{"id":50991,"date":"2023-09-20T09:16:13","date_gmt":"2023-09-20T09:16:13","guid":{"rendered":"https:\/\/medsname.com\/abamune-l\/"},"modified":"2026-05-16T05:24:27","modified_gmt":"2026-05-16T05:24:27","slug":"abamune-l","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/abamune-l\/","title":{"rendered":"Abamune L"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">Rychl\u00e1 odpov\u011b\u010f<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Abamune L<\/strong> \u2014 Abacavir + Lamivudine 600 + 300 mg (Cipla Inc). NRTI alternativa k re\u017eim\u016fm zalo\u017een\u00fdm na TDF \u2014 preferov\u00e1no u onemocn\u011bn\u00ed ledvin. P\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby je povinn\u00e9 testov\u00e1n\u00ed HLA-B*5701 (v p\u0159\u00edpad\u011b pozitivity hroz\u00ed t\u011b\u017ek\u00e1 hypersenzitivita).<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/li>\n<li>Diskr\u00e9tn\u00ed balen\u00ed v oby\u010dejn\u00e9 ob\u00e1lce<\/li>\n<li>Dod\u00e1n\u00ed po cel\u00e9m sv\u011bt\u011b<\/li>\n<li>Hodnoceno v\u00edce ne\u017e 1 400 z\u00e1kazn\u00edky (<a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">\u010d\u00edst recenze<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Z\u00e1ruka op\u011btovn\u00e9ho zasl\u00e1n\u00ed:<\/strong> pokud va\u0161e objedn\u00e1vka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f od odesl\u00e1n\u00ed, za\u0161leme ji znovu bez dal\u0161\u00edch n\u00e1klad\u016f. <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">P\u0159e\u010d\u00edst podm\u00ednky<\/a>.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Abamune L je expedov\u00e1n od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v neutr\u00e1ln\u00edm balen\u00ed, fakturace prob\u00edh\u00e1 p\u0159es regulovan\u00e9ho platebn\u00edho procesora (na v\u00fdpisu z \u00fa\u010dtu se zobraz\u00ed regulovan\u00fd platebn\u00ed procesor \u2014 nikdy MedsBase nebo n\u00e1zev l\u00e9ku). Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed 20-pracovn\u00ed denn\u00ed z\u00e1rukou na p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>\u010cern\u00e1 sk\u0159\u00ed\u0148ka: reaktivace HBV po vysazen\u00ed<\/strong><br \/>Pokud m\u00e1te koinfekci HBV (nebo nezn\u00e1m\u00fd stav HBV), vysazen\u00ed lamivudinu, tenofoviru nebo emtricitabinu m\u016f\u017ee vyvolat z\u00e1va\u017enou akutn\u00ed exacerbaci HBV s mo\u017enou dekompenzac\u00ed. P\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby testujte HBsAg\/HBV DNA a nikdy nep\u0159eru\u0161ujte l\u00e9\u010dbu bez dohledu hepatologa.<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Rezistence \u2014 adherence je kl\u00ed\u010dov\u00e1<\/strong><br \/>Adherence &gt;95 % je nutn\u00e1 k prevenci vzniku rezistence HIV. Vynechan\u00e9 d\u00e1vky nebo monoterapie v r\u00e1mci trojkombina\u010dn\u00edho re\u017eimu jsou \u010dast\u00fdmi p\u0159\u00ed\u010dinami selh\u00e1n\u00ed l\u00e9\u010dby. NRTI jako monoterapie nebo du\u00e1ln\u00ed terapie NEJSOU p\u0159ijatelnou l\u00e9\u010dbou HIV \u2014 v\u017edy kombinujte s alespo\u0148 jedn\u00edm l\u00e9kem z jin\u00e9 t\u0159\u00eddy.<\/div>\n<h2>Jak NRTI funguj\u00ed<\/h2>\n<p>Nukleosidov\u00e9\/nukleotidov\u00e9 inhibitory reverzn\u00ed transkript\u00e1zy (NRTI) jsou nukleosidov\u00e9 analogy, kter\u00e9 jsou uvnit\u0159 hostitelsk\u00e9 bu\u0148ky fosforylov\u00e1ny na aktivn\u00ed trifosf\u00e1tov\u00e9 formy. Sout\u011b\u017e\u00ed s p\u0159irozen\u00fdmi nukleotidy o za\u010dlen\u011bn\u00ed do rostouc\u00edho \u0159et\u011bzce virov\u00e9 DNA pomoc\u00ed HIV reverzn\u00ed transkript\u00e1zy. Po za\u010dlen\u011bn\u00ed \u0159et\u011bzec ukon\u010d\u00ed \u2014 virov\u00e1 replikace se zastav\u00ed.<\/p>\n<p>NRTI jsou z\u00e1kladem ka\u017ed\u00e9ho modern\u00edho re\u017eimu l\u00e9\u010dby HIV, kombinovan\u00e9ho s inhibitorem integr\u00e1zy (INSTI), nenukleosidov\u00fdm inhibitorem reverzn\u00ed transkript\u00e1zy (NNRTI) nebo inhibitorem prote\u00e1zy (PI) pro alespo\u0148 t\u0159\u00edl\u00e9kovou terapii.<\/p>\n<h2>Vedlej\u0161\u00ed \u00fa\u010dinky specifick\u00e9 pro t\u0159\u00eddu<\/h2>\n<ul>\n<li><strong>Mitochondri\u00e1ln\u00ed toxicita (star\u0161\u00ed NRTI \u2014 stavudin, didanosin, zidovudin):<\/strong> lipoatrofie, perifern\u00ed neuropatie, lakt\u00e1tov\u00e1 acid\u00f3za, jatern\u00ed steat\u00f3za. Modern\u00ed NRTI (TDF, TAF, FTC, 3TC, abakavir) maj\u00ed v\u00fdrazn\u011b ni\u017e\u0161\u00ed mitochondri\u00e1ln\u00ed toxicitu.<\/li>\n<li><strong>Tenofovir disoproxil (TDF):<\/strong> ren\u00e1ln\u00ed tubulopatie, Fanconiho syndrom, \u00fabytek kostn\u00ed denzity. P\u0159i ren\u00e1ln\u00edch\/kostn\u00edch pot\u00ed\u017e\u00edch p\u0159ej\u00edt na tenofovir alafenamid (TAF).<\/li>\n<li><strong>Abakavir:<\/strong> p\u0159ecitliv\u011blostn\u00ed reakce u nositel\u016f HLA-B*5701 (~5-8 % b\u011bloch\u016f, m\u00e9n\u011b u africk\u00e9 a asijsk\u00e9 populace). Test p\u0159ed zah\u00e1jen\u00edm; p\u0159i pozitivit\u011b absolutn\u00ed kontraindikace.<\/li>\n<li><strong>Lamivudin + emtricitabin:<\/strong> obecn\u011b dob\u0159e sn\u00e1\u0161eny; plat\u00ed upozorn\u011bn\u00ed u HBV koinfekce.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Vyl\u00e9\u010d\u00ed to HIV?<\/h3>\n<p>Ne. ART potla\u010duje virovou replikaci, umo\u017e\u0148uje obnovu imunity a sni\u017euje riziko p\u0159enosu t\u00e9m\u011b\u0159 na nulu (Nedetekovateln\u00e9 = Nep\u0159enosn\u00e9). Neeradikuje v\u0161ak HIV rezervo\u00e1ry. P\u0159i sou\u010dasn\u00fdch technologi\u00edch je l\u00e9\u010dba do\u017eivotn\u00ed.<\/p>\n<h3>Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Vezm\u011bte si l\u00e9k, kdy\u017e si vzpomenete, pokud jste se zpozdili 6 hodin vynechejte a pokra\u010dujte v b\u011b\u017en\u00e9m re\u017eimu \u2014 neduplikujte d\u00e1vku. Opakovan\u00e9 vynech\u00e1n\u00ed riskuje rezistenci; v\u017edy konzultujte probl\u00e9my s adherenc\u00ed s HIV t\u00fdmem.<\/p>\n<h3>A co testov\u00e1n\u00ed rezistence?<\/h3>\n<p>Genotypick\u00e9 testov\u00e1n\u00ed rezistence se doporu\u010duje p\u0159i diagn\u00f3ze HIV, p\u0159ed zah\u00e1jen\u00edm jak\u00e9hokoli re\u017eimu a p\u0159i virologick\u00e9m selh\u00e1n\u00ed. Rezistence m\u016f\u017ee b\u00fdt p\u0159\u00edtomna ji\u017e p\u0159edem (p\u0159enosn\u00e1 rezistence) nebo se vyvinout p\u0159i \u0161patn\u00e9 adherenci.<\/p>\n<h3>HBV koinfekce?<\/h3>\n<p>Kritick\u00e9 \u2014 p\u0159ed zah\u00e1jen\u00edm jak\u00e9hokoli re\u017eimu obsahuj\u00edc\u00edho lamivudin, tenofovir nebo emtricitabin je nutn\u00e9 testovat HBsAg a HBV DNA. Tyto l\u00e9ky p\u016fsob\u00ed tak\u00e9 proti HBV; jejich vysazen\u00ed m\u016f\u017ee zp\u016fsobit z\u00e1va\u017en\u00e9 vzplanut\u00ed HBV. P\u0159i koinfekci HBV\/HIV je v\u017edy nutn\u00e1 spolupr\u00e1ce specialist\u016f na HIV a hepatologii.<\/p>\n<h3>T\u011bhotenstv\u00ed?<\/h3>\n<p>Mnoho NRTI je bezpe\u010dn\u00fdch v t\u011bhotenstv\u00ed (tenofovir, lamivudin, emtricitabin, abakavir). Stavudin a didanosin by se m\u011bly vyhnout. Antiretrovirov\u00e9 re\u017eimy b\u011bhem t\u011bhotenstv\u00ed sni\u017euj\u00ed vertik\u00e1ln\u00ed p\u0159enos na &lt;1 % p\u0159i spr\u00e1vn\u00e9m veden\u00ed.<\/p>\n<h3>U=U?<\/h3>\n<p>Ano \u2014 Nedetekovateln\u00e9 = Nep\u0159enosn\u00e9. Lid\u00e9 \u017eij\u00edc\u00ed s HIV, kte\u0159\u00ed udr\u017euj\u00ed nedetekovatelnou virovou n\u00e1lo\u017e (&lt;200 kopi\u00ed\/mL) p\u0159i d\u016fsledn\u00e9 ART, nep\u0159en\u00e1\u0161ej\u00ed HIV pohlavn\u00edm stykem (studie PARTNER, PARTNER2, Opposites Attract).<\/p>\n<h3>Interakce l\u00e9k\u016f?<\/h3>\n<p>V\u011bt\u0161ina NRTI m\u00e1 m\u00e1lo interakc\u00ed (vylu\u010dov\u00e1ny ledvinami, bez v\u00fdznamn\u00e9ho vlivu na CYP). Tenofovir + ledipasvir: zv\u00fd\u0161en\u00e9 hladiny tenofoviru, sledujte funkci ledvin. Didanosin + ribavirin: vyvarujte se (lakt\u00e1tov\u00e1 acid\u00f3za). V\u017edy sd\u011blte v\u0161echny l\u00e9ky v\u010detn\u011b bylinn\u00fdch p\u0159\u00edpravk\u016f.<\/p>\n<h3>Sledov\u00e1n\u00ed funkce ledvin?<\/h3>\n<p>Tenofovir disoproxil (TDF) vy\u017eaduje sledov\u00e1n\u00ed funkce ledvin ka\u017ed\u00e9 3-6 m\u011bs\u00edc\u016f. P\u0159i eGFR &lt;50 mL\/min nebo v\u00fdskytu v\u00fdznamn\u00e9 proteinurie l\u00e9\u010dbu ukon\u010dete nebo p\u0159ejd\u011bte na tenofovir alafenamid (TAF).<\/p>\n<h3>Hustota kost\u00ed?<\/h3>\n<p>TDF m\u00edrn\u011b sni\u017euje hustotu kost\u00ed; zva\u017ete DEXA u dlouhodob\u00fdch u\u017eivatel\u016f s dal\u0161\u00edmi riziky osteopor\u00f3zy. TAF m\u00e1 minim\u00e1ln\u00ed vliv na kosti.<\/p>\n<h3>M\u016f\u017eu p\u00edt alkohol?<\/h3>\n<p>M\u00edrn\u00e1 konzumace alkoholu je p\u0159ijateln\u00e1. Nadm\u011brn\u00e1 konzumace alkoholu zhor\u0161uje adherenci a urychluje onemocn\u011bn\u00ed jater p\u0159i koinfekci HBV\/HCV. Vyvarujte se alkoholu, pokud jsou jatern\u00ed enzymy abnorm\u00e1ln\u00ed.<\/p>\n<p class=\"medsbase-link-boost-2026-05-16\" data-marker=\"mb-link-boost-ricovir-em\"><a href=\"https:\/\/medsbase.com\/cs\/what-is-hiv-prep-and-how-does-it-work\/\">Abamune L<\/a> je kombinace abakavir + lamivudin pou\u017eita, kdy\u017e je TDF kontraindikov\u00e1n kv\u016fli ren\u00e1ln\u00ed funkci; ekvivalentn\u00ed tenofovir-based formulace \u2014 a WHO-preferred PrEP formulace \u2014 je <a href=\"https:\/\/medsbase.com\/cs\/ricovir-em\/\">Ricovir-EM (tenofovir DF 300 mg + emtricitabin 200 mg)<\/a>.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Dal\u0161\u00ed l\u00e9ky na HIV a antivirotika<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/trioday\/\">Trioday<\/a> \u2014 TDF + 3TC + EFV \u2014 jednoduch\u00fd re\u017eim v jedn\u00e9 tablet\u011b od Cipla<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/triomune\/\">Triomune<\/a> \u2014 d4T + 3TC + NVP \u2014 star\u0161\u00ed 3v1 kombinace (na b\u00e1zi stavudinu)<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zepdon\/\">Zepdon<\/a> \u2014 raltegravir 400 mg \u2014 inhibitor integr\u00e1zy<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/abamune-l\/\">Abamune L<\/a> \u2014 abakavir + lamivudin \u2014 alternativn\u00ed z\u00e1klad NRTI<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tenvir-l\/\">Tenvir L<\/a> \u2014 tenofovir + lamivudin \u2014 alternativn\u00ed z\u00e1klad NRTI<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> L\u00e9\u010dba HIV je komplexn\u00ed, celo\u017eivotn\u00ed terapie. V\u00fdb\u011br l\u00e9k\u016f z\u00e1vis\u00ed na genotypu, testech rezistence, p\u0159idru\u017een\u00fdch onemocn\u011bn\u00edch a p\u0159edchoz\u00ed l\u00e9\u010db\u011b. Jakoukoli zm\u011bnu re\u017eimu konzultujte s odborn\u00edkem na HIV. Pro prevenci rezistence je nutn\u00e1 adherence &gt;95%. P\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby obsahuj\u00edc\u00ed tenofovir, lamivudin nebo emtricitabin testujte HBV \u2014 vysazen\u00ed m\u016f\u017ee u pacient\u016f s koinfekc\u00ed zp\u016fsobit z\u00e1va\u017en\u00e9 vzplanut\u00ed HBV.<\/div>","protected":false},"excerpt":{"rendered":"<p>Abamune L (Abacavir 600 mg + Lamivudine 300 mg) \u2014 Cipla NRTI alternativa k re\u017eim\u016fm zalo\u017een\u00fdm na TDF. Preferov\u00e1no u onemocn\u011bn\u00ed ledvin. P\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby je povinn\u00e9 testov\u00e1n\u00ed HLA-B*5701.<\/p>","protected":false},"featured_media":50992,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3304],"product_tag":[3308,3309,3310],"class_list":{"0":"post-50991","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hiv-medication","9":"product_tag-abacavir","10":"product_tag-abamune-l","11":"product_tag-lamivudine","13":"first","14":"outofstock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/50991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=50991"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/50992"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=50991"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=50991"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=50991"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=50991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}