{"id":61070,"date":"2024-02-28T07:23:11","date_gmt":"2024-02-28T07:23:11","guid":{"rendered":"https:\/\/medsname.com\/encorate-chrono\/"},"modified":"2026-05-01T10:49:16","modified_gmt":"2026-05-01T10:49:16","slug":"encorate-chrono","status":"publish","type":"product","link":"https:\/\/medsbase.com\/bg\/product\/encorate-chrono\/","title":{"rendered":"\u0415\u043d\u043a\u043e\u0440\u0430\u0442 \u0425\u0440\u043e\u043d\u043e"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Encorate Chrono?<\/h3>\n<p style=\"margin:0;\"><strong>\u0415\u043d\u043a\u043e\u0440\u0430\u0442 \u0425\u0440\u043e\u043d\u043e<\/strong> \u0435 <strong>200 \/ 300 \/ 400 \/ 500 \/ 600 mg sodium valproate \/ valproic acid extended-release (chrono \/ CR) tablet<\/strong> from Sun Pharma &mdash; an antiepileptic \/ mood-stabiliser \/ migraine preventive. In migraine prevention it is used at <strong>500-1,500 mg once daily<\/strong> as a third- or fourth-line preventive after propranolol, topiramate, and amitriptyline. <strong>Absolute contraindication in pregnancy and in women of childbearing potential without pregnancy-prevention programme<\/strong> &mdash; valproate causes a 10% risk of major congenital malformations (neural tube defects, craniofacial, cardiac, limb, urogenital) and a 30-40% risk of neurodevelopmental impairment (reduced IQ 7-10 points, autism spectrum). The EMA and MHRA have issued progressively stricter prescribing restrictions since 2014. Other important side effects: hepatotoxicity (idiosyncratic; serious rarely fatal), pancreatitis, thrombocytopenia, hyperammonaemia, weight gain, hair loss, tremor, and polycystic ovarian syndrome in women.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u041a\u0430\u043a\u0432\u043e \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u0442\u0435 \u0441 MedsBase:<\/strong> \u041f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b, \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u043e\u0442 WHO-GMP \u00b7 \u0414\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u00b7 \u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442 \u00b7 \u041d\u0430\u0434 1400 \u043f\u043e\u0442\u0432\u044a\u0440\u0434\u0435\u043d\u0438 <a href=\"https:\/\/medsbase.com\/bg\/reviews\/\">\u043e\u0442\u0437\u0438\u0432\u0430 \u043e\u0442 \u043a\u043b\u0438\u0435\u043d\u0442\u0438<\/a>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Encorate Chrono?<\/h2>\n<p>Encorate Chrono is an oral extended-release (chrono \/ CR) tablet of <strong>sodium valproate \/ valproic acid 200 \/ 300 \/ 400 \/ 500 \/ 600 mg<\/strong> from Sun Pharma, supplied in 30-180 tablet packs. Valproate is a branched short-chain fatty acid originally used as a solvent in pharmaceutical chemistry, later serendipitously discovered to have antiepileptic activity. It has been a first-line anticonvulsant for generalised and partial epilepsy since the 1970s and became the third drug with US FDA approval for migraine prophylaxis in 1996 (after propranolol and timolol).<\/p>\n<p>The <strong>Chrono \/ CR extended-release formulation<\/strong> allows once-daily dosing with smoother plasma levels than the immediate-release formulation &mdash; better tolerability (less peak-related nausea and tremor) and better adherence.<\/p>\n<h2 class=\"wp-block-heading\">How Valproate Prevents Migraine<\/h2>\n<p>Valproate works through multiple mechanisms relevant to migraine:<\/p>\n<ul>\n<li><strong>GABAergic potentiation<\/strong> &mdash; increases GABA synthesis and reduces its degradation, enhancing inhibitory tone in the trigeminal nucleus caudalis and cortex<\/li>\n<li><strong>Suppression of cortical spreading depression<\/strong> &mdash; the pathological wave that underlies migraine aura<\/li>\n<li><strong>Voltage-gated sodium-channel blockade<\/strong> &mdash; reduces neuronal hyperexcitability<\/li>\n<li><strong>Inhibition of NMDA-glutamate transmission<\/strong><\/li>\n<\/ul>\n<p>In migraine-prevention trials (Jensen 1994, Mathew 1995, Klapper 1997), valproate 500-1,500 mg\/day reduced monthly migraine frequency by ~50% in about half of treated patients.<\/p>\n<h2 class=\"wp-block-heading\">\u041e\u0434\u043e\u0431\u0440\u0435\u043d\u0438 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0438<\/h2>\n<ul>\n<li><strong>Migraine prophylaxis in adults<\/strong> &mdash; FDA-approved 1996<\/li>\n<li><strong>Generalised epilepsy<\/strong> &mdash; absence, myoclonic, tonic-clonic seizures (first-line)<\/li>\n<li><strong>Focal epilepsy<\/strong> (partial seizures) &mdash; alternative to carbamazepine<\/li>\n<li><strong>Bipolar disorder<\/strong> &mdash; acute mania and maintenance<\/li>\n<li><strong>Status epilepticus<\/strong> (IV formulation)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Encorate Chrono Dosage for Migraine Prevention<\/h2>\n<p>Valproate is <strong>titrated upward<\/strong> over 2-4 weeks to minimise nausea:<\/p>\n<ul>\n<li><strong>Week 1:<\/strong> 500 mg once daily with evening meal<\/li>\n<li><strong>Week 2:<\/strong> 750 mg once daily<\/li>\n<li><strong>Week 3+:<\/strong> 1,000 mg once daily (target; adjust 500-1,500 mg based on response and tolerance)<\/li>\n<li><strong>Assess benefit at 8-12 weeks.<\/strong> Keep a migraine diary to quantify change.<\/li>\n<li><strong>Therapeutic plasma levels<\/strong> are 50-100 &mu;g\/mL for seizure control; for migraine, levels are not routinely needed &mdash; dose by clinical response.<\/li>\n<\/ul>\n<p><strong>\u041c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433:<\/strong><\/p>\n<ul>\n<li>Baseline: LFTs (AST, ALT, bilirubin), FBC (platelet count), amylase, pregnancy test (women of childbearing potential), ammonia level (baseline)<\/li>\n<li>Month 1, 3, 6, then 6-monthly: LFTs, FBC<\/li>\n<li>Ammonia check if confusion or new cognitive symptoms<\/li>\n<\/ul>\n<p><strong>\u041f\u0440\u0435\u043a\u0440\u0430\u0442\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044f\u0442\u0430:<\/strong> taper over 2-4 weeks if stopping. In patients with co-existing epilepsy, never stop valproate without neurology input (seizure risk).<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:18px 0;border-radius:4px;\">\n<strong>&#9888;&#65039; PREGNANCY WARNING.<\/strong> Valproate is one of the most teratogenic drugs in routine clinical use. First-trimester exposure carries a <strong>~10% risk of major congenital malformations<\/strong> (neural tube defects, heart defects, cleft lip\/palate, limb defects, urogenital abnormalities) and a <strong>30-40% risk of neurodevelopmental impairment<\/strong> (reduced childhood IQ by 7-10 points, increased autism spectrum risk 5-fold). <strong>Valproate must NOT be used in pregnancy or in women of childbearing potential unless other options have failed and a formal pregnancy-prevention programme is in place.<\/strong> For migraine prevention, switch to <a href=\"https:\/\/medsbase.com\/bg\/inderal\/\">\u043f\u0440\u043e\u043f\u0440\u0430\u043d\u043e\u043b\u043e\u043b<\/a>, amitriptyline, or a CGRP antagonist before planning pregnancy.\n<\/div>\n<h2 class=\"wp-block-heading\">\u0421\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438<\/h2>\n<p><strong>Very common (&gt;10%):<\/strong> nausea, dyspepsia, drowsiness, tremor, weight gain, hair thinning \/ hair loss, alopecia (usually transient; hair regrows after dose reduction or stopping).<\/p>\n<p><strong>\u0427\u0435\u0441\u0442\u043e (1-10%):<\/strong> ataxia, dizziness, headache, transient elevation of LFTs, thrombocytopenia (usually mild and dose-related), amenorrhoea or irregular menses, polycystic ovarian syndrome (in younger women), decreased libido, peripheral oedema.<\/p>\n<p><strong>\u041d\u0435\u0447\u0435\u0441\u0442\u0438, \u043d\u043e \u0441\u0435\u0440\u0438\u043e\u0437\u043d\u0438:<\/strong><\/p>\n<ul>\n<li><strong>\u0425\u0435\u043f\u0430\u0442\u043e\u0442\u043e\u043a\u0441\u0438\u0447\u043d\u043e\u0441\u0442<\/strong> &mdash; idiosyncratic; typically in first 6 months; risk higher in children under 2, in patients with mitochondrial disorders (POLG mutations are an absolute contraindication), and in polytherapy. Presents as nausea, vomiting, fatigue, jaundice. Requires urgent LFT + discontinuation.<\/li>\n<li><strong>\u041f\u0430\u043d\u043a\u0440\u0435\u0430\u0442\u0438\u0442<\/strong> &mdash; rare but potentially fatal; presents with abdominal pain, nausea, vomiting, raised lipase<\/li>\n<li><strong>\u0425\u0438\u043f\u0435\u0440\u0430\u043c\u043e\u043d\u0438\u0435\u0432\u0430 \u0435\u043d\u0446\u0435\u0444\u0430\u043b\u043e\u043f\u0430\u0442\u0438\u044f<\/strong> &mdash; can occur with normal LFTs; presents as confusion, lethargy, new cognitive symptoms<\/li>\n<li><strong>Thrombocytopenia, leukopenia<\/strong> &mdash; dose-related; severe forms rare<\/li>\n<li><strong>\u0421\u0438\u043d\u0434\u0440\u043e\u043c \u043d\u0430 \u0421\u0442\u0438\u0432\u044a\u043d\u0441-\u0414\u0436\u043e\u043d\u0441\u044a\u043d \/ TEN<\/strong> &mdash; rare; stop immediately and seek urgent care<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u041f\u0440\u043e\u0442\u0438\u0432\u043e\u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f<\/h2>\n<ul>\n<li><strong>Pregnancy (absolute)<\/strong> and women of childbearing potential without pregnancy-prevention programme<\/li>\n<li><strong>Known or suspected POLG mitochondrial disorder<\/strong> (and children under 2 where POLG cannot be excluded) &mdash; risk of fatal hepatotoxicity<\/li>\n<li>Severe hepatic impairment or family history of severe hepatic dysfunction<\/li>\n<li>Acute porphyria<\/li>\n<li>Pancreatitis (personal history)<\/li>\n<li>Urea cycle disorders<\/li>\n<li>Hypersensitivity to valproate<\/li>\n<\/ul>\n<p><strong>\u041a\u044a\u0440\u043c\u0435\u043d\u0435:<\/strong> valproate passes into milk in low amounts (milk\/plasma ratio ~0.02). Generally considered acceptable during breastfeeding if the drug is needed; monitor the infant for unusual lethargy or poor feeding.<\/p>\n<h2 class=\"wp-block-heading\">\u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u0438 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f<\/h2>\n<ul>\n<li><strong>Lamotrigine<\/strong> &mdash; valproate doubles lamotrigine levels; dose lamotrigine at half the usual starting dose<\/li>\n<li><strong>Carbapenem antibiotics<\/strong> (meropenem, imipenem, ertapenem) &mdash; dramatically reduce valproate levels &mdash; seizure risk in epilepsy; avoid combination<\/li>\n<li><strong>Warfarin<\/strong> &mdash; valproate displaces warfarin from albumin; monitor INR<\/li>\n<li><strong>\u0410\u0441\u043f\u0438\u0440\u0438\u043d<\/strong> &mdash; displaces valproate from albumin; raises free valproate concentration<\/li>\n<li><strong>Phenytoin, carbamazepine<\/strong> &mdash; reduce valproate levels via CYP induction<\/li>\n<li><strong>Other CNS depressants<\/strong> (benzodiazepines, alcohol, opioids) &mdash; additive sedation<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0421\u044a\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435<\/h2>\n<p>Store below 25&deg;C in original blister. Protect from moisture. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">\u0427\u0435\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u043d\u0438 \u0432\u044a\u043f\u0440\u043e\u0441\u0438<\/h2>\n<h3 class=\"wp-block-heading\">How long until Encorate Chrono starts preventing migraines?<\/h3>\n<p>Allow 8-12 weeks at target dose for full effect. Keep a migraine diary recording days per month at baseline and at week 12. A clinically meaningful response is a 50% reduction in monthly migraine days.<\/p>\n<h3 class=\"wp-block-heading\">Is Encorate Chrono safe if I am planning pregnancy?<\/h3>\n<p><strong>\u041d\u0435.<\/strong> Valproate is one of the most teratogenic drugs in clinical use (~10% malformation risk, 30-40% neurodevelopmental impairment risk). Women of childbearing potential should be switched to a safer preventive (<a href=\"https:\/\/medsbase.com\/bg\/inderal\/\">\u043f\u0440\u043e\u043f\u0440\u0430\u043d\u043e\u043b\u043e\u043b<\/a> is preferred in pregnancy) before conception. A 3-month washout is usually recommended before trying to conceive. Valproate should not be used in women planning or able to become pregnant without a formal pregnancy-prevention programme.<\/p>\n<h3 class=\"wp-block-heading\">Why is the extended-release form different from Encorate IR?<\/h3>\n<p>Same molecule (sodium valproate \/ valproic acid), different release profile. Encorate Chrono is extended-release for once-daily dosing with smoother plasma levels. Better tolerability, better adherence. <a href=\"https:\/\/medsbase.com\/bg\/encorate\/\">Encorate IR<\/a> requires twice-daily dosing.<\/p>\n<h3 class=\"wp-block-heading\">Will Encorate Chrono make me gain weight?<\/h3>\n<p>Yes &mdash; weight gain is one of the most common side effects (average 3-5 kg over 6-12 months, more in some). Mechanism includes increased appetite, possibly altered glucose metabolism. If weight gain is problematic, consider switching to <a href=\"https:\/\/medsbase.com\/bg\/topicon\/\">topiramate<\/a> (which causes weight loss) or <a href=\"https:\/\/medsbase.com\/bg\/inderal\/\">\u043f\u0440\u043e\u043f\u0440\u0430\u043d\u043e\u043b\u043e\u043b<\/a> (weight-neutral).<\/p>\n<h3 class=\"wp-block-heading\">Why do I need blood tests on Encorate Chrono?<\/h3>\n<p>Valproate can cause hepatotoxicity, pancreatitis, thrombocytopenia, and hyperammonaemia. Baseline + periodic LFTs, full blood count, and clinical monitoring catch problems early. Therapeutic drug monitoring (levels 50-100 &mu;g\/mL) is not routinely needed for migraine prevention &mdash; dose by clinical response.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Encorate Chrono?<\/h3>\n<p>Avoid regular or heavy alcohol use. Alcohol is additive with valproate&#8217;s sedation and adds to hepatic stress. Occasional small amounts are not absolutely contraindicated but regular drinking raises the risk of hepatotoxicity. Alcohol is also a common migraine trigger; reducing intake often improves migraine independent of valproate.<\/p>\n<h3 class=\"wp-block-heading\">Can I stop Encorate Chrono abruptly?<\/h3>\n<p>No &mdash; taper over 2-4 weeks. Abrupt discontinuation can trigger rebound migraine and, in patients with any seizure tendency, seizure.<\/p>\n<h3 class=\"wp-block-heading\">Where can I buy Encorate Chrono online?<\/h3>\n<p>You can buy Encorate Chrono (sodium valproate 200 \/ 300 \/ 400 \/ 500 \/ 600 mg extended-release (chrono \/ CR) tablet, 30-180 tablet packs) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n<h2 class=\"wp-block-heading\">\u0421\u0440\u043e\u0434\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0437\u0430 \u043c\u0438\u0433\u0440\u0435\u043d\u0430 \u0432 MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/bg\/zolmist-nasal-spray\/\">Zolmist \u043d\u0430\u0437\u0430\u043b\u0435\u043d \u0441\u043f\u0440\u0435\u0439 \u2014 Zolmitriptan 5 mg (\u0431\u044a\u0440\u0437\u043e \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/zolitas-ods\/\">Zolitas ODS \u2014 Zolmitriptan 2.5\/5 mg \u0442\u0430\u0431\u043b\u0435\u0442\u043a\u0438 \u0437\u0430 \u043e\u0440\u0430\u043b\u043d\u0430 \u0434\u0438\u0441\u043f\u0435\u0440\u0441\u0438\u044f<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/maxtan\/\">Maxtan \u2014 Rizatriptan 5\/10 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/rizatop\/\">Rizatop \u2014 Rizatriptan 10 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/rizact\/\">\u0420\u0438\u0437\u0430\u043a\u0442 \u2014 \u0420\u0438\u0437\u0430\u0442\u0440\u0438\u043f\u0442\u0430\u043d (Cipla)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/sumitop\/\">Sumitop \u2014 Sumatriptan 25\/50\/100 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/anti-migraine\/\"><strong>\u0420\u0430\u0437\u0433\u043b\u0435\u0434\u0430\u0439\u0442\u0435 \u0432\u0441\u0438\u0447\u043a\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0437\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u043d\u0430 \u043c\u0438\u0433\u0440\u0435\u043d\u0430<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e \u0438\u0437\u0432\u0435\u0441\u0442\u0438\u0435.<\/strong> \u0422\u0430\u0437\u0438 \u0441\u0442\u0440\u0430\u043d\u0438\u0446\u0430 \u0435 \u0441\u0430\u043c\u043e \u0437\u0430 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u043e\u043d\u043d\u0438 \u0446\u0435\u043b\u0438 \u0438 \u043d\u0435 \u0437\u0430\u043c\u0435\u0441\u0442\u0432\u0430 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0442\u0435 \u0441\u044a\u0432\u0435\u0442\u0438 \u043d\u0430 \u043a\u0432\u0430\u043b\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u0437\u0434\u0440\u0430\u0432\u0435\u043d \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0441\u0442. \u0412\u0438\u043d\u0430\u0433\u0438 \u0441\u0435 \u043a\u043e\u043d\u0441\u0443\u043b\u0442\u0438\u0440\u0430\u0439\u0442\u0435 \u0441 \u0432\u0430\u0448\u0438\u044f \u043b\u0435\u043a\u0430\u0440 \u043f\u0440\u0435\u0434\u0438 \u0434\u0430 \u0437\u0430\u043f\u043e\u0447\u043d\u0435\u0442\u0435, \u043f\u0440\u043e\u043c\u0435\u043d\u0438\u0442\u0435 \u0438\u043b\u0438 \u0441\u043f\u0440\u0435\u0442\u0435 \u043f\u0440\u0438\u0435\u043c \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0437\u0430 \u043c\u0438\u0433\u0440\u0435\u043d\u0430.<\/div>\n<h3>\u0417\u0430\u0449\u043e \u0434\u0430 \u043f\u043e\u0440\u044a\u0447\u0432\u0430\u0442\u0435 \u043e\u0442 MedsBase<\/h3>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u043a\u0440\u0438\u0442\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 <a href=\"https:\/\/medsbase.com\/bg\/medsbase-re-shipment-assurance-policy\/\"><strong>\u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/strong><\/a> \u2014 \u0430\u043a\u043e \u0432\u0430\u0448\u0430\u0442\u0430 \u043f\u0440\u0430\u0442\u043a\u0430 \u043d\u0435 \u043f\u0440\u0438\u0441\u0442\u0438\u0433\u043d\u0435 \u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 20 \u0440\u0430\u0431\u043e\u0442\u043d\u0438 \u0434\u043d\u0438, \u043d\u0438\u0435 \u044f \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043c\u0435 \u043e\u0442\u043d\u043e\u0432\u043e.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u0421\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u0430\u043b\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u0438<\/h3>\n<p>\u0414\u0440\u0443\u0433\u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0438 \u0432 <strong>\u0425\u0440\u043e\u043d\u0438\u0447\u043d\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f<\/strong> \u043a\u043e\u0438\u0442\u043e \u043a\u043b\u0438\u0435\u043d\u0442\u0438\u0442\u0435 \u0441\u044a\u0449\u043e \u0440\u0430\u0437\u0433\u043b\u0435\u0436\u0434\u0430\u0442:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/bg\/carvego\/\">\u041a\u0430\u0440\u0432\u0435\u0433\u043e<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/hepcinat-lp\/\">Hepcinat LP<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/glucobay\/\">Glucobay<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/synaptol\/\">Synaptol<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/tenvir-af\/\">Tenvir AF<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Encorate Chrono is sodium valproate 200 \/ 300 \/ 400 \/ 500 \/ 600 mg extended-release (chrono \/ CR) tablets from Sun Pharma \u2014 once-daily dosing with smoother plasma levels than immediate-release Encorate. For migraine prevention: start 500 mg nightly, titrate to 1,000 mg nightly (range 500-1,500 mg). Same pregnancy and monitoring restrictions as all valproate products.<\/p>","protected":false},"featured_media":61071,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3553,3141,3223,3342,3554],"product_tag":[4973,4677,4898],"class_list":{"0":"post-61070","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-migraine","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-general-health","10":"product_cat-migraine-treatment","11":"product_tag-encorate-chrono","12":"product_tag-sodium-valproate","13":"product_tag-valproic-acid","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable","20":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product\/61070","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/comments?post=61070"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media\/61071"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media?parent=61070"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_brand?post=61070"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_cat?post=61070"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_tag?post=61070"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}