{"id":68994,"date":"2026-03-12T15:22:39","date_gmt":"2026-03-12T15:22:39","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=68994"},"modified":"2026-05-21T07:14:11","modified_gmt":"2026-05-21T07:14:11","slug":"cjc-1295-with-dac","status":"publish","type":"product","link":"https:\/\/medsbase.com\/bg\/product\/cjc-1295-with-dac\/","title":{"rendered":"CJC-1295 \u0441 DAC"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">Quick Answer \u2014 What is CJC-1295 with DAC?<\/h3>\n<p style=\"margin: 0;\"><strong>CJC-1295 \u0441 DAC<\/strong> is a synthetic analog of growth-hormone-releasing hormone (GHRH 1-29) modified with a <strong>Drug Affinity Complex (DAC)<\/strong> that binds plasma albumin covalently. The albumin binding extends plasma half-life from ~30 minutes to approximately 7\u00a0days, enabling weekly or twice-weekly research dosing. It is supplied in 2\u00a0mg and 5\u00a0mg lyophilized vials for laboratory research use only.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>\u041a\u0430\u043a\u0432\u043e \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u0442\u0435 \u0441 MedsBase:<\/strong> \u041f\u0435\u043f\u0442\u0438\u0434\u0438 \u0437\u0430 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f \u0432 \u043b\u0438\u043e\u0444\u0438\u043b\u0438\u0437\u0438\u0440\u0430\u043d\u0430 \u0444\u043e\u0440\u043c\u0430 \u00b7 HPLC \u226599% \u0447\u0438\u0441\u0442\u043e\u0442\u0430 (\u0441\u0435\u0440\u0442\u0438\u0444\u0438\u043a\u0430\u0442 \u0437\u0430 \u0430\u043d\u0430\u043b\u0438\u0437 \u043f\u0440\u0438 \u043f\u043e\u0438\u0441\u043a\u0432\u0430\u043d\u0435) \u00b7 \u0414\u0438\u0441\u043a\u0440\u0435\u0442\u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0430, \u0441\u0442\u0430\u0431\u0438\u043b\u043d\u0430 \u043d\u0430 \u0442\u0435\u043c\u043f\u0435\u0440\u0430\u0442\u0443\u0440\u0430 \u00b7 \u041c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u0435\u043d \u043a\u0443\u0440\u0438\u0435\u0440 \u0437\u0430 \u043f\u0435\u043f\u0442\u0438\u0434\u0438 \u00b7 \u041d\u0430\u0434 1,400 \u043f\u043e\u0442\u0432\u044a\u0440\u0434\u0435\u043d\u0438 <a href=\"https:\/\/medsbase.com\/bg\/reviews\/\">\u043e\u0442\u0437\u0438\u0432\u0430 \u043e\u0442 \u043a\u043b\u0438\u0435\u043d\u0442\u0438<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 \u0412\u0441\u044f\u043a\u0430 \u043f\u043e\u0440\u044a\u0447\u043a\u0430 \u0435 \u043f\u043e\u043a\u0440\u0438\u0442\u0430 \u043e\u0442 \u043d\u0430\u0448\u0430\u0442\u0430 <a href=\"https:\/\/medsbase.com\/bg\/medsbase-re-shipment-assurance-policy\/\"><strong>\u041f\u043e\u043b\u0438\u0442\u0438\u043a\u0430 \u0437\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430 \u0438\u0437\u043f\u0440\u0430\u0442\u043a\u0430<\/strong><\/a> \u2014 \u0430\u043a\u043e \u0432\u0430\u0448\u0430\u0442\u0430 \u043f\u0440\u0430\u0442\u043a\u0430 \u043d\u0435 \u043f\u0440\u0438\u0441\u0442\u0438\u0433\u043d\u0435 \u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 20 \u0440\u0430\u0431\u043e\u0442\u043d\u0438 \u0434\u043d\u0438, \u043d\u0438\u0435 \u044f \u0438\u0437\u043f\u0440\u0430\u0449\u0430\u043c\u0435 \u043e\u0442\u043d\u043e\u0432\u043e.<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px; text-align: left; width: 30%;\">\u0421\u043f\u0435\u0446\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u044f<\/th>\n<th style=\"padding: 8px 12px; text-align: left;\">\u0414\u0435\u0442\u0430\u0439\u043b<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>CAS \u043d\u043e\u043c\u0435\u0440<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">863288-34-0<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u041c\u043e\u043b\u0435\u043a\u0443\u043b\u043d\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">C<sub>165<\/sub>H<sub>269<\/sub>N<sub>47<\/sub>O<sub>46<\/sub><\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u041c\u043e\u043b\u0435\u043a\u0443\u043b\u043d\u043e \u0442\u0435\u0433\u043b\u043e<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">3647.25 Da<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u041f\u043e\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u043d\u043e\u0441\u0442<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">D-Ala-Tyr-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys-NH<sub>2<\/sub> conjugated to maleimidopropionyl-Lys (DAC linker for albumin binding)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0424\u043e\u0440\u043c\u0430<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u041b\u0438\u043e\u0444\u0438\u043b\u0438\u0437\u0438\u0440\u0430\u043d \u043f\u0440\u0430\u0445 (\u0438\u043b\u0438 \u043a\u0430\u043a\u0442\u043e \u0435 \u0434\u043e\u0441\u0442\u0430\u0432\u0435\u043d)<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0427\u0438\u0441\u0442\u043e\u0442\u0430<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u226599% (HPLC \u043f\u0440\u043e\u0432\u0435\u0440\u0435\u043d\u043e, \u0441\u0435\u0440\u0442\u0438\u0444\u0438\u043a\u0430\u0442 \u0437\u0430 \u0430\u043d\u0430\u043b\u0438\u0437 \u043f\u043e \u0437\u0430\u044f\u0432\u043a\u0430)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0421\u044a\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u041b\u0438\u043e\u0444\u0438\u043b\u0438\u0437\u0438\u0440\u0430\u043d: 2\u20138 \u00b0C (\u0445\u043b\u0430\u0434\u0438\u043b\u043d\u0438\u043a) \u0437\u0430 \u0440\u0430\u0431\u043e\u0442\u0435\u043d \u0437\u0430\u043f\u0430\u0441; \u221220 \u00b0C \u0437\u0430 \u0434\u044a\u043b\u0433\u043e\u0441\u0440\u043e\u0447\u043d\u043e \u0441\u044a\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435 \u043d\u0430 \u043d\u0435\u043e\u0442\u0432\u043e\u0440\u0435\u043d\u0438 \u0444\u043b\u0430\u043a\u043e\u043d\u0438. \u0420\u0435\u043a\u043e\u0441\u0442\u0438\u0442\u0443\u0438\u0440\u0430\u043d: 2\u20138 \u00b0C, \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430\u0439\u0442\u0435 \u0432 \u0440\u0430\u043c\u043a\u0438\u0442\u0435 \u043d\u0430 ~30 \u0434\u043d\u0438. \u0417\u0430\u0449\u0438\u0442\u0430\u0432\u0430\u0439\u0442\u0435 \u043e\u0442 \u0441\u0432\u0435\u0442\u043b\u0438\u043d\u0430. \u041d\u0435 \u0437\u0430\u043c\u0440\u0430\u0437\u044f\u0432\u0430\u0439\u0442\u0435 \u0438 \u0440\u0430\u0437\u043c\u0440\u0430\u0437\u044f\u0432\u0430\u0439\u0442\u0435 \u0440\u0435\u043a\u043e\u0441\u0442\u0438\u0442\u0443\u0438\u0440\u0430\u043d\u0438\u044f \u0440\u0430\u0437\u0442\u0432\u043e\u0440.<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0420\u0430\u0437\u0442\u0432\u043e\u0440\u0438\u043c\u043e\u0441\u0442<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u0411\u0430\u043a\u0442\u0435\u0440\u0438\u043e\u0441\u0442\u0430\u0442\u0438\u0447\u043d\u0430 \u0432\u043e\u0434\u0430 (\u043f\u0440\u0435\u043f\u043e\u0440\u044a\u0447\u0438\u0442\u0435\u043b\u043d\u0430) \u0438\u043b\u0438 \u0441\u0442\u0435\u0440\u0438\u043b\u043d\u0430 \u0432\u043e\u0434\u0430 \u0437\u0430 \u043f\u043e-\u043a\u0440\u0430\u0442\u043a\u0438 \u043f\u0435\u0440\u0438\u043e\u0434\u0438 \u043d\u0430 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>\u0417\u0430 \u0438\u0437\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u0441\u043a\u0430 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u0421\u0430\u043c\u043e \u0437\u0430 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f. \u041d\u0435 \u0437\u0430 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u043d\u0430 \u0438\u043b\u0438 \u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u043d\u0430 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u043f\u0440\u0438 \u0445\u043e\u0440\u0430 \u0438\u043b\u0438 \u0436\u0438\u0432\u043e\u0442\u043d\u0438.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>What Is CJC-1295 with DAC?<\/h2>\n<p><strong>CJC-1295<\/strong> is a synthetic 30-amino-acid analog of growth-hormone-releasing hormone (GHRH), specifically a modified form of the biologically-active GHRH (1-29) fragment. The &#8220;<strong>with DAC<\/strong>&#8221; suffix refers to a proprietary <strong>Drug Affinity Complex (DAC)<\/strong> \u2014 a maleimidopropionic acid residue attached to lysine-30 \u2014 which forms a covalent bond with serum albumin cysteine-34 <em>in vivo<\/em>.<\/p>\n<p>That albumin tether is the key innovation. Native GHRH has a plasma half-life measured in minutes (rapid DPP-IV degradation); CJC-1295 with DAC circulates bound to albumin for approximately <strong>7 \u0434\u043d\u0438<\/strong>, enabling weekly or twice-weekly research dosing while sustaining GH\/IGF-1 elevation between injections. This is a fundamentally different pharmacokinetic profile from the &#8220;without DAC&#8221; version (sometimes called Mod GRF 1-29) which retains native GHRH&#8217;s short half-life. Developed by ConjuChem, CJC-1295 is <strong>\u0441\u0430\u043c\u043e \u0437\u0430 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f<\/strong> and is not intended for human or veterinary diagnosis or therapy. For mechanism, research context, and stacking protocols, see our <a href=\"https:\/\/medsbase.com\/bg\/ipamorelin-cjc-1295-stack-guide\/\">Ipamorelin &amp; CJC-1295 research guide<\/a>.<\/p>\n<h2>Mechanism of Action \u2014 Extended-Release GHRH Agonism<\/h2>\n<p>CJC-1295 with DAC acts through two sequential mechanisms:<\/p>\n<ul>\n<li><strong>GHRH receptor agonism<\/strong> \u2014 the peptide binds GHRH receptors on pituitary somatotropes, stimulating growth-hormone synthesis and release. This is the same receptor and downstream pathway as endogenous GHRH.<\/li>\n<li><strong>Albumin-tethered extended half-life<\/strong> \u2014 the DAC lysine side chain forms a Michael-addition covalent bond with the free thiol on albumin cysteine-34. Albumin&#8217;s ~20-day half-life carries the peptide with it, protecting CJC-1295 from rapid DPP-IV cleavage and extending functional plasma half-life to ~7 days. The result is sustained exposure of pituitary cells to GHRH signal rather than the short pulses seen with native GHRH.<\/li>\n<li><strong>Hepatic IGF-1 amplification<\/strong> \u2014 elevated and sustained GH exposure drives hepatic IGF-1 production. The extended-release kinetics means IGF-1 levels remain elevated throughout the dosing interval rather than spiking and falling within hours.<\/li>\n<\/ul>\n<p>The practical research consequence: a single weekly injection maintains elevated GH and IGF-1 tone across the full interval, eliminating the need for multiple daily injections. When stacked with a GHRP such as <a href=\"https:\/\/medsbase.com\/bg\/ipamorelin\/\">\u0438\u043f\u0430\u043c\u043e\u0440\u0435\u043b\u0438\u043d<\/a> (which acts on the parallel ghrelin-receptor pathway), the combination produces larger GH pulses than either alone \u2014 the canonical GH-axis research stack.<\/p>\n<h2>\u041f\u0443\u0431\u043b\u0438\u043a\u0443\u0432\u0430\u043d\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u0441\u043a\u0438 \u043f\u0440\u0438\u043b\u043e\u0436\u0435\u043d\u0438\u044f<\/h2>\n<p>CJC-1295 with DAC is used in laboratory research contexts that investigate:<\/p>\n<ul>\n<li><strong>Hepatic IGF-1 elevation<\/strong> \u2014 sustained plasma IGF-1 response via extended-release GHRH signal (Teichman et al., J Clin Endocrinol Metab 2006)<\/li>\n<li><strong>Extended dosing protocols<\/strong> \u2014 weekly or twice-weekly research protocols made possible by the ~7-day half-life<\/li>\n<li><strong>Body composition research<\/strong> \u2014 lean mass, fat mass, and body-composition research in GH-axis modulation studies<\/li>\n<li><strong>Ipamorelin synergy research<\/strong> \u2014 the canonical &#8220;CJC-1295 + ipamorelin&#8221; research stack investigating GHRH + GHRP additive pharmacology<\/li>\n<li><strong>Sleep architecture<\/strong> \u2014 slow-wave sleep and nocturnal GH-axis research in preclinical models<\/li>\n<li><strong>Bone density research<\/strong> \u2014 osteoblast activity and bone mineral density research via GH\/IGF-1 axis modulation<\/li>\n<li><strong>Comparative GHRH research<\/strong> \u2014 side-by-side with <a href=\"https:\/\/medsbase.com\/bg\/sermorelin-peptide-guide\/\">sermorelin<\/a> \u0438 <a href=\"https:\/\/medsbase.com\/bg\/tesamorelin-peptide-guide\/\">tesamorelin<\/a> (both GHRH analogs without DAC) to isolate the extended-half-life effect<\/li>\n<\/ul>\n<p>For broader context on the GH-axis peptide landscape, see the <a href=\"https:\/\/medsbase.com\/bg\/peptides\/\">\u043a\u0430\u0442\u0430\u043b\u043e\u0433 \u0441 \u0438\u0437\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u0441\u043a\u0438 \u043f\u0435\u043f\u0442\u0438\u0434\u0438<\/a>.<\/p>\n<h2>\u041d\u0430\u043b\u0438\u0447\u043d\u0438 \u0434\u043e\u0437\u0438 \u0438 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u0438<\/h2>\n<p>MedsBase stocks CJC-1295 with DAC in the following lyophilized vial sizes. Each variation ships in 10-vial, 20-vial, or 30-vial pack formats:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u0421\u0438\u043b\u0430 \u043d\u0430 \u0444\u043b\u0430\u043a\u043e\u043d\u0430<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u0422\u0438\u043f\u0438\u0447\u043d\u043e \u043f\u0440\u0438\u043b\u043e\u0436\u0435\u043d\u0438\u0435<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u0420\u0430\u0437\u043c\u0435\u0440\u0438 \u043d\u0430 \u043e\u043f\u0430\u043a\u043e\u0432\u043a\u0438\u0442\u0435<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>2\u00a0mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Short protocols, pilot dosing \u2014 supports ~7 weekly administrations per vial<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10, 20 \u0438\u043b\u0438 30 \u0444\u043b\u0430\u043a\u043e\u043d\u0430<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>5 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Standard research strength \u2014 supports ~17 weekly administrations per vial<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10, 20 \u0438\u043b\u0438 30 \u0444\u043b\u0430\u043a\u043e\u043d\u0430<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Because CJC-1295 with DAC is typically dosed at 1\u20132\u00a0mg weekly (or 300\u2013500\u00a0mcg twice-weekly), a single vial covers an extended research duration. All strengths are supplied as lyophilized powder at 99%+ HPLC purity.<\/p>\n<h2>How It Compares \u2014 CJC-1295 with DAC vs Without DAC vs Ipamorelin<\/h2>\n<p>The three most-commonly-studied GH-axis peptides differ significantly in mechanism and dosing:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u041a\u0440\u0438\u0442\u0435\u0440\u0438\u0439<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">CJC-1295 \u0441 DAC<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">CJC-1295 \u0431\u0435\u0437 DAC<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">\u0418\u043f\u0430\u043c\u043e\u0440\u0435\u043b\u0438\u043d<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Peptide class<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">GHRH analog (modified)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">GHRH analog (Mod GRF 1-29)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">GHRP (ghrelin-receptor)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u041f\u0435\u0440\u0438\u043e\u0434 \u043d\u0430 \u043f\u043e\u043b\u0443\u0440\u0430\u0437\u043f\u0430\u0434<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">~7 days (albumin-bound)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">~30 minutes<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">~2 hours<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u0427\u0435\u0441\u0442\u043e\u0442\u0430 \u043d\u0430 \u043f\u0440\u0438\u0435\u043c\u0430\u043d\u0435<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">1\u20132x weekly<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">2\u20133x daily<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">2\u20133x daily<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>GH profile<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Sustained elevation<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Pulsatile, short<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Pulsatile burst<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>\u0422\u0438\u043f\u0438\u0447\u043d\u0430 \u0438\u0437\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u0441\u043a\u0430 \u0434\u043e\u0437\u0430<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">1\u20132\u00a0mg weekly<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">100\u2013200\u00a0mcg per pulse<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">200\u2013300\u00a0mcg per pulse<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Canonical partner<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u0418\u043f\u0430\u043c\u043e\u0440\u0435\u043b\u0438\u043d<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Ipamorelin (short-stack)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">CJC-1295 (with or without DAC)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>The full pharmacology comparison, stacking protocols, and when researchers select &#8220;with DAC&#8221; vs &#8220;without DAC&#8221; versions are covered in our <a href=\"https:\/\/medsbase.com\/bg\/ipamorelin-cjc-1295-stack-guide\/\">Ipamorelin + CJC-1295 research guide<\/a>.<\/p>\n<h2>\u0421\u044a\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435 \u0438 \u0440\u0435\u043a\u043e\u043d\u0441\u0442\u0438\u0442\u0443\u0438\u0440\u0430\u043d\u0435<\/h2>\n<p><strong>\u041f\u0440\u0435\u0434\u0438 \u0440\u0435\u043a\u043e\u043d\u0441\u0442\u0438\u0442\u0443\u0438\u0440\u0430\u043d\u0435:<\/strong> store lyophilized vials refrigerated at 2\u20138\u00a0\u00b0C in original packaging, stable up to 36 months. Avoid freeze-thaw cycles on the powder.<\/p>\n<p><strong>\u041f\u0440\u043e\u0446\u0435\u0434\u0443\u0440\u0430 \u0437\u0430 \u0440\u0435\u043a\u043e\u043d\u0441\u0442\u0438\u0442\u0443\u0438\u0440\u0430\u043d\u0435:<\/strong> inject bacteriostatic water down the side wall of the peptide vial per the dilution chart above. Swirl gently \u2014 do <strong>\u043d\u0435<\/strong> shake \u2014 and allow 5\u201310 minutes for full dissolution. A correctly reconstituted solution should be clear and colourless.<\/p>\n<p><strong>\u0421\u043b\u0435\u0434 \u0440\u0435\u043a\u043e\u043d\u0441\u0442\u0438\u0442\u0443\u0438\u0440\u0430\u043d\u0435:<\/strong> store refrigerated at 2\u20138\u00a0\u00b0C and use within 30 days. Do not freeze reconstituted solution \u2014 freeze-thaw cycles degrade peptide integrity.<\/p>\n<h2 id=\"faqs\">\u0427\u0435\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u043d\u0438 \u0432\u044a\u043f\u0440\u043e\u0441\u0438<\/h2>\n<h3>What is CJC-1295 with DAC used for in research?<\/h3>\n<p>CJC-1295 with DAC is used in laboratory research investigating extended-release GHRH signaling, hepatic IGF-1 elevation, body composition, GH-axis kinetics, sleep research, and synergistic stacking with GHRP peptides such as ipamorelin. It is <strong>\u043d\u0435<\/strong> FDA-approved and is sold here strictly for laboratory research use only.<\/p>\n<h3>What does &#8220;with DAC&#8221; mean?<\/h3>\n<p>DAC stands for <strong>Drug Affinity Complex<\/strong> \u2014 a maleimidopropionic-acid residue attached to the peptide that binds covalently to cysteine-34 on serum albumin. The albumin tether extends plasma half-life from ~30 minutes (native GHRH) to approximately 7 days, enabling weekly research dosing.<\/p>\n<h3>What is the difference between CJC-1295 with DAC and without DAC?<\/h3>\n<p>The core peptide sequence is the same. The &#8220;with DAC&#8221; version has the albumin-binding maleimide attached, giving ~7-day half-life and weekly dosing. The &#8220;without DAC&#8221; version (also called Mod GRF 1-29) lacks the albumin tether, has ~30-minute half-life, and requires multiple daily doses. Both have their research use cases. See our <a href=\"https:\/\/medsbase.com\/bg\/cjc-1295-without-dac\/\">CJC-1295 without DAC product page<\/a>.<\/p>\n<h3>What is the typical CJC-1295 with DAC research dose?<\/h3>\n<p>Published preclinical protocols typically use 1\u20132\u00a0mg once weekly, or 300\u2013500\u00a0mcg twice weekly. A 2\u00a0mg vial reconstituted with 2.0\u00a0mL bacteriostatic water yields 1.0\u00a0mg\/mL \u2014 30 ticks on a U-100 syringe delivers 300\u00a0mcg.<\/p>\n<h3>Is CJC-1295 FDA approved?<\/h3>\n<p>No. CJC-1295 was originally developed by ConjuChem but never received FDA or EMA regulatory approval for any indication. All CJC-1295 sold by research-use-only suppliers is for laboratory investigation, not therapy.<\/p>\n<h3>How should CJC-1295 with DAC be stored?<\/h3>\n<p>Lyophilized vials: refrigerated at 2\u20138\u00a0\u00b0C in original packaging, stable up to 36 months. Reconstituted solution: refrigerated at 2\u20138\u00a0\u00b0C, use within 30 days. Do not freeze reconstituted solution.<\/p>\n<h3>How do I reconstitute CJC-1295 with DAC?<\/h3>\n<p>Follow the reconstitution chart above. Add bacteriostatic water down the side wall of the vial, swirl gently, and allow 5\u201310 minutes for full dissolution. Do <strong>\u043d\u0435<\/strong> shake the vial.<\/p>\n<h3>Should I stack CJC-1295 with DAC with ipamorelin in research?<\/h3>\n<p>The CJC-1295 + ipamorelin pairing is the canonical GH-axis research stack. The two peptides bind different receptors (GHRH-R vs ghrelin-R) on the same pituitary cells, and their effects on GH release are synergistic \u2014 combined use produces larger GH pulses than either alone. See our <a href=\"https:\/\/medsbase.com\/bg\/ipamorelin-cjc-1295-stack-guide\/\">stack research guide<\/a> for protocols.<\/p>\n<h3>\u041a\u0430\u043a\u0432\u0438 \u0434\u043e\u0437\u0438 \u043f\u0440\u0435\u0434\u043b\u0430\u0433\u0430 MedsBase?<\/h3>\n<p>MedsBase carries CJC-1295 with DAC in 2\u00a0mg and 5\u00a0mg lyophilized vials. Each strength is available in 10-vial, 20-vial, or 30-vial pack sizes. All vials are supplied at 99%+ HPLC purity with a certificate of analysis on request.<\/p>\n<h3>Does CJC-1295 with DAC cause side effects in research?<\/h3>\n<p>Published preclinical research has reported a reasonable safety profile at typical research doses. The most commonly reported finding is transient injection-site redness. Long-term human safety data are not available because human trials were discontinued. Some studies have identified a risk of &#8220;GH bleed&#8221; (sustained elevation producing IGF-1 saturation) with very high doses.<\/p>\n<h3>What is the half-life of CJC-1295 With DAC?<\/h3>\n<p>CJC-1295 with DAC has a half-life of approximately 6\u20138 days, achieved through the Drug Affinity Complex (DAC) technology \u2014 a maleimidopropionic acid group that forms a covalent bond with circulating serum albumin. This dramatically extends the dosing interval; most research protocols use once-weekly or twice-weekly administration.<\/p>\n<h3>What does DAC mean in CJC-1295 with DAC?<\/h3>\n<p>DAC stands for Drug Affinity Complex \u2014 a reactive group attached to the peptide that, once injected, binds covalently to circulating albumin (half-life ~19 days), dramatically extending the peptide&#8217;s active period. The result is a continuous, non-pulsatile GH release pattern (often called a &#8220;GH bleed&#8221;), which differs from the pulsatile secretion produced by CJC-1295 without DAC or by Sermorelin.<\/p>\n<h3>Can I order CJC-1295 with DAC for international shipping?<\/h3>\n<p>Yes. MedsBase ships CJC-1295 with DAC worldwide from our dedicated peptide shipping network. Peptide-only orders qualify for our standalone peptide shipping service. Orders ship in temperature-controlled packaging with full tracking.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>\u0414\u0440\u0443\u0433\u0438 \u043f\u0435\u043f\u0442\u0438\u0434\u0438 \u0437\u0430 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f \u043d\u0430 \u0432\u044a\u0437\u0441\u0442\u0430\u043d\u043e\u0432\u044f\u0432\u0430\u043d\u0435 \u0438 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0438\u0442\u0435\u043b\u043d\u043e\u0441\u0442<\/h2>\n<ul>\n<li><a href=\"\/bg\/bpc-157\/\"><strong>BPC-157<\/strong><\/a> \u2014 \u0421\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u0435 \u0437\u0430 \u0437\u0430\u0449\u0438\u0442\u0430 \u043d\u0430 \u0442\u044f\u043b\u043e\u0442\u043e \u2014 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f \u043d\u0430 \u0432\u044a\u0437\u0441\u0442\u0430\u043d\u043e\u0432\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0441\u0443\u0445\u043e\u0436\u0438\u043b\u0438\u044f, \u043b\u0438\u0433\u0430\u043c\u0435\u043d\u0442\u0438 \u0438 \u0447\u0435\u0440\u0432\u0430\u0442\u0430<\/li>\n<li><a href=\"\/bg\/tb-500\/\"><strong>TB-500<\/strong><\/a> \u2014 \u0424\u0440\u0430\u0433\u043c\u0435\u043d\u0442 \u043e\u0442 \u0442\u0438\u043c\u043e\u0437\u0438\u043d \u0431\u0435\u0442\u0430-4 \u2014 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f \u043d\u0430 \u0432\u044a\u0437\u0441\u0442\u0430\u043d\u043e\u0432\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u043c\u0435\u043a\u0438 \u0442\u044a\u043a\u0430\u043d\u0438 \u0438 \u043a\u0440\u044a\u0432\u043e\u043d\u043e\u0441\u043d\u0438 \u0441\u044a\u0434\u043e\u0432\u0435<\/li>\n<li><a href=\"\/bg\/ipamorelin\/\"><strong>\u0418\u043f\u0430\u043c\u043e\u0440\u0435\u043b\u0438\u043d<\/strong><\/a> \u2014 \u0421\u0435\u043b\u0435\u043a\u0442\u0438\u0432\u0435\u043d \u0430\u0433\u043e\u043d\u0438\u0441\u0442 \u043d\u0430 \u0433\u0440\u0435\u043b\u0438\u043d \u2014 \u0447\u0438\u0441\u0442 \u0438\u043c\u043f\u0443\u043b\u0441 \u043d\u0430 \u0440\u0430\u0441\u0442\u0435\u0436\u0435\u043d \u0445\u043e\u0440\u043c\u043e\u043d \u0431\u0435\u0437 \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\/\u043f\u0440\u043e\u043b\u0430\u043a\u0442\u0438\u043d<\/li>\n<li><a href=\"\/bg\/ghk-cu\/\"><strong>GHK-Cu<\/strong><\/a> \u2014 \u041c\u0435\u0434\u0435\u043d \u043f\u0435\u043f\u0442\u0438\u0434 \u2014 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f \u043d\u0430 \u0440\u0435\u0433\u0435\u043d\u0435\u0440\u0430\u0446\u0438\u044f \u043d\u0430 \u043a\u043e\u0436\u0430 \u0438 \u0441\u044a\u0435\u0434\u0438\u043d\u0438\u0442\u0435\u043b\u043d\u0430 \u0442\u044a\u043a\u0430\u043d<\/li>\n<li><a href=\"\/bg\/igf-1-lr3\/\"><strong>IGF-1 LR3<\/strong><\/a> \u2014 Long-R3 IGF-1 analog \u2014 anabolic \/ regenerative research<\/li>\n<\/ul>\n<p><!-- medsbase-peptide-guide-cta --><\/p>\n<h2>\u0414\u043e\u043f\u044a\u043b\u043d\u0438\u0442\u0435\u043b\u043d\u0430 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/h2>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<p style=\"margin: 0 0 8px 0;\"><strong>\ud83d\udcd6 \u041d\u0430\u0443\u0447\u0435\u0442\u0435 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f\u0442\u0430 \u0437\u0430\u0434 \u0442\u043e\u0437\u0438 \u043f\u0435\u043f\u0442\u0438\u0434<\/strong><\/p>\n<p style=\"margin: 0;\">\u041f\u0440\u043e\u0447\u0435\u0442\u0435\u0442\u0435 \u043d\u0430\u0448\u0438\u044f \u043f\u044a\u043b\u0435\u043d \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u043d\u043e \u0431\u0430\u0437\u0438\u0440\u0430\u043d \u043d\u0430\u0440\u044a\u0447\u043d\u0438\u043a: <a href=\"https:\/\/medsbase.com\/bg\/ipamorelin-cjc-1295-stack-guide\/\"><strong>Ipamorelin &amp; CJC-1295 \u2014 mechanism, stacking &amp; protocols<\/strong><\/a>. Covers GHRH vs GHRP pharmacology, the rationale behind the canonical stack, published dosing protocols, reconstitution, and safety notes.<\/p>\n<\/div>\n<p><!-- pep-seo-v1 --><\/p>","protected":false},"excerpt":{"rendered":"<p>\u2705 Supports growth signaling<br \/>\n\u2705 Enhances metabolic regulation<br \/>\n\u2705 Promotes tissue regeneration<br \/>\n\u2705 Improves recovery pathways<br \/>\n\u2705 Boosts hormonal balance<\/p>\n<p><strong>CJC-1295 \u0441 DAC<\/strong> \u0441\u044a\u0434\u044a\u0440\u0436\u0430 \u0441\u0438\u043d\u0442\u0435\u0442\u0438\u0447\u043d\u043e \u043f\u0435\u043f\u0442\u0438\u0434\u043d\u043e \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u0435.<\/p>","protected":false},"featured_media":70944,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[5470],"class_list":{"0":"post-68994","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-cjc-1295-with-dac","9":"first","10":"instock","11":"shipping-taxable","12":"purchasable","13":"product-type-variable","14":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product\/68994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/comments?post=68994"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media\/70944"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/media?parent=68994"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_brand?post=68994"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_cat?post=68994"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/bg\/wp-json\/wp\/v2\/product_tag?post=68994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}