{"id":65535,"date":"2025-01-18T10:49:18","date_gmt":"2025-01-18T10:49:18","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=65535"},"modified":"2026-04-30T10:23:28","modified_gmt":"2026-04-30T10:23:28","slug":"restfine","status":"publish","type":"product","link":"https:\/\/medsbase.com\/bg\/product\/restfine\/","title":{"rendered":"Restfine"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1; border-left:4px solid #f5a623; padding:14px 18px; margin:0 0 18px 0;\">\n<h3 style=\"margin-top:0;\"><strong>\u0411\u044a\u0440\u0437 \u043e\u0442\u0433\u043e\u0432\u043e\u0440<\/strong><\/h3>\n<p><strong>Restfine<\/strong> \u0441\u044a\u0434\u044a\u0440\u0436\u0430 <strong>melatonin 10 mg<\/strong> \u2014 a high-dose formulation of the body&#8217;s natural sleep-onset hormone. The 10 mg strength is best suited to <strong>delayed sleep-phase disorder, severe shift work, age over 55<\/strong>, or patients who haven&#8217;t responded to lower doses. For typical adult insomnia, clinical evidence supports starting at 1\u20133 mg taken 30\u201360 minutes before bedtime \u2014 higher doses do not consistently improve outcomes and may cause more morning grogginess and vivid dreams.<\/p>\n<p><strong>15\u201330 \u043c\u0438\u043d\u0443\u0442\u0438<\/strong> 30\u201360 \u043c\u0438\u043d\u0443\u0442\u0438. <strong>\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u0435:<\/strong> short-term insomnia, jet lag, delayed sleep-phase disorder, shift work, blind non-24-hour sleep-wake disorder. <strong>\u041d\u0435 \u0441\u0435 \u043f\u0440\u0435\u043f\u043e\u0440\u044a\u0447\u0432\u0430 \u0437\u0430:<\/strong> chronic insomnia (CBT-I is first-line), pregnancy or breastfeeding without specialist input, autoimmune disease without specialist supervision.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f6f8; border-radius:6px; padding:14px 18px; margin:18px 0; display:flex; flex-wrap:wrap; gap:18px; font-size:14px;\">\n<span>\u2705 <strong>WHO-GMP certified<\/strong> \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b<\/span><br \/>\n<span>\ud83d\udce6 \u0414\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430<\/span><br \/>\n<span>\ud83c\udf0d \u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442<\/span><br \/>\n<span>\u2b50 <a href=\"https:\/\/medsbase.com\/bg\/reviews\/\">1,400+ \u043f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b\u0441\u043a\u0438 \u0440\u0435\u0432\u044e\u0442\u0430<\/a><\/span>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u043a\u0440\u0438\u0442\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 <a href=\"https:\/\/medsbase.com\/bg\/medsbase-re-shipment-assurance-policy\/\"><strong>\u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/strong><\/a> \u2014 \u0430\u043a\u043e \u0432\u0430\u0448\u0430\u0442\u0430 \u043f\u0440\u0430\u0442\u043a\u0430 \u043d\u0435 \u043f\u0440\u0438\u0441\u0442\u0438\u0433\u043d\u0435 \u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 20 \u0440\u0430\u0431\u043e\u0442\u043d\u0438 \u0434\u043d\u0438, \u043d\u0438\u0435 \u044f \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043c\u0435 \u043e\u0442\u043d\u043e\u0432\u043e.<\/p>\n<h3>\u0417\u0430\u0449\u043e \u0434\u0430 \u043f\u043e\u0440\u044a\u0447\u0432\u0430\u0442\u0435 \u043e\u0442 MedsBase<\/h3>\n<ul>\n<li><strong>\u0421\u0417\u041e-GMP \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u0446\u0438\u0440\u0430\u043d \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b<\/strong> \u2014 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u0438 \u0442\u0430\u0431\u043b\u0435\u0442\u043a\u0438 \u0441 \u043f\u0440\u043e\u0441\u043b\u0435\u0434\u0438\u043c\u043e\u0441\u0442 \u043d\u0430 \u043f\u0430\u0440\u0442\u0438\u0434\u0430.<\/li>\n<li><strong>\u0414\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430<\/strong> \u2014 \u043e\u0431\u0438\u043a\u043d\u043e\u0432\u0435\u043d\u0430 \u043f\u043b\u0438\u043a\u043e\u0432\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430, \u0431\u0435\u0437 \u043e\u0431\u043e\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f \u0437\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0438\u043b\u0438 \u0430\u043f\u0442\u0435\u043a\u0430 \u043e\u0442\u0432\u044a\u043d.<\/li>\n<li><strong>\u0413\u0430\u0440\u0430\u043d\u0446\u0438\u044f \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0434\u043e\u0441\u0442\u0430\u0432\u043a\u0430<\/strong> \u2014 \u0432\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u0437\u0430\u0441\u0442\u0440\u0430\u0445\u043e\u0432\u0430\u043d\u0430 (\u0432\u0438\u0436\u0442\u0435 \u0443\u0441\u043b\u043e\u0432\u0438\u044f\u0442\u0430 \u0432 \u043f\u043e\u043b\u0438\u0442\u0438\u043a\u0430\u0442\u0430).<\/li>\n<li><strong>\u0414\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u043f\u043e \u0446\u0435\u043b\u0438\u044f \u0441\u0432\u044f\u0442<\/strong> \u0441 \u043c\u043d\u043e\u0436\u0435\u0441\u0442\u0432\u043e \u043e\u043f\u0446\u0438\u0438 \u0437\u0430 \u043a\u0443\u0440\u0438\u0435\u0440.<\/li>\n<li><strong>1,400+ \u043f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b\u0441\u043a\u0438 \u0440\u0435\u0432\u044e\u0442\u0430<\/strong> \u043f\u0440\u0435\u0437 8 \u0433\u043e\u0434\u0438\u043d\u0438 \u0442\u044a\u0440\u0433\u043e\u0432\u0438\u044f.<\/li>\n<\/ul>\n<div style=\"background:#fff8e1; border-left:4px solid #f5a623; padding:14px 18px; margin:18px 0;\">\n<h3 style=\"margin-top:0;\">Important \u2014 high-dose formulation<\/h3>\n<p>Restfine is <strong>10 mg melatonin<\/strong>. Endogenous melatonin peaks at roughly 60\u201370 picograms per millilitre overnight; a single 10 mg dose produces serum levels several hundred times physiological. <strong>For typical adult insomnia, 0.5\u20133 mg is as effective as 5\u201310 mg in head-to-head trials<\/strong> (Brzezinski 2005 meta-analysis; Buscemi 2005 systematic review for AHRQ) and is associated with less next-morning grogginess and fewer vivid dreams.<\/p>\n<p>Reasonable indications for staying at 10 mg:<\/p>\n<ul>\n<li><strong>\u0417\u0430\u043a\u044a\u0441\u043d\u044f\u043b\u043e \u0444\u0430\u0437\u043e\u0432\u043e \u0441\u044a\u043d\u043d\u043e \u0440\u0430\u0437\u0441\u0442\u0440\u043e\u0439\u0441\u0442\u0432\u043e<\/strong> (DSPD) where lower doses gave inadequate phase-shift in a clinical trial.<\/li>\n<li><strong>Age over 55<\/strong> with measured low endogenous melatonin and inadequate response to 2 mg prolonged-release formulations.<\/li>\n<li><strong>Severe shift work<\/strong> requiring deep daytime sleep.<\/li>\n<li><strong>Tumour-related sleep disturbance<\/strong> where higher doses are sometimes used under specialist supervision.<\/li>\n<\/ul>\n<p>If you are using melatonin for typical insomnia and are new to it, <strong>quarter or half the tablet<\/strong> to start at 2.5\u20135 mg and only go higher if needed. Meloset (3 mg, Sun Pharma) is our lower-dose option.<\/p>\n<\/div>\n<h3>\u041a\u0430\u043a \u0434\u0435\u0439\u0441\u0442\u0432\u0430 \u043c\u0435\u043b\u0430\u0442\u043e\u043d\u0438\u043d\u044a\u0442<\/h3>\n<p>\u041c\u0435\u043b\u0430\u0442\u043e\u043d\u0438\u043d\u044a\u0442 \u0435 \u0445\u043e\u0440\u043c\u043e\u043d, \u0441\u0435\u043a\u0440\u0435\u0442\u0438\u0440\u0430\u043d \u043e\u0442 \u0435\u043f\u0438\u0444\u0438\u0437\u043d\u0430\u0442\u0430 \u0436\u043b\u0435\u0437\u0430 \u0432 \u043e\u0442\u0433\u043e\u0432\u043e\u0440 \u043d\u0430 \u0442\u044a\u043c\u043d\u0438\u043d\u0430. \u0422\u043e\u0439 \u0441\u0435 \u0441\u0432\u044a\u0440\u0437\u0432\u0430 \u0441 MT1 \u0438 MT2 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0438 \u0432 \u0441\u0443\u043f\u0440\u0430\u0445\u0438\u0430\u0437\u043c\u0430\u0442\u0438\u0447\u043d\u043e\u0442\u043e \u044f\u0434\u0440\u043e (SCN) \u2014 \u0433\u043b\u0430\u0432\u043d\u0438\u044f\u0442 \u0446\u0438\u0440\u043a\u0430\u0434\u0435\u043d \u0447\u0430\u0441\u043e\u0432\u043d\u0438\u043a \u0432 \u0445\u0438\u043f\u043e\u0442\u0430\u043b\u0430\u043c\u0443\u0441\u0430. \u0410\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 MT1 \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430 \u0431\u0443\u0434\u043d\u043e\u0441\u0442\u0442\u0430 (\u0437\u0430\u0441\u0438\u043f\u0432\u0430\u043d\u0435), \u0430 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 MT2 \u043f\u0440\u043e\u043c\u0435\u043d\u044f \u0444\u0430\u0437\u0430\u0442\u0430 \u043d\u0430 \u0446\u0438\u0440\u043a\u0430\u0434\u043d\u0438\u044f \u0440\u0438\u0442\u044a\u043c. \u0417\u0430 \u0440\u0430\u0437\u043b\u0438\u043a\u0430 \u043e\u0442 GABA-A \u0430\u0433\u043e\u043d\u0438\u0441\u0442\u0438\u0442\u0435 (Z-\u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430, \u0431\u0435\u043d\u0437\u043e\u0434\u0438\u0430\u0437\u0435\u043f\u0438\u043d\u0438), \u043c\u0435\u043b\u0430\u0442\u043e\u043d\u0438\u043d\u044a\u0442 \u043d\u0435 \u043f\u0440\u0438\u0447\u0438\u043d\u044f\u0432\u0430 \u043e\u0431\u0449\u0430 \u0434\u0435\u043f\u0440\u0435\u0441\u0438\u044f \u043d\u0430 \u0426\u041d\u0421, \u043d\u0435 \u0432\u043b\u043e\u0448\u0430\u0432\u0430 \u043a\u043e\u043d\u0441\u043e\u043b\u0438\u0434\u0430\u0446\u0438\u044f\u0442\u0430 \u043d\u0430 \u043f\u0430\u043c\u0435\u0442\u0442\u0430, \u043d\u0435 \u0432\u043e\u0434\u0438 \u0434\u043e \u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u0430 \u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0441\u0442 \u0438 \u043d\u0435 \u043d\u0430\u0440\u0443\u0448\u0430\u0432\u0430 \u043a\u043e\u0433\u043d\u0438\u0442\u0438\u0432\u043d\u0438\u0442\u0435 \u0444\u0443\u043d\u043a\u0446\u0438\u0438 \u043d\u0430 \u0441\u043b\u0435\u0434\u0432\u0430\u0449\u0438\u044f \u0434\u0435\u043d \u043f\u0440\u0438 \u0441\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u0438 \u0434\u043e\u0437\u0438.<\/p>\n<p>\u041f\u0440\u043e\u043c\u044f\u043d\u0430\u0442\u0430 \u043d\u0430 \u0444\u0430\u0437\u0430\u0442\u0430 \u0435 \u043f\u0440\u0438\u0447\u0438\u043d\u0430\u0442\u0430 \u0437\u0430\u0449\u043e \u0432\u0440\u0435\u043c\u0435\u0442\u043e \u043d\u0430 \u043f\u0440\u0438\u0435\u043c\u0430\u043d\u0435 \u0435 \u0432\u0430\u0436\u043d\u043e. \u041c\u0435\u043b\u0430\u0442\u043e\u043d\u0438\u043d\u044a\u0442, \u043f\u0440\u0438\u0435\u0442 \u043f\u0440\u0435\u0434\u0438 \u043b\u044f\u0433\u0430\u043d\u0435, \u0443\u0441\u043a\u043e\u0440\u044f\u0432\u0430 \u0437\u0430\u0441\u043f\u0438\u0432\u0430\u043d\u0435\u0442\u043e. \u041f\u0440\u0438\u0435\u0442 \u043a\u044a\u0441\u043d\u043e \u0441\u043b\u0435\u0434\u043e\u0431\u0435\u0434, \u0442\u043e\u0439 \u0438\u0437\u043c\u0435\u0441\u0442\u0432\u0430 \u0446\u0435\u043b\u0438\u044f \u0446\u0438\u0440\u043a\u0430\u0434\u0435\u043d \u0440\u0438\u0442\u044a\u043c \u043d\u0430\u043f\u0440\u0435\u0434 (\u043f\u043e\u043c\u0430\u0433\u0430 \u043f\u0440\u0438 \u0437\u0430\u0431\u0430\u0432\u0435\u043d\u043e \u0437\u0430\u0441\u043f\u0438\u0432\u0430\u043d\u0435 \u0438 \u0438\u0437\u0442\u043e\u0447\u0435\u043d \u0447\u0430\u0441\u043e\u0432\u043e\u0432\u0438 \u043f\u043e\u044f\u0441). \u041f\u0440\u0438\u0435\u0442 \u0440\u0430\u043d\u043e \u0441\u0443\u0442\u0440\u0438\u043d, \u0442\u043e\u0439 \u0437\u0430\u0431\u0430\u0432\u044f \u0440\u0438\u0442\u044a\u043c\u0430 (\u043f\u043e\u043c\u0430\u0433\u0430 \u043f\u0440\u0438 \u0437\u0430\u043f\u0430\u0434\u0435\u043d \u0447\u0430\u0441\u043e\u0432\u043e\u0432\u0438 \u043f\u043e\u044f\u0441 \u0438 \u043f\u0440\u0435\u0436\u0434\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e \u0437\u0430\u0441\u043f\u0438\u0432\u0430\u043d\u0435).<\/p>\n<h3>\u0414\u043e\u0437\u0438\u0440\u0430\u043d\u0435 \u043f\u043e \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u0435<\/h3>\n<table style=\"width:100%; border-collapse:collapse; margin:12px 0; font-size:14px;\">\n<thead>\n<tr style=\"background:#2c7cb0; color:#fff;\">\n<th style=\"padding:8px; text-align:left;\">\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u0435<\/th>\n<th style=\"padding:8px;\">\u0414\u043e\u0437\u0430<\/th>\n<th style=\"padding:8px;\">\u0412\u0440\u0435\u043c\u0435\u0432\u0438 \u0441\u0440\u043e\u043a<\/th>\n<th style=\"padding:8px;\">\u041f\u0440\u043e\u0434\u044a\u043b\u0436\u0438\u0442\u0435\u043b\u043d\u043e\u0441\u0442<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;\">Short-term insomnia (adults &lt; 55)<\/td>\n<td style=\"padding:8px; text-align:center;\">1\u20133 mg (start with quarter or half tablet)<\/td>\n<td style=\"padding:8px;\">30\u201360 \u043c\u0438\u043d\u0443\u0442\u0438 \u043f\u0440\u0435\u0434\u0438 \u043b\u044f\u0433\u0430\u043d\u0435<\/td>\n<td style=\"padding:8px;\">1\u20132 \u0441\u0435\u0434\u043c\u0438\u0446\u0438<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">\u0411\u0435\u0437\u0441\u044a\u043d\u0438\u0435 \u043d\u0430 \u0432\u044a\u0437\u0440\u0430\u0441\u0442 55+<\/td>\n<td style=\"padding:8px; text-align:center;\">2 mg PR or 5\u201310 mg IR<\/td>\n<td style=\"padding:8px;\">1\u20132 hours before bed<\/td>\n<td style=\"padding:8px;\">\u0434\u043e 13 \u0441\u0435\u0434\u043c\u0438\u0446\u0438 (NICE)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">\u0417\u0430\u043a\u044a\u0441\u043d\u044f\u043b\u043e \u0444\u0430\u0437\u043e\u0432\u043e \u0441\u044a\u043d\u043d\u043e \u0440\u0430\u0437\u0441\u0442\u0440\u043e\u0439\u0441\u0442\u0432\u043e<\/td>\n<td style=\"padding:8px; text-align:center;\">0.5\u20135 mg (titrate)<\/td>\n<td style=\"padding:8px;\">4\u20136 \u0447\u0430\u0441\u0430 \u043f\u0440\u0435\u0434\u0438 \u0436\u0435\u043b\u0430\u043d\u043e\u0442\u043e \u043d\u0430\u0447\u0430\u043b\u043e \u043d\u0430 \u0441\u044a\u043d\u044f<\/td>\n<td style=\"padding:8px;\">\u0432\u043e\u0434\u0435\u043d\u043e \u043e\u0442 \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0441\u0442<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">\u0418\u0437\u0442\u043e\u0447\u0435\u043d \u0434\u0436\u0435\u0442\u043b\u0430\u0433 (\u2265 5 \u0447\u0430\u0441\u043e\u0432\u0438 \u0437\u043e\u043d\u0438)<\/td>\n<td style=\"padding:8px; text-align:center;\">2\u20135 mg<\/td>\n<td style=\"padding:8px;\">\u043c\u0435\u0441\u0442\u043d\u043e \u0432\u0440\u0435\u043c\u0435 \u0437\u0430 \u043b\u044f\u0433\u0430\u043d\u0435 \u0432 \u0434\u0435\u0441\u0442\u0438\u043d\u0430\u0446\u0438\u044f\u0442\u0430, 2\u20134 \u043d\u043e\u0449\u0438<\/td>\n<td style=\"padding:8px;\">\u0434\u043e\u043a\u043e\u0433\u0430\u0442\u043e \u0441\u0435 \u0430\u0434\u0430\u043f\u0442\u0438\u0440\u0430<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">\u0421\u044a\u043d\u043d\u043e \u0440\u0430\u0437\u0441\u0442\u0440\u043e\u0439\u0441\u0442\u0432\u043e \u043f\u0440\u0438 \u0440\u0430\u0431\u043e\u0442\u0430 \u043d\u0430 \u0441\u043c\u0435\u043d\u0438<\/td>\n<td style=\"padding:8px; text-align:center;\">1\u201310 mg<\/td>\n<td style=\"padding:8px;\">\u043f\u0440\u0435\u0434\u0438 \u0434\u043d\u0435\u0432\u043d\u0438\u044f \u043f\u0435\u0440\u0438\u043e\u0434 \u043d\u0430 \u0441\u044a\u043d<\/td>\n<td style=\"padding:8px;\">\u043f\u043e \u0432\u0440\u0435\u043c\u0435 \u043d\u0430 \u0441\u043c\u044f\u043d\u0430<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">Non-24-hour sleep-wake (blind patients)<\/td>\n<td style=\"padding:8px; text-align:center;\">0.5\u201310 mg<\/td>\n<td style=\"padding:8px;\">fixed clock time daily<\/td>\n<td style=\"padding:8px;\">indefinite, specialist-led<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em>PR = prolonged-release. IR = immediate-release. Restfine is an immediate-release tablet.<\/em><\/p>\n<h3>\u0421\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438<\/h3>\n<p><strong>\u0427\u0435\u0441\u0442\u043e (\u043e\u0431\u0438\u043a\u043d\u043e\u0432\u0435\u043d\u043e \u043b\u0435\u043a\u0438 \u0438 \u043f\u0440\u0435\u0445\u043e\u0434\u043d\u0438):<\/strong> drowsiness or grogginess on waking, headache, mild dizziness, nausea, vivid dreams. Vivid dreams are dose-related \u2014 stepping down from 10 mg to 3 mg usually resolves them. Daytime sleepiness suggests the dose is too high or taken too late.<\/p>\n<p><strong>\u041f\u043e-\u0440\u044f\u0434\u043a\u043e:<\/strong> low mood transient (especially in patients with seasonal affective tendencies), reduced libido, mild blood-pressure changes (both directions reported), gastrointestinal upset, irritability, joint discomfort.<\/p>\n<p><strong>\u0420\u044f\u0434\u043a\u043e, \u043d\u043e \u0432\u0430\u0436\u043d\u043e:<\/strong> seizures (lower threshold reported in patients with epilepsy \u2014 caution and specialist input), allergic skin reactions, autoimmune flare in patients with rheumatoid arthritis or lupus.<\/p>\n<h3>\u0412\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f \u0441 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430<\/h3>\n<table style=\"width:100%; border-collapse:collapse; margin:12px 0; font-size:14px;\">\n<thead>\n<tr style=\"background:#2c7cb0; color:#fff;\">\n<th style=\"padding:8px; text-align:left;\">\u0424\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u043d\u0430 \u0433\u0440\u0443\u043f\u0430<\/th>\n<th style=\"padding:8px;\">\u0412\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435<\/th>\n<th style=\"padding:8px;\">\u0414\u0435\u0439\u0441\u0442\u0432\u0438\u0435<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;\">\u0424\u043b\u0443\u0432\u043e\u043a\u0441\u0430\u043c\u0438\u043d (SSRI)<\/td>\n<td style=\"padding:8px;\">\u0418\u043d\u0445\u0438\u0431\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 CYP1A2 \u043f\u043e\u0432\u0438\u0448\u0430\u0432\u0430 \u043d\u0438\u0432\u0430\u0442\u0430 \u043d\u0430 \u043c\u0435\u043b\u0430\u0442\u043e\u043d\u0438\u043d 17 \u043f\u044a\u0442\u0438<\/td>\n<td style=\"padding:8px;\">avoid combination \u2014 substitute another SSRI<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">Warfarin<\/td>\n<td style=\"padding:8px;\">\u0434\u043e\u043a\u043b\u0430\u0434\u0432\u0430\u043d\u0438 \u0441\u043b\u0443\u0447\u0430\u0438 \u043d\u0430 \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u043e INR<\/td>\n<td style=\"padding:8px;\">\u0441\u043b\u0435\u0434\u0435\u0442\u0435 INR \u0441\u043b\u0435\u0434 \u0437\u0430\u043f\u043e\u0447\u0432\u0430\u043d\u0435 \u0438\u043b\u0438 \u0441\u043f\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u043f\u0440\u0438\u0435\u043c\u0430<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">Diabetes medication (insulin, sulfonylureas)<\/td>\n<td style=\"padding:8px;\">\u043c\u0435\u043b\u0430\u0442\u043e\u043d\u0438\u043d\u044a\u0442 \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430 \u0441\u0435\u043a\u0440\u0435\u0446\u0438\u044f\u0442\u0430 \u043d\u0430 \u0438\u043d\u0441\u0443\u043b\u0438\u043d \u043f\u0440\u0435\u0437 \u043d\u043e\u0449\u0442\u0430<\/td>\n<td style=\"padding:8px;\">monitor fasting glucose; specialist input in T1DM<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">\u0410\u043d\u0442\u0438\u0445\u0438\u043f\u0435\u0440\u0442\u0435\u043d\u0437\u0438\u0432\u0438<\/td>\n<td style=\"padding:8px;\">may potentiate effect of nifedipine; may raise BP with some agents<\/td>\n<td style=\"padding:8px;\">monitor BP at start of treatment<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">Immunosuppressants (ciclosporin, methotrexate)<\/td>\n<td style=\"padding:8px;\">\u043c\u0435\u043b\u0430\u0442\u043e\u043d\u0438\u043d\u044a\u0442 \u0438\u043c\u0430 \u0438\u043c\u0443\u043d\u043e\u0441\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0430\u0449\u0438 \u0435\u0444\u0435\u043a\u0442\u0438<\/td>\n<td style=\"padding:8px;\">avoid in solid-organ transplant or active autoimmune disease<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">\u041a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u0430\u043d \u043e\u0440\u0430\u043b\u0435\u043d \u043a\u043e\u043d\u0442\u0440\u0430\u0446\u0435\u043f\u0442\u0438\u0432<\/td>\n<td style=\"padding:8px;\">CYP1A2 inhibition raises melatonin levels<\/td>\n<td style=\"padding:8px;\">consider lower melatonin dose<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">\u041a\u043e\u0444\u0435\u0438\u043d<\/td>\n<td style=\"padding:8px;\">caffeine inhibits melatonin metabolism mildly; both also CYP1A2 substrates<\/td>\n<td style=\"padding:8px;\">avoid caffeine within 6 hours of bedtime regardless<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">\u0411\u0435\u043d\u0437\u043e\u0434\u0438\u0430\u0437\u0435\u043f\u0438\u043d\u0438, Z-\u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430, \u0430\u043b\u043a\u043e\u0445\u043e\u043b, \u043e\u043f\u0438\u043e\u0438\u0434\u0438<\/td>\n<td style=\"padding:8px;\">\u0434\u043e\u043f\u044a\u043b\u043d\u0438\u0442\u0435\u043b\u0435\u043d \u0441\u0435\u0434\u0430\u0442\u0438\u0432\u0435\u043d \u0435\u0444\u0435\u043a\u0442<\/td>\n<td style=\"padding:8px;\">avoid combining; do not drink alcohol with melatonin<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">\u0410\u043d\u0442\u0438\u043a\u043e\u043d\u0432\u0443\u043b\u0441\u0430\u043d\u0442\u0438<\/td>\n<td style=\"padding:8px;\">\u043c\u043e\u0436\u0435 \u0434\u0430 \u043f\u043e\u043d\u0438\u0436\u0438 \u043f\u0440\u0430\u0433\u0430 \u043d\u0430 \u043f\u0440\u0438\u043f\u0430\u0434\u044a\u0446\u0438 (\u0441\u043f\u043e\u0440\u0430\u0434\u0438\u0447\u043d\u0438 \u0441\u043b\u0443\u0447\u0430\u0438)<\/td>\n<td style=\"padding:8px;\">\u043a\u043e\u043d\u0441\u0443\u043b\u0442\u0430\u0446\u0438\u044f \u0441\u044a\u0441 \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0441\u0442 \u043f\u0440\u0438 \u0435\u043f\u0438\u043b\u0435\u043f\u0441\u0438\u044f<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>\u041a\u043e\u043d\u0442\u0440\u0430\u0438\u043d\u0434\u0438\u043a\u0430\u0446\u0438\u0438 \u0438 \u043f\u0440\u0435\u0434\u043f\u0430\u0437\u043d\u0438 \u043c\u0435\u0440\u043a\u0438<\/h3>\n<ul>\n<li><strong>\u0411\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442 \u0438 \u043a\u044a\u0440\u043c\u0435\u043d\u0435<\/strong> \u2014 safety not established; avoid unless specialist-supervised.<\/li>\n<li><strong>\u0410\u043a\u0442\u0438\u0432\u043d\u043e \u0430\u0432\u0442\u043e\u0438\u043c\u0443\u043d\u043d\u043e \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435<\/strong> (RA, lupus, MS, IBD) \u2014 melatonin has immunostimulant effects; specialist input required.<\/li>\n<li><strong>\u0422\u0440\u0430\u043d\u0441\u043f\u043b\u0430\u043d\u0442\u0430\u0446\u0438\u044f \u043d\u0430 \u0442\u0432\u044a\u0440\u0434 \u043e\u0440\u0433\u0430\u043d \u043f\u0440\u0438 \u0438\u043c\u0443\u043d\u043e\u0441\u0443\u043f\u0440\u0435\u0441\u0438\u044f<\/strong> \u2014 \u0438\u0437\u0431\u044f\u0433\u0432\u0430\u0439\u0442\u0435.<\/li>\n<li><strong>\u0422\u0435\u0436\u043a\u043e \u0447\u0435\u0440\u043d\u043e\u0434\u0440\u043e\u0431\u043d\u043e \u0443\u0432\u0440\u0435\u0436\u0434\u0430\u043d\u0435<\/strong> \u2014 accumulation; reduce dose or avoid.<\/li>\n<li><strong>\u0415\u043f\u0438\u043b\u0435\u043f\u0441\u0438\u044f<\/strong> \u2014 case reports of lowered seizure threshold; specialist input.<\/li>\n<li><strong>\u0414\u0435\u0446\u0430 \u0438 \u044e\u043d\u043e\u0448\u0438 \u043f\u043e\u0434 18 \u0433\u043e\u0434\u0438\u043d\u0438<\/strong> \u2014 only under specialist paediatric supervision (used in autism spectrum sleep disturbance; not for typical childhood insomnia).<\/li>\n<li><strong>Driving or operating machinery<\/strong> \u2014 do not drive within 8 hours of dose, particularly in the first few nights.<\/li>\n<li><strong>Alcohol<\/strong> \u2014 avoid; potentiates sedation and blunts melatonin&#8217;s circadian effect.<\/li>\n<\/ul>\n<h3>\u0421\u044a\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435<\/h3>\n<p>Store at 15\u201330\u00b0C (room temperature) in the original blister, away from direct sunlight, heat, and humidity. Do not refrigerate. Keep out of reach of children. Do not use after the expiry date printed on the strip.<\/p>\n<h2 id=\"faqs\">\u0427\u0435\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u043d\u0438 \u0432\u044a\u043f\u0440\u043e\u0441\u0438<\/h2>\n<h3>Is 10 mg melatonin too high for typical insomnia?<\/h3>\n<p>For most adults under 55 with typical short-term insomnia, yes \u2014 0.5\u20133 mg has the same sleep-onset effect with less morning grogginess and fewer vivid dreams. Use 10 mg if lower doses haven&#8217;t worked, for delayed sleep-phase disorder under specialist input, for severe shift work, or for age 55+ with confirmed low endogenous melatonin.<\/p>\n<h3>Can I split a Restfine tablet in half?<\/h3>\n<p>Yes. Restfine is an immediate-release uncoated tablet \u2014 splitting in half gives ~5 mg, in quarters gives ~2.5 mg. Use a tablet splitter for accuracy. Do not crush or chew if you find the taste unpleasant \u2014 it is bitter.<\/p>\n<h3>How long does melatonin take to work?<\/h3>\n<p>30\u201360 minutes for sleep onset. Peak plasma concentration is roughly 60 minutes after an oral immediate-release dose; half-life is 30\u201350 minutes. The phase-shifting effect on circadian rhythm builds over several nights.<\/p>\n<h3>Is melatonin habit-forming?<\/h3>\n<p>No. Melatonin does not cause physical dependence, tolerance, or rebound insomnia in standard short-term use. This is its main advantage over benzodiazepines and Z-drugs (zolpidem, zopiclone). Long-term use (more than 3 months) has less evidence and should be reviewed with your doctor periodically.<\/p>\n<h3>Can I take melatonin with alcohol?<\/h3>\n<p>No. Alcohol fragments sleep architecture, suppresses REM, and disrupts the circadian rhythm \u2014 the opposite of what melatonin is trying to do. The combination produces additive next-day grogginess without improving sleep quality.<\/p>\n<h3>Will melatonin help with chronic insomnia (more than 3 months)?<\/h3>\n<p>Modestly at best. The most effective long-term treatment for chronic insomnia is cognitive-behavioural therapy for insomnia (CBT-I), not pharmacotherapy. Online programmes are widely available. If insomnia persists despite CBT-I and good sleep hygiene, sleep-medicine review can identify contributors (sleep apnoea, restless legs, depression, perimenopause).<\/p>\n<h3>Does melatonin work for jet lag?<\/h3>\n<p>Yes \u2014 particularly for eastward travel across 5+ time zones. Take 2\u20135 mg at local bedtime at the destination for 2\u20134 nights. Westward travel responds less to melatonin (the body adapts more easily to delaying the clock than advancing it). Combine with bright daylight exposure at the destination.<\/p>\n<h3>Can I take melatonin for shift work?<\/h3>\n<p>Yes \u2014 melatonin before the daytime sleep period helps shift workers consolidate sleep. The challenge is finding the right time: it is roughly the start of your &ldquo;biological night&rdquo;, which depends on your shift pattern. Avoid taking before driving home from a night shift \u2014 wait until you are at home and ready for bed.<\/p>\n<h3>Does melatonin interact with my contraceptive pill?<\/h3>\n<p>Combined oral contraceptives raise endogenous melatonin levels by about 20% via CYP1A2 inhibition. This usually does not require a melatonin dose change, but if you are sensitive to morning grogginess on melatonin, consider stepping down from 10 mg to 3 mg.<\/p>\n<h3>Can melatonin trigger an autoimmune flare?<\/h3>\n<p>It can. Melatonin has immunostimulant effects \u2014 useful in some research settings but a problem in active rheumatoid arthritis, lupus, multiple sclerosis, and inflammatory bowel disease. Get specialist input before using melatonin if you have any active autoimmune condition.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3>\u0414\u0440\u0443\u0433\u0438 \u043f\u043e\u043c\u043e\u0449\u043d\u0438 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u0430 \u0437\u0430 \u0441\u044a\u043d \u0438 \u0445\u0438\u043f\u043d\u043e\u0442\u0438\u0447\u043d\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430<\/h3>\n<p>\u041b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430\u0442\u0430 \u043f\u043e-\u0434\u043e\u043b\u0443 \u043b\u0435\u043a\u0443\u0432\u0430\u0442 \u0441\u044a\u0449\u043e\u0442\u043e \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435 \u0447\u0440\u0435\u0437 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u0438 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0438. \u0418\u0437\u0431\u043e\u0440\u044a\u0442 \u0437\u0430\u0432\u0438\u0441\u0438 \u043e\u0442 \u0432\u044a\u0437\u0440\u0430\u0441\u0442\u0442\u0430, \u0441\u044a\u043f\u044a\u0442\u0441\u0442\u0432\u0430\u0449\u0430\u0442\u0430 \u0434\u0435\u043f\u0440\u0435\u0441\u0438\u044f \u0438\u043b\u0438 \u0442\u0440\u0435\u0432\u043e\u0436\u043d\u043e\u0441\u0442 \u0438 \u043e\u0442 \u0442\u043e\u0432\u0430 \u043a\u043e\u043b\u043a\u043e \u043a\u0440\u0430\u0442\u043a\u043e\u0441\u0440\u043e\u0447\u043d\u043e \u0438\u043b\u0438 \u0434\u044a\u043b\u0433\u043e\u0441\u0440\u043e\u0447\u043d\u043e \u0449\u0435 \u0431\u044a\u0434\u0435 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430\u043d\u0435\u0442\u043e.<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/bg\/meloset\/\"><strong>Meloset (Melatonin 3 mg)<\/strong><\/a> \u2014 standard-dose melatonin (Sun Pharma).<\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/trazalon\/\"><strong>Trazalon (Trazodone 50 mg)<\/strong><\/a> \u2014 \u0445\u0438\u043f\u043d\u043e\u0442\u0438\u043a \u0432 \u043d\u0438\u0441\u043a\u0438 \u0434\u043e\u0437\u0438 \u0438\u0437\u0432\u044a\u043d \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u0442\u0430 \u2014 \u043d\u0430\u0439-\u0447\u0435\u0441\u0442\u043e \u0438\u0437\u043f\u0438\u0441\u0432\u0430\u043d \u043f\u043e\u043c\u043e\u0449\u043d\u0438\u043a \u0437\u0430 \u0441\u044a\u043d \u0438\u0437\u0432\u044a\u043d \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u0442\u0430 \u0432 \u0441\u0432\u0435\u0442\u043e\u0432\u0435\u043d \u043c\u0430\u0449\u0430\u0431.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/mirzacan\/\"><strong>Mirzacan (Mirtazapine 30 mg)<\/strong><\/a> \u2014 \u0441\u0435\u0434\u0430\u0442\u0438\u0432\u0435\u043d \u0442\u0435\u0442\u0440\u0430\u0446\u0438\u043a\u043b\u0438\u0447\u0435\u043d \u0430\u043d\u0442\u0438\u0434\u0435\u043f\u0440\u0435\u0441\u0430\u043d\u0442 \u2014 \u043f\u043e\u043b\u0435\u0437\u0435\u043d, \u043a\u043e\u0433\u0430\u0442\u043e \u0434\u0435\u043f\u0440\u0435\u0441\u0438\u044f\u0442\u0430 \u0438 \u0431\u0435\u0437\u0441\u044a\u043d\u0438\u0435\u0442\u043e \u0441\u044a\u0449\u0435\u0441\u0442\u0432\u0443\u0432\u0430\u0442 \u0435\u0434\u043d\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/spectra\/\"><strong>\u0421\u043f\u0435\u043a\u0442\u0440\u0430 (\u0414\u043e\u043a\u0441\u0435\u043f\u0438\u043d)<\/strong><\/a> \u2014 \u043d\u0438\u0441\u043a\u0430 \u0434\u043e\u0437\u0430 \u0434\u043e\u043a\u0441\u0435\u043f\u0438\u043d (3\u20136 mg) \u0437\u0430 \u043f\u043e\u0434\u0434\u044a\u0440\u0436\u0430\u043d\u0435 \u043d\u0430 \u0441\u044a\u043d\u044f \u043f\u0440\u0438 \u0432\u044a\u0437\u0440\u0430\u0441\u0442\u043d\u0438 \u0441 \u0431\u0435\u0437\u0441\u044a\u043d\u0438\u0435.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/bg\/atarax\/\"><strong>\u0410\u0442\u0430\u0440\u0430\u043a\u0441 (\u0425\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u0437\u0438\u043d 25 mg)<\/strong><\/a> \u2014 \u0441\u0435\u0434\u0430\u0442\u0438\u0432\u0435\u043d \u0430\u043d\u0442\u0438\u0445\u0438\u0441\u0442\u0430\u043c\u0438\u043d \u0437\u0430 \u043a\u0440\u0430\u0442\u043a\u043e\u0441\u0440\u043e\u0447\u043d\u043e \u0431\u0435\u0437\u0441\u044a\u043d\u0438\u0435, \u0441\u0432\u044a\u0440\u0437\u0430\u043d\u043e \u0441 \u0442\u0440\u0435\u0432\u043e\u0436\u043d\u043e\u0441\u0442.<\/li>\n<\/ul>\n<h3>\u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e \u043f\u0440\u0435\u0434\u0443\u043f\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435<\/h3>\n<p>\u0422\u0430\u0437\u0438 \u0441\u0442\u0440\u0430\u043d\u0438\u0446\u0430 \u0435 \u0441 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u0442\u0435\u043b\u043d\u0430 \u0446\u0435\u043b \u0438 \u043d\u0435 \u0437\u0430\u043c\u0435\u0441\u0442\u0432\u0430 \u0438\u043d\u0434\u0438\u0432\u0438\u0434\u0443\u0430\u043b\u043d\u0438\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438 \u0441\u044a\u0432\u0435\u0442. \u0423\u043f\u043e\u0440\u0438\u0442\u043e\u0442\u043e \u0431\u0435\u0437\u0441\u044a\u043d\u0438\u0435 (\u043f\u043e\u0432\u0435\u0447\u0435 \u043e\u0442 3 \u043c\u0435\u0441\u0435\u0446\u0430) \u0438\u0437\u0438\u0441\u043a\u0432\u0430 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435 \u0437\u0430 \u0441\u043a\u0440\u0438\u0442\u0438 \u043f\u0440\u0438\u0447\u0438\u043d\u0438 \u2014 \u0434\u0435\u043f\u0440\u0435\u0441\u0438\u044f, \u0442\u0440\u0435\u0432\u043e\u0436\u043d\u043e\u0441\u0442, \u0441\u044a\u043d\u043d\u0430 \u0430\u043f\u043d\u0435\u044f, \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u043d\u0430 \u043d\u0435\u0441\u043f\u043e\u043a\u043e\u0439\u043d\u0438\u0442\u0435 \u043a\u0440\u0430\u043a\u0430, \u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0430 \u0431\u043e\u043b\u043a\u0430, \u043f\u0435\u0440\u0438\u043c\u0435\u043d\u043e\u043f\u0430\u0443\u0437\u0430, \u0445\u0438\u043f\u0435\u0440\u0442\u0438\u0440\u0435\u043e\u0438\u0434\u0438\u0437\u044a\u043c. \u041a\u043e\u0433\u043d\u0438\u0442\u0438\u0432\u043d\u043e-\u043f\u043e\u0432\u0435\u0434\u0435\u043d\u0447\u0435\u0441\u043a\u0430\u0442\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0437\u0430 \u0431\u0435\u0437\u0441\u044a\u043d\u0438\u0435 (\u041a\u041f\u0422-\u0411) \u0435 \u043d\u0430\u0439-\u0435\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u0430\u0442\u0430 \u0434\u044a\u043b\u0433\u043e\u0441\u0440\u043e\u0447\u043d\u0430 \u0438\u043d\u0442\u0435\u0440\u0432\u0435\u043d\u0446\u0438\u044f. \u041a\u043e\u043d\u0441\u0443\u043b\u0442\u0438\u0440\u0430\u0439\u0442\u0435 \u0441\u0435 \u0441 \u0432\u0430\u0448\u0438\u044f \u043b\u0435\u043a\u0430\u0440 \u043f\u0440\u0435\u0434\u0438 \u0437\u0430\u043f\u043e\u0447\u0432\u0430\u043d\u0435, \u0441\u043f\u0438\u0440\u0430\u043d\u0435 \u0438\u043b\u0438 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u0441\u044a\u043d\u043e\u0442\u0432\u043e\u0440\u043d\u0438 \u2014 \u043e\u0441\u043e\u0431\u0435\u043d\u043e \u0430\u043a\u043e \u043f\u0440\u0438\u0435\u043c\u0430\u0442\u0435 \u0432\u0430\u0440\u0444\u0430\u0440\u0438\u043d, \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u0437\u0430 \u0434\u0438\u0430\u0431\u0435\u0442, \u0438\u043c\u0443\u043d\u043e\u0441\u0443\u043f\u0440\u0435\u0441\u0430\u043d\u0442\u0438, \u0444\u043b\u0443\u0432\u043e\u043a\u0441\u0430\u043c\u0438\u043d \u0438\u043b\u0438 \u043e\u0440\u0430\u043b\u043d\u0438 \u043a\u043e\u043d\u0442\u0440\u0430\u0446\u0435\u043f\u0442\u0438\u0432\u0438, \u0438\u043b\u0438 \u0438\u043c\u0430\u0442\u0435 \u0430\u0432\u0442\u043e\u0438\u043c\u0443\u043d\u043d\u043e \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435. \u0410\u043a\u043e \u0431\u0435\u0437\u0441\u044a\u043d\u0438\u0435\u0442\u043e \u0435 \u0441\u044a\u043f\u0440\u043e\u0432\u043e\u0434\u0435\u043d\u043e \u0441 \u0443\u0441\u0442\u043e\u0439\u0447\u0438\u0432\u043e \u043f\u043e\u043d\u0438\u0436\u0435\u043d\u043e \u043d\u0430\u0441\u0442\u0440\u043e\u0435\u043d\u0438\u0435, \u0431\u0435\u0437\u043d\u0430\u0434\u0435\u0436\u0434\u043d\u043e\u0441\u0442 \u0438\u043b\u0438 \u043c\u0438\u0441\u043b\u0438 \u0437\u0430 \u0441\u0430\u043c\u043e\u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0430\u043d\u0435, \u0441\u0432\u044a\u0440\u0436\u0435\u0442\u0435 \u0441\u0435 \u0441 \u043a\u0440\u0438\u0437\u0438\u0441\u043d\u0430 \u043b\u0438\u043d\u0438\u044f (\u0421\u0410\u0429 988, \u0412\u0435\u043b\u0438\u043a\u043e\u0431\u0440\u0438\u0442\u0430\u043d\u0438\u044f \u0421\u0430\u043c\u0430\u0440\u0438\u0442\u044f\u043d\u0438 116 123, \u0438\u043b\u0438 <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).<\/p>","protected":false},"excerpt":{"rendered":"<p>Restfine (melatonin 10 mg) \u2014 high-dose pineal-hormone tablet for delayed sleep-phase disorder, severe shift work, and age 55+ insomnia. Non-addictive, no rebound; lower-dose Meloset 3 mg available for typical adult insomnia.<\/p>","protected":false},"featured_media":65536,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[3887],"product_tag":[3888,5346],"class_list":{"0":"post-65535","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-sleeping-tablets","7":"product_tag-melatonin","8":"product_tag-restfine","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product\/65535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/comments?post=65535"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media\/65536"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media?parent=65535"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_brand?post=65535"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_cat?post=65535"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_tag?post=65535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}