{"id":51620,"date":"2023-09-20T09:23:32","date_gmt":"2023-09-20T09:23:32","guid":{"rendered":"https:\/\/medsname.com\/cozartan\/"},"modified":"2026-05-01T10:49:11","modified_gmt":"2026-05-01T10:49:11","slug":"cozartan","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/cozartan\/","title":{"rendered":"Cozartan"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Cozartan?<\/h3>\n<p style=\"margin:0;\"><strong>Cozartan<\/strong> je <strong>losartan draseln\u00fd<\/strong> tablety dostupn\u00e9 v <strong>25, 50 a 100 mg<\/strong> s\u00edle. Je to <strong>blok\u00e1tor receptoru pro angiotensin II (ARB)<\/strong> pou\u017e\u00edvan\u00e1 k l\u00e9\u010db\u011b <strong>hypertenze, diabetick\u00e1 nefropatie a srde\u010dn\u00ed selh\u00e1n\u00ed<\/strong>, a <strong>sn\u00ed\u017een\u00ed rizika mozkov\u00e9 p\u0159\u00edhody<\/strong> u pacient\u016f s hypertrofi\u00ed lev\u00e9 komory. Obvykl\u00e1 d\u00e1vka pro dosp\u011bl\u00e9 je <strong>50 mg jednou denn\u011b<\/strong>, s mo\u017enost\u00ed titrace na 100 mg v p\u0159\u00edpad\u011b pot\u0159eby. Klinicky ekvivalentn\u00ed p\u0159\u00edpravku Merck <strong>Cozaar<sup>\u00ae<\/sup><\/strong>.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<p><strong>Cozartan<\/strong> je generikum od Unichem <strong>losartan draseln\u00fd<\/strong> tableta. Losartan byl prvn\u00edm blok\u00e1torem receptoru pro angiotensin II (ARB) schv\u00e1len\u00fdm FDA (1995) a st\u00e1le pat\u0159\u00ed mezi nej\u010dast\u011bji p\u0159edepisovan\u00e9 l\u00e9ky na krevn\u00ed tlak na sv\u011bt\u011b. Cozartan obsahuje stejnou \u00fa\u010dinnou l\u00e1tku ve stejn\u00fdch sil\u00e1ch jako origin\u00e1ln\u00ed p\u0159\u00edpravek Merck <strong>Cozaar<sup>\u00ae<\/sup><\/strong>.<\/p>\n<p>ARB, jako je losartan, poskytuj\u00ed stejn\u00fd \u00fa\u010dinek na sn\u00ed\u017een\u00ed krevn\u00edho tlaku jako ACE inhibitory (lisinopril, ramipril, perindopril), ale bez typick\u00e9ho <strong>such\u00e9ho ka\u0161le<\/strong> kter\u00fd vede 10\u201315 % pacient\u016f k ukon\u010den\u00ed l\u00e9\u010dby ACE inhibitory. Z tohoto d\u016fvodu jsou losartan a dal\u0161\u00ed ARB \u010dasto voleny jako l\u00e9ky prvn\u00ed volby u prim\u00e1rn\u00ed hypertenze, zejm\u00e9na u pacient\u016f, kte\u0159\u00ed zaznamenali ka\u0161el p\u0159i u\u017e\u00edv\u00e1n\u00ed ACE inhibitor\u016f.<\/p>\n<h2 class=\"wp-block-heading\">Co je Cozartan?<\/h2>\n<p>Cozartan je p\u0159edpisov\u00fd antihypertenzivum ze t\u0159\u00eddy <strong>blok\u00e1tor receptoru pro angiotensin II (ARB)<\/strong> . Kompetitivn\u011b blokuje AT\u2081 podtyp receptoru pro angiotensin II, \u010d\u00edm\u017e oslabuje presorick\u00fd, sod\u00edk-zadr\u017euj\u00edc\u00ed a vazokonstrik\u010dn\u00ed \u00fa\u010dinky angiotensinu II.<\/p>\n<p>Cozartan je indikov\u00e1n k l\u00e9\u010db\u011b:<\/p>\n<ul>\n<li><strong>Esenci\u00e1ln\u00ed hypertenze<\/strong> \u2014 terapie prvn\u00ed volby nebo jako dopl\u0148kov\u00e1 l\u00e9\u010dba<\/li>\n<li><strong>Diabetick\u00e1 nefropatie<\/strong> u diabetu 2. typu \u2014 zpomaluje progresi proteinurick\u00e9 choroby ledvin<\/li>\n<li><strong>Hypertrofie lev\u00e9 komory<\/strong> \u2014 sn\u00ed\u017een\u00ed rizika c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody u pacient\u016f s LVH (studie LIFE)<\/li>\n<li><strong>Srde\u010dn\u00ed selh\u00e1n\u00ed<\/strong> se sn\u00ed\u017eenou ejek\u010dn\u00ed frakc\u00ed \u2014 u pacient\u016f s intoleranc\u00ed ACE inhibitor\u016f<\/li>\n<li><strong>Chronick\u00e9 onemocn\u011bn\u00ed ledvin<\/strong> s proteinuri\u00ed \u2014 renoprotektivn\u00ed \u00fa\u010dinek<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Jak funguje Cozartan?<\/h2>\n<p>Angiotensin II je efektorov\u00fd hormon syst\u00e9mu renin-angiotensin-aldosteron (RAAS). Zvy\u0161uje krevn\u00ed tlak t\u0159emi hlavn\u00edmi mechanismy, kter\u00e9 jsou v\u0161echny blokov\u00e1ny losartanem:<\/p>\n<ul>\n<li><strong>Vazokonstrikce<\/strong> \u2014 antagonismus losartanu umo\u017e\u0148uje syst\u00e9movou a ren\u00e1ln\u00ed vazodilataci<\/li>\n<li><strong>Uvol\u0148ov\u00e1n\u00ed aldosteronu<\/strong> \u2014 blok\u00e1da sni\u017euje retenci sod\u00edku a vody<\/li>\n<li><strong>Sympatick\u00e1 stimulace a srde\u010dn\u00ed remodelace<\/strong> \u2014 losartan sni\u017euje dlouhodob\u00e9 hypertrofick\u00e9 a fibrotick\u00e9 \u00fa\u010dinky angiotensinu II na srdce a ledviny<\/li>\n<\/ul>\n<p>Samotn\u00fd losartan je m\u00edrn\u00fd blok\u00e1tor receptor\u016f. Jeho \u00fa\u010dinek je z velk\u00e9 \u010d\u00e1sti zprost\u0159edkov\u00e1n jeho aktivn\u00edm metabolitem <strong>EXP3174<\/strong>, kter\u00fd vznik\u00e1 v j\u00e1trech p\u016fsoben\u00edm CYP2C9 a je 10\u201340\u00d7 \u00fa\u010dinn\u011bj\u0161\u00ed s polo\u010dasem 6\u20139 hodin. Proto se losartan obvykle pod\u00e1v\u00e1 jednou denn\u011b ke kontrole krevn\u00edho tlaku.<\/p>\n<p><strong>V\u00fdrazn\u00fd vedlej\u0161\u00ed benefit:<\/strong> losartan je mezi blok\u00e1tory AT1 receptor\u016f v\u00fdjime\u010dn\u00fd sv\u00fdm <strong>urikosurick\u00fdm<\/strong> \u00fa\u010dinkem, sni\u017euje s\u00e9rovou hladinu kyseliny mo\u010dov\u00e9 p\u0159ibli\u017en\u011b o 10\u201315%. D\u00edky tomu je preferovanou volbou u hypertonik\u016f s dnou nebo zv\u00fd\u0161enou hladinou kyseliny mo\u010dov\u00e9.<\/p>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed a pod\u00e1v\u00e1n\u00ed p\u0159\u00edpravku Cozartan<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indikace<\/th>\n<th>Po\u010d\u00e1te\u010dn\u00ed<\/th>\n<th>C\u00edlov\u00e1 \/ maxim\u00e1ln\u00ed<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Hypertenze (standardn\u00ed)<\/strong><\/td>\n<td>50 mg jednou denn\u011b<\/td>\n<td>A\u017e 100 mg jednou denn\u011b po 3\u20136 t\u00fddnech v p\u0159\u00edpad\u011b pot\u0159eby<\/td>\n<\/tr>\n<tr>\n<td><strong>Hypertenze s objemovou deplec\u00ed \/ u star\u0161\u00edch pacient\u016f<\/strong><\/td>\n<td>25 mg jednou denn\u011b<\/td>\n<td>Postupn\u011b zvy\u0161ovat d\u00e1vku podle tolerance<\/td>\n<\/tr>\n<tr>\n<td><strong>Diabetick\u00e1 nefropatie<\/strong><\/td>\n<td>50 mg jednou denn\u011b<\/td>\n<td>100 mg jednou denn\u011b (c\u00edlov\u00e9 d\u00e1vkov\u00e1n\u00ed dle studie RENAAL)<\/td>\n<\/tr>\n<tr>\n<td><strong>Srde\u010dn\u00ed selh\u00e1n\u00ed (nesn\u00e1\u0161enlivost ACE inhibitor\u016f)<\/strong><\/td>\n<td>12,5 mg jednou denn\u011b<\/td>\n<td>Postupn\u011b titrovat na 50 mg (a\u017e na 150 mg ve studii HEAAL)<\/td>\n<\/tr>\n<tr>\n<td><strong>LVH \/ sn\u00ed\u017een\u00ed rizika c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody<\/strong><\/td>\n<td>50 mg jednou denn\u011b<\/td>\n<td>100 mg jednou denn\u011b (c\u00edlov\u00e9 d\u00e1vkov\u00e1n\u00ed dle studie LIFE)<\/td>\n<\/tr>\n<tr>\n<td><strong>Porucha funkce jater<\/strong><\/td>\n<td>25 mg jednou denn\u011b<\/td>\n<td>Losartan a jeho metabolit jsou eliminov\u00e1ny j\u00e1try<\/td>\n<\/tr>\n<tr>\n<td><strong>M\u00edrn\u00e9 a\u017e st\u0159edn\u00ed po\u0161kozen\u00ed ledvin<\/strong><\/td>\n<td>Bez rutinn\u00ed \u00fapravy d\u00e1vkov\u00e1n\u00ed<\/td>\n<td>Monitorovat hladinu K\u207a a kreatininu<\/td>\n<\/tr>\n<tr>\n<td><strong>T\u011b\u017ek\u00e9 ren\u00e1ln\u00ed posti\u017een\u00ed \/ dial\u00fdza<\/strong><\/td>\n<td>Za\u010dn\u011bte s 25 mg; opatrn\u011b<\/td>\n<td>Pod dohledem specialisty<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">Jak spr\u00e1vn\u011b u\u017e\u00edvat Cozartan<\/h3>\n<ul>\n<li>Tabletu spolkn\u011bte celou a zapijte vodou<\/li>\n<li>Lze u\u017e\u00edvat s j\u00eddlem i bez j\u00eddla (potrava m\u00edrn\u011b sni\u017euje vrcholovou plazmatickou hladinu, ale neovliv\u0148uje celkov\u00fd \u00fa\u010dinek)<\/li>\n<li>U\u017e\u00edvejte v <strong>stejnou denn\u00ed dobu<\/strong> pro stabiln\u00ed kontrolu krevn\u00edho tlaku<\/li>\n<li>\u00dapln\u00fd antihypertenzn\u00ed \u00fa\u010dinek se m\u016f\u017ee projevit za <strong>3\u20136 t\u00fddn\u016f<\/strong> ne\u010dekejte okam\u017eitou zm\u011bnu krevn\u00edho tlaku<\/li>\n<li><strong>Nep\u0159est\u00e1vejte n\u00e1hle<\/strong> p\u0159i srde\u010dn\u00edm selh\u00e1n\u00ed nebo po dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed \u2014 vysazujte postupn\u011b pod l\u00e9ka\u0159sk\u00fdm dohledem<\/li>\n<li>Pravideln\u011b kontrolujte krevn\u00ed tlak; c\u00edlem jsou hodnoty stanoven\u00e9 l\u00e9ka\u0159em (obvykle &lt;140\/90, nebo &lt;130\/80 u diabetu a CKD)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky Cozartanu<\/h2>\n<p>Losartan je obecn\u011b dob\u0159e sn\u00e1\u0161en \u2014 profil ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f je lep\u0161\u00ed ne\u017e u ACE inhibitor\u016f (nevyvol\u00e1v\u00e1 typick\u00fd such\u00fd ka\u0161el).<\/p>\n<table>\n<thead>\n<tr>\n<th>Z\u00e1va\u017enost<\/th>\n<th>Vedlej\u0161\u00ed \u00fa\u010dinek<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>B\u011b\u017en\u00e9 (\u22651 ze 100)<\/strong><\/td>\n<td>Z\u00e1vrat\u011b (zejm\u00e9na prvn\u00ed d\u00e1vka), \u00fanava, bolest hlavy, ortostatick\u00e1 hypotenze<\/td>\n<\/tr>\n<tr>\n<td><strong>M\u00e9n\u011b \u010dast\u00e9<\/strong><\/td>\n<td>Bolesti zad, ucpan\u00fd nos, m\u00edrn\u00e9 gastrointestin\u00e1ln\u00ed pot\u00ed\u017ee, p\u0159echodn\u00e1 hyperkal\u00e9mie, zv\u00fd\u0161en\u00fd kreatinin<\/td>\n<\/tr>\n<tr>\n<td><strong>Vz\u00e1cn\u00e9, ale z\u00e1va\u017en\u00e9<\/strong><\/td>\n<td>Angioed\u00e9m (m\u00e9n\u011b \u010dast\u00fd ne\u017e u inhibitor\u016f ACE, ale mo\u017en\u00fd), hyperkal\u00e9mie, akutn\u00ed po\u0161kozen\u00ed ledvin (zejm\u00e9na u bilater\u00e1ln\u00ed sten\u00f3zy ren\u00e1ln\u00ed art\u00e9rie), t\u011b\u017ek\u00e1 hypotenze, rabdomyol\u00fdza<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Na rozd\u00edl od inhibitor\u016f ACE, ARB nezp\u016fsobuj\u00ed charakteristick\u00fd p\u0159etrv\u00e1vaj\u00edc\u00ed such\u00fd ka\u0161el.<\/strong> Toto je hlavn\u00ed d\u016fvod, pro\u010d se rozhodnout pro losartan nam\u00edsto lisinoprilu nebo ramiprilu u pacient\u016f, kte\u0159\u00ed zaznamenali ka\u0161el.<\/p>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>Hypotenze prvn\u00edho pod\u00e1n\u00ed.<\/strong> Hypotenze prvn\u00edho pod\u00e1n\u00ed.<\/li>\n<li><strong>Pacienti s objemovou deplec\u00ed (na diuretik\u00e1ch, dehydratovan\u00fdch, s n\u00edzk\u00fdm obsahem sod\u00edku) mohou zaznamenat v\u00fdrazn\u00fd pokles TK. Za\u010dn\u011bte s 25 mg a vezm\u011bte prvn\u00ed d\u00e1vku p\u0159ed span\u00edm.<\/strong> Funkce ledvin a drasl\u00edk.<\/li>\n<li><strong>Zkontrolujte kreatinin, eGFR a s\u00e9rov\u00fd drasl\u00edk 2\u20134 t\u00fddny po zah\u00e1jen\u00ed nebo zv\u00fd\u0161en\u00ed d\u00e1vky. M\u00edrn\u00fd vzestup kreatininu je o\u010dek\u00e1v\u00e1n a NEN\u00cd d\u016fvodem k zastaven\u00ed; vzestup &gt;30 % vy\u017eaduje p\u0159ezkoum\u00e1n\u00ed.<\/strong> Vyh\u00fdbejte se \u2014 m\u016f\u017ee vyvolat akutn\u00ed po\u0161kozen\u00ed ledvin<\/li>\n<li><strong>T\u011bhotenstv\u00ed.<\/strong> <strong>Kontraindikov\u00e1no<\/strong> \u2014 Blok\u00e1tory RAAS zp\u016fsobuj\u00ed po\u0161kozen\u00ed plodu ve druh\u00e9m a t\u0159et\u00edm trimestru (ren\u00e1ln\u00ed ageneze, oligohydramnion, hypoplazie lebky). Okam\u017eit\u011b p\u0159eru\u0161te l\u00e9\u010dbu, pokud je zji\u0161t\u011bno t\u011bhotenstv\u00ed<\/li>\n<li><strong>Kojen\u00ed.<\/strong> Nedoporu\u010duje se \u2014 up\u0159ednost\u0148uj\u00ed se alternativy<\/li>\n<li><strong>Angioed\u00e9m.<\/strong> Vz\u00e1cn\u00e9, ale potenci\u00e1ln\u011b \u017eivot ohro\u017euj\u00edc\u00ed \u2014 pokud dojde k otoku d\u00fdchac\u00edch cest, okam\u017eit\u011b p\u0159eru\u0161te l\u00e9\u010dbu a vyhledejte neodkladnou p\u00e9\u010di<\/li>\n<li><strong>Lithium.<\/strong> Losartan zvy\u0161uje hladinu lithia \u2014 vyh\u00fdbejte se nebo pe\u010dliv\u011b monitorujte<\/li>\n<li><strong>NSAID.<\/strong> Pravideln\u00e9 u\u017e\u00edv\u00e1n\u00ed NSAID m\u016f\u017ee negovat \u00fa\u010dinek sni\u017eov\u00e1n\u00ed krevn\u00edho tlaku a urychlit po\u0161kozen\u00ed ledvin<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace \u2014 Kdo by NEM\u011aL u\u017e\u00edvat Cozartan<\/h2>\n<ul>\n<li>T\u011bhotenstv\u00ed (v\u0161echny trimestry, ale zejm\u00e9na 2. a 3.)<\/li>\n<li>Kojen\u00ed<\/li>\n<li>P\u0159ecitliv\u011blost na losartan nebo jakoukoli pomocnou l\u00e1tku<\/li>\n<li>Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed aliskirenu u pacient\u016f s diabetem<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed<\/li>\n<li>Bilater\u00e1ln\u00ed sten\u00f3za ren\u00e1ln\u00edch tepen<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table>\n<thead>\n<tr>\n<th>L\u00e9\u010divo \/ T\u0159\u00edda<\/th>\n<th>Interakce<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>\u0160et\u0159\u00edc\u00ed diuretika (spironolacton, amilorid) \/ dopl\u0148ky drasl\u00edku \/ n\u00e1hrady soli<\/strong><\/td>\n<td>Riziko hyperkal\u00e9mie \u2014 monitorujte K\u207a<\/td>\n<\/tr>\n<tr>\n<td><strong>NSAID (ibuprofen, naproxen, diklofenak)<\/strong><\/td>\n<td>Sni\u017euje antihypertenzn\u00ed \u00fa\u010dinek; aditivn\u00ed nefrotoxicita \u2014 vyhn\u011bte se pravideln\u00e9mu u\u017e\u00edv\u00e1n\u00ed<\/td>\n<\/tr>\n<tr>\n<td><strong>Lithium<\/strong><\/td>\n<td>Sni\u017euje ren\u00e1ln\u00ed clearance \u2014 zvy\u0161uje hladiny lithia; monitorujte<\/td>\n<\/tr>\n<tr>\n<td><strong>Aliskiren (p\u0159\u00edm\u00fd inhibitor reninu)<\/strong><\/td>\n<td>Kontraindikov\u00e1no u diabetik\u016f; vyhn\u011bte se kombinaci u v\u0161ech pacient\u016f<\/td>\n<\/tr>\n<tr>\n<td><strong>ACE inhibitory<\/strong><\/td>\n<td>Dvojit\u00e1 blok\u00e1da RAAS obecn\u011b nedoporu\u010dena \u2014 zv\u00fd\u0161en\u00e9 riziko AKI a hyperkal\u00e9mie<\/td>\n<\/tr>\n<tr>\n<td><strong>Inhibitory CYP2C9 (flukonazol, rifampicin)<\/strong><\/td>\n<td>Ovliv\u0148uj\u00ed p\u0159em\u011bnu na aktivn\u00ed metabolit EXP3174 \u2014 m\u016f\u017ee zm\u011bnit \u00fa\u010dinnost<\/td>\n<\/tr>\n<tr>\n<td><strong>Alkohol<\/strong><\/td>\n<td>Aditivn\u00ed vazodilatace a hypotenze \u2014 m\u00edrn\u00fd p\u0159\u00edjem<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Pokyny k uchov\u00e1v\u00e1n\u00ed<\/h2>\n<ul>\n<li>Skladujte pod 30 \u00b0C na such\u00e9m m\u00edst\u011b, mimo p\u0159\u00edm\u00e9 slune\u010dn\u00ed sv\u011btlo<\/li>\n<li>Uchov\u00e1vejte v p\u016fvodn\u00edm blistrov\u00e9m obalu<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed<\/li>\n<li>Nepou\u017e\u00edvejte po uplynut\u00ed data expirace<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/losar\/\" rel=\"noopener\">Losar<\/a> \u2014 Unichem losartan, alternativn\u00ed zna\u010dka<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/telma\/\" rel=\"noopener\">Telma<\/a> \u2014 telmisartan, p\u0159\u00edbuzn\u00fd ARB s del\u0161\u00edm polo\u010dasem (24 h)<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/high-blood-pressure-medication\/\" rel=\"noopener\">Prohl\u00e9dn\u011bte si v\u0161echny l\u00e9ky na krevn\u00ed tlak \u2192<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/heart-blood-pressure\/\" rel=\"noopener\">Kategorie Srdce a krevn\u00ed tlak<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">K \u010demu se pou\u017e\u00edv\u00e1 Cozartan?<\/h3>\n<p>Cozartan (losartan) se pou\u017e\u00edv\u00e1 k l\u00e9\u010db\u011b <strong>hypertenze, diabetick\u00e9 nefropatie, srde\u010dn\u00edho selh\u00e1n\u00ed a hypertrofie lev\u00e9 komory<\/strong> (sn\u00ed\u017een\u00ed rizika mrtvice). Pou\u017e\u00edv\u00e1 se tak\u00e9 u chronick\u00e9ho onemocn\u011bn\u00ed ledvin s proteinuri\u00ed pro sv\u016fj renoprotektivn\u00ed \u00fa\u010dinek.<\/p>\n<h3 class=\"wp-block-heading\">Jak rychle Cozartan \u00fa\u010dinkuje?<\/h3>\n<p>N\u011bjak\u00fd \u00fa\u010dinek na sn\u00ed\u017een\u00ed krevn\u00edho tlaku za\u010d\u00edn\u00e1 ji\u017e do <strong>6 hodin<\/strong> po prvn\u00ed d\u00e1vce. Pln\u00fd antihypertenzn\u00ed \u00fa\u010dinek se rozv\u00edj\u00ed b\u011bhem. V\u011bt\u0161ina lid\u00ed dos\u00e1hne c\u00edlov\u00e9ho krevn\u00edho tlaku po titraci d\u00e1vky. <strong>3\u20136 t\u00fddn\u016f<\/strong>. Je losartan lep\u0161\u00ed ne\u017e ACE inhibitor?.<\/p>\n<h3 class=\"wp-block-heading\">Oba jsou vysoce \u00fa\u010dinn\u00e9. Hlavn\u00ed praktick\u00fd rozd\u00edl je v<\/h3>\n<p>Both are highly effective. The main practical difference is the <strong>Such\u00fd ka\u0161el zp\u016fsoben\u00fd ACE inhibitory<\/strong> (postihuje ~10\u201315 % pacient\u016f), kter\u00fd ARB jako losartan nezp\u016fsobuj\u00ed. Pokud jde o kardiovaskul\u00e1rn\u00ed v\u00fdsledky, jsou tyto dv\u011b t\u0159\u00eddy l\u00e9k\u016f v z\u00e1sad\u011b podobn\u00e9.<\/p>\n<h3 class=\"wp-block-heading\">Mohu u\u017e\u00edvat Cozartan s j\u00eddlem?<\/h3>\n<p>Oboj\u00ed je mo\u017en\u00e9. J\u00eddlo m\u016f\u017ee m\u00edrn\u011b sn\u00ed\u017eit maxim\u00e1ln\u00ed plazmatickou koncentraci, ale neovlivn\u00ed celkov\u00fd \u00fa\u010dinek na sn\u00ed\u017een\u00ed krevn\u00edho tlaku.<\/p>\n<h3 class=\"wp-block-heading\">Je losartan bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n<p><strong>Ne<\/strong> \u2014 losartan je v t\u011bhotenstv\u00ed kontraindikov\u00e1n. M\u016f\u017ee zp\u016fsobit z\u00e1va\u017en\u00e9 po\u0161kozen\u00ed plodu v\u010detn\u011b malformace ledvin a hypoplazie lebky ve 2. a 3. trimestru. P\u0159i pl\u00e1novan\u00e9m nebo potvrzen\u00e9m t\u011bhotenstv\u00ed p\u0159ejd\u011bte na antihypertenzivum bezpe\u010dn\u00e9 v t\u011bhotenstv\u00ed (labetalol, nifedipin, methyldopa).<\/p>\n<h3 class=\"wp-block-heading\">Sni\u017euje Cozartan hladinu kyseliny mo\u010dov\u00e9?<\/h3>\n<p>Ano \u2014 losartan je jedin\u00fdm ARB s v\u00fdznamn\u00fdm urikosurick\u00fdm \u00fa\u010dinkem, kter\u00fd sni\u017euje s\u00e9rovou hladinu kyseliny mo\u010dov\u00e9 asi o 10\u201315 %. Je proto preferovanou volbou pro hypertoniky, kte\u0159\u00ed trp\u00ed tak\u00e9 dnou nebo vysokou hladinou kyseliny mo\u010dov\u00e9.<\/p>\n<h3 class=\"wp-block-heading\">Zp\u016fsob\u00ed Cozartan such\u00fd ka\u0161el?<\/h3>\n<p>Velmi nepravd\u011bpodobn\u00e9. Such\u00fd ka\u0161el je vedlej\u0161\u00edm \u00fa\u010dinkem ACE inhibitor\u016f (spojen\u00fdm s akumulac\u00ed bradykininu) a u ARB, jako je losartan, se vyskytuje jen z\u0159\u00eddka.<\/p>\n<h3 class=\"wp-block-heading\">Mohu p\u0159estat u\u017e\u00edvat Cozartan, kdy\u017e se mi normalizuje krevn\u00ed tlak?<\/h3>\n<p><strong>Ne<\/strong> \u2014 hypertenze je obvykle celo\u017eivotn\u00ed stav. Pokud l\u00e9k vysad\u00edte, krevn\u00ed tlak se vr\u00e1t\u00ed na hodnoty p\u0159ed l\u00e9\u010dbou a ztrat\u00edte dlouhodobou kardiovaskul\u00e1rn\u00ed ochranu.<\/p>\n<h3 class=\"wp-block-heading\">Mohu u\u017e\u00edvat Cozartan s jin\u00fdmi antihypertenzivy?<\/h3>\n<p>Ano \u2014 kombinovan\u00e1 terapie je b\u011b\u017en\u00e1. \u010cast\u00e9 kombinace jsou s blok\u00e1tory kalciov\u00fdch kan\u00e1l\u016f (amlodipin) nebo thiazidov\u00fdmi diuretiky. Vyhn\u011bte se kombinaci s ACE inhibitory nebo aliskirenem (du\u00e1ln\u00ed blok\u00e1da RAAS).<\/p>\n<h3 class=\"wp-block-heading\">\u010cemu bych se m\u011bl vyhnout p\u0159i u\u017e\u00edv\u00e1n\u00ed Cozartanu?<\/h3>\n<p>Pravideln\u00e9 vysok\u00e9 d\u00e1vky NSAID, n\u00e1hra\u017eky soli obsahuj\u00edc\u00ed chlorid draseln\u00fd, vysok\u00e1 konzumace alkoholu a dehydratace. Pokud se nec\u00edt\u00edte dob\u0159e se zvracen\u00edm nebo pr\u016fjmem, do\u010dasn\u011b vynechejte d\u00e1vku a vyhledejte radu \u2014 akutn\u00ed dehydratace + ARB m\u016f\u017ee zp\u016fsobit po\u0161kozen\u00ed ledvin.<\/p>\n<p><!-- medsbase-faq-h3-converted --><\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lonax\/\">Lonax<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/sorbitrate\/\">Sorbitrate<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lobet\/\">Lobet<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ritocom\/\">Ritocom<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/olmin\/\">Olmin<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Sni\u017euje vysok\u00fd krevn\u00ed tlak<br \/>\n\u2705 Sni\u017euje riziko mrtvice<br \/>\n\u2705 Sni\u017euje srde\u010dn\u00ed selh\u00e1n\u00ed<br \/>\n\u2705 Chr\u00e1n\u00ed ledviny<br \/>\n\u2705 Zlep\u0161uje zdrav\u00ed srdce<\/p>\n<p><span style=\"color: #000000;\">L\u00e9\u010divo Ciplar obsahuje Losartan<\/span><\/p>","protected":false},"featured_media":51621,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260,3356],"product_tag":[5742,5746,5741,3383,5744,5745,5743,3384,4447],"class_list":{"0":"post-51620","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_cat-high-blood-pressure-medication","10":"product_tag-arb","11":"product_tag-blood-pressure","12":"product_tag-cozaar-generic","13":"product_tag-cozartan","14":"product_tag-diabetic-nephropathy","15":"product_tag-heart-failure","16":"product_tag-hypertension","17":"product_tag-losartan","18":"product_tag-losartan-potassium","20":"first","21":"instock","22":"shipping-taxable","23":"purchasable","24":"product-type-variable","25":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/51620","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=51620"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/51621"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=51620"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=51620"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=51620"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=51620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}