{"id":62135,"date":"2024-03-10T06:02:02","date_gmt":"2024-03-10T06:02:02","guid":{"rendered":"https:\/\/medsname.com\/malegra-fxt-plus\/"},"modified":"2026-05-04T05:53:15","modified_gmt":"2026-05-04T05:53:15","slug":"malegra-fxt-plus","status":"publish","type":"product","link":"https:\/\/medsbase.com\/bg\/product\/malegra-fxt-plus\/","title":{"rendered":"Malegra FXT Plus"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Malegra FXT Plus?<\/h3>\n<p style=\"margin:0;\"><strong>Malegra FXT Plus<\/strong> \u0441\u044a\u0434\u044a\u0440\u0436\u0430 <strong>sildenafil 100 mg + fluoxetine 60 mg<\/strong> \u0438 \u0441\u0435 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430 \u043f\u0440\u0438 \u0435\u0440\u0435\u043a\u0442\u0438\u043b\u043d\u0430 \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u044f \u0441 \u043f\u0440\u0435\u0436\u0434\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u0430 \u0435\u044f\u043a\u0443\u043b\u0430\u0446\u0438\u044f. \u0414\u043e\u0441\u0442\u0430\u0432\u044f \u0441\u0435 \u0432 <strong>sildenafil 100 mg + fluoxetine 60 mg<\/strong>. \u041a\u043b\u0438\u043d\u0438\u0447\u043d\u0438\u044f\u0442 \u0435\u0444\u0435\u043a\u0442 \u043f\u0440\u043e\u0434\u044a\u043b\u0436\u0430\u0432\u0430 \u043e\u043a\u043e\u043b\u043e <strong>4\u20136 hours for ED; fluoxetine steady-state over weeks<\/strong>. \u041f\u0440\u043e\u0438\u0437\u0432\u0435\u0434\u0435\u043d\u043e \u043e\u0442 Sunrise Remedies.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u041a\u0430\u043a\u0432\u043e \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u0442\u0435 \u0441 MedsBase:<\/strong> \u041f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b, \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u043e\u0442 WHO-GMP \u00b7 \u0414\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u00b7 \u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442 \u00b7 \u041d\u0430\u0434 1400 \u043f\u043e\u0442\u0432\u044a\u0440\u0434\u0435\u043d\u0438 <a href=\"https:\/\/medsbase.com\/bg\/reviews\/\">\u043e\u0442\u0437\u0438\u0432\u0430 \u043e\u0442 \u043a\u043b\u0438\u0435\u043d\u0442\u0438<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u043a\u0440\u0438\u0442\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 <a href=\"https:\/\/medsbase.com\/bg\/medsbase-re-shipment-assurance-policy\/\"><strong>\u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/strong><\/a> \u2014 \u0430\u043a\u043e \u0432\u0430\u0448\u0430\u0442\u0430 \u043f\u0440\u0430\u0442\u043a\u0430 \u043d\u0435 \u043f\u0440\u0438\u0441\u0442\u0438\u0433\u043d\u0435 \u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 20 \u0440\u0430\u0431\u043e\u0442\u043d\u0438 \u0434\u043d\u0438, \u043d\u0438\u0435 \u044f \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043c\u0435 \u043e\u0442\u043d\u043e\u0432\u043e.<\/p>\n<h3>\u0417\u0430\u0449\u043e \u0434\u0430 \u043f\u043e\u0440\u044a\u0447\u0432\u0430\u0442\u0435 \u043e\u0442 MedsBase<\/h3>\n<p>\u041d\u0430\u0448\u0438\u0442\u0435 \u0433\u0435\u043d\u0435\u0440\u0438\u0447\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0441\u0435 \u0434\u043e\u0441\u0442\u0430\u0432\u044f\u0442 \u043e\u0442 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b\u0438, \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d\u0438 \u043e\u0442 WHO-GMP, \u0438 \u0441\u0435 \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u0442 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442 \u0432 \u0434\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430, \u043e\u0431\u0438\u043a\u043d\u043e\u0432\u0435\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u2014 \u0431\u0435\u0437 \u0438\u043c\u0435 \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e\u0442\u043e \u0432\u044a\u043d\u0448\u043d\u043e \u043d\u0430 \u043f\u0440\u0430\u0442\u043a\u0430\u0442\u0430. \u041f\u043b\u0430\u0449\u0430\u043d\u0438\u044f\u0442\u0430 \u0441 \u043a\u0430\u0440\u0442\u0430 \u0441\u0435 \u043e\u0431\u0440\u0430\u0431\u043e\u0442\u0432\u0430\u0442 \u0447\u0440\u0435\u0437 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430\u043d \u043f\u0440\u043e\u0446\u0435\u0441\u043e\u0440 (\u043e\u043f\u0438\u0441\u0430\u043d\u0438\u0435\u0442\u043e \u043d\u0430 \u0438\u0437\u0432\u043b\u0435\u0447\u0435\u043d\u0438\u0435\u0442\u043e \u0432\u043a\u043b\u044e\u0447\u0432\u0430 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430\u043d \u043f\u0440\u043e\u0446\u0435\u0441\u043e\u0440 \u0437\u0430 \u043f\u043b\u0430\u0449\u0430\u043d\u0435 \u0441 \u043a\u0430\u0440\u0442\u0430 \u2014 \u043d\u0438\u043a\u043e\u0433\u0430 \u201cMedsBase\u201d \u0438\u043b\u0438 \u0438\u043c\u0435 \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e). \u041f\u0440\u0438\u0435\u043c\u0430\u0442 \u0441\u0435 \u0441\u044a\u0449\u043e \u043a\u0440\u0438\u043f\u0442\u043e\u0432\u0430\u043b\u0443\u0442\u0438 \u0438 \u0431\u0430\u043d\u043a\u043e\u0432 \u043f\u0440\u0435\u0432\u043e\u0434 SEPA. \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u0434\u043a\u0440\u0435\u043f\u0435\u043d\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 \u043f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u0433\u0430\u0440\u0430\u043d\u0442\u0438\u0440\u0430\u043d\u043e \u043f\u0440\u0435\u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043d\u0435.<\/p>\n<p><strong>Malegra FXT Plus<\/strong> \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u0430 <strong>\u0441\u0438\u043b\u0434\u0435\u043d\u0430\u0444\u0438\u043b 100 \u043c\u0433<\/strong> (a short-acting PDE5 inhibitor for erectile dysfunction) with <strong>fluoxetine 60 mg<\/strong> (a long-acting SSRI that can delay ejaculation). Unlike dapoxetine-based combinations, fluoxetine is a <strong>daily-use SSRI<\/strong> \u2014 the ejaculation-delay effect builds over weeks of regular use rather than immediately from a single dose.<\/p>\n<p>Manufactured by Sunrise Remedies, Malegra FXT Plus is intended for men with <strong>\u0441\u044a\u0432\u043c\u0435\u0441\u0442\u043d\u0430 \u0435\u0440\u0435\u043a\u0442\u0438\u043b\u043d\u0430 \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u044f \u0438 \u043f\u0440\u0435\u0436\u0434\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u0430 \u0435\u044f\u043a\u0443\u043b\u0430\u0446\u0438\u044f<\/strong> who are already on (or planning to start) daily SSRI therapy for PE.<\/p>\n<h2 class=\"wp-block-heading\">What Is Malegra FXT Plus?<\/h2>\n<p>Malegra FXT Plus is a combination tablet containing:<\/p>\n<ul>\n<li><strong>Sildenafil 100 mg<\/strong> \u2014 a PDE5 inhibitor that improves erectile response; effects last 4\u20136 hours<\/li>\n<li><strong>Fluoxetine 60 mg<\/strong> \u2014 an SSRI that extends ejaculatory latency when taken regularly over weeks<\/li>\n<\/ul>\n<p><strong>\u0412\u0430\u0436\u043d\u043e:<\/strong> unlike dapoxetine, fluoxetine is <strong>\u043d\u0435<\/strong> an on-demand PE drug \u2014 it requires continuous daily dosing (typically 4\u20136 weeks to take full effect) and should be reviewed by a doctor before starting. Many clinicians prefer dapoxetine (as in <a href=\"https:\/\/medsbase.com\/bg\/super-tadalis-sx\/\" rel=\"noopener\">Super Tadalis Sx<\/a> \u0438\u043b\u0438 <a href=\"https:\/\/medsbase.com\/bg\/super-vilitra\/\" rel=\"noopener\">Super Vilitra<\/a>) for the PE side of combined treatment because it is specifically engineered for on-demand use.<\/p>\n<h2 class=\"wp-block-heading\">How Does Malegra FXT Plus Work?<\/h2>\n<ul>\n<li><strong>Sildenafil<\/strong> blocks PDE5 in the corpus cavernosum, prolonging cyclic GMP activity and allowing increased blood inflow during sexual arousal<\/li>\n<li><strong>Fluoxetine<\/strong> selectively inhibits the serotonin transporter; raised synaptic serotonin delays the ejaculatory reflex. This effect builds over 2\u20136 weeks of daily use<\/li>\n<\/ul>\n<p>Because fluoxetine&#8217;s active metabolite (norfluoxetine) has a half-life of 7\u201315 days, the SSRI effect accumulates slowly and persists long after stopping.<\/p>\n<h2 class=\"wp-block-heading\">\u0423\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u0438 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f<\/h2>\n<ul>\n<li><strong>Co-existing erectile dysfunction and premature ejaculation<\/strong> \u2014 where daily SSRI therapy is acceptable<\/li>\n<li><strong>ED with depressive symptoms<\/strong> \u2014 rarely, where the fluoxetine component is also treating mood<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Malegra FXT Plus Dosage and Administration<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0421\u0446\u0435\u043d\u0430\u0440\u0438\u0439<\/th>\n<th>\u041f\u0440\u0435\u043f\u043e\u0440\u044a\u0447\u0438\u0442\u0435\u043b\u0435\u043d \u043f\u043e\u0434\u0445\u043e\u0434<\/th>\n<th>\u0411\u0435\u043b\u0435\u0436\u043a\u0438<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>First-time combination use<\/strong><\/td>\n<td>1 tablet daily under medical supervision<\/td>\n<td>Sildenafil effect is per-tablet on-demand; fluoxetine effect builds over 2\u20136 weeks<\/td>\n<\/tr>\n<tr>\n<td><strong>ED \u2014 single dose<\/strong><\/td>\n<td>100 mg sildenafil component works per tablet<\/td>\n<td>30\u201360 min before activity<\/td>\n<\/tr>\n<tr>\n<td><strong>PE \u2014 sustained effect<\/strong><\/td>\n<td>Fluoxetine requires 2\u20136 weeks of daily dosing<\/td>\n<td>Not effective as a one-off &#8220;pop-a-pill&#8221; for PE<\/td>\n<\/tr>\n<tr>\n<td><strong>\u041b\u0435\u043a \u0447\u0435\u0440\u043d\u043e\u0434\u0440\u043e\u0431\u0435\u043d \u0441\u0440\u0438\u0432<\/strong><\/td>\n<td>Reduce dose; caution<\/td>\n<td>Fluoxetine is heavily hepatically cleared<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0422\u0435\u0436\u043a\u043e \u0443\u0432\u0440\u0435\u0436\u0434\u0430\u043d\u0435 \u043d\u0430 \u0447\u0435\u0440\u043d\u0438\u044f \u0434\u0440\u043e\u0431 \u0438\u043b\u0438 \u0431\u044a\u0431\u0440\u0435\u0446\u0438\u0442\u0435<\/strong><\/td>\n<td>\u0418\u0437\u0431\u044f\u0433\u0432\u0430\u0439\u0442\u0435<\/td>\n<td>Use separate lower-dose components<\/td>\n<\/tr>\n<tr>\n<td><strong>Maximum sildenafil exposure<\/strong><\/td>\n<td>1 \u0442\u0430\u0431\u043b\u0435\u0442\u043a\u0430 \u043d\u0430 \u0432\u0441\u0435\u043a\u0438 24 \u0447\u0430\u0441\u0430<\/td>\n<td>Do not exceed \u2014 contains a full 100 mg sildenafil dose<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">How to Take Malegra FXT Plus Properly<\/h3>\n<ul>\n<li>Swallow whole with water \u2014 food has modest impact; a fatty meal slows sildenafil onset<\/li>\n<li>For PE benefit, take daily at roughly the same time (fluoxetine steady-state takes 2\u20136 weeks)<\/li>\n<li>For ED benefit, take 30\u201360 min before activity<\/li>\n<li>Do not exceed one tablet per 24 hours<\/li>\n<li>Do not combine with MAOIs \u2014 14-day washout required<\/li>\n<li>Avoid abrupt discontinuation after weeks of use \u2014 fluoxetine has a long tail but some men experience SSRI-discontinuation symptoms<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Side Effects of Malegra FXT Plus<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u041a\u043e\u043c\u043f\u043e\u043d\u0435\u043d\u0442 \/ \u0422\u0435\u0436\u0435\u0441\u0442<\/th>\n<th>\u0421\u0442\u0440\u0430\u043d\u0438\u0447\u0435\u043d \u0435\u0444\u0435\u043a\u0442<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>\u0421\u0438\u043b\u0434\u0435\u043d\u0430\u0444\u0438\u043b \u2014 \u0447\u0435\u0441\u0442\u0438<\/strong><\/td>\n<td>Headache, flushing, dyspepsia, nasal congestion, visual disturbance<\/td>\n<\/tr>\n<tr>\n<td><strong>Fluoxetine \u2014 common<\/strong><\/td>\n<td>Nausea, insomnia, sexual dysfunction (ironic but real \u2014 delayed\/absent orgasm), anxiety, weight change, somnolence<\/td>\n<\/tr>\n<tr>\n<td><strong>Fluoxetine \u2014 less common<\/strong><\/td>\n<td>Suicidal ideation (especially in first weeks), QT prolongation, bleeding risk, hyponatraemia in elderly<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0420\u044f\u0434\u043a\u043e<\/strong><\/td>\n<td>Serotonin syndrome (with other serotonergic drugs), Stevens-Johnson syndrome, priapism<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Black-box style caution:<\/strong> SSRI initiation can transiently increase suicidal thoughts, particularly in young adults. Regular contact with a prescriber during the first weeks of use is essential.<\/p>\n<h2 class=\"wp-block-heading\">\u041f\u0440\u0435\u0434\u0443\u043f\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u044f \u0438 \u043f\u0440\u0435\u0434\u043f\u0430\u0437\u043d\u0438 \u043c\u0435\u0440\u043a\u0438<\/h2>\n<ul>\n<li><strong>\u0421\u044a\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u044a\u0434\u043e\u0432\u0430 \u0433\u043e\u0434\u043d\u043e\u0441\u0442 \u0437\u0430 \u0441\u0435\u043a\u0441<\/strong> \u2014 \u0441\u0435\u043a\u0441\u0443\u0430\u043b\u043d\u0430\u0442\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442 \u043f\u043e\u0441\u0442\u0430\u0432\u044f \u0441\u044a\u0440\u0434\u0435\u0447\u043d\u0430\u0442\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u0430 \u043f\u043e\u0434 \u043d\u0430\u0442\u043e\u0432\u0430\u0440\u0432\u0430\u043d\u0435. \u041c\u044a\u0436\u0435\u0442\u0435 \u0441 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u0430\u043d\u0433\u0438\u043d\u0430, \u0441\u043a\u043e\u0440\u043e\u0448\u0435\u043d \u0438\u043d\u0444\u0430\u0440\u043a\u0442 \u043d\u0430 \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430 (\u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 90 \u0434\u043d\u0438), \u043d\u0435\u043a\u043e\u043d\u0442\u0440\u043e\u043b\u0438\u0440\u0430\u043d\u0430 \u0430\u0440\u0438\u0442\u043c\u0438\u044f \u0438\u043b\u0438 \u0442\u0435\u0436\u043a\u0430 \u0441\u044a\u0440\u0434\u0435\u0447\u043d\u0430 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u044a\u0447\u043d\u043e\u0441\u0442 \u0442\u0440\u044f\u0431\u0432\u0430 \u0434\u0430 \u043f\u0440\u0435\u043c\u0438\u043d\u0430\u0442 \u043a\u0430\u0440\u0434\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u043d \u043f\u0440\u0435\u0434\u0438\u0448 \u043f\u0440\u0435\u0434\u0438 \u0437\u0430\u043f\u043e\u0447\u0432\u0430\u043d\u0435 \u043d\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0441 PDE5 \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440<\/li>\n<li><strong>\u041a\u0440\u044a\u0432\u043d\u043e \u043d\u0430\u043b\u044f\u0433\u0430\u043d\u0435<\/strong> \u2014 PDE5 \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440\u0438\u0442\u0435 \u043f\u0440\u0438\u0447\u0438\u043d\u044f\u0432\u0430\u0442 \u043b\u0435\u043a\u0438, \u043f\u0440\u0435\u0445\u043e\u0434\u043d\u0438 \u043d\u0430\u043c\u0430\u043b\u0435\u043d\u0438\u044f \u043d\u0430 \u043a\u0440\u044a\u0432\u043d\u043e\u0442\u043e \u043d\u0430\u043b\u044f\u0433\u0430\u043d\u0435; \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430\u0439\u0442\u0435 \u0441 \u043f\u0440\u0435\u0434\u043f\u0430\u0437\u043b\u0438\u0432\u043e\u0441\u0442 \u043f\u0440\u0438 \u043f\u0440\u0438\u0435\u043c \u043d\u0430 \u043c\u043d\u043e\u0436\u0435\u0441\u0442\u0432\u043e \u0430\u043d\u0442\u0438\u0445\u0438\u043f\u0435\u0440\u0442\u0435\u043d\u0437\u0438\u0432\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430<\/li>\n<li><strong>\u041f\u0440\u0438\u0430\u043f\u0438\u0437\u044a\u043c<\/strong> \u2014 \u043f\u043e-\u0432\u0438\u0441\u043e\u043a \u0440\u0438\u0441\u043a \u043f\u0440\u0438 \u043c\u044a\u0436\u0435 \u0441\u044a\u0441 \u0441\u0435\u0440\u043f\u043e\u0432\u0438\u0434\u043d\u043e-\u043a\u043b\u0435\u0442\u044a\u0447\u043d\u0430 \u0430\u043d\u0435\u043c\u0438\u044f, \u043c\u043d\u043e\u0436\u0435\u0441\u0442\u0432\u0435\u043d \u043c\u0438\u0435\u043b\u043e\u043c \u0438\u043b\u0438 \u043b\u0435\u0432\u043a\u0435\u043c\u0438\u044f; \u043f\u043e\u0442\u044a\u0440\u0441\u0435\u0442\u0435 \u0441\u043f\u0435\u0448\u043d\u0430 \u043f\u043e\u043c\u043e\u0449, \u0430\u043a\u043e \u0435\u0440\u0435\u043a\u0446\u0438\u044f\u0442\u0430 \u043f\u0440\u043e\u0434\u044a\u043b\u0436\u0430\u0432\u0430 \u043f\u043e\u0432\u0435\u0447\u0435 \u043e\u0442 4 \u0447\u0430\u0441\u0430<\/li>\n<li><strong>\u0417\u0440\u0435\u043d\u0438\u0435<\/strong> \u2014 \u043f\u0440\u0435\u043a\u0440\u0430\u0442\u0435\u0442\u0435 \u043f\u0440\u0438\u0435\u043c\u0430 \u0438 \u043f\u043e\u0442\u044a\u0440\u0441\u0435\u0442\u0435 \u043f\u0440\u0435\u0433\u043b\u0435\u0434 \u043f\u0440\u0438 \u0432\u043d\u0435\u0437\u0430\u043f\u043d\u0438 \u043f\u0440\u043e\u043c\u0435\u043d\u0438 \u0432 \u0437\u0440\u0435\u043d\u0438\u0435\u0442\u043e; \u0441\u0430 \u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0438\u0440\u0430\u043d\u0438 \u0440\u0435\u0434\u043a\u0438 \u0441\u043b\u0443\u0447\u0430\u0438 \u043d\u0430 \u043d\u0435\u0430\u0440\u0442\u0435\u0440\u0438\u0438\u0442\u043d\u0430 \u0438\u0448\u0435\u043c\u0438\u0447\u043d\u0430 \u043e\u043f\u0442\u0438\u0447\u043d\u0430 \u043d\u0435\u0432\u0440\u043e\u043f\u0430\u0442\u0438\u044f (NAION)<\/li>\n<li><strong>\u0421\u043b\u0443\u0445<\/strong> \u2014 \u0441\u043f\u043e\u0440\u0430\u0434\u0438\u0447\u043d\u0438 \u0441\u043b\u0443\u0447\u0430\u0438 \u043d\u0430 \u0432\u043d\u0435\u0437\u0430\u043f\u043d\u0430 \u0441\u0435\u043d\u0437\u043e\u0440\u043d\u0430 \u043d\u0435\u0432\u0440\u0430\u043b\u043d\u0430 \u0437\u0430\u0433\u0443\u0431\u0430 \u043d\u0430 \u0441\u043b\u0443\u0445\u0430 \u2014 \u043f\u0440\u0435\u043a\u0440\u0430\u0442\u0435\u0442\u0435 \u043f\u0440\u0438\u0435\u043c\u0430 \u0438 \u043a\u043e\u043d\u0441\u0443\u043b\u0442\u0438\u0440\u0430\u0439\u0442\u0435 \u0441\u0435 \u0441 \u043b\u0435\u043a\u0430\u0440, \u0430\u043a\u043e \u0441\u0435 \u043f\u0440\u043e\u044f\u0432\u044f\u0442<\/li>\n<li><strong>Alcohol<\/strong> \u2014 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u0435\u043d \u043f\u0440\u0438\u0435\u043c \u043d\u0430 \u0430\u043b\u043a\u043e\u0445\u043e\u043b \u0432 \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u044f \u0441 \u043a\u043e\u0439\u0442\u043e \u0438 \u0434\u0430 \u0435 PDE5 \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440 \u043c\u043e\u0436\u0435 \u0434\u0430 \u0443\u0441\u0438\u043b\u0438 \u0437\u0430\u043c\u0430\u044f\u043d\u043e\u0441\u0442, \u0433\u043b\u0430\u0432\u043e\u0431\u043e\u043b\u0438\u0435 \u0438 \u043d\u0438\u0441\u043a\u043e \u043a\u0440\u044a\u0432\u043d\u043e \u043d\u0430\u043b\u044f\u0433\u0430\u043d\u0435<\/li>\n<li><strong>Grapefruit juice<\/strong> \u2014 \u0438\u043d\u0445\u0438\u0431\u0438\u0440\u0430 CYP3A4 \u0438 \u043c\u043e\u0436\u0435 \u0434\u0430 \u043f\u043e\u0432\u0438\u0448\u0438 \u043d\u0438\u0432\u0430\u0442\u0430 \u0432 \u043a\u0440\u044a\u0432\u0442\u0430<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u041f\u0440\u043e\u0442\u0438\u0432\u043e\u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f \u2014 \u041a\u043e\u0439 \u041d\u0415 \u0422\u0440\u044f\u0431\u0432\u0430 \u0434\u0430 \u041f\u0440\u0438\u0435\u043c\u0430 \u0422\u043e\u0432\u0430 \u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e<\/h2>\n<ul>\n<li><strong>\u0415\u0434\u043d\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u0430 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u0441 \u043d\u0438\u0442\u0440\u0430\u0442\u0438<\/strong> \u2014 GTN, \u0438\u0437\u043e\u0441\u043e\u0440\u0431\u0438\u0434 \u043c\u043e\u043d\u043e\/\u0434\u0438\u043d\u0438\u0442\u0440\u0430\u0442, \u043d\u0438\u043a\u043e\u0440\u0430\u043d\u0434\u0438\u043b, \u0430\u043c\u0438\u043b \u043d\u0438\u0442\u0440\u0438\u0442 (\u201cpoppers\u201d)<\/li>\n<li><strong>\u0415\u0434\u043d\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u0430 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u0441\u044a\u0441 \u0441\u0442\u0438\u043c\u0443\u043b\u0430\u0442\u043e\u0440\u0438 \u043d\u0430 \u0433\u0443\u0430\u043d\u0438\u043b\u0430\u0442\u0446\u0438\u043a\u043b\u0430\u0437\u0430\u0442\u0430<\/strong> \u043a\u0430\u0442\u043e \u0440\u0438\u043e\u0446\u0438\u0433\u0443\u0430\u0442<\/li>\n<li>\u0421\u043a\u043e\u0440\u043e\u0448\u0435\u043d \u0438\u043d\u0444\u0430\u0440\u043a\u0442 \u043d\u0430 \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430 (\u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 90 \u0434\u043d\u0438), \u043d\u0435\u0441\u0442\u0430\u0431\u0438\u043b\u043d\u0430 angina pectoris \u0438\u043b\u0438 angina pectoris \u043f\u043e \u0432\u0440\u0435\u043c\u0435 \u043d\u0430 \u043f\u043e\u043b\u043e\u0432\u0438 \u043a\u043e\u043d\u0442\u0430\u043a\u0442<\/li>\n<li>\u0421\u044a\u0440\u0434\u0435\u0447\u043d\u0430 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u044a\u0447\u043d\u043e\u0441\u0442 NYHA \u043a\u043b\u0430\u0441 II \u0438\u043b\u0438 \u043f\u043e-\u0432\u0438\u0441\u043e\u043a\u0430 \u043f\u0440\u0435\u0437 \u043f\u043e\u0441\u043b\u0435\u0434\u043d\u0438\u0442\u0435 6 \u043c\u0435\u0441\u0435\u0446\u0430<\/li>\n<li>\u041d\u0435\u043a\u043e\u043d\u0442\u0440\u043e\u043b\u0438\u0440\u0430\u043d\u0430 \u0430\u0440\u0438\u0442\u043c\u0438\u044f, \u0445\u0438\u043f\u043e\u0442\u043e\u043d\u0438\u044f (\u043a\u0440\u044a\u0432\u043d\u043e \u043d\u0430\u043b\u044f\u0433\u0430\u043d\u0435 170\/100)<\/li>\n<li>\u0418\u043d\u0441\u0443\u043b\u0442 \u043f\u0440\u0435\u0437 \u043f\u043e\u0441\u043b\u0435\u0434\u043d\u0438\u0442\u0435 6 \u043c\u0435\u0441\u0435\u0446\u0430<\/li>\n<li>\u0418\u0437\u0432\u0435\u0441\u0442\u043d\u0430 \u043d\u0435\u0430\u0440\u0442\u0435\u0440\u0438\u0442\u0438\u0447\u043d\u0430 \u043f\u0440\u0435\u0434\u043d\u0430 \u0438\u0448\u0435\u043c\u0438\u0447\u043d\u0430 \u043e\u043f\u0442\u0438\u0447\u043d\u0430 \u043d\u0435\u0432\u0440\u043e\u043f\u0430\u0442\u0438\u044f (NAION) \u0432 \u0435\u0434\u043d\u043e\u0442\u043e \u0438\u043b\u0438 \u0434\u0432\u0435\u0442\u0435 \u043e\u0447\u0438<\/li>\n<li>\u0422\u0435\u0436\u043a\u043e \u0443\u0432\u0440\u0435\u0436\u0434\u0430\u043d\u0435 \u043d\u0430 \u0447\u0435\u0440\u043d\u0438\u044f \u0434\u0440\u043e\u0431 (Child-Pugh C)<\/li>\n<li>\u0425\u0438\u043f\u0435\u0440\u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u043d\u043e\u0441\u0442 \u043a\u044a\u043c \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0442\u043e \u0432\u0435\u0449\u0435\u0441\u0442\u0432\u043e \u0438\u043b\u0438 \u043a\u044a\u043c \u043d\u044f\u043a\u043e\u0439 \u043e\u0442 \u043f\u043e\u043c\u043e\u0449\u043d\u0438\u0442\u0435 \u0432\u0435\u0449\u0435\u0441\u0442\u0432\u0430<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u0438 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e \/ \u041a\u043b\u0430\u0441<\/th>\n<th>\u0412\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>\u041d\u0438\u0442\u0440\u0430\u0442\u0438 (GTN, ISMN, ISDN, \u0430\u043c\u0438\u043b \u043d\u0438\u0442\u0440\u0438\u0442\/\u201dpoppers\u201d)<\/strong><\/td>\n<td><strong>\u0410\u0431\u0441\u043e\u043b\u044e\u0442\u043d\u0430 \u043a\u043e\u043d\u0442\u0440\u0430\u0438\u043d\u0434\u0438\u043a\u0430\u0446\u0438\u044f<\/strong> \u2014 \u0442\u0435\u0436\u043a\u0430, \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b\u043d\u043e \u0444\u0430\u0442\u0430\u043b\u043d\u0430 \u0445\u0438\u043f\u043e\u0442\u043e\u043d\u0438\u044f<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0410\u043b\u0444\u0430-\u0431\u043b\u043e\u043a\u0430\u0442\u043e\u0440\u0438 (\u0434\u043e\u043a\u0441\u0430\u0437\u043e\u0437\u0438\u043d, \u0442\u0430\u043c\u0441\u0443\u043b\u043e\u0437\u0438\u043d, \u0430\u043b\u0444\u0443\u0437\u043e\u0437\u0438\u043d)<\/strong><\/td>\n<td>\u0414\u043e\u043f\u044a\u043b\u043d\u0438\u0442\u0435\u043b\u043d\u043e \u043f\u043e\u043d\u0438\u0436\u0430\u0432\u0430\u043d\u0435 \u043d\u0430 \u043a\u0440\u044a\u0432\u043d\u043e\u0442\u043e \u043d\u0430\u043b\u044f\u0433\u0430\u043d\u0435 \u2014 \u043f\u044a\u0440\u0432\u043e \u0441\u0442\u0430\u0431\u0438\u043b\u0438\u0437\u0438\u0440\u0430\u0439\u0442\u0435 \u0434\u043e\u0437\u0430\u0442\u0430 \u043d\u0430 \u0430\u043b\u0444\u0430-\u0431\u043b\u043e\u043a\u0430\u0442\u043e\u0440\u0430, \u0437\u0430\u043f\u043e\u0447\u043d\u0435\u0442\u0435 \u0441 \u043d\u0430\u0439-\u043d\u0438\u0441\u043a\u0430\u0442\u0430 \u0434\u043e\u0437\u0430 PDE5<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0418\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440\u0438 \u043d\u0430 CYP3A4 (\u043a\u0435\u0442\u043e\u043a\u043e\u043d\u0430\u0437\u043e\u043b, \u0438\u0442\u0440\u0430\u043a\u043e\u043d\u0430\u0437\u043e\u043b, \u0440\u0438\u0442\u043e\u043d\u0430\u0432\u0438\u0440, \u043a\u043b\u0430\u0440\u0438\u0442\u0440\u043e\u043c\u0438\u0446\u0438\u043d)<\/strong><\/td>\n<td>\u041f\u043e\u0432\u0438\u0448\u0430\u0432\u0430\u0442 \u043d\u0438\u0432\u0430\u0442\u0430 \u043d\u0430 PDE5 \u0432 \u043f\u043b\u0430\u0437\u043c\u0430\u0442\u0430 \u2014 \u043d\u0430\u043c\u0430\u043b\u0435\u0442\u0435 \u0434\u043e\u0437\u0430\u0442\u0430 \u0438\u043b\u0438 \u0438\u0437\u0431\u044f\u0433\u0432\u0430\u0439\u0442\u0435 \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u044f\u0442\u0430<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0418\u043d\u0434\u0443\u043a\u0442\u043e\u0440\u0438 \u043d\u0430 CYP3A4 (\u0440\u0438\u0444\u0430\u043c\u043f\u0438\u0446\u0438\u043d, \u0444\u0435\u043d\u0438\u0442\u043e\u0438\u043d, \u043a\u0430\u0440\u0431\u0430\u043c\u0430\u0437\u0435\u043f\u0438\u043d, \u0437\u0432\u0435\u0440\u043e\u0431\u043e\u0439)<\/strong><\/td>\n<td>\u041d\u0430\u043c\u0430\u043b\u044f\u0432\u0430\u0442 \u043d\u0438\u0432\u0430\u0442\u0430 \u043d\u0430 PDE5 \u0432 \u043f\u043b\u0430\u0437\u043c\u0430\u0442\u0430 \u2014 \u0435\u0444\u0438\u043a\u0430\u0441\u043d\u043e\u0441\u0442\u0442\u0430 \u043c\u043e\u0436\u0435 \u0434\u0430 \u0431\u044a\u0434\u0435 \u043d\u0430\u043c\u0430\u043b\u0435\u043d\u0430<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0420\u0438\u043e\u0446\u0438\u0433\u0443\u0430\u0442 \u0438 \u0434\u0440\u0443\u0433\u0438 \u0441\u0442\u0438\u043c\u0443\u043b\u0430\u0442\u043e\u0440\u0438 \u043d\u0430 sGC<\/strong><\/td>\n<td>\u041a\u043e\u043d\u0442\u0440\u0430\u0438\u043d\u0434\u0438\u043a\u0438\u0440\u0430\u043d\u043e \u2014 \u0440\u0438\u0441\u043a \u043e\u0442 \u0442\u0435\u0436\u043a\u0430 \u0445\u0438\u043f\u043e\u0442\u043e\u043d\u0438\u044f<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0414\u0440\u0443\u0433\u0438 \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440\u0438 \u043d\u0430 PDE5<\/strong><\/td>\n<td>\u041d\u0435 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u0430\u0439\u0442\u0435 \u2014 \u0434\u043e\u0431\u0430\u0432\u0435\u043d\u0438 \u0441\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u0431\u0435\u0437 \u0434\u043e\u043f\u044a\u043b\u043d\u0438\u0442\u0435\u043b\u043d\u0430 \u0435\u0444\u0438\u043a\u0430\u0441\u043d\u043e\u0441\u0442<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0410\u043d\u0442\u0438\u0445\u0438\u043f\u0435\u0440\u0442\u0435\u043d\u0437\u0438\u0432\u0438<\/strong><\/td>\n<td>\u041d\u0435\u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u043d\u043e \u0434\u043e\u0431\u0430\u0432\u0435\u043d\u043e \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u043a\u0440\u044a\u0432\u043d\u043e\u0442\u043e \u043d\u0430\u043b\u044f\u0433\u0430\u043d\u0435 \u2014 \u043e\u0431\u0438\u043a\u043d\u043e\u0432\u0435\u043d\u043e \u043a\u043b\u0438\u043d\u0438\u0447\u043d\u043e \u043d\u0435\u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u043d\u043e<\/td>\n<\/tr>\n<tr>\n<td><strong>Grapefruit juice<\/strong><\/td>\n<td>\u0418\u043d\u0445\u0438\u0431\u0438\u0440\u0430 CYP3A4 \u2014 \u0438\u0437\u0431\u044f\u0433\u0432\u0430\u0439\u0442\u0435 \u0433\u043e\u043b\u0435\u043c\u0438 \u0438\u043b\u0438 \u0440\u0435\u0434\u043e\u0432\u043d\u0438 \u0434\u043e\u0437\u0438<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u0412\u0438\u043d\u0430\u0433\u0438 \u0441\u043f\u043e\u0434\u0435\u043b\u044f\u0439\u0442\u0435 \u043f\u044a\u043b\u0435\u043d \u0441\u043f\u0438\u0441\u044a\u043a \u043d\u0430 \u0442\u0435\u043a\u0443\u0449\u0438\u0442\u0435 \u0441\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430, \u0432\u043a\u043b\u044e\u0447\u0438\u0442\u0435\u043b\u043d\u043e \u0431\u0435\u0437\u0440\u0435\u0446\u0435\u043f\u0442\u0443\u0440\u043d\u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0438, \u0440\u0435\u043a\u0440\u0435\u0430\u0442\u0438\u0432\u043d\u0438 \u043d\u0430\u0440\u043a\u043e\u0442\u0438\u0446\u0438 \u0438 \u0431\u0438\u043b\u043a\u043e\u0432\u0438 \u0434\u043e\u0431\u0430\u0432\u043a\u0438, \u0441 \u0432\u0430\u0448\u0438\u044f \u043b\u0435\u043a\u0430\u0440, \u043f\u0440\u0435\u0434\u0438 \u0434\u0430 \u0437\u0430\u043f\u043e\u0447\u043d\u0435\u0442\u0435 \u043f\u0440\u0438\u0435\u043c\u0430 \u043d\u0430 \u0442\u043e\u0432\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u043e.<\/p>\n<h2 class=\"wp-block-heading\">\u041a\u0430\u043a\u0432\u043e \u0434\u0430 \u043f\u0440\u0430\u0432\u0438\u0442\u0435 \u043f\u0440\u0438 \u043f\u0440\u0435\u0434\u043e\u0437\u0438\u0440\u0430\u043d\u0435<\/h2>\n<p>\u0421\u0438\u043c\u043f\u0442\u043e\u043c\u0438\u0442\u0435 \u043d\u0430 \u043f\u0440\u0435\u0434\u043e\u0437\u0438\u0440\u0430\u043d\u0435 \u0441 PDE5 \u0432\u043a\u043b\u044e\u0447\u0432\u0430\u0442 \u0442\u0435\u0436\u043a\u0430 \u0433\u043b\u0430\u0432\u043e\u0431\u043e\u043b\u0438\u0435, \u0438\u0437\u0440\u0430\u0437\u0435\u043d\u0430 \u0445\u0438\u043f\u043e\u0442\u043e\u043d\u0438\u044f, \u0437\u0430\u043c\u0430\u044f\u043d\u043e\u0441\u0442, \u0431\u043e\u043b\u043a\u0438 \u0432 \u0433\u044a\u0440\u0431\u0430 \u0438\u043b\u0438 \u043c\u0443\u0441\u043a\u0443\u043b\u0438\u0442\u0435 \u0438 \u043f\u0440\u043e\u0434\u044a\u043b\u0436\u0438\u0442\u0435\u043b\u043d\u0430 \u0435\u0440\u0435\u043a\u0446\u0438\u044f. \u041b\u0435\u0447\u0435\u043d\u0438\u0435\u0442\u043e \u0435 \u043f\u043e\u0434\u0434\u044a\u0440\u0436\u0430\u0449\u043e, \u0441 \u0432\u044a\u0437\u0441\u0442\u0430\u043d\u043e\u0432\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0442\u0435\u0447\u043d\u043e\u0441\u0442\u0438\u0442\u0435 \u0438 \u043a\u0430\u0440\u0434\u0438\u0430\u043b\u0435\u043d \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433. \u0421\u0432\u044a\u0440\u0436\u0435\u0442\u0435 \u0441\u0435 \u043d\u0435\u0437\u0430\u0431\u0430\u0432\u043d\u043e \u0441 \u043c\u0435\u0441\u0442\u043d\u0430\u0442\u0430 \u0441\u0438 \u0441\u043b\u0443\u0436\u0431\u0430 \u0437\u0430 \u043e\u0442\u0440\u043e\u0432\u0438 \u0438\u043b\u0438 \u0441\u043f\u0435\u0448\u043d\u043e \u043e\u0442\u0434\u0435\u043b\u0435\u043d\u0438\u0435, \u0430\u043a\u043e \u0441\u0435 \u0437\u0430\u043f\u043e\u0434\u043e\u0437\u0440\u0435 \u043f\u0440\u0435\u0434\u043e\u0437\u0438\u0440\u0430\u043d\u0435.<\/p>\n<h2 class=\"wp-block-heading\">\u0418\u043d\u0441\u0442\u0440\u0443\u043a\u0446\u0438\u0438 \u0437\u0430 \u0441\u044a\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435<\/h2>\n<ul>\n<li>\u0421\u044a\u0445\u0440\u0430\u043d\u044f\u0432\u0430\u0439\u0442\u0435 \u043f\u0440\u0438 \u0442\u0435\u043c\u043f\u0435\u0440\u0430\u0442\u0443\u0440\u0430 \u043f\u043e\u0434 30\u00b0C \u043d\u0430 \u0441\u0443\u0445\u043e \u043c\u044f\u0441\u0442\u043e, \u0434\u0430\u043b\u0435\u0447\u0435 \u043e\u0442 \u043f\u0440\u044f\u043a\u0430 \u0441\u043b\u044a\u043d\u0447\u0435\u0432\u0430 \u0441\u0432\u0435\u0442\u043b\u0438\u043d\u0430<\/li>\n<li>\u0417\u0430\u043f\u0430\u0437\u0432\u0430\u0439\u0442\u0435 \u0432 \u043e\u0440\u0438\u0433\u0438\u043d\u0430\u043b\u043d\u0430\u0442\u0430 \u0431\u043b\u0438\u0441\u0442\u0435\u0440\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430 \u0434\u043e \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430<\/li>\n<li>\u0414\u044a\u0440\u0436\u0435\u0442\u0435 \u0434\u0430\u043b\u0435\u0447 \u043e\u0442 \u0434\u0435\u0446\u0430 \u0438 \u0434\u043e\u043c\u0430\u0448\u043d\u0438 \u043b\u044e\u0431\u0438\u043c\u0446\u0438<\/li>\n<li>\u041d\u0435 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430\u0439\u0442\u0435 \u0441\u043b\u0435\u0434 \u0438\u0437\u0442\u0438\u0447\u0430\u043d\u0435 \u043d\u0430 \u0441\u0440\u043e\u043a\u0430 \u043d\u0430 \u0433\u043e\u0434\u043d\u043e\u0441\u0442, \u043f\u043e\u0441\u043e\u0447\u0435\u043d \u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430\u0442\u0430<\/li>\n<li>\u0418\u0437\u0445\u0432\u044a\u0440\u043b\u044f\u0439\u0442\u0435 \u043d\u0435\u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430\u043d\u0438\u0442\u0435 \u0442\u0430\u0431\u043b\u0435\u0442\u043a\u0438 \u0447\u0440\u0435\u0437 \u0441\u0438\u0441\u0442\u0435\u043c\u0430\u0442\u0430 \u0437\u0430 \u0432\u0440\u044a\u0449\u0430\u043d\u0435 \u0432 \u0430\u043f\u0442\u0435\u043a\u0438\u0442\u0435, \u043a\u044a\u0434\u0435\u0442\u043e \u0435 \u043d\u0430\u043b\u0438\u0447\u043d\u0430<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0421\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u0430\u043b\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u0438 \u0432 MedsBase<\/h2>\n<p>\u0422\u044a\u0440\u0441\u0438\u0442\u0435 \u0441\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u043e\u043f\u0446\u0438\u0438 \u0437\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u043d\u0430 \u0435\u0440\u0435\u043a\u0442\u0438\u043b\u043d\u0430 \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u044f \u0438\u043b\u0438 \u0441\u0435\u043a\u0441\u0443\u0430\u043b\u043d\u043e \u0437\u0434\u0440\u0430\u0432\u0435?<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/bg\/modula\/\" rel=\"noopener\">Modula<\/a> \u2014 \u0442\u0430\u0434\u0430\u043b\u0430\u0444\u0438\u043b 5 mg, \u0438\u0434\u0435\u0430\u043b\u0435\u043d \u0437\u0430 \u0434\u044a\u043b\u0433\u043e\u0441\u0440\u043e\u0447\u043d\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0441 \u043d\u0438\u0441\u043a\u0430 \u0434\u043e\u0437\u0430 \u0432\u0435\u0434\u043d\u044a\u0436 \u0434\u043d\u0435\u0432\u043d\u043e<\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/vidalista\/\" rel=\"noopener\">Vidalista<\/a> \u2014 Centurion Labs \u0442\u0430\u0434\u0430\u043b\u0430\u0444\u0438\u043b, 2.5 \u0434\u043e 80 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/tadacip\/\" rel=\"noopener\">Tadacip<\/a> \u2014 Cipla tadalafil 20 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/megalis\/\" rel=\"noopener\">Megalis<\/a> \u2014 Macleods tadalafil 10 mg \/ 20 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/suhagra\/\" rel=\"noopener\">Suhagra<\/a> \u2014 Cipla sildenafil 25\/50\/100 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/erectile-dysfunction\/\" rel=\"noopener\">\u0420\u0430\u0437\u0433\u043b\u0435\u0434\u0430\u0439\u0442\u0435 \u0432\u0441\u0438\u0447\u043a\u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0437\u0430 \u0435\u0440\u0435\u043a\u0442\u0438\u043b\u043d\u0430 \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u044f \u2192<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u0427\u0435\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u043d\u0438 \u0432\u044a\u043f\u0440\u043e\u0441\u0438<\/h2>\n<h3 class=\"wp-block-heading\">Is Malegra FXT Plus on-demand or daily?<\/h3>\n<p><strong>Mixed.<\/strong> The sildenafil component is on-demand (per-tablet ED effect). The fluoxetine component is daily \u2014 and requires 2\u20136 weeks of regular dosing to reach full PE-delay effect. Fluoxetine is NOT useful as a single-dose PE drug.<\/p>\n<h3 class=\"wp-block-heading\">Why not just use dapoxetine instead?<\/h3>\n<p>Dapoxetine is engineered for on-demand use with a short half-life \u2014 simpler, cleaner pharmacology for PE. Fluoxetine is only appropriate when you want long-term SSRI cover (for mood or chronic PE) and are willing to tolerate daily SSRI side effects. For most men with co-existing ED + PE, a dapoxetine-based combination like <a href=\"https:\/\/medsbase.com\/bg\/super-tadalis-sx\/\" rel=\"noopener\">Super Tadalis Sx<\/a> \u0438\u043b\u0438 <a href=\"https:\/\/medsbase.com\/bg\/super-vilitra\/\" rel=\"noopener\">Super Vilitra<\/a> is more practical.<\/p>\n<h3 class=\"wp-block-heading\">When does the PE-delay effect start?<\/h3>\n<p>Fluoxetine requires <strong>2\u20136 weeks<\/strong> of daily use to reach full effect. If you expect an immediate effect from the first tablet, this product will disappoint \u2014 switch to a dapoxetine-based combination.<\/p>\n<h3 class=\"wp-block-heading\">How long does the sildenafil effect last?<\/h3>\n<p>4\u20136 hours per tablet, as with any sildenafil product.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Malegra FXT Plus with alcohol?<\/h3>\n<p>Moderate alcohol with sildenafil alone is usually fine. Fluoxetine amplifies alcohol&#8217;s sedation and impairs judgement \u2014 best to limit strictly.<\/p>\n<h3 class=\"wp-block-heading\">Does fluoxetine cause sexual side effects?<\/h3>\n<p>Ironically, yes \u2014 delayed or absent orgasm is one of fluoxetine&#8217;s most common side effects, which is actually what produces the PE-delay benefit. In some men this becomes excessive (&#8220;anorgasmia&#8221;) and may require dose reduction or switching drugs.<\/p>\n<h3 class=\"wp-block-heading\">Can I stop Malegra FXT Plus abruptly?<\/h3>\n<p>Fluoxetine has a long half-life, so discontinuation symptoms are rarer than with short-half-life SSRIs. Even so, taper under medical guidance rather than stopping suddenly after weeks of use.<\/p>\n<h3 class=\"wp-block-heading\">Is Malegra FXT Plus safe for men with heart conditions?<\/h3>\n<p>Contraindicated with nitrates, within 90 days of MI, or in unstable angina. Fluoxetine can modestly prolong QT \u2014 caution with other QT-prolonging drugs. Cardiac review recommended.<\/p>\n<h3 class=\"wp-block-heading\">What if Malegra FXT Plus doesn&#8217;t work for my PE?<\/h3>\n<p>Allow 6 weeks of daily use first. If still inadequate, switch to a dapoxetine-based combination, add behavioural therapy (stop-start technique), or consider topical anaesthetics under medical supervision.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Malegra FXT Plus if I&#8217;m already on another SSRI?<\/h3>\n<p><strong>\u041d\u0435.<\/strong> Do not combine fluoxetine with another SSRI \u2014 serotonin syndrome risk. Wash out the existing SSRI under medical supervision before starting fluoxetine.<\/p>\n<p><!-- medsbase-faq-h3-converted --><\/p>\n<p class=\"medsbase-link-boost-2026-05-04\" data-marker=\"mb-link-boost-malegra-fxt\"><a href=\"https:\/\/medsbase.com\/bg\/malegra-fxt-plus\/\">Malegra FXT Plus<\/a> is the higher-strength sildenafil 100 mg + fluoxetine 60 mg tablet; for users who tolerate fluoxetine 40 mg and prefer the lower SSRI shoulder, the standard-strength <a href=\"https:\/\/medsbase.com\/bg\/malegra-fxt\/\">Malegra FXT (\u0441\u0438\u043b\u0434\u0435\u043d\u0430\u0444\u0438\u043b 100 mg + \u0444\u043b\u0443\u043e\u043a\u0441\u0435\u0442\u0438\u043d 40 mg)<\/a> is the corresponding step-down option in the same brand line.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u0421\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u0430\u043b\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u0438<\/h3>\n<p>\u0414\u0440\u0443\u0433\u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0438 \u0432 <strong>\u041c\u044a\u0436\u043a\u043e \u0437\u0434\u0440\u0430\u0432\u0435<\/strong> \u043a\u043e\u0438\u0442\u043e \u043a\u043b\u0438\u0435\u043d\u0442\u0438\u0442\u0435 \u0441\u044a\u0449\u043e \u0440\u0430\u0437\u0433\u043b\u0435\u0436\u0434\u0430\u0442:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/bg\/tadarise\/\">Tadarise<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/vriligy\/\">Vriligy<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/super-vilitra\/\">Super Vilitra<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/p-force-fort\/\">P-Force Fort<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/finrest\/\">Finrest<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-guide-dapoxetine --><\/p>\n<p style=\"margin:20px 0 0;padding:12px 16px;background:#f4f8fb;border-left:3px solid #2c7cb0;border-radius:3px;font-size:14px\">\ud83d\udcda <strong>\u041d\u0430\u0443\u0447\u0435\u0442\u0435 \u043f\u043e\u0432\u0435\u0447\u0435:<\/strong> <a href=\"https:\/\/medsbase.com\/bg\/what-is-dapoxetine-and-how-its-used-for-pe-treatment\/\">\u041a\u0443\u043f\u0435\u0442\u0435 Dapoxetine \u043e\u043d\u043b\u0430\u0439\u043d (2026): \u0421\u0430\u043c\u043e\u0441\u0442\u043e\u044f\u0442\u0435\u043b\u043d\u0438 \u0438 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u0430\u043d\u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0438 \u2014 \u041d\u0435 \u0435 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0430 \u0440\u0435\u0446\u0435\u043f\u0442\u0430<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u2705 \u041b\u0435\u043a\u0443\u0432\u0430 \u0435\u0440\u0435\u043a\u0442\u0438\u043b\u043d\u0430 \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u044f<br \/>\n\u2705 \u0417\u0430\u0431\u0430\u0432\u044f \u043f\u0440\u0435\u0436\u0434\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e \u0435\u044f\u043a\u0443\u043b\u0438\u0440\u0430\u043d\u0435<br \/>\n\u2705 Enhances stamina<br \/>\n\u2705 \u041f\u043e\u0434\u043e\u0431\u0440\u044f\u0432\u0430 \u043d\u0430\u0441\u0442\u0440\u043e\u0435\u043d\u0438\u0435\u0442\u043e<br \/>\n\u2705 \u041f\u043e\u0432\u0438\u0448\u0430\u0432\u0430 \u0441\u0430\u043c\u043e\u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0435\u0442\u043e<\/p>\n<p>Malegra FXT Plus contains Sildenafil 100 mg + Fluoxetine 60 mg.<\/p>","protected":false},"featured_media":62136,"comment_status":"closed","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3143,3142,3145,3151],"product_tag":[5659,5658,3173,5103,5655,3153,5657],"class_list":{"0":"post-62135","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-erectile-dysfunction","8":"product_cat-mens-health","9":"product_cat-premature-ejaculation-treatment","10":"product_cat-sildenafil","11":"product_tag-combination-tablet","12":"product_tag-ed-pe","13":"product_tag-fluoxetine","14":"product_tag-malegra-fxt-plus","15":"product_tag-premature-ejaculation","16":"product_tag-sildenafil","17":"product_tag-ssri","19":"first","20":"instock","21":"shipping-taxable","22":"purchasable","23":"product-type-variable","24":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product\/62135","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/comments?post=62135"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media\/62136"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media?parent=62135"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_brand?post=62135"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_cat?post=62135"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_tag?post=62135"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}