u0440\u0430\u043d\u043e \u043f\u043b\u0430\u0449\u0430\u043d\u0435<\/strong> \u00b7 <strong>\ud83d\udcb3 \u041f\u0440\u043e\u0432\u0435\u0440\u0435\u043d \u043f\u0440\u043e\u0446\u0435\u0441\u043e\u0440<\/strong> \u00b7 <strong>\ud83d\ude9a \u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442<\/strong> \u00b7 <strong>\u2b50 4.9\/5 \u043e\u0442 \u043d\u0430\u0434 1,400 \u043a\u043b\u0438\u0435\u043d\u0442\u0438<\/strong>\n<\/div>\n<h2>What Is Rofaday?<\/h2>\n<p>Rofaday is an oral PDE4 inhibitor for severe COPD. Roflumilast is the only PDE4 inhibitor licensed for COPD \u2014 sold internationally as Daxas (AstraZeneca) and Daliresp. It is a niche but well-evidenced add-on for the chronic bronchitis phenotype.<\/p>\n<h2>How Does Rofaday Work?<\/h2>\n<p>Phosphodiesterase-4 (PDE4) is the dominant cyclic AMP-degrading enzyme in inflammatory cells (neutrophils, macrophages, eosinophils, T-cells). Inhibiting PDE4 raises cyclic AMP in these cells, suppressing:<\/p>\n<ul>\n<li>Neutrophil chemotaxis and degranulation in airways<\/li>\n<li>Macrophage cytokine release (TNF-\u03b1, IL-8)<\/li>\n<li>Airway smooth-muscle proliferation and fibroblast activation<\/li>\n<li>Mucus hypersecretion and goblet-cell hyperplasia<\/li>\n<\/ul>\n<p>The clinical result is a 15\u201317% reduction in COPD exacerbation rate when added to optimal inhaled therapy.<\/p>\n<h2>\u0423\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u0438 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f<\/h2>\n<ul>\n<li><strong>Severe COPD (FEV1 &lt;50% predicted) with chronic bronchitis<\/strong> and a history of exacerbations, on top of optimal LAMA + LABA (\u00b1 ICS)<\/li>\n<li><strong>Frequent exacerbator phenotype<\/strong> with persistent productive cough<\/li>\n<\/ul>\n<h2>Rofaday Dosage<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u041f\u0430\u0446\u0438\u0435\u043d\u0442<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0414\u043e\u0437\u0430<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0427\u0435\u0441\u0442\u043e\u0442\u0430<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Adults \u2014 start<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>250 mcg<\/strong> for first 4 weeks<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0412\u0435\u0434\u043d\u044a\u0436 \u0434\u043d\u0435\u0432\u043d\u043e<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0412\u044a\u0437\u0440\u0430\u0441\u0442\u043d\u0438 \u2014 \u043f\u043e\u0434\u0434\u044a\u0440\u0436\u0430\u0449\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044f<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>500 mcg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Once daily, with or without food<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0425\u0435\u043f\u0430\u0442\u0430\u043b\u043d\u0430 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u044a\u0447\u043d\u043e\u0441\u0442<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Avoid (Child-Pugh B\/C)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Side Effects of Rofaday<\/h2>\n<ul>\n<li><strong>\u041e\u0442\u0441\u043b\u0430\u0431\u0432\u0430\u043d\u0435<\/strong> (averages 2\u20133 kg in trials \u2014 monitor; reverse if &gt;5%)<\/li>\n<li>Diarrhoea, nausea (commonest reason for discontinuation; usually settles after first 2\u20134 weeks)<\/li>\n<li>\u0413\u043b\u0430\u0432\u043e\u0431\u043e\u043b\u0438\u0435<\/li>\n<li>Insomnia, anxiety<\/li>\n<li>Dyspepsia, abdominal pain<\/li>\n<li>Mood changes \u2014 depression, anxiety; rarely suicidal ideation (warning)<\/li>\n<\/ul>\n<p><strong>\u0421\u0435\u0440\u0438\u043e\u0437\u043d\u0438 \u2014 \u0441\u043f\u0440\u0435\u0442\u0435 \u0438 \u043f\u043e\u0442\u044a\u0440\u0441\u0435\u0442\u0435 \u043f\u043e\u043c\u043e\u0449:<\/strong><\/p>\n<ul>\n<li>Severe weight loss (&gt;5% body weight)<\/li>\n<li>New or worsening depression, suicidal thoughts<\/li>\n<li>Severe persistent diarrhoea<\/li>\n<li>\u0422\u0435\u0436\u043a\u0430 \u0430\u043b\u0435\u0440\u0433\u0438\u0447\u043d\u0430 \u0440\u0435\u0430\u043a\u0446\u0438\u044f<\/li>\n<\/ul>\n<h2>\u041f\u0440\u0435\u0434\u0443\u043f\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u044f \u0438 \u043f\u0440\u0435\u0434\u043f\u0430\u0437\u043d\u0438 \u043c\u0435\u0440\u043a\u0438<\/h2>\n<ul>\n<li><strong>Mood and behaviour:<\/strong> screen for depression before starting; warn patients\/families to report new mood symptoms.<\/li>\n<li><strong>Weight loss:<\/strong> baseline and 3-monthly weight monitoring; if loss exceeds 5%, review or stop.<\/li>\n<li><strong>\u0425\u0435\u043f\u0430\u0442\u0430\u043b\u043d\u0430 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u044a\u0447\u043d\u043e\u0441\u0442:<\/strong> avoid in Child-Pugh B and C.<\/li>\n<li><strong>4-week dose titration<\/strong> (250 mcg) reduces GI side effects and diarrhoea \u2014 most patients can then tolerate 500 mcg.<\/li>\n<li><strong>Not a bronchodilator<\/strong> \u2014 does not replace LAMA, LABA, or ICS.<\/li>\n<li><strong>\u0411\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442 \u0438 \u043a\u044a\u0440\u043c\u0435\u043d\u0435:<\/strong> \u043a\u043e\u043d\u0442\u0440\u0430\u0438\u043d\u0434\u0438\u0446\u0438\u0440\u0430\u043d\u043e.<\/li>\n<li><strong>\u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u0438 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f:<\/strong> CYP3A4 inducers (rifampicin) reduce levels \u2014 avoid. Strong CYP1A2 inhibitors (fluvoxamine, ciprofloxacin) raise levels \u2014 caution.<\/li>\n<\/ul>\n<h2>\u041f\u0440\u043e\u0442\u0438\u0432\u043e\u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f<\/h2>\n<ul>\n<li>Hypersensitivity to roflumilast<\/li>\n<li>Moderate-to-severe hepatic impairment (Child-Pugh B\/C)<\/li>\n<li>\u0411\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442<\/li>\n<\/ul>\n<h2>\u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u0438 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0412\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0449 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0415\u0444\u0435\u043a\u0442<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u041a\u0430\u043a\u0432\u043e \u0434\u0430 \u043f\u0440\u0430\u0432\u0438\u0442\u0435<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">CYP3A4 inducers (rifampicin, phenobarbital, phenytoin, carbamazepine)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce roflumilast levels by 50%<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0418\u0437\u0431\u044f\u0433\u0432\u0430\u0439\u0442\u0435<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Strong CYP1A2 inhibitors (fluvoxamine, ciprofloxacin, enoxacin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Raise roflumilast levels \u2014 increase side effect risk<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Caution; consider lower dose<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Oral contraceptives containing gestodene<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Modest increase in roflumilast levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">No dose adjustment usually needed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>\u0421\u044a\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435<\/h2>\n<ul>\n<li>\u0421\u044a\u0445\u0440\u0430\u043d\u044f\u0432\u0430\u0439\u0442\u0435 \u043f\u0440\u0438 \u0442\u0435\u043c\u043f\u0435\u0440\u0430\u0442\u0443\u0440\u0430 \u043f\u043e\u0434 <strong>25\u00b0C<\/strong> \u043d\u0430 \u0445\u043b\u0430\u0434\u043d\u043e, \u0441\u0443\u0445\u043e \u043c\u044f\u0441\u0442\u043e, \u0434\u0430\u043b\u0435\u0447\u0435 \u043e\u0442 \u043f\u0440\u044f\u043a\u0430 \u0441\u043b\u044a\u043d\u0447\u0435\u0432\u0430 \u0441\u0432\u0435\u0442\u043b\u0438\u043d\u0430.<\/li>\n<li>\u0417\u0430\u043f\u0430\u0437\u0432\u0430\u0439\u0442\u0435 \u0432 \u043e\u0440\u0438\u0433\u0438\u043d\u0430\u043b\u043d\u0430\u0442\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u0434\u043e \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430, \u0437\u0430 \u0434\u0430 \u0441\u0435 \u043f\u0440\u0435\u0434\u043f\u0430\u0437\u0438 \u043e\u0442 \u0432\u043b\u0430\u0433\u0430 \u0438 \u0441\u0432\u0435\u0442\u043b\u0438\u043d\u0430.<\/li>\n<li>\u041d\u0435 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430\u0439\u0442\u0435 \u0441\u043b\u0435\u0434 \u0438\u0437\u0442\u0438\u0447\u0430\u043d\u0435 \u043d\u0430 \u0441\u0440\u043e\u043a\u0430 \u043d\u0430 \u0433\u043e\u0434\u043d\u043e\u0441\u0442, \u043e\u0442\u043f\u0435\u0447\u0430\u0442\u0430\u043d \u0432\u044a\u0440\u0445\u0443 \u0431\u043b\u0438\u0441\u0442\u0435\u0440\u0430.<\/li>\n<li>\u0414\u044a\u0440\u0436\u0435\u0442\u0435 \u0438\u0437\u0432\u044a\u043d \u043e\u0431\u0441\u0435\u0433\u0430 \u043d\u0430 \u0434\u0435\u0446\u0430\u0442\u0430.<\/li>\n<\/ul>\n<h2>\u0421\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u0430\u043b\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u0438 \u0432 MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/bg\/asthalin-inhaler\/\"><strong>Asthalin Inhaler \u2014 \u0441\u0430\u043b\u0431\u0443\u0442\u0430\u043c\u043e\u043b \u0437\u0430 \u043e\u0431\u043b\u0435\u043a\u0447\u0430\u0432\u0430\u043d\u0435 \u043d\u0430 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u0438\u0442\u0435<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/budecort-inhaler\/\"><strong>Budecort Inhaler \u2014 \u0431\u0443\u0434\u0435\u0441\u043e\u043d\u0438\u0434 ICS \u0437\u0430 \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0430<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/foracort-inhaler\/\"><strong>Foracort Inhaler \u2014 \u0431\u0443\u0434\u0435\u0441\u043e\u043d\u0438\u0434 + \u0444\u043e\u0440\u043c\u043e\u0442\u0435\u0440\u043e\u043b ICS-LABA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/tiova-inhaler\/\"><strong>Tiova Inhaler \u2014 \u0442\u0438\u043e\u0442\u0440\u043e\u043f\u0438\u0443\u043c LAMA \u0437\u0430 \u0425\u041e\u0411\u0411<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/montair\/\"><strong>Montair \u2014 \u043c\u043e\u043d\u0442\u0435\u043b\u0443\u043a\u0430\u0441\u0442 LTRA \u0442\u0430\u0431\u043b\u0435\u0442\u043a\u0430<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u0427\u0435\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u043d\u0438 \u0432\u044a\u043f\u0440\u043e\u0441\u0438<\/h2>\n<h3>When is Rofaday added?<\/h3>\n<p>For severe COPD (FEV1 <50% predicted) with chronic bronchitis phenotype and a history of frequent exacerbations on top of optimal LAMA + LABA (\u00b1 ICS). Not for mild COPD or asthma.<\/p>\n<h3>Why must I start at 250 mcg?<\/h3>\n<p>A 4-week titration at 250 mcg dramatically reduces GI side effects (diarrhoea, nausea) \u2014 most patients can then move to the maintenance 500 mcg without intolerance.<\/p>\n<h3>How much does Rofaday reduce exacerbations?<\/h3>\n<p>About 15\u201317% reduction in moderate-to-severe COPD exacerbations in landmark trials (M2-124, M2-125, REACT). Most benefit seen in the chronic bronchitis with frequent exacerbator phenotype.<\/p>\n<h3>Will Rofaday make me lose weight?<\/h3>\n<p>Yes \u2014 average 2\u20133 kg in trials. Monitor weight at baseline and every 3 months. If loss exceeds 5%, review indication or stop.<\/p>\n<h3>\u0410 \u043a\u0430\u043a\u0432\u043e \u0441\u0442\u0430\u0432\u0430 \u0441 \u043f\u0440\u043e\u043c\u0435\u043d\u0438\u0442\u0435 \u0432 \u043d\u0430\u0441\u0442\u0440\u043e\u0435\u043d\u0438\u0435\u0442\u043e?<\/h3>\n<p>Rare but reported. Screen for depression at baseline; counsel patient and family to report new mood symptoms, anxiety, or suicidal thoughts. Stop and review.<\/p>\n<h3>Is Rofaday a bronchodilator?<\/h3>\n<p>No \u2014 it is anti-inflammatory only. Continue your LAMA, LABA, and (where indicated) ICS inhalers.<\/p>\n<h3>Can I take Rofaday during pregnancy?<\/h3>\n<p>\u041f\u0440\u043e\u0442\u0438\u0432\u043e\u043f\u043e\u043a\u0430\u0437\u0430\u043d\u043e.<\/p>\n<h3>How does Rofaday compare to triple therapy?<\/h3>\n<p>Triple inhaler (Triohale) and Rofaday tackle COPD exacerbations through different mechanisms (bronchodilation + inflammation suppression vs PDE4-mediated anti-inflammation). Some patients benefit from both.<\/p>\n<h3>What are the most important drug interactions?<\/h3>\n<p>Rifampicin (and other CYP3A4 inducers) reduce Rofaday levels by half \u2014 avoid. Strong CYP1A2 inhibitors (fluvoxamine, ciprofloxacin) raise levels \u2014 caution.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>\u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430 \u043a\u043b\u0430\u0443\u0437\u0430:<\/strong> \u0422\u0430\u0437\u0438 \u0441\u0442\u0440\u0430\u043d\u0438\u0446\u0430 \u0435 \u0441 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u0442\u0435\u043b\u043d\u0430 \u0446\u0435\u043b \u0438 \u043d\u0435 \u0437\u0430\u043c\u0435\u0441\u0442\u0432\u0430 \u043f\u0440\u043e\u0444\u0435\u0441\u0438\u043e\u043d\u0430\u043b\u043d\u0438\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438 \u0441\u044a\u0432\u0435\u0442. \u0412\u0438\u043d\u0430\u0433\u0438 \u0441\u0435 \u043a\u043e\u043d\u0441\u0443\u043b\u0442\u0438\u0440\u0430\u0439\u0442\u0435 \u0441 \u043a\u0432\u0430\u043b\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u0437\u0434\u0440\u0430\u0432\u0435\u043d \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0441\u0442 \u043f\u0440\u0435\u0434\u0438 \u0434\u0430 \u0437\u0430\u043f\u043e\u0447\u043d\u0435\u0442\u0435, \u0441\u043f\u0440\u0435\u0442\u0435 \u0438\u043b\u0438 \u043f\u0440\u043e\u043c\u0435\u043d\u0438\u0442\u0435 \u0438\u043d\u0445\u0430\u043b\u0430\u0442\u043e\u0440 \u0438\u043b\u0438 \u0434\u0438\u0445\u0430\u0442\u0435\u043b\u043d\u043e \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e, \u043e\u0441\u043e\u0431\u0435\u043d\u043e \u0430\u043a\u043e \u0438\u043c\u0430\u0442\u0435 \u0434\u0440\u0443\u0433\u0438 \u0437\u0434\u0440\u0430\u0432\u043e\u0441\u043b\u043e\u0432\u043d\u0438 \u043f\u0440\u043e\u0431\u043b\u0435\u043c\u0438, \u043f\u0440\u0438\u0435\u043c\u0430\u0442\u0435 \u0434\u0440\u0443\u0433\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430, \u0441\u0442\u0435 \u0431\u0440\u0435\u043c\u0435\u043d\u043d\u0438 \u0438\u043b\u0438 \u043a\u044a\u0440\u043c\u0438\u0442\u0435, \u0438\u043b\u0438 \u0441\u0442\u0435 \u043d\u0430\u0434 65 \u0433\u043e\u0434\u0438\u043d\u0438.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u0421\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u0430\u043b\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u0438<\/h3>\n<p>\u0414\u0440\u0443\u0433\u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0438 \u0432 <strong>\u0425\u0440\u043e\u043d\u0438\u0447\u043d\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f<\/strong> \u043a\u043e\u0438\u0442\u043e \u043a\u043b\u0438\u0435\u043d\u0442\u0438\u0442\u0435 \u0441\u044a\u0449\u043e \u0440\u0430\u0437\u0433\u043b\u0435\u0436\u0434\u0430\u0442:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/bg\/glycomet-gp\/\">Glycomet-GP<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/loratin\/\">Loratin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/lasix\/\">Lasix<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/decdan\/\">\u0414\u0435\u043a\u0434\u0430\u043d<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/hydrocl\/\">Hydrocl<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Reduces lung inflammation<br \/>\n\u2705 Improves lung function<br \/>\n\u2705 Treats chronic bronchitis<br \/>\n\u2705 Decreases COPD exacerbations<br \/>\n\u2705 Enhances breathing capacity<\/p>\n<p>Rofaday contains Roflumilast.<\/p>","protected":false},"featured_media":60488,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[4868,4869],"class_list":{"0":"post-60487","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-rofaday","10":"product_tag-roflumilast","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product\/60487","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/comments?post=60487"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media\/60488"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media?parent=60487"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_brand?post=60487"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_cat?post=60487"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_tag?post=60487"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}