{"id":50997,"date":"2023-09-20T09:16:14","date_gmt":"2023-09-20T09:16:14","guid":{"rendered":"https:\/\/medsname.com\/centrex\/"},"modified":"2026-04-30T16:19:01","modified_gmt":"2026-04-30T16:19:01","slug":"centrex","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/centrex\/","title":{"rendered":"Centrex"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">Rychl\u00e1 odpov\u011b\u010f<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Centrex<\/strong> \u2014 valacyclovir 500\/1000 mg (Centurion Lab). Profarmaceutikum acykloviru \u2014 pro genit\u00e1ln\u00ed herpes (po\u010d\u00e1te\u010dn\u00ed + suprese), herpes labialis (opary), herpes zoster (p\u00e1sov\u00fd opar) a profylaxi CMV u transplantac\u00ed. Up\u0159ednost\u0148ov\u00e1n p\u0159ed acyklovirem pro lep\u0161\u00ed adherenci: lep\u0161\u00ed peror\u00e1ln\u00ed biologick\u00e1 dostupnost umo\u017e\u0148uje d\u00e1vkov\u00e1n\u00ed 2-3\u00d7 denn\u011b.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/li>\n<li>Diskr\u00e9tn\u00ed balen\u00ed v oby\u010dejn\u00e9 ob\u00e1lce<\/li>\n<li>Dod\u00e1n\u00ed po cel\u00e9m sv\u011bt\u011b<\/li>\n<li>Hodnoceno v\u00edce ne\u017e 1 400 z\u00e1kazn\u00edky (<a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">\u010d\u00edst recenze<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Z\u00e1ruka op\u011btovn\u00e9ho zasl\u00e1n\u00ed:<\/strong> pokud va\u0161e objedn\u00e1vka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f od odesl\u00e1n\u00ed, za\u0161leme ji znovu bez dal\u0161\u00edch n\u00e1klad\u016f. <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">P\u0159e\u010d\u00edst podm\u00ednky<\/a>.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Centrex je odes\u00edl\u00e1n od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m balen\u00ed, fakturov\u00e1n p\u0159es regulovan\u00e9ho platebn\u00edho procesora (na v\u00fdpisu z karty se zobraz\u00ed regulovan\u00fd platebn\u00ed procesor \u2014 nikdy MedsBase nebo n\u00e1zev l\u00e9ku). Ka\u017ed\u00e1 objedn\u00e1vka je kryta na\u0161\u00ed 20-pracovn\u00ed z\u00e1rukou na p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>\u00daprava d\u00e1vkov\u00e1n\u00ed p\u0159i ren\u00e1ln\u00ed insuficienci + hydratace<\/strong><br \/>Valacyclovir se vylu\u010duje ledvinami; dehydratace m\u016f\u017ee zp\u016fsobit krystalizaci a akutn\u00ed po\u0161kozen\u00ed ledvin. Udr\u017eujte dostate\u010dn\u00fd p\u0159\u00edjem tekutin. Upravte d\u00e1vku pro CrCl &lt;50 mL\/min. Opatrnost u star\u0161\u00edch pacient\u016f.<\/div>\n<h2>D\u00e1vkov\u00e1n\u00ed podle indikace<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:12px 0;\">\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;border:1px solid #ddd;\">Indikace<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;\">D\u00e1vka<\/th>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Po\u010d\u00e1te\u010dn\u00ed genit\u00e1ln\u00ed herpes (imunokompetentn\u00ed)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">1 g 2\u00d7 denn\u011b \u00d7 7-10 dn\u00ed<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Recidivuj\u00edc\u00ed genit\u00e1ln\u00ed herpes (za\u010d\u00edt do 24 hodin)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">500 mg 2\u00d7 denn\u011b po dobu 3 dn\u016f NEBO 1 g 1\u00d7 denn\u011b po dobu 5 dn\u016f<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Supresivn\u00ed terapie (\u22656 epizod\/rok)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">500 mg nebo 1 g 1\u00d7 denn\u011b dlouhodob\u011b<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Opary (za\u010d\u00edt p\u0159i prvn\u00edch prodrom\u00e1ln\u00edch p\u0159\u00edznac\u00edch)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">2 g 2\u00d7 denn\u011b po dobu 1 dne (jednodenn\u00ed re\u017eim)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">P\u00e1sov\u00fd opar (herpes zoster, &lt;72 hodin od v\u00fdsevu vyr\u00e1\u017eky)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">1 g 3\u00d7 denn\u011b po dobu 7 dn\u016f<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Prevence p\u0159enosu HSV na partnera (p\u0159i dodr\u017eov\u00e1n\u00ed bezpe\u010dn\u011bj\u0161\u00edho sexu\u00e1ln\u00edho chov\u00e1n\u00ed)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">500 mg 1\u00d7 denn\u011b dlouhodob\u011b<\/td>\n<\/tr>\n<\/table>\n<p>\u00daprava d\u00e1vkov\u00e1n\u00ed je nutn\u00e1 p\u0159i CrCl &lt;50 ml\/min. Dostate\u010dn\u00e1 hydratace b\u011bhem terapie sni\u017euje riziko krystalizace.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Valacyclovir vs acyclovir \u2014 kter\u00fd je lep\u0161\u00ed?<\/h3>\n<p>Stejn\u00e1 \u00fa\u010dinn\u00e1 molekula (acyclovir). Valacyclovir m\u00e1 3-5\u00d7 vy\u0161\u0161\u00ed peror\u00e1ln\u00ed biologickou dostupnost a umo\u017e\u0148uje d\u00e1vkov\u00e1n\u00ed 2-3\u00d7 denn\u011b nam\u00edsto 5\u00d7, co\u017e v\u00fdrazn\u011b zlep\u0161uje adherenci. Pro t\u011b\u017ek\u00e1 onemocn\u011bn\u00ed (HSV encefalitida, neonat\u00e1ln\u00ed HSV) je st\u00e1le preferov\u00e1n intraven\u00f3zn\u00ed acyclovir.<\/p>\n<h3>Kdy zah\u00e1jit l\u00e9\u010dbu?<\/h3>\n<p>Do 24 hodin od n\u00e1stupu p\u0159\u00edznak\u016f u epizodick\u00e9ho genit\u00e1ln\u00edho herpesu. Do 72 hodin od v\u00fdsevu u p\u00e1sov\u00e9ho oparu. P\u0159i prvn\u00edch prodrom\u00e1ln\u00edch p\u0159\u00edznac\u00edch u oparu. \u010c\u00edm d\u0159\u00edve = krat\u0161\u00ed propuknut\u00ed.<\/p>\n<h3>Jak dlouho trv\u00e1 suprese?<\/h3>\n<p>Minim\u00e1ln\u011b 6-12 m\u011bs\u00edc\u016f pro supresi genit\u00e1ln\u00edho herpesu u pacient\u016f s \u010dast\u00fdmi recidivami. Ro\u010dn\u00ed p\u0159ehodnocen\u00ed \u2014 p\u0159irozen\u00fd pr\u016fb\u011bh \u010dasto znamen\u00e1 zlep\u0161en\u00ed v pr\u016fb\u011bhu let, tak\u017ee p\u0159eru\u0161en\u00ed terapie je rozumn\u00e9.<\/p>\n<h3>Vedlej\u0161\u00ed \u00fa\u010dinky?<\/h3>\n<p>Obecn\u011b dob\u0159e sn\u00e1\u0161en: bolest hlavy, nevolnost, \u00fanava, z\u00e1vrat\u011b. Vz\u00e1cn\u011b: trombotick\u00e1 trombocytopenick\u00e1 purpura\/hemolyticko-uremick\u00fd syndrom (TTP\/HUS) u imunokompromitovan\u00fdch pacient\u016f (varov\u00e1n\u00ed FDA), akutn\u00ed po\u0161kozen\u00ed ledvin (zejm\u00e9na p\u0159i dehydrataci).<\/p>\n<h3>T\u011bhotenstv\u00ed?<\/h3>\n<p>Valacyclovir je \u0161iroce pou\u017e\u00edv\u00e1n v t\u011bhotenstv\u00ed (kategorie B), zejm\u00e9na supresivn\u00ed terapie od 36. t\u00fddne u HSV-pozitivn\u00edch \u017een k prevenci neonat\u00e1ln\u00edho HSV. Proberte s porodnick\u00fdm t\u00fdmem.<\/p>\n<h3>Interakce l\u00e9k\u016f?<\/h3>\n<p>Minimum v\u00fdznamn\u00fdch interakc\u00ed. Vyhn\u011bte se kombinaci s dal\u0161\u00edmi nefrotoxick\u00fdmi l\u00e9ky (chronick\u00e1 NSAID, aminoglykosidy). Probenecid + cimetidin m\u00edrn\u011b zvy\u0161uj\u00ed hladiny \u2014 obvykle klinicky nev\u00fdznamn\u00e9.<\/p>\n<h3>\u00daprava d\u00e1vkov\u00e1n\u00ed p\u0159i ren\u00e1ln\u00ed insuficienci?<\/h3>\n<p>Nutn\u00e1 p\u0159i CrCl &lt;50 mL\/min. Riziko kumulace, neuropsychiatrick\u00fdch p\u0159\u00edznak\u016f (zmatenost, halucinace) p\u0159i ren\u00e1ln\u00edm selh\u00e1n\u00ed zejm\u00e9na u star\u0161\u00edch pacient\u016f.<\/p>\n<h3>Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Vezm\u011bte, kdy\u017e si vzpomenete, pokud nen\u00ed t\u00e9m\u011b\u0159 \u010das na dal\u0161\u00ed d\u00e1vku. Neduplikujte d\u00e1vky. Vynech\u00e1n\u00ed d\u00e1vek u epizodick\u00e9 terapie sni\u017euje \u00fa\u010dinek; u suprese jsou ob\u010dasn\u00e9 vynechan\u00e9 d\u00e1vky tolerovateln\u00e9, ale konzistence je d\u016fle\u017eit\u00e1 pro prevenci p\u0159enosu.<\/p>\n<h3>Vyl\u00e9\u010d\u00ed to herpes?<\/h3>\n<p>Ne \u2014 herpes infekce je celo\u017eivotn\u00ed. Antivirotika sni\u017euj\u00ed replikaci viru b\u011bhem propuknut\u00ed a preventuj\u00ed p\u0159enos, ale neodstra\u0148uj\u00ed latentn\u00ed virus. Nov\u00fd v\u00fdzkum zam\u011b\u0159en\u00fd na l\u00e9\u010dbu (CRISPR, genov\u00e1 editace) je experiment\u00e1ln\u00ed.<\/p>\n<h3>Jak\u00e9 je riziko p\u0159enosu?<\/h3>\n<p>Supresivn\u00ed valacyklovir u HSV-pozitivn\u00edho partnera sni\u017euje p\u0159enos na negativn\u00edho partnera p\u0159ibli\u017en\u011b o 50 % (Corey 2004). V kombinaci s d\u016fsledn\u00fdm pou\u017e\u00edv\u00e1n\u00edm kondom\u016f a vyh\u00fdb\u00e1n\u00edm se pohlavn\u00edmu styku b\u011bhem v\u00fdsevu se riziko p\u0159enosu d\u00e1le sni\u017euje.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Dal\u0161\u00ed antivirotika<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zimivir\/\">Zimivir<\/a> \u2014 valacyklovir 500\/1000 mg \u2014 alternativn\u00ed zna\u010dka<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/natclovir\/\">Natclovir<\/a> \u2014 valacyklovir \u2014 zna\u010dka Natco<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/centrex\/\">Centrex<\/a> \u2014 valacyklovir 500\/1000 mg \u2014 zna\u010dka Centurion<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/valgan\/\">Valgan<\/a> \u2014 valganciklovir 450 mg \u2014 pro CMV u transplantovan\u00fdch<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zovirax\/\">Zovirax<\/a> \u2014 acyklovir \u2014 star\u0161\u00ed alternativa<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro informaci a nenahrazuje l\u00e9ka\u0159skou p\u00e9\u010di kvalifikovan\u00e9ho odborn\u00edka. Proberte jak\u00e9koli nov\u00e9 l\u00e9ky se sv\u00fdm l\u00e9ka\u0159em nebo l\u00e9k\u00e1rn\u00edkem.<\/div>","protected":false},"excerpt":{"rendered":"<p>Centrex (Valacyclovir 500\/1000 mg) \u2014 acyklovir profarmaceutikum od Centurion Lab pro l\u00e9\u010dbu HSV v\u010detn\u011b po\u010d\u00e1te\u010dn\u00edho a recidivuj\u00edc\u00edho genit\u00e1ln\u00edho herpesu, opar\u016f a herpes zoster.<\/p>","protected":false},"featured_media":50998,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3304],"product_tag":[3312,3313],"class_list":{"0":"post-50997","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hiv-medication","9":"product_tag-centrex","10":"product_tag-valacyclovir","12":"first","13":"outofstock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/50997","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=50997"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/50998"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=50997"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=50997"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=50997"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=50997"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}