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Onglyza<\/strong> je zna\u010dka saxagliptin<\/strong> (2,5 mg nebo 5 mg), inhibitor DPP-4<\/strong> (dipeptidyl peptid\u00e1za-4 inhibitor, tak\u00e9 naz\u00fdvan\u00fd \u201cgliptin\u201d) pou\u017e\u00edvan\u00fd k diabetu 2. typu<\/strong>. P\u016fsob\u00ed blokov\u00e1n\u00edm enzymu DPP-4, kter\u00fd norm\u00e1ln\u011b rozkl\u00e1d\u00e1 inkretinov\u00e9 hormony (GLP-1 a GIP). Vy\u0161\u0161\u00ed hladiny inkretinu stimuluj\u00ed uvol\u0148ov\u00e1n\u00ed inzul\u00ednu a potla\u010duj\u00ed glukagon pouze kdy\u017e je hladina gluk\u00f3zy v krvi vysok\u00e1<\/strong> \u2014 tak\u017ee inhibitory DPP-4 maj\u00ed gluk\u00f3zo-z\u00e1visl\u00fd \u00fa\u010dinek a nezp\u016fsobuj\u00ed hypoglyk\u00e9mii<\/strong> jako monoterapie. Sn\u00ed\u017een\u00ed HbA1c: 0,6\u20130,8 bod\u016f. Neutr\u00e1ln\u00ed v\u016f\u010di hmotnosti. Jednou denn\u011b (v\u011bt\u0161ina gliptin\u016f). Prvn\u00ed DPP-4, kter\u00fd dokon\u010dil kardiovaskul\u00e1rn\u00ed v\u00fdsledkovou studii (SAVOR-TIMI 53). Sign\u00e1l srde\u010dn\u00edho selh\u00e1n\u00ed znamen\u00e1, \u017ee jin\u00e9 inhibitory DPP-4 jsou obvykle up\u0159ednost\u0148ov\u00e1ny, pokud je HF probl\u00e9mem. Kardiovaskul\u00e1rn\u011b neutr\u00e1ln\u00ed pro MACE v SAVOR-TIMI 53, ale spojen s m\u00edrn\u00fdm zv\u00fd\u0161en\u00edm hospitalizac\u00ed pro srde\u010dn\u00ed selh\u00e1n\u00ed<\/strong>. Pou\u017e\u00edvejte opatrn\u011b u pacient\u016f se st\u00e1vaj\u00edc\u00edm srde\u010dn\u00edm selh\u00e1n\u00edm. D\u00e1vka: 5 mg jednou denn\u011b. Sni\u017ete na 2,5 mg\/den, pokud eGFR < 45 ml\/min\/1,73 m\u00b2 nebo pokud je p\u0159edeps\u00e1n se siln\u00fdmi inhibitory CYP3A4\/5 (ketokonazol, klarithromycin, ritonavir). Hlavn\u00ed vedlej\u0161\u00ed \u00fa\u010dinky jsou m\u00edrn\u00e9 \u2014 p\u0159\u00edznaky horn\u00edch cest d\u00fdchac\u00edch, bolest hlavy, vz\u00e1cn\u011b pankreatitida. Vyhn\u011bte se u diabetu 1. typu a DKA.<\/p>\n<\/div>\n \ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n Onglyza je peror\u00e1ln\u00ed antidiabetikum obsahuj\u00edc\u00ed saxagliptin<\/strong> (2,5 mg nebo 5 mg), vyr\u00e1b\u011bn\u00e9 spole\u010dnost\u00ed AstraZeneca. Dostupn\u00e9 v balen\u00edch po 30, 60, 90 nebo 180 tablet\u00e1ch. P\u0159edepisuje se dosp\u011bl\u00fdm s diabetem 2. typu, obvykle spolu s metforminem nebo jako l\u00e9k druh\u00e9 \u010di t\u0159et\u00ed linie.<\/p>\n saxagliptin pat\u0159\u00ed do t\u0159\u00eddy inhibitor\u016f DPP-4 (\u201cgliptiny\u201d) \u2014 poprv\u00e9 schv\u00e1len 2009 (p\u016fvodn\u00ed zna\u010dka: Onglyza, AstraZeneca \/ Bristol-Myers Squibb). Gliptiny jsou \u0161iroce pou\u017e\u00edv\u00e1ny, proto\u017ee jsou neutr\u00e1ln\u00ed v\u016f\u010di hmotnosti, maj\u00ed n\u00edzk\u00e9 riziko hypoglyk\u00e9mie a mohou b\u00fdt pou\u017eity v cel\u00e9m spektru ren\u00e1ln\u00edch funkc\u00ed s odpov\u00eddaj\u00edc\u00ed \u00fapravou d\u00e1vky.<\/p>\n Po j\u00eddle st\u0159evo uvol\u0148uje dva inkretinov\u00e9 hormony \u2014 GLP-1 (glukagonu podobn\u00fd peptid-1)<\/strong> a GIP (gluk\u00f3za-dependentn\u00ed insulinotropn\u00ed peptid)<\/strong>. Tyto hormony signalizuj\u00ed slinivce, aby uvolnila inzulin, a j\u00e1tr\u016fm, aby potla\u010dila glukagon, ale jsou rychle rozkl\u00e1d\u00e1ny enzymem dipeptidyl peptid\u00e1zou-4 (DPP-4)<\/strong> b\u011bhem n\u011bkolika minut.<\/p>\n saxagliptin blokuje DPP-4. T\u00edm zvy\u0161uje hladiny aktivn\u00edho GLP-1 a GIP, co\u017e vede k:<\/p>\n Proto\u017ee uvol\u0148ov\u00e1n\u00ed inzul\u00ednu je z\u00e1visl\u00e9 na gluk\u00f3ze<\/em>, inhibitory DPP-4 samy o sob\u011b nezp\u016fsobuj\u00ed hypoglyk\u00e9mii. Typick\u00fd pokles HbA1c: 0,6\u20130,8 procentn\u00edch bod\u016f<\/strong>. Vliv na hmotnost: neutr\u00e1ln\u00ed. Vliv na krevn\u00ed tlak a lipidy: neutr\u00e1ln\u00ed.<\/p>\n Standardn\u00ed d\u00e1vka:<\/strong> 5 mg jednou denn\u011b. Sn\u00ed\u017eit na 2,5 mg\/den, pokud eGFR < 45 ml\/min\/1,73 m\u00b2 nebo p\u0159i sou\u010dasn\u00e9m pod\u00e1v\u00e1n\u00ed siln\u00fdch inhibitor\u016f CYP3A4\/5 (ketokonazol, klarithromycin, ritonavir). Onglyza lze u\u017e\u00edvat s j\u00eddlem i bez j\u00eddla.<\/p>\n Inhibitory DPP-4 pat\u0159\u00ed mezi nejl\u00e9pe sn\u00e1\u0161en\u00e9 peror\u00e1ln\u00ed antidiabetika. V\u011bt\u0161ina ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f je m\u00edrn\u00e1 a podobn\u00e1 v r\u00e1mci cel\u00e9 t\u0159\u00eddy.<\/p>\n \u010cast\u00e9:<\/strong><\/p>\n M\u00e9n\u011b \u010dast\u00e9, ale d\u016fle\u017eit\u00e9:<\/strong><\/p>\n Jako monoterapie je hypoglyk\u00e9mie velmi vz\u00e1cn\u00e1. P\u0159i kombinaci se sulfonylmo\u010dovinami nebo inzulinem m\u016f\u017ee b\u00fdt nutn\u00e9 sn\u00ed\u017eit d\u00e1vky t\u011bchto l\u00e1tek.<\/p>\n Skladujte p\u0159\u00edpravek Onglyza p\u0159i teplot\u011b do 30 \u00b0C na such\u00e9m m\u00edst\u011b, v p\u016fvodn\u00edm blistru. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/p>\n <\/p>\n Ano. Onglyza obsahuje stejnou \u00fa\u010dinnou l\u00e1tku jako origin\u00e1ln\u00ed p\u0159\u00edpravek. Regula\u010dn\u00ed org\u00e1ny vy\u017eaduj\u00ed bioekvivalenci, tak\u017ee klinick\u00fd \u00fa\u010dinek je p\u0159i stejn\u00e9 d\u00e1vce stejn\u00fd.<\/p>\n Studie SAVOR-TIMI 53 zjistila 27% relativn\u00ed n\u00e1r\u016fst hospitalizac\u00ed pro srde\u010dn\u00ed selh\u00e1n\u00ed u saxagliptinu ve srovn\u00e1n\u00ed s placebem (3,5 % vs 2,8 % za 2 roky). MACE byl neutr\u00e1ln\u00ed. V\u011bt\u0161ina doporu\u010den\u00ed rad\u00ed vyhnout se saxagliptinu u pacient\u016f se zaveden\u00fdm srde\u010dn\u00edm selh\u00e1n\u00edm a v takov\u00e9m p\u0159\u00edpad\u011b up\u0159ednost\u0148ovat sitagliptin nebo linagliptin.<\/p>\n Sama o sob\u011b ne. Inhibitory DPP-4 p\u016fsob\u00ed gluk\u00f3zo-z\u00e1visl\u00fdm zp\u016fsobem \u2013 zvy\u0161uj\u00ed uvol\u0148ov\u00e1n\u00ed inzul\u00ednu pouze p\u0159i vysok\u00e9 hladin\u011b gluk\u00f3zy v krvi. Hypoglyk\u00e9mie se st\u00e1v\u00e1 probl\u00e9mem pouze p\u0159i kombinaci Onglyzy se sulfonylureou, meglitinidem nebo inzul\u00ednem.<\/p>\n Ne \u2014 inhibitory DPP-4 jsou neutr\u00e1ln\u00ed z hlediska hmotnosti. To je jeden z hlavn\u00edch d\u016fvod\u016f, pro\u010d jsou u pacient\u016f s nadv\u00e1hou preferov\u00e1ny p\u0159ed sulfonylureami.<\/p>\n Akutn\u00ed pankreatitida je vz\u00e1cn\u00fd, ale zdokumentovan\u00fd t\u0159\u00eddn\u00ed \u00fa\u010dinek. Absolutn\u00ed riziko je mal\u00e9 a rozs\u00e1hl\u00e9 studie (TECOS, CARMELINA, SAVOR) obecn\u011b neprok\u00e1zaly statisticky v\u00fdznamn\u00e9 zv\u00fd\u0161en\u00ed. P\u0159i rozvoji siln\u00e9 bolesti b\u0159icha \u2014 zejm\u00e9na bolesti vyza\u0159uj\u00edc\u00ed do zad \u2014 okam\u017eit\u011b p\u0159eru\u0161te l\u00e9\u010dbu a vyhledejte l\u00e9ka\u0159skou pomoc.<\/p>\n Hladina gluk\u00f3zy nala\u010dno za\u010dne klesat b\u011bhem prvn\u00edho t\u00fddne. Maxim\u00e1ln\u00ed \u00fa\u010dinek na HbA1c je po 12 t\u00fddnech. Pokud HbA1c neklesne alespo\u0148 o 0,3\u20130,5 % po 3 m\u011bs\u00edc\u00edch, m\u011bla by b\u00fdt zv\u00e1\u017eena jin\u00e1 l\u00e9\u010dba (inhibitor SGLT-2 nebo agonista GLP-1).<\/p>\n Ano \u2014 inhibitory DPP-4 lze vysadit n\u00e1hle bez rizika rebound hyperglyk\u00e9mie. Pokud se objev\u00ed siln\u00e1 bolest b\u0159icha, puch\u00fd\u0159e na k\u016f\u017ei nebo siln\u00e1 bolest kloub\u016f, p\u0159esta\u0148te l\u00e9k u\u017e\u00edvat a kontaktujte l\u00e9ka\u0159e.<\/p>\n Onglyzu (2,5 mg nebo 5 mg) si m\u016f\u017eete objednat na MedsBase v balen\u00edch po 30, 60, 90 nebo 180 tablet\u00e1ch. Dod\u00e1v\u00e1me po cel\u00e9m sv\u011bt\u011b, s diskr\u00e9tn\u00edm balen\u00edm a origin\u00e1ln\u00edmi v\u00fdrobky certifikovan\u00fdmi WHO-GMP.<\/p>\n ⚡ Quick Answer — What is Onglyza? Onglyza is a brand of saxagliptin (2.5 mg or 5 mg), a DPP-4 inhibitor (dipeptidyl peptidase-4 inhibitor, also called a “gliptin”) used for type 2 diabetes. It works by blocking the enzyme DPP-4, which normally breaks down incretin hormones (GLP-1 and GIP). Higher incretin levels stimulate insulin release and […]\n","protected":false},"featured_media":50731,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3230,3231],"product_tag":[],"class_list":{"0":"post-50730","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-diabetes","9":"product_cat-diabetes-medication","11":"first","12":"outofstock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/50730","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=50730"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/50731"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=50730"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=50730"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=50730"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=50730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Co je Onglyza?<\/h2>\n
Jak funguje p\u0159\u00edpravek Onglyza?<\/h2>\n
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D\u00e1vkov\u00e1n\u00ed a pod\u00e1n\u00ed<\/h2>\n
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Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n
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Interakce s l\u00e9\u010divy<\/h2>\n
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Kdo by nem\u011bl u\u017e\u00edvat p\u0159\u00edpravek Onglyza?<\/h2>\n
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Skladov\u00e1n\u00ed<\/h2>\n
\u010casto kladen\u00e9 dotazy<\/h2>\n
Je Onglyza tot\u00e9\u017e co saxagliptin?<\/h3>\n
Zp\u016fsobuje saxagliptin srde\u010dn\u00ed selh\u00e1n\u00ed?<\/h3>\n
Zp\u016fsobuje Onglyza n\u00edzkou hladinu cukru v krvi?<\/h3>\n
Zp\u016fsobuje Onglyza p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze?<\/h3>\n
M\u016f\u017ee Onglyza zp\u016fsobit pankreatitidu?<\/h3>\n
Jak dlouho trv\u00e1, ne\u017e Onglyza za\u010dne \u00fa\u010dinkovat?<\/h3>\n
Mohu n\u00e1hle p\u0159estat u\u017e\u00edvat Onglyzu, pokud se nec\u00edt\u00edm dob\u0159e?<\/h3>\n
Kde si mohu koupit Onglyzu online?<\/h3>\n
Souvisej\u00edc\u00ed l\u00e9ky na diabetes<\/h2>\n
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