{"id":52069,"date":"2023-09-20T09:28:27","date_gmt":"2023-09-20T09:28:27","guid":{"rendered":"https:\/\/medsname.com\/cetislim\/"},"modified":"2026-04-30T10:25:17","modified_gmt":"2026-04-30T10:25:17","slug":"cetislim","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/cetislim\/","title":{"rendered":"Cetislim"},"content":{"rendered":"
\n

Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Cetislim<\/strong> obsahuje cetilistat<\/strong>, inhibitor pankreatick\u00e9 lip\u00e1zy ze skupiny benzoxazin\u016f se stejn\u00fdm mechanismem \u00fa\u010dinku jako orlistat, ale strukturn\u011b odli\u0161n\u00e1 molekula. Schv\u00e1leno v Indii a Japonsku<\/strong> (nikoliv v USA\/EU) pro l\u00e9\u010dbu obezity u dosp\u011bl\u00fdch; standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9 je 120 mg t\u0159ikr\u00e1t denn\u011b s hlavn\u00edmi j\u00eddly. Cetilistat m\u00e1 oproti orlistatu klinickou v\u00fdhodu v ni\u017e\u0161\u00ed v\u00fdskyt olejovit\u00fdch stolicov\u00fdch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f<\/strong> v p\u0159\u00edm\u00fdch srovn\u00e1vac\u00edch studi\u00edch p\u0159i stejn\u00e9 inhibici lip\u00e1zy. Skladem v d\u00e1vce 60 mg.<\/p>\n<\/div>\n

\n\u2705 WHO-GMP certifikov\u00e1no<\/strong> v\u00fdrobce (Akumentis Healthcare)<\/span>
\n\ud83d\udce6 Diskr\u00e9tn\u00ed balen\u00ed<\/span>
\n\ud83c\udf0d Celosv\u011btov\u00e1 doprava<\/span>
\n\ud83d\udc65 D\u016fv\u011b\u0159uje n\u00e1m 1 400+ z\u00e1kazn\u00edk\u016f \u2014 \u010d\u00edst recenze<\/a><\/span>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

MedsBase z\u00edsk\u00e1v\u00e1 Cetislim<\/strong> p\u0159\u00edmo od Akumentis Healthcare, v\u00fdrobce farmaceutik certifikovan\u00e9ho WHO-GMP. Cetilistat je schv\u00e1len indick\u00fdm CDSCO a japonsk\u00fdm PMDA \u2014 v sou\u010dasnosti nen\u00ed schv\u00e1len FDA ani EMA, ale plat\u00ed indick\u00e9 farmakope\u00e1ln\u00ed standardy a molekula je na asijsk\u00e9m trhu od roku 2013. Diskr\u00e9tn\u00ed balen\u00ed, r\u016fzn\u00e9 mo\u017enosti platby (kryptom\u011bny \/ SEPA \/ kreditn\u00ed karta) a na\u0161e 20denn\u00ed z\u00e1ruka op\u011btovn\u00e9 dod\u00e1vky.<\/p>\n

Jak Cetislim funguje<\/h3>\n

Cetilistat je kovalentn\u00ed inhibitor \u017ealude\u010dn\u00ed a pankreatick\u00e9 lip\u00e1zy<\/strong>. Stejn\u011b jako orlistat blokuje hydrol\u00fdzu triglycerid\u016f ve st\u0159evn\u00edm lumen, tak\u017ee dietn\u00ed tuk nen\u00ed rozlo\u017een na voln\u00e9 mastn\u00e9 kyseliny a monoacylglyceroly a nem\u016f\u017ee b\u00fdt vst\u0159eb\u00e1n. P\u0159ibli\u017en\u011b 30% dietn\u00edho tuku<\/strong> je vylou\u010deno stolic\u00ed. Syst\u00e9mov\u00e1 absorpce je < 1% \u2014 \u00fa\u010dinek je zcela lumin\u00e1ln\u00ed, co\u017e je d\u016fvod, pro\u010d maj\u00ed jak orlistat, tak cetilistat relativn\u011b p\u0159\u00edzniv\u00fd bezpe\u010dnostn\u00ed profil ve srovn\u00e1n\u00ed s centr\u00e1ln\u011b p\u016fsob\u00edc\u00edmi l\u00e9ky na hubnut\u00ed.<\/p>\n

Farmakologick\u00fd argument pro cetilistat oproti orlistatu spo\u010d\u00edv\u00e1 v region\u00e1ln\u00ed selektivit\u011b vazby<\/strong>: cetilistat se v\u00e1\u017ee s m\u00edrn\u011b odli\u0161nou kinetikou, kter\u00e1 v p\u0159\u00edm\u00fdch studi\u00edch financovan\u00fdch Alizyme\/Norgine a v indick\u00e9 postmarketingov\u00e9 studii z roku 2014 vedla k men\u0161\u00edmu v\u00fdskytu olejovit\u00e9 stolice \/ urgentn\u00edmu nutk\u00e1n\u00ed na stolici<\/strong> p\u0159i stejn\u00fdch c\u00edlov\u00fdch hodnot\u00e1ch \u00fabytku hmotnosti. Celkov\u00e1 \u00fa\u010dinnost je zhruba srovnateln\u00e1 s orlistatem 120 mg TID.<\/p>\n

Indikace a schv\u00e1len\u00ed<\/h3>\n
    \n
  • Indie (CDSCO 2013):<\/strong> obezita u dosp\u011bl\u00fdch s BMI \u2265 30 nebo \u2265 27 s komorbiditou, jako dopln\u011bk ke zm\u011bn\u011b \u017eivotn\u00edho stylu.<\/li>\n
  • Japonsko (PMDA 2013):<\/strong> schv\u00e1leno pro obezitu s diabetem mellitem 2. typu, dyslipid\u00e9mi\u00ed nebo hypertenz\u00ed.<\/li>\n
  • USA \/ EU \/ UK:<\/strong> v sou\u010dasn\u00e9 dob\u011b neschv\u00e1leno \u2013 f\u00e1ze III v\u00fdvoje pozastavena po ne\u00fasp\u011bchu spole\u010dnosti Alizyme v roce 2008; n\u011bkter\u00e9 formulace pokro\u010dily pod r\u016fzn\u00fdmi sponzory, ale k roku 2026 nebylo ud\u011bleno \u017e\u00e1dn\u00e9 povolen\u00ed k uveden\u00ed na trh.<\/li>\n<\/ul>\n

    Srovn\u00e1vac\u00ed kl\u00ed\u010dov\u00e9 studie v japonsk\u00e9 (Kopelman 2010, Obezita<\/em>) a indick\u00e9 (Bansal 2014, Indian J Pharmacol<\/em>) kohort\u011b prok\u00e1zaly pr\u016fm\u011brnou ztr\u00e1tu hmotnosti 3,85\u20134,32 kg za 24 t\u00fddn\u016f<\/strong> p\u0159i u\u017e\u00edv\u00e1n\u00ed cetilistatu 120 mg TID ve srovn\u00e1n\u00ed s 1,86 kg u placeba, co\u017e je zhruba ekvivalentn\u00ed orlistatu 120 mg TID. Hlavn\u00edm rozd\u00edlem cetilistatu je ni\u017e\u0161\u00ed v\u00fdskyt mastn\u00fdch stolic.<\/p>\n

    D\u00e1vkov\u00e1n\u00ed<\/h3>\n\n\n\n\n\n\n\n\n
    Indikace<\/th>\nD\u00e1vkov\u00e1n\u00ed Cetislim<\/th>\nKdy<\/th>\n<\/tr>\n<\/thead>\n
    D\u00e1vka pro dosp\u011bl\u00e9 schv\u00e1len\u00e1 CDSCO\/PMDA<\/td>\n120 mg peror\u00e1ln\u011b t\u0159ikr\u00e1t denn\u011b<\/td>\nS j\u00eddlem nebo do 1 hodiny po hlavn\u00edm j\u00eddle obsahuj\u00edc\u00edm tuk<\/td>\n<\/tr>\n
    Ni\u017e\u0161\u00ed s\u00edla Cetislim 60 mg<\/td>\n60 mg t\u0159ikr\u00e1t denn\u011b (pokud je 60 mg jedin\u00e1 dostupn\u00e1 forma, dv\u011b tablety po 60 mg na d\u00e1vku, aby se dos\u00e1hlo 120 mg t\u0159ikr\u00e1t denn\u011b)<\/td>\nViz v\u00fd\u0161e. Ov\u011b\u0159te s\u00edlu na blistru a v p\u0159\u00edpad\u011b nejistoty se pora\u010fte s l\u00e9ka\u0159em<\/td>\n<\/tr>\n
    Vynechan\u00e9 j\u00eddlo\/j\u00eddlo bez tuku<\/td>\nVynechejte d\u00e1vku<\/td>\n\u017d\u00e1dn\u00fd u\u017eitek, pokud nen\u00ed v potrav\u011b tuk k inhibici<\/td>\n<\/tr>\n
    Multivitamin (povinn\u00fd)<\/td>\nDenn\u00ed d\u00e1vka obsahuj\u00edc\u00ed A, D, E, K<\/td>\nP\u0159ed span\u00edm, s odstupem \u2265 2 hodin od jak\u00e9koli d\u00e1vky cetilistatu<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Standardn\u00ed d\u00e1vka cetilistatu schv\u00e1len\u00e1 CDSCO je 120 mg t\u0159ikr\u00e1t denn\u011b<\/strong>. Pokud v\u00e1\u0161 Cetislim balen\u00ed obsahuje tablety 60 mg, d\u00e1vka jsou dv\u011b tablety t\u0159ikr\u00e1t denn\u011b s hlavn\u00edmi j\u00eddly. Kontrola ve stylu NICE po 12 t\u00fddnech: ukon\u010dete, pokud \u00fabytek hmotnosti < 5%.<\/p>\n

    Vedlej\u0161\u00ed \u00fa\u010dinky<\/h3>\n
      \n
    • \u010cast\u00e9:<\/strong> mastn\u00e1\/olejovit\u00e1 stolice, nutk\u00e1n\u00ed na stolici, bolesti b\u0159icha, plynatost s v\u00fdtokem \u2014 ni\u017e\u0161\u00ed frekvence ne\u017e u orlistatu p\u0159i stejn\u00e9 inhibici lip\u00e1zy (data ze srovn\u00e1vac\u00ed studie).<\/li>\n
    • M\u00e9n\u011b \u010dast\u00e9:<\/strong> nevolnost, bolest hlavy, zv\u00fd\u0161en\u00e9 jatern\u00ed enzymy (p\u0159echodn\u00e9).<\/li>\n
    • Vz\u00e1cn\u00e9:<\/strong> p\u0159ecitliv\u011blost, choleliti\u00e1za, idiosynkratick\u00e1 hepatotoxicita (mechanismus t\u0159\u00eddn\u00edho \u00fa\u010dinku \u2014 viz literatura orlistatu).<\/li>\n
    • Dlouhodob\u011b:<\/strong> sn\u00ed\u017een\u00e1 absorpce vitam\u00edn\u016f rozpustn\u00fdch v tuc\u00edch A, D, E, K \u2014 povinn\u00fd multivitamin p\u0159ed span\u00edm.<\/li>\n<\/ul>\n

      L\u00e9kov\u00e9 interakce a kontraindikace<\/h3>\n

      L\u00e9kov\u00e9 interakce obecn\u011b odpov\u00eddaj\u00ed orlistatu \u2014 sn\u00ed\u017een\u00e1 absorpce levothyroxinu, cyklosporinu, warfarinu (vitamin K), antiepileptik, HIV antiretrovirotik a amiodaronu<\/strong>. Farmakokinetick\u00e1 data o specifick\u00fdch interakc\u00edch cetilistatu jsou m\u00e9n\u011b podrobn\u00e1 ne\u017e u orlistatu; pova\u017eujte seznam interakc\u00ed orlistatu za konzervativn\u00ed pracovn\u00ed soubor.<\/p>\n

      Kontraindikace:<\/strong> t\u011bhotenstv\u00ed a kojen\u00ed, syndrom chronick\u00e9 malabsorpce, cholest\u00e1za, aktivn\u00ed porucha p\u0159\u00edjmu potravy, p\u0159ecitliv\u011blost, t\u011b\u017ek\u00e9 po\u0161kozen\u00ed jater.<\/p>\n

      Skladov\u00e1n\u00ed<\/h3>\n

      Cetislim skladujte p\u0159i teplot\u011b do 25 \u00b0C, v p\u016fvodn\u00edm blistru, mimo dosah vlhkosti a p\u0159\u00edm\u00e9ho slune\u010dn\u00edho sv\u011btla. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/p>\n

      \u010casto kladen\u00e9 dotazy<\/h2>\n

      Pro\u010d nen\u00ed cetilistat schv\u00e1len v USA nebo EU?<\/h3>\n

      Cetilistat pro\u0161el klinick\u00fdmi studiemi f\u00e1ze III v roce 2008 pod spole\u010dnost\u00ed Alizyme, ale p\u016fvodn\u00ed sponsor narazil na komer\u010dn\u00ed obt\u00ed\u017ee p\u0159ed z\u00edsk\u00e1n\u00edm marketingov\u00e9 autorizace. Indick\u00fd (CDSCO 2013) a japonsk\u00fd (PMDA 2013) regul\u00e1to\u0159i schv\u00e1lili molekulu na z\u00e1klad\u011b region\u00e1ln\u00edch dat f\u00e1ze III. K roku 2026 nen\u00ed schv\u00e1len\u00ed FDA ani EMA, p\u0159i\u010dem\u017e molekula z\u016fst\u00e1v\u00e1 v aktivn\u00edm komer\u010dn\u00edm pou\u017eit\u00ed v Indii a Japonsku s prok\u00e1zan\u00fdmi postmarketingov\u00fdmi daty. Pova\u017eujte cetilistat za region\u00e1ln\u011b specifick\u00fd ekvivalent orlistatu \u2013 mechanismus \u00fa\u010dinku je stejn\u00fd.<\/p>\n

      Je Cetislim \u00fa\u010dinn\u011bj\u0161\u00ed ne\u017e orlistat?<\/h3>\n

      \u010cist\u00e1 ztr\u00e1ta hmotnosti ve srovn\u00e1vac\u00edch studi\u00edch je p\u0159ibli\u017en\u011b srovnateln\u00e1<\/strong> \u2013 cetilistat 120 mg TID a orlistat 120 mg TID vykazuj\u00ed podobn\u00fd \u00fabytek hmotnosti za 12\u201324 t\u00fddn\u016f u ob\u00e9zn\u00edch dosp\u011bl\u00fdch. Rozd\u00edl cetilistatu spo\u010d\u00edv\u00e1 v sn\u00e1\u0161enlivosti, nikoli \u00fa\u010dinnosti<\/strong>: ni\u017e\u0161\u00ed v\u00fdskyt mastn\u00e9 stolice a nutk\u00e1n\u00ed na stolici p\u0159i stejn\u00e9 d\u00e1vce.<\/p>\n

      Mohu p\u0159ej\u00edt z orlistatu na cetilistat?<\/h3>\n

      Ano \u2014 mechanismy \u00fa\u010dinku jsou farmakologicky ekvivalentn\u00ed, tak\u017ee p\u0159echod je rozumn\u00fd, pokud jsou ne\u017e\u00e1douc\u00ed \u00fa\u010dinky orlistatu nesnesiteln\u00e9. P\u0159esta\u0148te u\u017e\u00edvat orlistat a za\u010dn\u011bte s cetilistatem p\u0159i dal\u0161\u00edm hlavn\u00edm j\u00eddle \u2014 nen\u00ed t\u0159eba vynech\u00e1vat \u017e\u00e1dnou pauzu, proto\u017ee oba l\u00e9ky p\u016fsob\u00ed lok\u00e1ln\u011b ve st\u0159ev\u011b.<\/p>\n

      Mus\u00edm i nad\u00e1le dodr\u017eovat n\u00edzkotu\u010dnou dietu?<\/h3>\n

      Ano. Cetilistat funguje stejn\u00fdm zp\u016fsobem jako orlistat \u2014 m\u00e9n\u011b ne\u017e 30 % energie z tuk\u016f v ka\u017ed\u00e9m hlavn\u00edm j\u00eddle je standardn\u00ed doporu\u010den\u00ed. Konzumace tu\u010dn\u00e9ho j\u00eddla st\u00e1le zp\u016fsob\u00ed v\u00fdrazn\u00fd n\u00e1r\u016fst ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f (v\u00fdhoda cetilistatu v toleranci je p\u0159i st\u0159edn\u00edm p\u0159\u00edjmu tuk\u016f, ne p\u0159i neomezen\u00e9m p\u0159\u00edjmu).<\/p>\n

      Pot\u0159ebuji s cetilistatem multivitamin?<\/h3>\n

      Ano \u2014 stejn\u00e9 pravidlo jako u orlistatu. U\u017e\u00edvejte denn\u011b multivitamin obsahuj\u00edc\u00ed vitam\u00edny A, D, E, K rozpustn\u00e9 v tuc\u00edch p\u0159ed span\u00edm, s odstupem alespo\u0148 2 hodin od jak\u00e9koli d\u00e1vky cetilistatu.<\/p>\n

      Mohu u\u017e\u00edvat cetilistat s l\u00e9ky na diabetes?<\/h3>\n

      Ano. Cetilistat je v Japonsku schv\u00e1len speci\u00e1ln\u011b pro obezitu spojenou s diabetem 2. typu. Jak budete hubnout, va\u0161e inzulinov\u00e1 senzitivita se zlep\u0161\u00ed a d\u00e1vky metforminu, sulfonylurey, SGLT-2 inhibitor\u016f, GLP-1 agonist\u016f a inzulinu m\u016f\u017ee b\u00fdt t\u0159eba sn\u00ed\u017eit. Prvn\u00ed m\u011bs\u00edc sledujte dom\u00e1c\u00ed glyk\u00e9mii t\u00fddn\u011b.<\/p>\n

      Je cetilistat bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed nebo p\u0159i kojen\u00ed?<\/h3>\n

      Ne \u2014 t\u011bhotenstv\u00ed a kojen\u00ed jsou kontraindikace. Mechanismus malabsorpce tuk\u016f rozpustn\u00fdch vitam\u00edn\u016f vytv\u00e1\u0159\u00ed stejn\u00e9 teoretick\u00e9 riziko pro plod\/kojence jako orlistat. P\u0159esta\u0148te u\u017e\u00edvat Cetislim, jakmile je podez\u0159en\u00ed na t\u011bhotenstv\u00ed.<\/p>\n

      Co kdy\u017e cetilistat u m\u011b nezab\u00edr\u00e1?<\/h3>\n

      Hodnocen\u00ed po 12 t\u00fddnech podle standard\u016f NICE \u2014 pokud je \u00fabytek hmotnosti < 5 % v\u00fdchoz\u00ed v\u00e1hy i p\u0159es d\u016fsledn\u00e9 u\u017e\u00edv\u00e1n\u00ed a zm\u011bnu \u017eivotn\u00edho stylu, p\u0159eru\u0161te l\u00e9\u010dbu a zva\u017ete alternativy. V\u00fdrazn\u011bj\u0161\u00ed \u00fabytek hmotnosti obvykle vy\u017eaduje agonisty GLP-1 receptor\u016f (semaglutid, liraglutid, tirzepatid) nebo, u t\u011b\u017ek\u00e9 obezity, bariatrickou operaci.<\/p>\n

      Jsou mastn\u00e9 stolice zn\u00e1mkou toho, \u017ee cetilistat funguje?<\/h3>\n

      Ano \u2014 neabsorbovan\u00fd tuk proch\u00e1zej\u00edc\u00ed st\u0159evem je p\u0159\u00edm\u00fdm d\u016fkazem inhibice lip\u00e1zy. Intenzita je z\u00e1visl\u00e1 na d\u00e1vce a obsahu tuku ve strav\u011b. M\u00edrn\u00e9 p\u0159\u00edznaky po norm\u00e1ln\u00edm j\u00eddle znamenaj\u00ed, \u017ee l\u00e9k funguje na o\u010dek\u00e1van\u00e9 \u00farovni. Siln\u00e9 p\u0159\u00edznaky po ka\u017ed\u00e9m j\u00eddle obvykle znamenaj\u00ed, \u017ee j\u00eddla jsou p\u0159\u00edli\u0161 tu\u010dn\u00e1.<\/p>\n

      Jak se cetilistat srovn\u00e1v\u00e1 s bylinn\u00fdmi dopl\u0148ky na hubnut\u00ed?<\/h3>\n

      Cetilistat m\u00e1 data o \u00fa\u010dinnosti z kl\u00ed\u010dov\u00fdch studi\u00ed f\u00e1ze III a schv\u00e1len\u00ed CDSCO\/PMDA; bylinn\u00e9 dopl\u0148ky (Garcinia cambogia \/ sm\u011bsi HCA, katechiny zelen\u00e9ho \u010daje, konjugovan\u00e1 kyselina linolov\u00e1) obvykle vykazuj\u00ed men\u0161\u00ed \u00fa\u010dinky (\u010dasto statisticky v\u00fdznamn\u00e9, ale klinicky skromn\u00e9 \u2013 m\u00e9n\u011b ne\u017e 1 kg za 12 t\u00fddn\u016f) a slab\u0161\u00ed sledov\u00e1n\u00ed bezpe\u010dnosti. Orlistat a cetilistat jsou dv\u011b l\u00e9\u010diva pro l\u00e9ka\u0159skou kontrolu hmotnosti podlo\u017een\u00e1 d\u016fkazy; bylinn\u00e9 p\u0159\u00edpravky je nejl\u00e9pe ch\u00e1pat jako podporu \u017eivotn\u00edho stylu, nikoli jako prim\u00e1rn\u00ed terapii.<\/p>\n

      Dal\u0161\u00ed l\u00e9ky na hubnut\u00ed<\/h2>\n

      <\/p>\n

        \n<\/ul>\n
        \n

        Zdravotn\u00ed prohl\u00e1\u0161en\u00ed.<\/strong> Informace na t\u00e9to str\u00e1nce jsou ur\u010deny pro vzd\u011bl\u00e1vac\u00ed \u00fa\u010dely a nem\u011bly by nahrazovat individu\u00e1ln\u00ed l\u00e9ka\u0159skou radu. Farmakologick\u00e9 hubnut\u00ed je nej\u00fa\u010dinn\u011bj\u0161\u00ed v kombinaci se strukturovanou zm\u011bnou stravy a fyzickou aktivitou a nen\u00ed vhodn\u00e9 pro ka\u017ed\u00e9ho \u2013 t\u011bhotenstv\u00ed, kojen\u00ed, poruchy p\u0159\u00edjmu potravy, chronick\u00e1 malabsorbce, z\u00e1va\u017en\u00e1 psychiatrick\u00e1 onemocn\u011bn\u00ed a nekontrolovan\u00e9 kardiovaskul\u00e1rn\u00ed onemocn\u011bn\u00ed m\u011bn\u00ed vhodnost jak\u00e9hokoli l\u00e9ku na hubnut\u00ed. Pokud je va\u0161e BMI \u2265 40 (nebo \u2265 35 s v\u00fdznamnou komorbiditou souvisej\u00edc\u00ed s hmotnost\u00ed), proberte s va\u0161\u00edm praktick\u00fdm l\u00e9ka\u0159em mo\u017enost bariatrick\u00e9 operace.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

        Cetislim (cetilistat 60 mg od Akumentis Healthcare) \u2014 nov\u011bj\u0161\u00ed inhibitor pankreatick\u00e9 lip\u00e1zy ze skupiny benzoxazin\u016f se stejn\u00fdm mechanismem \u00fa\u010dinku jako orlistat, ale s ni\u017e\u0161\u00ed m\u00edrou vedlej\u0161\u00edch \u00fa\u010dink\u016f typu mastn\u00e9 stolice v p\u0159\u00edm\u00fdch srovn\u00e1vac\u00edch studi\u00edch. Schv\u00e1leno v Indii\/Japonsku pro obezitu u dosp\u011bl\u00fdch.<\/p>","protected":false},"featured_media":52070,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3445],"product_tag":[3453,3454],"class_list":{"0":"post-52069","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-weight-loss-medication","9":"product_tag-cetilistat","10":"product_tag-cetislim","12":"first","13":"outofstock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/52069","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=52069"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/52070"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=52069"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=52069"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=52069"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=52069"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}