{"id":52192,"date":"2023-09-20T09:30:03","date_gmt":"2023-09-20T09:30:03","guid":{"rendered":"https:\/\/medsname.com\/vesigard\/"},"modified":"2026-04-30T10:25:15","modified_gmt":"2026-04-30T10:25:15","slug":"vesigard","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/vesigard\/","title":{"rendered":"Vesigard"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Vesigard<\/strong> obsahuje darifenacin s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm 7,5 mg \/ 15 mg<\/strong> vyr\u00e1b\u00ed spole\u010dnost Cipla Inc. Pou\u017e\u00edv\u00e1 se p\u0159i p\u0159\u00edznac\u00edch hyperaktivn\u00edho mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e (OAB) \u2014 urgentn\u00ed mo\u010den\u00ed, \u010dast\u00e9 mo\u010den\u00ed a urgentn\u00ed inkontinence. U\u017e\u00edvejte p\u0159esn\u011b podle pokyn\u016f l\u00e9ka\u0159e \u2014 ned\u00e1vkujte si l\u00e9k sami.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

\ud83d\udd12 \u0160ifrovan\u00e9 platby<\/strong> \u00b7 \ud83d\udcb3 Ov\u011b\u0159en\u00fd platebn\u00ed procesor<\/strong> \u00b7 \ud83d\ude9a Doprava do cel\u00e9ho sv\u011bta<\/strong> \u00b7 \u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong><\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Ka\u017ed\u00e1 \u0161ar\u017ee je dod\u00e1v\u00e1na od v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Objedn\u00e1vky jsou odes\u00edl\u00e1ny v neutr\u00e1ln\u00edch obalech od na\u0161ich partnersk\u00fdch distribu\u010dn\u00edch center a jsou chr\u00e1n\u011bny na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>. Slou\u017eili jsme ji\u017e 1 400+ ov\u011b\u0159en\u00fdm z\u00e1kazn\u00edk\u016fm<\/strong> s pr\u016fm\u011brn\u00fdm hodnocen\u00edm 4,9\/5<\/strong> nap\u0159\u00ed\u010d v\u00edce ne\u017e 600 l\u00e9ky.<\/p>\n

Co je Vesigard a jak p\u016fsob\u00ed<\/h2>\n

Vesigard obsahuje darifenacin<\/strong>, selektivn\u00ed antagonista M3 muskarinov\u00fdch receptor\u016f<\/strong>. Detruzor (hladk\u00fd sval mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e) se stahuje p\u0159edev\u0161\u00edm prost\u0159ednictv\u00edm M3 receptor\u016f; jejich blokov\u00e1n\u00ed sni\u017euje mimovoln\u00ed stahy a s nimi spojen\u00e9 urgentn\u00ed p\u0159\u00edznaky a frekvenci mo\u010den\u00ed. Selektivita darifenacinu v\u016f\u010di M3 receptor\u016fm (~10\u00d7 vy\u0161\u0161\u00ed ne\u017e u M1, M2) poskytuje o n\u011bco \u010dist\u0161\u00ed vedlej\u0161\u00ed \u00fa\u010dinek ne\u017e star\u0161\u00ed neselektivn\u00ed antimuskarinika \u2014 ni\u017e\u0161\u00ed riziko kognitivn\u00edch vedlej\u0161\u00edch \u00fa\u010dink\u016f a tachykardie \u2014 sucho v \u00fastech a z\u00e1cpa v\u0161ak p\u0159etrv\u00e1vaj\u00ed, proto\u017ee stejn\u00e9 M3 receptory jsou p\u0159\u00edtomny ve slinn\u00fdch \u017el\u00e1z\u00e1ch a st\u0159evech.<\/p>\n

Vesigard se pou\u017e\u00edv\u00e1 k skupiny p\u0159\u00edznak\u016f spojen\u00fdch s hyperaktivn\u00edm mo\u010dov\u00fdm m\u011bch\u00fd\u0159em (OAB)<\/strong>: urgentn\u00ed mo\u010den\u00ed (n\u00e1hl\u00e1 siln\u00e1 pot\u0159eba mo\u010dit), \u010dast\u00e9 mo\u010den\u00ed (\u2265 8 mikc\u00ed za 24 hodin), nykturie a urgentn\u00ed inkontinence. Nen\u00ed ur\u010den pro stresovou inkontinenci (\u00fanik p\u0159i ka\u0161li\/k\u00fdchnut\u00ed), retenci mo\u010di nebo obstrukci spojenou s BPH.<\/p>\n

D\u00e1vkov\u00e1n\u00ed a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Skupina pacient\u016f<\/th>\nDoporu\u010den\u00e1 d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Dosp\u011bl\u00ed s OAB \u2014 po\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/td>\n7,5 mg jednou denn\u011b<\/strong><\/td>\n<\/tr>\n
Dosp\u011bl\u00ed \u2014 \u00faprava d\u00e1vky po 2 t\u00fddnech v p\u0159\u00edpad\u011b pot\u0159eby<\/td>\nZv\u00fd\u0161it na 15 mg jednou denn\u011b<\/strong><\/td>\n<\/tr>\n
Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed siln\u00e9ho inhibitoru CYP3A4 (ketokonazol, itrakonazol, klarithromycin, ritonavir, nefazodon)<\/td>\nOmezit na 7,5 mg\/den; vyvarujte se d\u00e1vky 15 mg<\/td>\n<\/tr>\n
St\u0159edn\u011b t\u011b\u017ek\u00e9 po\u0161kozen\u00ed jater (Child-Pugh B)<\/td>\nOmezit na 7,5 mg\/den<\/td>\n<\/tr>\n
T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed (Child-Pugh C)<\/td>\nVyhnout se<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

U\u017e\u00edvejte cel\u00e9, s j\u00eddlem nebo bez j\u00eddla, ve stejnou denn\u00ed dobu.<\/strong> Nedr\u0165te, ne\u017ev\u00fdkejte ani nel\u00e1mejte \u2013 modifikovan\u00e1 matrix zaji\u0161\u0165uje 24hodinov\u00e9 uvol\u0148ov\u00e1n\u00ed. Zlep\u0161en\u00ed p\u0159\u00edznak\u016f nast\u00e1v\u00e1 b\u011bhem 1\u20132 t\u00fddn\u016f; pln\u00fd \u00fa\u010dinek za 4\u20136 t\u00fddn\u016f. P\u0159i absenci \u00fa\u010dinku po 8 t\u00fddnech l\u00e9\u010dbu ukon\u010dete a p\u0159ehodno\u0165te.<\/p>\n

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\u26a0 Anticholinergn\u00ed z\u00e1t\u011b\u017e \u2013 zejm\u00e9na u star\u0161\u00edch dosp\u011bl\u00fdch<\/strong><\/p>\n

Darifenacin zvy\u0161uje celkovou anticholinergn\u00ed z\u00e1t\u011b\u017e<\/strong> z jin\u00fdch l\u00e9k\u016f (TCA, sedativn\u00ed antihistaminika, oxybutynin, hyoscin, n\u011bkter\u00e9 l\u00e9ky na Parkinsonovu chorobu). Vysok\u00e1 anticholinergn\u00ed z\u00e1t\u011b\u017e po m\u011bs\u00edce byla spojena s poklesem kognitivn\u00edch funkc\u00ed a zv\u00fd\u0161en\u00fdm rizikem demence<\/strong> u star\u0161\u00edch dosp\u011bl\u00fdch. P\u0159ehodno\u0165te sou\u010dasn\u011b u\u017e\u00edvan\u00e9 l\u00e9ky a pou\u017e\u00edvejte nejni\u017e\u0161\u00ed \u00fa\u010dinnou d\u00e1vku. Mirabegron (beta-3 agonista bez anticholinergn\u00edho \u00fa\u010dinku) je alternativou, pokud je z\u00e1t\u011b\u017e probl\u00e9mem.<\/p>\n<\/div>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Vedlej\u0161\u00ed \u00fa\u010dinek<\/th>\nFrekvence<\/th>\nPozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n
Sucho v \u00fastech<\/strong><\/td>\nVelmi \u010dast\u00e9 (~20%)<\/td>\n\u017dv\u00fdka\u010dky bez cukru, hydratace, pop\u00edjen\u00ed vody; obvykle ustane<\/td>\n<\/tr>\n
Z\u00e1cpa<\/strong><\/td>\nVelmi \u010dast\u00e9 (~15%)<\/td>\nZv\u00fd\u0161it p\u0159\u00edjem vl\u00e1kniny a tekutin; objemov\u00e9 proj\u00edmadlo p\u0159i p\u0159etrv\u00e1v\u00e1n\u00ed<\/td>\n<\/tr>\n
Such\u00e9 o\u010di<\/td>\nB\u011b\u017en\u00e9<\/td>\nZvlh\u010duj\u00edc\u00ed kapky<\/td>\n<\/tr>\n
Nesn\u00e1\u0161enlivost \u017ealudku \/ nevolnost<\/td>\nB\u011b\u017en\u00e9<\/td>\nU\u017e\u00edvejte s j\u00eddlem<\/td>\n<\/tr>\n
Rozmazan\u00e9 vid\u011bn\u00ed<\/td>\nB\u011b\u017en\u00e9<\/td>\nVyhnout se \u0159\u00edzen\u00ed, dokud si nezvyknete<\/td>\n<\/tr>\n
Zadr\u017eov\u00e1n\u00ed mo\u010di<\/td>\nM\u00e9n\u011b \u010dast\u00e9<\/td>\nP\u0159eru\u0161it a konzultovat \u2014 riziko p\u0159i BPH<\/td>\n<\/tr>\n
Tachykardie<\/td>\nM\u00e9n\u011b \u010dast\u00e9<\/td>\nNi\u017e\u0161\u00ed ne\u017e u neselektivn\u00edch l\u00e1tek<\/td>\n<\/tr>\n
Kognitivn\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky (pam\u011b\u0165, zmatenost)<\/td>\nM\u00e9n\u011b \u010dast\u00e9<\/td>\nVy\u0161\u0161\u00ed riziko u star\u0161\u00edch dosp\u011bl\u00fdch<\/td>\n<\/tr>\n
Akutn\u00ed glaukom s uzav\u0159en\u00fdm \u00fahlem<\/td>\nVz\u00e1cn\u00e9<\/td>\nBolest o\u010d\u00ed \u2192 urgentn\u00ed oftalmologick\u00e9 vy\u0161et\u0159en\u00ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Interakce l\u00e9k\u016f<\/h2>\n\n\n\n\n\n\n\n\n\n
Kombinace<\/th>\n\u00da\u010dinek<\/th>\n\u00da\u010dinek<\/th>\n<\/tr>\n<\/thead>\n
Siln\u00e9 inhibitory CYP3A4 (ketokonazol, itrakonazol, ritonavir, klarithromycin)<\/td>\nV\u00fdrazn\u00e9 zv\u00fd\u0161en\u00ed hladin darifenacinu<\/td>\nMaxim\u00e1ln\u00ed d\u00e1vka 7,5 mg; vyvarovat se 15 mg<\/td>\n<\/tr>\n
Siln\u00e9 induktory CYP3A4 (rifampicin, fenytoin, karbamazepin)<\/td>\nZtr\u00e1ta \u00fa\u010dinku<\/td>\nP\u0159echod na alternativu nez\u00e1vislou na CYP3A4<\/td>\n<\/tr>\n
Jin\u00e9 anticholinergika (oxybutynin, TCA, sedativn\u00ed antihistaminika, hyoscin)<\/td>\nKumulativn\u00ed sucho v \u00fastech, z\u00e1cpa, kognitivn\u00ed poruchy<\/td>\nSni\u017ete z\u00e1t\u011b\u017e tam, kde je to mo\u017en\u00e9<\/td>\n<\/tr>\n
Substr\u00e1ty CYP2D6 s \u00fazk\u00fdm terapeutick\u00fdm rozmez\u00edm (flekainid, imipramin)<\/td>\nHladiny mohou stoupat v d\u016fsledku inhibice CYP2D6<\/td>\nMonitorujte \/ upravte d\u00e1vkov\u00e1n\u00ed<\/td>\n<\/tr>\n
Digoxin<\/td>\nM\u00edrn\u00e9 zv\u00fd\u0161en\u00ed hladin digoxinu<\/td>\nRutinn\u00ed monitorov\u00e1n\u00ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Kdo by nem\u011bl u\u017e\u00edvat Vesigard<\/h2>\n