{"id":50535,"date":"2023-09-20T09:09:56","date_gmt":"2023-09-20T09:09:56","guid":{"rendered":"https:\/\/medsname.com\/isotroin\/"},"modified":"2026-04-30T10:25:36","modified_gmt":"2026-04-30T10:25:36","slug":"isotroin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/isotroin\/","title":{"rendered":"Isotroin"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Isotroin?<\/h3>\n<p style=\"margin:0;\"><strong>Isotroin<\/strong> je peror\u00e1ln\u00ed <strong>isotretinoin<\/strong> tobolka dostupn\u00e1 v <strong>s\u00edle 5, 10, 20 a 30 mg<\/strong> pou\u017e\u00edvan\u00e1 k l\u00e9\u010db\u011b <strong>t\u011b\u017ek\u00e9ho, rezistentn\u00edho nebo zjizvuj\u00edc\u00edho akn\u00e9<\/strong> kter\u00fd selhal u jin\u00fdch l\u00e9\u010debn\u00fdch postup\u016f. Je to jedin\u00fd l\u00e9k, kter\u00fd dok\u00e1\u017ee vyvolat <strong>trvalou remisi<\/strong> akn\u00e9 zmen\u0161en\u00edm mazov\u00fdch \u017el\u00e1z. Obvykl\u00e9 d\u00e1vkov\u00e1n\u00ed je <strong>0,5\u20131 mg\/kg\/den<\/strong> po dobu 16\u201324 t\u00fddn\u016f. <strong>Vysoce teratogenn\u00ed<\/strong> \u2014 je nutn\u00e1 p\u0159\u00edsn\u00e1 prevence t\u011bhotenstv\u00ed. Vyr\u00e1b\u00ed spole\u010dnost Cipla jako generikum p\u016fvodn\u00edho p\u0159\u00edpravku od Roche <strong>Roaccutane<sup>\u00ae<\/sup><\/strong>.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<p><strong>Isotroin<\/strong> je zna\u010dka Cipla <strong>or\u00e1ln\u00ed isotretinoin<\/strong> \u2014 nej\u00fa\u010dinn\u011bj\u0161\u00ed dostupn\u00e1 farmakologick\u00e1 l\u00e9\u010dba t\u011b\u017ek\u00e9ho akn\u00e9. Jedn\u00e1 se o 13-<em>cis<\/em>-kyselina retinov\u00e1, deriv\u00e1t vitaminu A, kter\u00fd z\u00e1sadn\u011b m\u011bn\u00ed chov\u00e1n\u00ed mazov\u00fdch \u017el\u00e1z a folikul\u00e1rn\u00edho prost\u0159ed\u00ed, kter\u00e9 zp\u016fsobuje akn\u00e9. Isotretinoin je jedin\u00fd l\u00e9k na akn\u00e9, kter\u00fd m\u016f\u017ee zp\u016fsobit <strong>dlouhodobou remisi<\/strong>, a u mnoha pacient\u016f jedin\u00e1 16\u201324t\u00fddenn\u00ed k\u00fara akn\u00e9 trvale odstran\u00ed.<\/p>\n<p>Isotroin obsahuje stejnou \u00fa\u010dinnou l\u00e1tku ve stejn\u00fdch koncentrac\u00edch jako zna\u010dkov\u00fd p\u0159\u00edpravek od spole\u010dnosti Roche <strong>Roaccutane<sup>\u00ae<\/sup><\/strong> (prod\u00e1van\u00fd jako Accutane<sup>\u00ae<\/sup> na n\u011bkter\u00fdch trz\u00edch) za zlomek ceny. Isotretinoin je na Seznamu z\u00e1kladn\u00edch l\u00e9k\u016f WHO a je p\u0159edepisov\u00e1n po cel\u00e9m sv\u011bt\u011b v r\u00e1mci strukturovan\u00fdch program\u016f prevence t\u011bhotenstv\u00ed kv\u016fli sv\u00e9mu z\u00e1va\u017en\u00e9mu teratogenn\u00edmu potenci\u00e1lu.<\/p>\n<h2 class=\"wp-block-heading\">Co je Isotroin?<\/h2>\n<p>Isotroin je p\u0159edpisov\u00fd peror\u00e1ln\u00ed retinoid, kter\u00fd sou\u010dasn\u011b c\u00edl\u00ed na \u010dty\u0159i hlavn\u00ed mechanismy akn\u00e9: nadm\u011brnou produkci mazu, folikul\u00e1rn\u00ed hyperkeratinizaci, <em>Cutibacterium acnes<\/em> kolonizaci a z\u00e1n\u011bt. Na rozd\u00edl od topick\u00fdch retinoid\u016f, kter\u00e9 p\u016fsob\u00ed hlavn\u011b na folikul\u00e1rn\u00ed keratinizaci, isotretinoin zmen\u0161uje samotnou mazovou \u017el\u00e1zu, \u010d\u00edm\u017e sni\u017euje produkci mazu a\u017e o <strong>90%<\/strong> b\u011bhem l\u00e9\u010dby.<\/p>\n<p>Isotroin je indikov\u00e1n pro:<\/p>\n<ul>\n<li><strong>T\u011b\u017ek\u00e1 nodulocystick\u00e1 akn\u00e9<\/strong> \u2014 hlubok\u00e9 bolestiv\u00e9 cysty, riziko zjizven\u00ed<\/li>\n<li><strong>St\u0159edn\u011b t\u011b\u017ek\u00e9 akn\u00e9 nereaguj\u00edc\u00ed na jin\u00e9 l\u00e9\u010dby<\/strong> \u2014 topick\u00e9 retinoidy, peror\u00e1ln\u00ed antibiotika, kombinovan\u00e9 peror\u00e1ln\u00ed antikoncepce<\/li>\n<li><strong>Akn\u00e9 s v\u00fdznamn\u00fdm rizikem zjizven\u00ed<\/strong> nebo psychologick\u00fd dopad<\/li>\n<li><strong>Gram-negativn\u00ed folikulitida<\/strong> \u2014 komplikace dlouhodob\u00e9ho u\u017e\u00edv\u00e1n\u00ed peror\u00e1ln\u00edch antibiotik<\/li>\n<li><strong>T\u011b\u017ek\u00e1 r\u016f\u017eovka<\/strong> (n\u00edzk\u00e1 d\u00e1vka) \u2014 off-label, zejm\u00e9na papulopustul\u00e1rn\u00ed a fymat\u00f3zn\u00ed varianty<\/li>\n<li><strong>Odoln\u00e1 hidradenitis suppurativa<\/strong> (m\u00edrn\u00e9 p\u0159\u00edpady) \u2014 off-label<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Jak funguje Isotroin?<\/h2>\n<p>Isotretinoin p\u016fsob\u00ed n\u011bkolika mechanismy:<\/p>\n<ul>\n<li><strong>Atrofie mazov\u00fdch \u017el\u00e1z<\/strong> \u2014 v\u00e1\u017ee se na jadern\u00e9 receptory kyseliny retinov\u00e9, co\u017e spou\u0161t\u00ed apopt\u00f3zu sebocyt\u016f a 70\u201390% sn\u00ed\u017een\u00ed produkce mazu<\/li>\n<li><strong>Normalizuje folikul\u00e1rn\u00ed keratinizaci<\/strong> \u2014 zabra\u0148uje vzniku mikrokomedonu (p\u0159edch\u016fdce ka\u017ed\u00e9 akn\u00e9 l\u00e9ze)<\/li>\n<li><strong>Sni\u017euje <em>C. acnes<\/em> kolonizaci<\/strong> \u2014 nep\u0159\u00edmo, odstran\u011bn\u00edm anaerobn\u00edho prost\u0159ed\u00ed bohat\u00e9ho na maz, kter\u00e9 bakterie pot\u0159ebuje<\/li>\n<li><strong>Protiz\u00e1n\u011btliv\u00e9 \u00fa\u010dinky<\/strong> \u2014 sni\u017euje signalizaci p\u0159es toll-like receptory a redukuje chemotaxi neutrofil\u016f<\/li>\n<\/ul>\n<p>Maxim\u00e1ln\u00ed plazmatick\u00e1 koncentrace je dosa\u017eena za 2\u20134 hodiny po pod\u00e1n\u00ed. <strong>Absorpce se zdvojn\u00e1sob\u00ed p\u0159i pod\u00e1n\u00ed s tu\u010dn\u00fdm j\u00eddlem<\/strong> \u2014 v\u017edy u\u017e\u00edvejte s j\u00eddlem. Polo\u010das rozpadu je p\u0159ibli\u017en\u011b 20 hodin. Klinick\u00e9 zlep\u0161en\u00ed je obvykle patrn\u00e9 do <strong>6\u20138 t\u00fddn\u016f<\/strong>; \u00fapln\u00e9 vymizen\u00ed projev\u016f do 16\u201324 t\u00fddn\u016f ve v\u011bt\u0161in\u011b p\u0159\u00edpad\u016f.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>T\u011b\u017ek\u00e1 nodulocystick\u00e1 akn\u00e9<\/strong> \u2014 prvn\u00ed volba podle v\u011bt\u0161iny dermatologick\u00fdch doporu\u010den\u00ed<\/li>\n<li><strong>St\u0159edn\u011b t\u011b\u017ek\u00e9 akn\u00e9, kter\u00e9 nereagovalo na konven\u010dn\u00ed terapii<\/strong><\/li>\n<li><strong>Akn\u00e9 s postz\u00e1n\u011btliv\u00fdmi jizvami nebo hyperpigmentac\u00ed<\/strong><\/li>\n<li><strong>T\u011b\u017ek\u00e1 r\u016f\u017eovka<\/strong> (mimo indikaci, n\u00edzk\u00e1 d\u00e1vka)<\/li>\n<li><strong>Gram-negativn\u00ed folikulitida<\/strong><\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed a pod\u00e1v\u00e1n\u00ed p\u0159\u00edpravku Isotroin<\/h2>\n<table>\n<thead>\n<tr>\n<th>Sc\u00e9n\u00e1\u0159<\/th>\n<th>D\u00e1vka<\/th>\n<th>Pozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Standardn\u00ed l\u00e9\u010debn\u00fd re\u017eim<\/strong><\/td>\n<td>Po\u010d\u00e1te\u010dn\u00ed d\u00e1vka 0,5 mg\/kg\/den, titrov\u00e1no na 1 mg\/kg\/den<\/td>\n<td>Celkov\u00fd kumulativn\u00ed c\u00edl 120\u2013150 mg\/kg<\/td>\n<\/tr>\n<tr>\n<td><strong>Typick\u00fd dosp\u011bl\u00fd o hmotnosti 60 kg<\/strong><\/td>\n<td>30 mg denn\u011b (lze rozd\u011blit na 10 mg r\u00e1no + 20 mg ve\u010der)<\/td>\n<td>16\u201324 t\u00fddn\u016f k dosa\u017een\u00ed kumulativn\u00ed d\u00e1vky<\/td>\n<\/tr>\n<tr>\n<td><strong>N\u00edzkod\u00e1vkov\u00fd protokol<\/strong><\/td>\n<td>20 mg obden<\/td>\n<td>L\u00e9pe sn\u00e1\u0161en; del\u0161\u00ed doba k dosa\u017een\u00ed kumulativn\u00ed d\u00e1vky<\/td>\n<\/tr>\n<tr>\n<td><strong>R\u016f\u017eovka (mimo indikaci)<\/strong><\/td>\n<td>10\u201320 mg denn\u011b<\/td>\n<td>3\u20136 m\u011bs\u00edc\u016f l\u00e9\u010dby pod dermatologick\u00fdm dohledem<\/td>\n<\/tr>\n<tr>\n<td><strong>Porucha funkce jater<\/strong><\/td>\n<td>Vyhnout se<\/td>\n<td>Isotretinoin je metabolizov\u00e1n j\u00e1try<\/td>\n<\/tr>\n<tr>\n<td><strong>Porucha funkce ledvin<\/strong><\/td>\n<td>Za\u010d\u00edt s ni\u017e\u0161\u00ed d\u00e1vkou<\/td>\n<td>Mo\u017en\u00e1 kumulace<\/td>\n<\/tr>\n<tr>\n<td><strong>Maxim\u00e1ln\u00ed d\u00e1vka<\/strong><\/td>\n<td>2 mg\/kg\/den<\/td>\n<td>Vy\u0161\u0161\u00ed d\u00e1vky jsou z\u0159\u00eddka pot\u0159eba<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">Jak spr\u00e1vn\u011b u\u017e\u00edvat Isotroin<\/h3>\n<ul>\n<li>V\u017edy u\u017e\u00edvejte s j\u00eddlem \u2014 <strong>absorpce se zdvojn\u00e1sob\u00ed<\/strong> s tu\u010dn\u00fdm j\u00eddlem<\/li>\n<li>Polykejte tobolky cel\u00e9 \u2014 nerozkusujte ani neotv\u00edrejte<\/li>\n<li>U\u017e\u00edvejte ve stejnou denn\u00ed dobu pro stabiln\u00ed hladiny<\/li>\n<li>Hydratujte rty a poko\u017eku pr\u016fb\u011b\u017en\u011b \u2014 vysu\u0161ov\u00e1n\u00ed je b\u011b\u017en\u00e9<\/li>\n<li><strong>Ned\u00e1vejte krev<\/strong> b\u011bhem l\u00e9\u010dby a po dobu 1 m\u011bs\u00edce po n\u00ed (d\u016fvody prevence t\u011bhotenstv\u00ed)<\/li>\n<li><strong>P\u0159\u00edsn\u00e1 prevence t\u011bhotenstv\u00ed<\/strong> po celou dobu l\u00e9\u010dby a minim\u00e1ln\u011b 1 m\u011bs\u00edc po posledn\u00ed d\u00e1vce u \u017een v reproduk\u010dn\u00edm v\u011bku<\/li>\n<li>Vyhn\u011bte se dal\u0161\u00edm dopl\u0148k\u016fm s vitaminem A a tetracyklinov\u00fdm antibiotik\u016fm<\/li>\n<li>B\u011bhem l\u00e9\u010dby a 6 m\u011bs\u00edc\u016f po n\u00ed se vyvarujte voskov\u00e1n\u00ed, laserov\u00e9 l\u00e9\u010dby a dermabraze<\/li>\n<li>Pou\u017e\u00edvejte denn\u011b opalovac\u00ed kr\u00e9m s SPF 30+ \u2014 isotretinoin zvy\u0161uje fotocitlivost<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky Isotroinu<\/h2>\n<p>Vedlej\u0161\u00ed \u00fa\u010dinky jsou p\u0159edv\u00eddateln\u00e9, z\u00e1visl\u00e9 na d\u00e1vkov\u00e1n\u00ed a po vysazen\u00ed vratn\u00e9 \u2014 krom\u011b teratogenity a vz\u00e1cn\u00fdch p\u0159etrv\u00e1vaj\u00edc\u00edch probl\u00e9m\u016f.<\/p>\n<table>\n<thead>\n<tr>\n<th>Z\u00e1va\u017enost<\/th>\n<th>Vedlej\u0161\u00ed \u00fa\u010dinek<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>T\u00e9m\u011b\u0159 u v\u0161ech<\/strong><\/td>\n<td>Cheilitis (such\u00e9 popraskan\u00e9 rty), xer\u00f3za (such\u00e1 k\u016f\u017ee), such\u00e9 o\u010di, such\u00e1 nosn\u00ed sliznice s epistax\u00ed, m\u00edrn\u00e1 myalgie<\/td>\n<\/tr>\n<tr>\n<td><strong>B\u011b\u017en\u00e9<\/strong><\/td>\n<td>Po\u010d\u00e1te\u010dn\u00ed vzplanut\u00ed akn\u00e9 (2.\u20136. t\u00fdden), bolest hlavy, \u00fanava, artralgie, bolest zad, fotosenzitivita, zv\u00fd\u0161en\u00e9 triglyceridy, m\u00edrn\u011b zv\u00fd\u0161en\u00e9 jatern\u00ed enzymy<\/td>\n<\/tr>\n<tr>\n<td><strong>M\u00e9n\u011b \u010dast\u00e9<\/strong><\/td>\n<td>\u0158\u00eddnut\u00ed vlas\u016f, zhor\u0161en\u00e9 no\u010dn\u00ed vid\u011bn\u00ed, zm\u011bny menstruace, zv\u00fd\u0161en\u00e9 pocen\u00ed<\/td>\n<\/tr>\n<tr>\n<td><strong>Vz\u00e1cn\u00e9, ale z\u00e1va\u017en\u00e9<\/strong><\/td>\n<td>T\u011b\u017ek\u00e1 deprese \/ sebevra\u017eedn\u00e9 my\u0161lenky, z\u00e1n\u011btliv\u00e9 onemocn\u011bn\u00ed st\u0159ev (asociace diskutabiln\u00ed), pseudotumor cerebri (benign\u00ed intrakrani\u00e1ln\u00ed hypertenze), pankreatitida, t\u011b\u017ek\u00e1 hepatitida, Stevens-Johnson\u016fv syndrom<\/td>\n<\/tr>\n<tr>\n<td><strong>Teratogenita<\/strong><\/td>\n<td>Z\u00e1va\u017en\u00e9 fet\u00e1ln\u00ed malformace (CNS, kardiovaskul\u00e1rn\u00ed, kraniofaci\u00e1ln\u00ed) \u2014 absolutn\u00ed kontraindikace v t\u011bhotenstv\u00ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Po\u010d\u00e1te\u010dn\u00ed vzplanut\u00ed akn\u00e9 ve 2.\u20136. t\u00fddnu je b\u011b\u017en\u00e9 a o\u010dek\u00e1van\u00e9<\/strong> \u2014 neznamen\u00e1 to selh\u00e1n\u00ed l\u00e9\u010dby. Pokra\u010dujte v terapii. P\u0159i z\u00e1va\u017en\u00e9m pr\u016fb\u011bhu m\u016f\u017ee dermatolog p\u0159idat kr\u00e1tkodobou peror\u00e1ln\u00ed kortikosteroidn\u00ed kryc\u00ed terapii.<\/p>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>Prevence t\u011bhotenstv\u00ed je nezbytn\u00e1.<\/strong> \u017deny v reproduk\u010dn\u00edm v\u011bku mus\u00ed pou\u017e\u00edvat dv\u011b formy \u00fa\u010dinn\u00e9 antikoncepce od 1 m\u011bs\u00edce p\u0159ed za\u010d\u00e1tkem l\u00e9\u010dby, po celou dobu l\u00e9\u010dby a 1 m\u011bs\u00edc po posledn\u00ed d\u00e1vce. M\u011bs\u00ed\u010dn\u00ed t\u011bhotensk\u00e9 testy jsou standardem.<\/li>\n<li><strong>Darov\u00e1n\u00ed krve.<\/strong> Ned\u00e1vejte krev b\u011bhem l\u00e9\u010dby ani 1 m\u011bs\u00edc po n\u00ed \u2014 t\u011bhotn\u00e1 p\u0159\u00edjemkyn\u011b by mohla z\u00edskat teratogenn\u00ed hladiny<\/li>\n<li><strong>Du\u0161evn\u00ed zdrav\u00ed.<\/strong> N\u011bkte\u0159\u00ed pacienti mohou poci\u0165ovat zm\u011bny n\u00e1lady nebo depresi. Aktivn\u011b sledujte n\u00e1ladu a neprodlen\u011b nahlaste jak\u00e9koli zhor\u0161en\u00ed<\/li>\n<li><strong>Laboratorn\u00ed monitorov\u00e1n\u00ed.<\/strong> Z\u00e1kladn\u00ed vy\u0161et\u0159en\u00ed jatern\u00edch test\u016f, lipid\u016f a t\u011bhotensk\u00fd test, pot\u00e9 opakovat m\u011bs\u00ed\u010dn\u011b b\u011bhem l\u00e9\u010dby. P\u0159eru\u0161it, pokud triglyceridy &gt;500 mg\/dL nebo jatern\u00ed testy stoupnou &gt;3\u00d7 nad normu<\/li>\n<li><strong>Spole\u010dn\u00e9 pod\u00e1v\u00e1n\u00ed tetracyklin\u016f je kontraindikov\u00e1no<\/strong> \u2014 riziko benign\u00ed intrakrani\u00e1ln\u00ed hypertenze<\/li>\n<li><strong>Dopln\u011bk stravy s vitaminem A<\/strong> mus\u00ed b\u00fdt vylou\u010deno \u2014 riziko aditivn\u00ed hypervitamin\u00f3zy A<\/li>\n<li><strong>Alkohol.<\/strong> P\u0159\u00edsn\u011b omezit \u2014 aditivn\u00ed hepat\u00e1ln\u00ed a lipidov\u00e9 \u00fa\u010dinky<\/li>\n<li><strong>Ko\u017en\u00ed z\u00e1kroky.<\/strong> Po dobu 6 m\u011bs\u00edc\u016f po l\u00e9\u010db\u011b se vyvarujte voskov\u00e1n\u00ed, laseru, dermabrazi nebo chemick\u00fdm peeling\u016fm<\/li>\n<li><strong>Nositel\u00e9 \u010do\u010dek.<\/strong> Kontaktn\u00ed \u010do\u010dky \u010dasto zp\u016fsobuj\u00ed nepohodl\u00ed kv\u016fli such\u00fdm o\u010d\u00edm \u2014 m\u011bjte po ruce n\u00e1hradn\u00ed br\u00fdle<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace \u2014 Kdo by NEM\u011aL u\u017e\u00edvat Isotroin<\/h2>\n<ul>\n<li><strong>T\u011bhotenstv\u00ed nebo pl\u00e1novan\u00e9 t\u011bhotenstv\u00ed do 1 m\u011bs\u00edce po l\u00e9\u010db\u011b<\/strong><\/li>\n<li>Kojen\u00ed<\/li>\n<li>P\u0159ecitliv\u011blost na isotretinoin, jin\u00e9 retinoidy, ara\u0161\u00eddy \/ s\u00f3ju (excipiens v kapsl\u00edch)<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed<\/li>\n<li>T\u011b\u017ek\u00e1 hyperlipid\u00e9mie<\/li>\n<li>Hypervitamin\u00f3za A<\/li>\n<li>Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed tetracyklin\u016f<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table>\n<thead>\n<tr>\n<th>L\u00e9\u010divo \/ T\u0159\u00edda<\/th>\n<th>Interakce<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Tetracykliny (doxycyklin, minocyklin)<\/strong><\/td>\n<td><strong>Vyhnout se<\/strong> \u2014 aditivn\u00ed riziko pseudotumor cerebri<\/td>\n<\/tr>\n<tr>\n<td><strong>Dopl\u0148ky stravy s vitaminem A a \u03b2-karotenem<\/strong><\/td>\n<td>Aditivn\u00ed hypervitamin\u00f3za A \u2014 vyvarujte se<\/td>\n<\/tr>\n<tr>\n<td><strong>N\u00edzkod\u00e1vkovan\u00e1 progestinov\u00e1 antikoncepce \u201cmini-pilulka\u201d<\/strong><\/td>\n<td>M\u016f\u017ee b\u00fdt m\u00e9n\u011b spolehliv\u00e1 \u2014 pou\u017eijte kombinovanou peror\u00e1ln\u00ed antikoncepci nebo nitrod\u011blo\u017en\u00ed t\u011bl\u00edsko<\/td>\n<\/tr>\n<tr>\n<td><strong>Kortikosteroidy<\/strong><\/td>\n<td>Lze p\u0159idat k potla\u010den\u00ed po\u010d\u00e1te\u010dn\u00edho vzplanut\u00ed akn\u00e9; aditivn\u00ed riziko sn\u00ed\u017een\u00ed hustoty kost\u00ed p\u0159i dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed<\/td>\n<\/tr>\n<tr>\n<td><strong>Fenytoin<\/strong><\/td>\n<td>M\u016f\u017ee sni\u017eovat sv\u00e9 vlastn\u00ed hladiny<\/td>\n<\/tr>\n<tr>\n<td><strong>Alkohol<\/strong><\/td>\n<td>Aditivn\u00ed hepat\u00e1ln\u00ed\/ lipidov\u00e1 toxicita \u2014 p\u0159\u00edsn\u011b omezte<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Pokyny k uchov\u00e1v\u00e1n\u00ed<\/h2>\n<ul>\n<li>Skladujte p\u0159i teplot\u011b pod 30 \u00b0C, chr\u00e1n\u011bno p\u0159ed sv\u011btlem<\/li>\n<li>Uchov\u00e1vejte v p\u016fvodn\u00edm blistrov\u00e9m obalu<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed a dom\u00e1c\u00edch zv\u00ed\u0159at<\/li>\n<li>Nepou\u017e\u00edvejte po uplynut\u00ed data expirace<\/li>\n<li>Nepou\u017eit\u00e9 tobolky bezpe\u010dn\u011b zlikvidujte \u2014 nesd\u00edlejte je s nik\u00fdm<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/accufine\/\" rel=\"noopener\">Accufine<\/a> \u2014 alternativn\u00ed zna\u010dka isotretinoinu<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tretiva\/\" rel=\"noopener\">Tretiva<\/a> \u2014 isotretinoin od Cipla ve vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/isofair\/\" rel=\"noopener\">Isofair<\/a> \u2014 dal\u0161\u00ed zna\u010dka isotretinoinu<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/isotretinoin-vs-tretinoin\/\" rel=\"noopener\">Pr\u016fvodce: Isotretinoin vs Tretinoin \u2014 kter\u00fd si vybrat<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/acne-treatment\/\" rel=\"noopener\">Prohl\u00e9dn\u011bte si v\u0161echny p\u0159\u00edpravky na akn\u00e9 \u2192<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Jak dlouho trv\u00e1 l\u00e9\u010dba p\u0159\u00edpravkem Isotroin?<\/h3>\n<p>V\u011bt\u0161ina l\u00e9\u010debn\u00fdch k\u00far trv\u00e1 <strong>16\u201324 t\u00fddn\u016f<\/strong> a c\u00edlem je kumulativn\u00ed d\u00e1vka 120\u2013150 mg\/kg. Pro pacienta v\u00e1\u017e\u00edc\u00edho 60 kg to zhruba odpov\u00edd\u00e1 7 200\u20139 000 mg celkem \u2014 asi 5 m\u011bs\u00edc\u016f p\u0159i d\u00e1vce 40\u201360 mg\/den.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d je po\u010d\u00e1te\u010dn\u00ed vzplanut\u00ed akn\u00e9 b\u011b\u017en\u00e9?<\/h3>\n<p>Produkce mazu rychle kles\u00e1, uvol\u0148uje se nahromad\u011bn\u00fd <em>C. acnes<\/em> a obsah folikul\u016f. V\u00fdsledn\u00e1 z\u00e1n\u011btliv\u00e1 reakce zp\u016fsobuje kr\u00e1tk\u00e9 vzplanut\u00ed v t\u00fddnech 2\u20136, kter\u00e9 ustoup\u00ed, jakmile se folikul normalizuje. Je to <strong>ne<\/strong> zn\u00e1mka ne\u00fasp\u011bchu l\u00e9\u010dby.<\/p>\n<h3 class=\"wp-block-heading\">Vr\u00e1t\u00ed se mi akn\u00e9 po u\u017e\u00edv\u00e1n\u00ed Isotroinu?<\/h3>\n<p>P\u0159ibli\u017en\u011b <strong>60\u201370 % pacient\u016f<\/strong> dos\u00e1hne trval\u00e9 remise po kompletn\u00ed l\u00e9\u010db\u011b. Asi 20\u201330 % pot\u0159ebuje druh\u00fd cyklus; skute\u010dn\u00ed non-responde\u0159i jsou vz\u00e1cn\u00ed. Kumulativn\u00ed d\u00e1vka je kl\u00ed\u010dov\u00e1 \u2013 p\u0159ed\u010dasn\u00e9 ukon\u010den\u00ed zvy\u0161uje riziko relapsu.<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017eu p\u00edt alkohol p\u0159i u\u017e\u00edv\u00e1n\u00ed Isotroinu?<\/h3>\n<p><strong>P\u0159\u00edsn\u011b omezte.<\/strong> Isotretinoin zvy\u0161uje triglyceridy a m\u00edrn\u011b zat\u011b\u017euje j\u00e1tra; alkohol oba tyto \u00fa\u010dinky zesiluje. Mnoho dermatolog\u016f povol\u00ed p\u0159\u00edle\u017eitostnou m\u00edrnou konzumaci; denn\u00ed nebo nadm\u011brn\u00e9 pit\u00ed se nedoporu\u010duje.<\/p>\n<h3 class=\"wp-block-heading\">Je Isotroin bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n<p><strong>Ne<\/strong> \u2014 isotretinoin je jedn\u00edm z nejsiln\u011bj\u0161\u00edch teratogen\u016f v medic\u00edn\u011b. T\u011b\u017ek\u00e9 malformace CNS, kardiovaskul\u00e1rn\u00edho syst\u00e9mu a obli\u010deje se vyskytuj\u00ed u vysok\u00e9ho pod\u00edlu exponovan\u00fdch t\u011bhotenstv\u00ed. Je nutn\u00e1 p\u0159\u00edsn\u00e1 antikoncepce.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d nem\u016f\u017eu p\u0159i u\u017e\u00edv\u00e1n\u00ed Isotroinu podstupovat voskov\u00e1n\u00ed nebo laser?<\/h3>\n<p>L\u00e9k zten\u010duje poko\u017eku a \u010din\u00ed ji k\u0159eh\u010d\u00ed \u2013 voskov\u00e1n\u00ed a laserov\u00e9 z\u00e1kroky mohou zp\u016fsobit jizvy, keloidy nebo hlubok\u00e1 poran\u011bn\u00ed. Po\u010dkejte <strong>6 m\u011bs\u00edc\u016f<\/strong> po ukon\u010den\u00ed l\u00e9\u010dby p\u0159ed jak\u00fdmikoli t\u011bmito procedurami.<\/p>\n<h3 class=\"wp-block-heading\">Souvis\u00ed Isotroin s depres\u00ed?<\/h3>\n<p>Souvislost je sporn\u00e1. Nejnov\u011bj\u0161\u00ed rozs\u00e1hl\u00e9 studie ukazuj\u00ed, \u017ee pacienti l\u00e9\u010den\u00ed na akn\u00e9, pokud v\u016fbec, sp\u00ed\u0161e za\u017e\u00edvaj\u00ed <strong>zlep\u0161en\u00e1<\/strong> n\u00e1lada s vy\u010di\u0161t\u011bnou poko\u017ekou. P\u0159esto je t\u0159eba aktivn\u011b sledovat n\u00e1ladu; jsou hl\u00e1\u0161eny ojedin\u011bl\u00e9 p\u0159\u00edpady z\u00e1va\u017en\u00fdch zm\u011bn n\u00e1lady b\u011bhem l\u00e9\u010dby, kter\u00e9 by m\u011bly v\u00e9st k l\u00e9ka\u0159sk\u00e9 kontrole.<\/p>\n<h3 class=\"wp-block-heading\">Jak m\u00e1m pe\u010dovat o such\u00e9 rty a poko\u017eku?<\/h3>\n<p>Aplikujte neutr\u00e1ln\u00ed balz\u00e1m na rty ka\u017ed\u00fdch 1\u20132 hodiny, pou\u017e\u00edvejte hust\u00fd hydrata\u010dn\u00ed kr\u00e9m bez parfemace a vyhn\u011bte se drsn\u00fdm \u010distic\u00edm prost\u0159edk\u016fm. O\u010dn\u00ed kapky na suchost a nosn\u00ed sprej se soln\u00fdm roztokem na suchost \u2014 \u010dasto jsou pot\u0159eba oboj\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Jakou d\u00e1vku bych m\u011bl za\u010d\u00edt u\u017e\u00edvat?<\/h3>\n<p>V\u011bt\u0161ina dermatolog\u016f za\u010d\u00edn\u00e1 na <strong>0,5 mg\/kg\/den<\/strong>, s postupn\u00fdm zvy\u0161ov\u00e1n\u00edm na 1 mg\/kg\/den podle tolerance. Ni\u017e\u0161\u00ed d\u00e1vky (nap\u0159. 20 mg obden) se st\u00e1le \u010dast\u011bji pou\u017e\u00edvaj\u00ed u st\u0159edn\u011b z\u00e1va\u017en\u00e9ho akn\u00e9 \u2014 jsou l\u00e9pe sn\u00e1\u0161eny, del\u0161\u00ed dobu trv\u00e1n\u00ed a maj\u00ed podobnou kumulativn\u00ed \u00fa\u010dinnost.<\/p>\n<h3 class=\"wp-block-heading\">Isotretinoin vs tretinoin \u2014 kter\u00fd je kter\u00fd?<\/h3>\n<p><strong>Isotretinoin<\/strong> (Isotroin) je <strong>peror\u00e1ln\u00ed<\/strong> retinoid pro t\u011b\u017ek\u00e9 akn\u00e9. <strong>Tretinoin<\/strong> je topick\u00fd kr\u00e9m\/gel pro m\u00edrn\u011bj\u0161\u00ed akn\u00e9 a fotoaging. Zcela odli\u0161n\u00e9 pou\u017eit\u00ed \u2014 viz n\u00e1\u0161 <a href=\"https:\/\/medsbase.com\/cs\/isotretinoin-vs-tretinoin\/\" rel=\"noopener\">srovn\u00e1vac\u00ed pr\u016fvodce<\/a>.<\/p>\n<p><!-- medsbase-faq-h3-converted --><\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>L\u00e9\u010dba akn\u00e9<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/melrio-cream\/\">Melrio kr\u00e9m<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tufacne\/\">Tufacne<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/signatret\/\">Signatret<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/deriva-cms-gel\/\">Deriva CMS gel<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tretizen\/\">Tretizen<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<h5>\u2705 \u00da\u010dinn\u011b l\u00e9\u010d\u00ed t\u011b\u017ek\u00e9 akn\u00e9<br \/>\n\u2705 Zlep\u0161uje vzhled poko\u017eky<br \/>\n\u2705 \u00da\u010dinn\u011b sni\u017euje z\u00e1n\u011bt<br \/>\n\u2705 Podporuje proces hojen\u00ed poko\u017eky<br \/>\n\u2705 Reguluje tvorbu ko\u017en\u00edho mazu<\/h5>\n<p><span style=\"color: #999999;\">obsahuje Isotretinoin<\/span><\/p>","protected":false},"featured_media":50536,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3215,3141,3223],"product_tag":[5731,5729,5735,5645,3219,3227,5733,5734,5730,5732],"class_list":{"0":"post-50535","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-acne-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-13-cis-retinoic-acid","10":"product_tag-accutane-generic","11":"product_tag-acne-treatment","12":"product_tag-cipla","13":"product_tag-isotretinoin","14":"product_tag-isotroin","15":"product_tag-nodulocystic-acne","16":"product_tag-oral-retinoid","17":"product_tag-roaccutane","18":"product_tag-severe-acne","20":"first","21":"instock","22":"shipping-taxable","23":"purchasable","24":"product-type-variable","25":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/50535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=50535"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/50536"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=50535"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=50535"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=50535"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=50535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}