{"id":66697,"date":"2025-05-01T13:11:44","date_gmt":"2025-05-01T13:11:44","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=66697"},"modified":"2026-05-10T08:48:12","modified_gmt":"2026-05-10T08:48:12","slug":"dicaris-adults-tablet","status":"publish","type":"product","link":"https:\/\/medsbase.com\/bg\/product\/dicaris-adults-tablet\/","title":{"rendered":"Dicaris Adults Tablet"},"content":{"rendered":"

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Quick Answer — What is Dicaris Adults Tablet?<\/h3>\n
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Dicaris Adults Tablet<\/strong> \u0435 levamisole 150 mg<\/strong> \u043e\u0442 Janssen<\/strong>. Levamisole is both an anthelmintic<\/strong> (first-line for ascariasis worldwide before albendazole displaced it) and an immunomodulator<\/strong> used in steroid-dependent or frequently-relapsing nephrotic syndrome to reduce relapse rate. Standard adult anthelmintic dose: 150 mg single dose<\/strong>; immunomodulatory dose: 2.5 mg\/kg every other day in nephrotic syndrome.<\/p>\n<\/div>\n<\/div>\n

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What is Dicaris Adults Tablet?<\/h2>\n

Dicaris Adults Tablet<\/strong> \u0441\u044a\u0434\u044a\u0440\u0436\u0430 levamisole 150 mg<\/strong> \u043e\u0442 Janssen<\/strong>. Originally developed as a veterinary anthelmintic, levamisole was widely used in human medicine for ascariasis from the 1960s until albendazole and mebendazole displaced it as first-line. It retains an important second indication: immunomodulation in childhood nephrotic syndrome<\/strong>, where it reduces relapse frequency in steroid-dependent disease and lets clinicians reduce cumulative steroid dose.<\/p>\n

\u041c\u0435\u0445\u0430\u043d\u0438\u0437\u044a\u043c \u043d\u0430 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435<\/h2>\n

As an anthelmintic, levamisole is a nicotinic acetylcholine receptor agonist<\/strong> on parasite muscle, causing spastic paralysis (similar mechanism to pyrantel). The paralysed worm is passed in stool.<\/p>\n

As an immunomodulator, levamisole appears to restore depressed cell-mediated immunity<\/strong> — it enhances T-cell function, monocyte and macrophage activity, and natural killer cell response. The exact mechanism in nephrotic syndrome remains incompletely understood but the clinical effect (reduced relapse) is well-established in randomised trials.<\/p>\n

Dicaris Adults Tablet indications and dose<\/h2>\n\n\n\n\n\n\n\n\n
\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u0435<\/th>\n\u0414\u043e\u0437\u0430<\/th>\n\u0413\u0440\u0430\u0444\u0438\u043a<\/th>\n<\/tr>\n<\/thead>\n
Ascariasis (adults)<\/td>\n150 mg<\/td>\n\u0415\u0434\u043d\u043e\u043a\u0440\u0430\u0442\u043d\u0430 \u0434\u043e\u0437\u0430<\/td>\n<\/tr>\n
Ascariasis (children)<\/td>\n2.5 mg\/kg<\/td>\n\u0415\u0434\u043d\u043e\u043a\u0440\u0430\u0442\u043d\u0430 \u0434\u043e\u0437\u0430<\/td>\n<\/tr>\n
Hookworm (light burden)<\/td>\n150 mg<\/td>\nSingle dose, repeat at 7 days if needed<\/td>\n<\/tr>\n
Steroid-dependent nephrotic syndrome (specialist)<\/td>\n2.5 mg\/kg<\/td>\nEvery other day for 12–24 months under nephrologist supervision<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Take with or after a meal to reduce nausea.<\/p>\n

Specialist supervision for nephrotic syndrome.<\/strong> Long-course levamisole for nephrotic syndrome requires nephrology supervision. Mandatory neutrophil monitoring (FBC every 4–6 weeks for the first 6 months, then every 3 months) is essential because of the well-described risk of agranulocytosis. Stop immediately at signs of infection or oral ulceration.<\/div>\n

\u0421\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438<\/h2>\n