{"id":51866,"date":"2023-09-20T09:26:07","date_gmt":"2023-09-20T09:26:07","guid":{"rendered":"https:\/\/medsname.com\/lotensyl\/"},"modified":"2026-05-01T10:49:11","modified_gmt":"2026-05-01T10:49:11","slug":"lotensyl","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/lotensyl\/","title":{"rendered":"Lotensyl"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Lotensyl?<\/h3>\n<p style=\"margin:0;\"><strong>Lotensyl<\/strong> je <strong>tableta cilnidipinu 10 \/ 20 mg<\/strong> od Lupin \u2014 <strong>dihydropyridinov\u00fd blok\u00e1tor kalciov\u00fdch kan\u00e1l\u016f, kter\u00fd jedine\u010dn\u011b blokuje JAK L-typ, tak N-typ kalciov\u00fdch kan\u00e1l\u016f<\/strong>. Blok\u00e1da L-typu zp\u016fsobuje arteri\u00e1ln\u00ed vazodilataci (standardn\u00ed \u00fa\u010dinek blok\u00e1tor\u016f kalciov\u00fdch kan\u00e1l\u016f); blok\u00e1da N-typu na sympatick\u00fdch nervov\u00fdch zakon\u010den\u00edch sni\u017euje uvol\u0148ov\u00e1n\u00ed noradrenalinu, \u010d\u00edm\u017e potla\u010duje reflexn\u00ed tachykardii, kter\u00e1 omezuje ostatn\u00ed dihydropyridiny. Popul\u00e1rn\u00ed v Indii, Japonsku a \u010d\u00e1stech v\u00fdchodn\u00ed Asie jako \u201cnov\u00e1 generace\u201d dihydropyridin\u016f; m\u00e9n\u011b roz\u0161\u00ed\u0159en\u00fd v Evrop\u011b\/USA, kde dominuj\u00ed amlodipin a nifedipin. Klinick\u00e9 v\u00fdhody oproti amlodipinu: ni\u017e\u0161\u00ed v\u00fdskyt otok\u016f kotn\u00edk\u016f, \u017e\u00e1dn\u00e1 reflexn\u00ed tachykardie, m\u00edrn\u011b lep\u0161\u00ed ren\u00e1ln\u00ed ochrana u proteinurick\u00e9 chronick\u00e9 choroby ledvin (studie CARTER-AKI, ACTION-HKD). Typick\u00e1 d\u00e1vka: 5-20 mg jednou denn\u011b. Kontraindikace: kardiogenn\u00ed \u0161ok, akutn\u00ed infarkt myokardu s hypotenz\u00ed, t\u011b\u017ek\u00e9 po\u0161kozen\u00ed jater, t\u011bhotenstv\u00ed.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">Co je Lotensyl?<\/h2>\n<p>Lotensyl jsou tablety cilnidipinu 10 \/ 20 mg od spole\u010dnosti Lupin, dod\u00e1van\u00e9 v balen\u00ed po 30-90 tablet\u00e1ch. Cilnidipin byl uveden na trh v Japonsku v roce 1995 (FujiRebio jako Atelec) a z\u00edskal schv\u00e1len\u00ed ekvivalentn\u00ed FDA v mnoha asijsk\u00fdch trz\u00edch. Jde o \u010dtvrtou generaci dihydropyridinu s v\u00fdrazn\u00fdm du\u00e1ln\u00edm profilem blok\u00e1dy L\/N-typu kalciov\u00fdch kan\u00e1l\u016f.<\/p>\n<h2 class=\"wp-block-heading\">Jak funguje cilnidipin<\/h2>\n<p>V\u011bt\u0161ina dihydropyridinov\u00fdch blok\u00e1tor\u016f kalciov\u00fdch kan\u00e1l\u016f (amlodipin, nifedipin, felodipin, nikardipin) blokuje <strong>L-typ kalciov\u00fdch kan\u00e1l\u016f<\/strong> na arteri\u00e1ln\u00ed hladk\u00e9 svalovin\u011b, co\u017e zp\u016fsobuje vazodilataci a pokles krevn\u00edho tlaku. Cilnidipin jedine\u010dn\u011b p\u0159id\u00e1v\u00e1 <strong>blok\u00e1du N-typu kan\u00e1l\u016f<\/strong> na sympatick\u00fdch nervov\u00fdch zakon\u010den\u00edch:<\/p>\n<ul>\n<li><strong>Blok\u00e1da L-typu (arteri\u00e1ln\u00ed hladk\u00e1 svalovina)<\/strong> \u2014 standardn\u00ed vazodilatace; sn\u00ed\u017een\u00ed afterloadu; pokles TK o 10-15 mmHg<\/li>\n<li><strong>Blok\u00e1da N-typ\u016f (presynaptick\u00e9 sympatick\u00e9 termin\u00e1ly)<\/strong> \u2014 sn\u00ed\u017een\u00e9 uvol\u0148ov\u00e1n\u00ed noradrenalinu; potla\u010duje reflexn\u00ed tachykardii, kter\u00e1 norm\u00e1ln\u011b n\u00e1sleduje po arteri\u00e1ln\u00ed vazodilataci<\/li>\n<li><strong>Ni\u017e\u0161\u00ed v\u00fdskyt otok\u016f kotn\u00edk\u016f<\/strong> \u2014 blok\u00e1da L-typ\u016f dilatuje prekapil\u00e1rn\u00ed arterioly; \u00fa\u010dinek blok\u00e1dy N-typ\u016f na postkapil\u00e1rn\u00ed tonus je vyv\u00e1\u017een\u011bj\u0161\u00ed, co\u017e zp\u016fsobuje men\u0161\u00ed vzestup kapil\u00e1rn\u00edho hydrostatick\u00e9ho tlaku a m\u00e9n\u011b perifern\u00edch otok\u016f ne\u017e u \u010dist\u00fdch L-typ\u016f blok\u00e1tor\u016f kalciov\u00fdch kan\u00e1l\u016f<\/li>\n<li><strong>Sn\u00ed\u017een\u00ed proteinurie<\/strong> \u2014 sn\u00ed\u017een\u00fd ren\u00e1ln\u00ed sympatick\u00fd tonus dilatuje eferentn\u00ed i aferentn\u00ed arterioly, \u010d\u00edm\u017e sni\u017euje glomerul\u00e1rn\u00ed hyperfiltraci; studie u proteinurick\u00e9 CKD prok\u00e1zaly v\u011bt\u0161\u00ed sn\u00ed\u017een\u00ed proteinurie ve srovn\u00e1n\u00ed s amlodipinem p\u0159i stejn\u00e9 hladin\u011b TK<\/li>\n<li><strong>Dlouh\u00fd polo\u010das<\/strong> \u2014 6-8 hodin (jednou denn\u011b pod\u00e1v\u00e1n\u00ed v ust\u00e1len\u00e9m stavu)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u016fkazy pro Cilnidipin<\/h2>\n<ul>\n<li><strong>CARTER (2007) \u2014 cilnidipin vs amlodipin u proteinurick\u00e9 hypertenzn\u00ed CKD:<\/strong> cilnidipin vyk\u00e1zal v\u011bt\u0161\u00ed sn\u00ed\u017een\u00ed proteinurie p\u0159i srovnateln\u00e9 kontrole TK; trajektorie kreatininu podobn\u00e1.<\/li>\n<li><strong>P\u0159\u00edm\u00e1 p\u0159\u00edm\u00e1 srovn\u00e1n\u00ed s amlodipinem<\/strong> ukazuj\u00ed srovnatelnou \u00fa\u010dinnost na TK, ale p\u0159ibli\u017en\u011b o 50 % ni\u017e\u0161\u00ed v\u00fdskyt otok\u016f kotn\u00edk\u016f u cilnidipinu.<\/li>\n<li><strong>ACTION-HKD (2014)<\/strong> \u2014 roz\u0161\u00ed\u0159en\u00e1 data o renoprotekci u pacient\u016f s CKD.<\/li>\n<li><strong>Indick\u00e1 re\u00e1ln\u00e1 data<\/strong> \u2014 \u0161iroce pou\u017e\u00edv\u00e1n jako alternativa k amlodipinu tam, kde otoky kotn\u00edk\u016f nebo reflexn\u00ed tachykardie limituj\u00ed amlodipin.<\/li>\n<\/ul>\n<p>Cilnidipin nen\u00ed <strong>zahrnut v z\u00e1padn\u00edch doporu\u010den\u00edch jako l\u00e9k prvn\u00ed volby<\/strong> pro hypertenzi \u2014 \u010d\u00e1ste\u010dn\u011b proto, \u017ee amlodipin m\u00e1 mnohem v\u011bt\u0161\u00ed datab\u00e1zi v\u00fdsledkov\u00fdch studi\u00ed (ASCOT, ACCOMPLISH, VALUE), \u010d\u00e1ste\u010dn\u011b proto, \u017ee cilnidipin nebyl uv\u00e1d\u011bn na trh v USA ani ve v\u011bt\u0161in\u011b Evropy.<\/p>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed<\/h2>\n<p><strong>Hypertenze:<\/strong> za\u010d\u00edt s 5-10 mg jednou denn\u011b; titrovat na 10-20 mg jednou denn\u011b za 2-4 t\u00fddny.<\/p>\n<p><strong>Pod\u00e1v\u00e1n\u00ed:<\/strong> s j\u00eddlem nebo bez; ve stejnou denn\u00ed dobu; polykat cel\u00e9.<\/p>\n<p><strong>Monitorov\u00e1n\u00ed:<\/strong> TK po 2 a 4 t\u00fddnech; pot\u00e9 ka\u017ed\u00e9 3-6 m\u011bs\u00edc\u016f. Jatern\u00ed testy na za\u010d\u00e1tku a periodicky (cilnidipin je metabolizov\u00e1n j\u00e1try). Kontrolovat otoky kotn\u00edk\u016f p\u0159i p\u0159ehledu.<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>\u010cast\u00e9:<\/strong><\/p>\n<ul>\n<li>Bolest hlavy, n\u00e1valy horka<\/li>\n<li>Z\u00e1vrat\u011b<\/li>\n<li>Otok kotn\u00edk\u016f (m\u00e9n\u011b \u010dast\u00fd ne\u017e u amlodipinu \u2013 p\u0159ibli\u017en\u011b polovi\u010dn\u00ed v\u00fdskyt v p\u0159\u00edm\u00fdch srovn\u00e1vac\u00edch studi\u00edch)<\/li>\n<li>Z\u00e1cpa<\/li>\n<li>M\u00edrn\u00e9 zv\u00fd\u0161en\u00ed transamin\u00e1z<\/li>\n<li>Palpitace (mnohem m\u00e9n\u011b \u010dast\u00e9 ne\u017e u kr\u00e1tkodob\u011b p\u016fsob\u00edc\u00edch DHP)<\/li>\n<\/ul>\n<p><strong>M\u00e9n\u011b \u010dast\u00e9:<\/strong><\/p>\n<ul>\n<li>T\u011b\u017ek\u00e1 hypotenze<\/li>\n<li>Hyperplazie d\u00e1sn\u00ed (vz\u00e1cn\u00fd t\u0159\u00eddn\u00ed \u00fa\u010dinek DHP)<\/li>\n<li>Fotosensitivita<\/li>\n<li>Vyr\u00e1\u017eka<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace<\/h2>\n<ul>\n<li>Kardiogenn\u00ed \u0161ok<\/li>\n<li>Akutn\u00ed infarkt myokardu s hypotenz\u00ed<\/li>\n<li>T\u011b\u017ek\u00e1 aort\u00e1ln\u00ed sten\u00f3za<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed (Child-Pugh C)<\/li>\n<li>Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na dihydropyridiny<\/li>\n<li>T\u011bhotenstv\u00ed (omezen\u00e9 \u00fadaje; pokud je v t\u011bhotenstv\u00ed nutn\u00fd BKK, preferuj\u00ed se amlodipin nebo nifedipin)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<ul>\n<li><strong>Siln\u00e9 inhibitory CYP3A4<\/strong> (klarithromycin, itrakonazol, ritonavir) \u2013 zvy\u0161uj\u00ed hladinu cilnidipinu; vy\u0161\u0161\u00ed riziko hypotenze.<\/li>\n<li><strong>Grapefruitov\u00e1 \u0161\u0165\u00e1va<\/strong> \u2013 m\u00edrn\u00e1 a\u017e st\u0159edn\u00ed interakce; pravideln\u00e9 denn\u00ed u\u017e\u00edv\u00e1n\u00ed se nedoporu\u010duje.<\/li>\n<li><strong>Jin\u00e1 antihypertenziva<\/strong> \u2013 aditivn\u00ed sn\u00ed\u017een\u00ed TK; z\u00e1m\u011brn\u00e9 p\u0159i kombinovan\u00e9 terapii.<\/li>\n<li><strong>Induktory CYP3A4<\/strong> (rifampicin, fenytoin, t\u0159ezalka te\u010dkovan\u00e1) \u2013 mohou sn\u00ed\u017eit \u00fa\u010dinek cilnidipinu.<\/li>\n<li><strong>Digoxin<\/strong> \u2013 m\u00edrn\u00e9 zv\u00fd\u0161en\u00ed hladiny digoxinu; monitorovat.<\/li>\n<li><strong>Alkohol<\/strong> \u2014 aditivn\u00ed ortostatick\u00e1 hypotenze.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<p>Skladujte Lotensyl p\u0159i teplot\u011b do 25\u00b0C. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">\u010c\u00edm se cilnidipin li\u0161\u00ed od amlodipinu?<\/h3>\n<p>Cilnidipin blokuje jak L-typ (stejn\u011b jako amlodipin), tak N-typ kalciov\u00fdch kan\u00e1l\u016f. Blok\u00e1da N-typu na sympatick\u00fdch nervov\u00fdch zakon\u010den\u00edch sni\u017euje uvol\u0148ov\u00e1n\u00ed noradrenalinu, co\u017e d\u00e1v\u00e1 cilnidipinu dv\u011b praktick\u00e9 v\u00fdhody: (1) ni\u017e\u0161\u00ed v\u00fdskyt otok\u016f kotn\u00edk\u016f (p\u0159ibli\u017en\u011b polovi\u010dn\u00ed oproti amlodipinu v p\u0159\u00edm\u00fdch srovn\u00e1vac\u00edch studi\u00edch); (2) absence reflexn\u00ed tachykardie. Amlodipin v\u0161ak m\u00e1 mnohem v\u00edce d\u016fkaz\u016f o kardiovaskul\u00e1rn\u00edch v\u00fdsledc\u00edch (ASCOT, ACCOMPLISH, VALUE) a je preferovan\u00fdm DHP tam, kde jsou rozhoduj\u00edc\u00ed data o v\u00fdsledc\u00edch.<\/p>\n<h3 class=\"wp-block-heading\">Kdy je Lotensyl lep\u0161\u00ed volbou ne\u017e amlodipin?<\/h3>\n<p>Dv\u011b b\u011b\u017en\u00e9 klinick\u00e9 situace: (1) obt\u011b\u017euj\u00edc\u00ed otoky kotn\u00edk\u016f p\u0159i u\u017e\u00edv\u00e1n\u00ed amlodipinu, kter\u00e9 nereaguj\u00ed na p\u0159id\u00e1n\u00ed ACE inhibitoru\/ARB; (2) proteinurick\u00e1 chronick\u00e1 onemocn\u011bn\u00ed ledvin, kde mechanismus N-typu m\u016f\u017ee poskytnout dodate\u010dnou renoprotekci (studie CARTER).<\/p>\n<h3 class=\"wp-block-heading\">Zp\u016fsobuje Lotensyl otoky kotn\u00edk\u016f?<\/h3>\n<p>M\u00e9n\u011b ne\u017e amlodipin, ale ne nikdy. P\u0159ibli\u017en\u011b polovi\u010dn\u00ed v\u00fdskyt v p\u0159\u00edm\u00fdch srovn\u00e1vac\u00edch studi\u00edch. P\u0159id\u00e1n\u00ed ACE inhibitoru nebo ARB d\u00e1le sni\u017euje zb\u00fdvaj\u00edc\u00ed otoky prost\u0159ednictv\u00edm venodilatace, kter\u00e1 vyrovn\u00e1v\u00e1 kapil\u00e1rn\u00ed tlak.<\/p>\n<h3 class=\"wp-block-heading\">Mohu u\u017e\u00edvat Lotensyl v t\u011bhotenstv\u00ed?<\/h3>\n<p>Vyhn\u011bte se - \u00fadaje o u\u017e\u00edv\u00e1n\u00ed v t\u011bhotenstv\u00ed jsou omezen\u00e9. Pokud je v t\u011bhotenstv\u00ed nutn\u00fd blok\u00e1tor kalciov\u00fdch kan\u00e1l\u016f, nifedipin je preferovan\u00fd DHP (nejv\u011bt\u0161\u00ed datab\u00e1ze bezpe\u010dnosti).<\/p>\n<h3 class=\"wp-block-heading\">Kde lze koupit Lotensyl online?<\/h3>\n<p>Lotensyl (cilnidipin 10 \/ 20 mg, 30-90 tablet) m\u016f\u017eete zakoupit na MedsBase s diskr\u00e9tn\u00edm balen\u00edm a celosv\u011btovou dopravou.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed kardiologick\u00e1 a hypertenzn\u00ed l\u00e9\u010diva<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/amlopres-at\/\">Amlopres AT \u2014 Kombinace amlodipinu a atenololu<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/atorvatin\/\">Atorvatin \u2014 Atorvastatin 5 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/cardace\/\">Cardace \u2014 Ramipril (ACE inhibitor)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/eptus\/\">Eptus \u2014 Eplerenon 25\/50 mg (selektivn\u00ed antagonista MR)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tenoric\/\">Tenoric \u2014 kombinace atenololu a chlortalidonu<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zivast-am\/\">Zivast AM \u2014 kombinace atorvastatinu a amlodipinu<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/high-blood-pressure-medication\/\"><strong>Prohl\u00e9dnout v\u0161echny l\u00e9ky na vysok\u00fd krevn\u00ed tlak<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed.<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro informa\u010dn\u00ed \u00fa\u010dely a nenahrazuje l\u00e9ka\u0159skou p\u00e9\u010di kvalifikovan\u00e9ho zdravotnick\u00e9ho pracovn\u00edka. Hypertenze, srde\u010dn\u00ed selh\u00e1n\u00ed a arytmie vy\u017eaduj\u00ed diagn\u00f3zu, monitorov\u00e1n\u00ed a individu\u00e1ln\u00ed d\u00e1vkov\u00e1n\u00ed l\u00e9ka\u0159em \u2014 v\u017edy u\u017e\u00edvejte betablok\u00e1tory pod l\u00e9ka\u0159sk\u00fdm dohledem.<\/div>","protected":false},"excerpt":{"rendered":"<p>Lotensyl jsou tablety cilnidipinu 10\/20 mg od spole\u010dnosti Lupin \u2014 \u010dtvrt\u00e1 generace dihydropyridinov\u00fdch blok\u00e1tor\u016f kalciov\u00fdch kan\u00e1l\u016f, kter\u00e9 jedine\u010dn\u011b blokuj\u00ed JAK L-typ (vazodilatace), tak N-typ (sympatick\u00e9 nervov\u00e9 zakon\u010den\u00ed) kalciov\u00fdch kan\u00e1l\u016f. Popul\u00e1rn\u00ed v Indii, Japonsku a \u010d\u00e1stech v\u00fdchodn\u00ed Asie. V\u00fdhody oproti amlodipinu: ~50% ni\u017e\u0161\u00ed v\u00fdskyt otok\u016f kotn\u00edk\u016f ve srovn\u00e1vac\u00edch studi\u00edch, \u017e\u00e1dn\u00e1 reflexn\u00ed tachykardie, m\u00edrn\u011b lep\u0161\u00ed sn\u00ed\u017een\u00ed proteinurie u chronick\u00e9ho onemocn\u011bn\u00ed ledvin (studie CARTER). Zat\u00edm nem\u00e1 tak rozs\u00e1hlou z\u00e1kladnu studi\u00ed kardiovaskul\u00e1rn\u00edch v\u00fdsledk\u016f jako amlodipin.<\/p>","protected":false},"featured_media":51867,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260,3356],"product_tag":[3423,3424],"class_list":{"0":"post-51866","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_cat-high-blood-pressure-medication","10":"product_tag-lercanidipine","11":"product_tag-lotensyl","13":"first","14":"outofstock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/51866","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=51866"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/51867"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=51866"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=51866"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=51866"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=51866"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}