{"id":52251,"date":"2023-09-20T09:31:01","date_gmt":"2023-09-20T09:31:01","guid":{"rendered":"https:\/\/medsname.com\/hepcinat-lp\/"},"modified":"2026-05-01T10:49:12","modified_gmt":"2026-05-01T10:49:12","slug":"hepcinat-lp","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/hepcinat-lp\/","title":{"rendered":"Hepcinat LP"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:16px 20px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin-top:0;\">Rychl\u00e1 odpov\u011b\u010f \u2014 Hepcinat LP (Sofosbuvir 400 mg + Ledipasvir 90 mg)<\/h3>\n<ul>\n<li><strong>Aktivn\u00ed slo\u017eky:<\/strong> sofosbuvir 400 mg + ledipasvir 90 mg, tableta s pevnou d\u00e1vkou, u\u017e\u00edvan\u00e1 jednou denn\u011b.<\/li>\n<li><strong>Indikace:<\/strong> chronick\u00e1 infekce virem hepatitidy C (HCV), genotypy 1, 4, 5 a 6 u dosp\u011bl\u00fdch \u2014 generikum p\u0159\u00edpravku Harvoni (Gilead).<\/li>\n<li><strong>Mechanismus \u00fa\u010dinku:<\/strong> sofosbuvir je inhibitorem nukleotidov\u00e9 polymer\u00e1zy NS5B; ledipasvir je inhibitorem NS5A. Kombinace sou\u010dasn\u011b c\u00edl\u00ed na dva esenci\u00e1ln\u00ed proteiny HCV.<\/li>\n<li><strong>\u00dasp\u011b\u0161nost l\u00e9\u010dby:<\/strong> 94\u201399% setrval\u00e9 virologick\u00e9 odpov\u011bdi (SVR12) u v\u011bt\u0161iny re\u017eim\u016f \u2014 funk\u010dn\u00ed vyl\u00e9\u010den\u00ed HCV za 12 t\u00fddn\u016f u pacient\u016f bez p\u0159edchoz\u00ed l\u00e9\u010dby a bez cirh\u00f3zy.<\/li>\n<li><strong>L\u00e9\u010dba je kurativn\u00ed<\/strong>, nikoli chronick\u00e1 suprese. Jakmile je dosa\u017eeno SVR12 (HCV RNA nedetekovateln\u00e1 12 t\u00fddn\u016f po l\u00e9\u010db\u011b), je HCV eradikov\u00e1no a tablety se vysazuj\u00ed.<\/li>\n<li><strong>U\u017e\u00edvejte s opatrnost\u00ed spolu s:<\/strong> amiodaronem (riziko bradykardie \u2014 obvykle kontraindikov\u00e1no), siln\u00fdmi induktory CYP\/P-gp (rifampicin, t\u0159ezalka te\u010dkovan\u00e1, antikonvulziva \u2014 sni\u017euj\u00ed expozici DAA) a l\u00e9ky sni\u017euj\u00edc\u00edmi kyselost (PPI \u2014 sni\u017euj\u00ed absorpci ledipasviru; pokud mo\u017eno odd\u011blte pod\u00e1n\u00ed o &gt;= 12 hodin).<\/li>\n<\/ul>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2>Co je Hepcinat LP?<\/h2>\n<p>Hepcinat LP je tableta s pevnou d\u00e1vkou obsahuj\u00edc\u00ed <strong>Ledipasvir 90 mg<\/strong> a <strong>Sofosbuvir 400 mg<\/strong>, vyr\u00e1b\u011bn\u00fd spole\u010dnost\u00ed Natco Pharma \u2014 jedn\u00edm z nejv\u011bt\u0161\u00edch specializovan\u00fdch farmaceutick\u00fdch podnik\u016f v Indii. Jde o p\u0159\u00edmo p\u016fsob\u00edc\u00ed antivirotikum (DAA) pro l\u00e9\u010dbu <strong>chronick\u00e9 infekce virem hepatitidy C (HCV)<\/strong> s m\u00edrou vyl\u00e9\u010den\u00ed p\u0159esahuj\u00edc\u00ed 95 % u v\u011bt\u0161iny pacient\u016f.<\/p>\n<p>Hepcinat LP je generick\u00fdm ekvivalentem p\u0159\u00edpravku <strong>Harvoni<\/strong> (Gilead Sciences), kter\u00fd revolu\u010dn\u011b zm\u011bnil l\u00e9\u010dbu hepatitidy C po sv\u00e9m uveden\u00ed na trh v roce 2014 za cenu 94 500 USD za l\u00e9\u010debn\u00fd cyklus v USA. Hepcinat LP poskytuje stejn\u00e9 klinick\u00e9 v\u00fdsledky za zlomek ceny, \u010d\u00edm\u017e zp\u0159\u00edstup\u0148uje l\u00e9\u010dbu hepatitidy C pacient\u016fm po cel\u00e9m sv\u011bt\u011b.<\/p>\n<h2>Co l\u00e9\u010d\u00ed Hepcinat LP?<\/h2>\n<p>Hepcinat LP je schv\u00e1len k l\u00e9\u010db\u011b chronick\u00e9 hepatitidy C u dosp\u011bl\u00fdch s n\u00e1sleduj\u00edc\u00edmi genotypy:<\/p>\n<table>\n<thead>\n<tr>\n<th>Genotyp HCV<\/th>\n<th>D\u00e9lka l\u00e9\u010dby<\/th>\n<th>\u00dasp\u011b\u0161nost l\u00e9\u010dby (SVR12)<\/th>\n<th>Pozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Genotyp 1<\/strong><\/td>\n<td>12 t\u00fddn\u016f (8 t\u00fddn\u016f u vybran\u00fdch pacient\u016f)<\/td>\n<td>97\u201399 %<\/td>\n<td>Nej\u010dast\u011bj\u0161\u00ed genotyp v USA a Evrop\u011b<\/td>\n<\/tr>\n<tr>\n<td><strong>Genotyp 4<\/strong><\/td>\n<td>12 t\u00fddnech<\/td>\n<td>93\u201395 %<\/td>\n<td>\u010cast\u00fd v Egypt\u011b a na St\u0159edn\u00edm v\u00fdchod\u011b<\/td>\n<\/tr>\n<tr>\n<td><strong>Genotyp 5<\/strong><\/td>\n<td>12 t\u00fddnech<\/td>\n<td>95%+<\/td>\n<td>Vyskytuje se p\u0159edev\u0161\u00edm v Ji\u017en\u00ed Africe<\/td>\n<\/tr>\n<tr>\n<td><strong>Genotyp 6<\/strong><\/td>\n<td>12 t\u00fddnech<\/td>\n<td>96%+<\/td>\n<td>\u010cast\u00fd v jihov\u00fdchodn\u00ed Asii<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>8t\u00fddenn\u00ed l\u00e9\u010dba<\/strong> m\u016f\u017ee b\u00fdt dosta\u010duj\u00edc\u00ed pro pacienty s genotypem 1 bez p\u0159edchoz\u00ed l\u00e9\u010dby, bez cirh\u00f3zy a s v\u00fdchoz\u00ed hladinou HCV RNA pod 6 milion\u016f IU\/ml.<\/p>\n<p>Pro <strong>genotypy 2 a 3<\/strong>, kombinace Sofosbuvir + Velpatasvir, jako je <a href=\"\/cs\/velasof\/\">Velasof<\/a> nebo <a href=\"\/cs\/velpanat\/\">Velpanat<\/a> se doporu\u010duje m\u00edsto toho, proto\u017ee pokr\u00fdvaj\u00ed v\u0161echny genotypy HCV.<\/p>\n<h2>Jak Hepcinat LP funguje<\/h2>\n<p>Hepcinat LP kombinuje dv\u011b p\u0159\u00edmo p\u016fsob\u00edc\u00ed antivirotika, kter\u00e1 c\u00edl\u00ed na r\u016fzn\u00e1 stadia replika\u010dn\u00edho cyklu hepatitidy C:<\/p>\n<ul>\n<li><strong>Sofosbuvir (400 mg)<\/strong> \u2014 Nukleotidov\u00fd analog inhibitoru NS5B polymer\u00e1zy. Za\u010dle\u0148uje se do virov\u00e9 RNA \u0159et\u011bzce b\u011bhem replikace, co\u017e zp\u016fsobuje p\u0159ed\u010dasn\u00e9 ukon\u010den\u00ed \u0159et\u011bzce. T\u00edm blokuje kop\u00edrov\u00e1n\u00ed viru.<\/li>\n<li><strong>Ledipasvir (90 mg)<\/strong> \u2014 Inhibitor NS5A, kter\u00fd blokuje protein nezbytn\u00fd pro virovou replikaci i sestaven\u00ed nov\u00fdch virov\u00fdch \u010d\u00e1stic. C\u00edlen\u00edm na NS5A Ledipasvir zabra\u0148uje mno\u017een\u00ed viru a uvol\u0148ov\u00e1n\u00ed nov\u00fdch kopi\u00ed do krevn\u00edho \u0159e\u010di\u0161t\u011b.<\/li>\n<\/ul>\n<p>\u00datokem na HCV ve dvou r\u016fzn\u00fdch bodech sou\u010dasn\u011b dosahuje Hepcinat LP rychl\u00e9 potla\u010den\u00ed viru a zabra\u0148uje vzniku kmen\u016f rezistentn\u00edch na l\u00e9ky \u2014 probl\u00e9m, kter\u00fd tr\u00e1pil d\u0159\u00edv\u011bj\u0161\u00ed l\u00e9\u010dby hepatitidy C s jedn\u00edm \u010dinidlem.<\/p>\n<h2>D\u00e1vkov\u00e1n\u00ed a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed Hepcinat LP<\/h2>\n<ul>\n<li>U\u017eijte <strong>jedna tableta jednou denn\u011b<\/strong>, s j\u00eddlem nebo bez j\u00eddla.<\/li>\n<li>Tabletu spolkn\u011bte celou a zapijte vodou \u2014 nedr\u0165te, nel\u00e1mejte a ne\u017ev\u00fdkejte.<\/li>\n<li>U\u017e\u00edvejte p\u0159\u00edpravek Hepcinat LP ve <strong>stejnou denn\u00ed dobu<\/strong> pro udr\u017een\u00ed stabiln\u00ed hladiny l\u00e9ku v krvi.<\/li>\n<li>Pokud vynech\u00e1te d\u00e1vku, u\u017eijte ji co nejd\u0159\u00edve, jak si vzpomenete, je\u0161t\u011b tent\u00fd\u017e den. Pokud ji\u017e nastal n\u00e1sleduj\u00edc\u00ed den, vynechanou d\u00e1vku vynechejte a pokra\u010dujte v pravideln\u00e9m d\u00e1vkov\u00e1n\u00ed.<\/li>\n<li><strong>Nep\u0159eru\u0161ujte l\u00e9\u010dbu p\u0159ed\u010dasn\u011b<\/strong>, ani kdy\u017e se c\u00edt\u00edte dob\u0159e. Dokon\u010den\u00ed cel\u00e9ho l\u00e9\u010debn\u00e9ho cyklu je nezbytn\u00e9, aby nedo\u0161lo k op\u011btovn\u00e9mu vzplanut\u00ed viru.<\/li>\n<\/ul>\n<h3>D\u00e9lka l\u00e9\u010dby<\/h3>\n<table>\n<thead>\n<tr>\n<th>Typ pacienta<\/th>\n<th>D\u00e9lka<\/th>\n<th>Pot\u0159ebn\u00e9 tablety<\/th>\n<th>Cena na MedsBase<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>L\u00e9\u010dba u pacient\u016f bez p\u0159edchoz\u00ed l\u00e9\u010dby, bez cirh\u00f3zy a s n\u00edzkou virovou n\u00e1lo\u017e\u00ed<\/td>\n<td>8 t\u00fddn\u016f<\/td>\n<td>56 tablet (2 balen\u00ed)<\/td>\n<td>$999<\/td>\n<\/tr>\n<tr>\n<td>L\u00e9\u010dba u pacient\u016f bez p\u0159edchoz\u00ed l\u00e9\u010dby, bez cirh\u00f3zy<\/td>\n<td>12 t\u00fddnech<\/td>\n<td>84 tablet (3 balen\u00ed)<\/td>\n<td>$1,428<\/td>\n<\/tr>\n<tr>\n<td>L\u00e9\u010dba u pacient\u016f bez p\u0159edchoz\u00ed l\u00e9\u010dby s kompenzovanou cirh\u00f3zou<\/td>\n<td>12 t\u00fddnech<\/td>\n<td>84 tablet<\/td>\n<td>$1,428<\/td>\n<\/tr>\n<tr>\n<td>L\u00e9\u010dba u pacient\u016f s p\u0159edchoz\u00ed l\u00e9\u010dbou, bez cirh\u00f3zy<\/td>\n<td>12 t\u00fddnech<\/td>\n<td>84 tablet<\/td>\n<td>$1,428<\/td>\n<\/tr>\n<tr>\n<td>L\u00e9\u010dba u pacient\u016f s p\u0159edchoz\u00ed l\u00e9\u010dbou s kompenzovanou cirh\u00f3zou<\/td>\n<td>24 t\u00fddn\u016f<\/td>\n<td>168 tablet (6 balen\u00ed)<\/td>\n<td>Kontaktujte n\u00e1s<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Co je SVR12 (Setrval\u00e1 virologick\u00e1 odpov\u011b\u010f)?<\/h2>\n<p>SVR12 znamen\u00e1, \u017ee virus hepatitidy C je <strong>nedetekovateln\u00fd ve va\u0161\u00ed krvi 12 t\u00fddn\u016f po ukon\u010den\u00ed l\u00e9\u010dby<\/strong>. Dos\u00e1hnut\u00ed SVR12 je pova\u017eov\u00e1no za funk\u010dn\u00ed vyl\u00e9\u010den\u00ed \u2014 v\u00edce ne\u017e 99 % pacient\u016f, kte\u0159\u00ed dos\u00e1hnou SVR12, z\u016fst\u00e1v\u00e1 trvale bez viru. V\u00e1\u0161 l\u00e9ka\u0159 na\u0159\u00edd\u00ed krevn\u00ed test (HCV RNA PCR) 12 t\u00fddn\u016f po l\u00e9\u010db\u011b, aby potvrdil vyl\u00e9\u010den\u00ed.<\/p>\n<h2>Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p>Hepcinat LP pat\u0159\u00ed mezi nejl\u00e9pe sn\u00e1\u0161en\u00e9 l\u00e9\u010debn\u00e9 p\u0159\u00edpravky proti hepatitid\u011b C. V\u011bt\u0161ina pacient\u016f dokon\u010d\u00ed celou l\u00e9\u010dbu s minim\u00e1ln\u00edmi nebo \u017e\u00e1dn\u00fdmi vedlej\u0161\u00edmi \u00fa\u010dinky.<\/p>\n<h3>B\u011b\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h3>\n<ul>\n<li>\u00danava (hl\u00e1\u0161ena u ~15 % pacient\u016f)<\/li>\n<li>Bolest hlavy (~11 %)<\/li>\n<li>Nevolnost (~7 %)<\/li>\n<li>Nespavost<\/li>\n<li>Pr\u016fjem<\/li>\n<\/ul>\n<p>Tyto \u00fa\u010dinky jsou obvykle m\u00edrn\u00e9 a nevy\u017eaduj\u00ed p\u0159eru\u0161en\u00ed l\u00e9\u010dby.<\/p>\n<h3>Z\u00e1va\u017en\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky (vz\u00e1cn\u00e9)<\/h3>\n<ul>\n<li><strong>Bradykardie (zpomalen\u00e1 srde\u010dn\u00ed frekvence)<\/strong> \u2014 Hl\u00e1\u0161eno p\u0159i u\u017e\u00edv\u00e1n\u00ed s amiodaronem. Tato kombinace je kontraindikov\u00e1na.<\/li>\n<li><strong>Reaktivace hepatitidy B<\/strong> \u2014 Pacienti s koinfekc\u00ed HBV mus\u00ed b\u00fdt monitorov\u00e1ni, proto\u017ee potla\u010den\u00ed HCV m\u016f\u017ee vyvolat vzplanut\u00ed HBV.<\/li>\n<\/ul>\n<h2>D\u016fle\u017eit\u00e9 l\u00e9kov\u00e9 interakce<\/h2>\n<ul>\n<li><strong>Amiodaron<\/strong> \u2014 NIKDY neu\u017e\u00edvejte s Hepcinat LP. M\u016f\u017ee zp\u016fsobit \u017eivot ohro\u017euj\u00edc\u00ed bradykardii.<\/li>\n<li><strong>Rifampin, karbamazepin, fenytoin, t\u0159ezalka te\u010dkovan\u00e1<\/strong> \u2014 Siln\u00e9 induktory P-gp, kter\u00e9 v\u00fdrazn\u011b sni\u017euj\u00ed hladiny sofosbuviru a ledipasviru, co\u017e m\u016f\u017ee v\u00e9st k selh\u00e1n\u00ed l\u00e9\u010dby.<\/li>\n<li><strong>Inhibitory protonov\u00e9 pumpy (omeprazol, esomeprazol)<\/strong> \u2014 Sni\u017euje absorpci Ledipasviru. V p\u0159\u00edpad\u011b pot\u0159eby u\u017eijte PPI v d\u00e1vce nep\u0159esahuj\u00edc\u00ed 20 mg, nejm\u00e9n\u011b 2 hodiny p\u0159ed p\u0159\u00edpravkem Hepcinat LP.<\/li>\n<li><strong>Antacida (Tums, Maalox)<\/strong> \u2014 Odd\u011blte u\u017eit\u00edm nejm\u00e9n\u011b 4 hodiny od p\u0159\u00edpravku Hepcinat LP.<\/li>\n<li><strong>Rosuvastatin<\/strong> \u2014 Hladiny mohou stoupat; omezte na 10 mg\/den.<\/li>\n<li><strong>HIV antiretrovirotika<\/strong> \u2014 Hladiny Tenofoviru mohou stoupat p\u0159i kombinaci s ur\u010dit\u00fdmi re\u017eimy l\u00e9\u010dby HIV. Doporu\u010duje se sledov\u00e1n\u00ed funkce ledvin. P\u0159\u00edpravky jako <a href=\"\/cs\/tenvir-af\/\">Tenvir AF<\/a> (zalo\u017een\u00e9 na TAF) jsou preferov\u00e1ny p\u0159ed re\u017eimy zalo\u017een\u00fdmi na TDF.<\/li>\n<\/ul>\n<h2>Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>Koinfekce hepatitidou B:<\/strong> V\u0161ichni pacienti by m\u011bli b\u00fdt p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby testov\u00e1ni na HBV. Reaktivace HBV m\u016f\u017ee zp\u016fsobit v\u00e1\u017en\u00e9 po\u0161kozen\u00ed jater nebo smrt.<\/li>\n<li><strong>Dekompenzovan\u00e1 cirh\u00f3za:<\/strong> Hepcinat LP se nedoporu\u010duje u pacient\u016f s dekompenzovan\u00fdm jatern\u00edm onemocn\u011bn\u00edm (Child-Pugh B nebo C). M\u00edsto toho lze zv\u00e1\u017eit re\u017eim obsahuj\u00edc\u00ed Sofosbuvir + Velpatasvir + Voxilaprevir.<\/li>\n<li><strong>Porucha funkce ledvin:<\/strong> Nen\u00ed nutn\u00e1 \u00faprava d\u00e1vky p\u0159i m\u00edrn\u00e9m a\u017e st\u0159edn\u00edm po\u0161kozen\u00ed ledvin. Nedoporu\u010duje se p\u0159i t\u011b\u017ek\u00e9m po\u0161kozen\u00ed ledvin (eGFR &lt; 30 ml\/min).<\/li>\n<li><strong>T\u011bhotenstv\u00ed:<\/strong> Nedostatek \u00fadaj\u016f k potvrzen\u00ed bezpe\u010dnosti. Vyvarujte se pou\u017eit\u00ed, pokud to nen\u00ed nezbytn\u011b nutn\u00e9.<\/li>\n<\/ul>\n<h2>Hepcinat LP vs. ostatn\u00ed l\u00e9\u010dba hepatitidy C<\/h2>\n<p>MedsBase nab\u00edz\u00ed n\u011bkolik l\u00e9k\u016f na hepatitidu C. Zde je jejich srovn\u00e1n\u00ed:<\/p>\n<table>\n<thead>\n<tr>\n<th>Produkt<\/th>\n<th>Aktivn\u00ed slo\u017eky<\/th>\n<th>Pokryt\u00e9 genotypy<\/th>\n<th>Cena (12t\u00fddenn\u00ed l\u00e9\u010dba)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Hepcinat LP<\/strong><\/td>\n<td>Ledipasvir 90 mg + Sofosbuvir 400 mg<\/td>\n<td>1, 4, 5, 6<\/td>\n<td>$1,428<\/td>\n<\/tr>\n<tr>\n<td><a href=\"\/cs\/ledifos\/\">Ledifos<\/a><\/td>\n<td>Ledipasvir 90 mg + Sofosbuvir 400 mg<\/td>\n<td>1, 4, 5, 6<\/td>\n<td>Zkontrolovat cenu<\/td>\n<\/tr>\n<tr>\n<td><a href=\"\/cs\/hepcvir-l\/\">Hepcvir L<\/a><\/td>\n<td>Ledipasvir 90 mg + Sofosbuvir 400 mg<\/td>\n<td>1, 4, 5, 6<\/td>\n<td>Zkontrolovat cenu<\/td>\n<\/tr>\n<tr>\n<td><a href=\"\/cs\/myhep-lvir\/\">MyHep LVIR<\/a><\/td>\n<td>Ledipasvir 90 mg + Sofosbuvir 400 mg<\/td>\n<td>1, 4, 5, 6<\/td>\n<td>Zkontrolovat cenu<\/td>\n<\/tr>\n<tr>\n<td><a href=\"\/cs\/velasof\/\">Velasof<\/a><\/td>\n<td>Velpatasvir 100 mg + Sofosbuvir 400 mg<\/td>\n<td><strong>V\u0161e (1\u20136)<\/strong><\/td>\n<td>Zkontrolovat cenu<\/td>\n<\/tr>\n<tr>\n<td><a href=\"\/cs\/velpanat\/\">Velpanat<\/a><\/td>\n<td>Velpatasvir 100 mg + Sofosbuvir 400 mg<\/td>\n<td><strong>V\u0161e (1\u20136)<\/strong><\/td>\n<td>Zkontrolovat cenu<\/td>\n<\/tr>\n<tr>\n<td><a href=\"\/cs\/myhep-all\/\">MyHep All<\/a><\/td>\n<td>Velpatasvir 100 mg + Sofosbuvir 400 mg<\/td>\n<td><strong>V\u0161e (1\u20136)<\/strong><\/td>\n<td>Zkontrolovat cenu<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Kter\u00fd si vybrat?<\/strong> Pokud v\u00edte, \u017ee v\u00e1\u0161 genotyp HCV je 1, 4, 5 nebo 6, Hepcinat LP je osv\u011bd\u010den\u00e1 a cenov\u011b v\u00fdhodn\u00e1 volba. Pokud si nejste jisti sv\u00fdm genotypem, pan-genotypick\u00e1 varianta jako <a href=\"\/cs\/velasof\/\">Velasof<\/a> nebo <a href=\"\/cs\/velpanat\/\">Velpanat<\/a> pokr\u00fdv\u00e1 v\u0161echny genotypy a eliminuje pot\u0159ebu genotypiza\u010dn\u00edch test\u016f.<\/p>\n<h2>Skladov\u00e1n\u00ed<\/h2>\n<p>Skladujte p\u0159i pokojov\u00e9 teplot\u011b (20\u201325\u00b0C \/ 68\u201377\u00b0F). Chra\u0148te p\u0159ed vlhkost\u00ed a p\u0159\u00edm\u00fdm slune\u010dn\u00edm sv\u011btlem. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed. Nepou\u017e\u00edvejte po uplynut\u00ed data exspirace uveden\u00e9ho na obalu.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Jak\u00e1 je \u00fasp\u011b\u0161nost l\u00e9\u010dby p\u0159\u00edpravkem Hepcinat LP?<\/h3>\n<p>Klinick\u00e9 studie a re\u00e1ln\u00e9 studie prokazuj\u00ed \u00fasp\u011b\u0161nost l\u00e9\u010dby (SVR12) ve v\u00fd\u0161i <strong>95\u201399%<\/strong> u pacient\u016f s hepatitidou C genotypu 1. \u00dasp\u011b\u0161nost l\u00e9\u010dby u genotyp\u016f 4, 5 a 6 je podobn\u011b vysok\u00e1, obvykle p\u0159esahuje 93 %.<\/p>\n<h3>Je Hepcinat LP stejn\u00fd jako Harvoni?<\/h3>\n<p>Ano. Hepcinat LP je generick\u00e1 verze p\u0159\u00edpravku Harvoni, obsahuje stejn\u00e9 \u00fa\u010dinn\u00e9 l\u00e1tky (Ledipasvir 90 mg + Sofosbuvir 400 mg) ve stejn\u00fdch d\u00e1vk\u00e1ch. Vyr\u00e1b\u00ed jej spole\u010dnost Natco Pharma na z\u00e1klad\u011b dobrovoln\u00e9 licence od spole\u010dnosti Gilead Sciences a je bioekvivalentn\u00ed s origin\u00e1ln\u00edm p\u0159\u00edpravkem.<\/p>\n<h3>Jak dlouho mus\u00edm u\u017e\u00edvat Hepcinat LP?<\/h3>\n<p>V\u011bt\u0161ina pacient\u016f u\u017e\u00edv\u00e1 Hepcinat LP po dobu <strong>12 t\u00fddn\u016f (84 dn\u00ed)<\/strong>. N\u011bkte\u0159\u00ed l\u00e9\u010dbou nezat\u00ed\u017een\u00ed pacienti bez cirh\u00f3zy a s n\u00edzkou virovou n\u00e1lo\u017e\u00ed mohou m\u00edt n\u00e1rok na 8t\u00fddenn\u00ed l\u00e9\u010dbu. Pacienti s cirh\u00f3zou, kte\u0159\u00ed ji\u017e l\u00e9\u010dbu podstoupili, mohou pot\u0159ebovat 24 t\u00fddn\u016f. V\u00e1\u0161 l\u00e9ka\u0159 ur\u010d\u00ed vhodn\u00e9 trv\u00e1n\u00ed l\u00e9\u010dby.<\/p>\n<h3>M\u016f\u017ee Hepcinat LP vyl\u00e9\u010dit v\u0161echny typy hepatitidy C?<\/h3>\n<p>Hepcinat LP je nej\u00fa\u010dinn\u011bj\u0161\u00ed pro genotypy HCV 1, 4, 5 a 6. Pro genotypy 2 a 3 je vhodn\u011bj\u0161\u00ed kombinace Sofosbuvir + Velpatasvir (nap\u0159\u00edklad <a href=\"\/cs\/velasof\/\">Velasof<\/a>) se doporu\u010duje m\u00edsto toho.<\/p>\n<h3>Jak\u00e9 testy pot\u0159ebuji p\u0159ed zah\u00e1jen\u00edm u\u017e\u00edv\u00e1n\u00ed p\u0159\u00edpravku Hepcinat LP?<\/h3>\n<p>P\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby by v\u00e1\u0161 l\u00e9ka\u0159 m\u011bl objednat: test na genotyp HCV, virovou n\u00e1lo\u017e HCV (RNA PCR), test na povrchov\u00fd antigen hepatitidy B, jatern\u00ed testy a test funkce ledvin (eGFR). Pokud se p\u0159edpokl\u00e1d\u00e1 cirh\u00f3za, m\u016f\u017ee b\u00fdt doporu\u010deno vy\u0161et\u0159en\u00ed FibroScan nebo jatern\u00ed biopsie.<\/p>\n<h3>Mohu u\u017e\u00edvat Hepcinat LP, pokud m\u00e1m cirh\u00f3zu?<\/h3>\n<p>Ano \u2014 Hepcinat LP je \u00fa\u010dinn\u00fd u pacient\u016f s <strong>kompenzovanou cirh\u00f3zou<\/strong> (Child-Pugh A). Doporu\u010duje se 12t\u00fddenn\u00ed l\u00e9\u010dba. Nicm\u00e9n\u011b <strong>nen\u00ed doporu\u010den pro dekompenzovanou cirh\u00f3zu<\/strong> (Child-Pugh B nebo C), kter\u00e1 vy\u017eaduje odborn\u00e9 veden\u00ed.<\/p>\n<h3>Mohu u\u017e\u00edvat Hepcinat LP s l\u00e9ky na HIV?<\/h3>\n<p>Hepcinat LP lze pou\u017e\u00edt s v\u011bt\u0161inou antiretrovirov\u00fdch re\u017eim\u016f pro HIV. Nicm\u00e9n\u011b hladiny Tenofovir disoproxil fumar\u00e1tu (TDF) se mohou zv\u00fd\u0161it p\u0159i kombinaci s Ledipasvirem, proto by m\u011bla b\u00fdt monitorov\u00e1na ren\u00e1ln\u00ed funkce. Re\u017eimy zalo\u017een\u00e9 na TAF jako <a href=\"\/cs\/tenvir-af\/\">Tenvir AF<\/a> jsou obecn\u011b preferov\u00e1ny.<\/p>\n<h3>Pot\u0159ebuji p\u0159edpis k n\u00e1kupu Hepcinat LP?<\/h3>\n<p>V MedsBase m\u016f\u017eete objednat Hepcinat LP online bez p\u0159edpisu. Nab\u00edz\u00edme diskr\u00e9tn\u00ed balen\u00ed a celosv\u011btovou dopravu. D\u016frazn\u011b doporu\u010dujeme konzultovat hepatologa nebo gastroenterologa p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby, aby ur\u010dil spr\u00e1vn\u00e9 trv\u00e1n\u00ed a monitoroval va\u0161i reakci.<\/p>\n<h2>Odm\u00edtnut\u00ed odpov\u011bdnosti<\/h2>\n<p>Na\u0161\u00edm jedin\u00fdm z\u00e1m\u011brem je zajistit, aby spot\u0159ebitel\u00e9 z\u00edskali informace, kter\u00e9 jsou odborn\u011b ov\u011b\u0159en\u00e9, p\u0159esn\u00e9 a d\u016fv\u011bryhodn\u00e9. Informace zde obsa\u017een\u00e9 by v\u0161ak NEM\u011aLY b\u00fdt pou\u017e\u00edv\u00e1ny jako n\u00e1hrada za radu kvalifikovan\u00e9ho l\u00e9ka\u0159e. Informace poskytovan\u00e9 zde jsou pouze pro informa\u010dn\u00ed \u00fa\u010dely. Nemus\u00ed zahrnovat v\u0161echny mo\u017en\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky, l\u00e9kov\u00e9 interakce, varov\u00e1n\u00ed nebo upozorn\u011bn\u00ed. Pros\u00edm, pora\u010fte se se sv\u00fdm l\u00e9ka\u0159em a proberte v\u0161echny sv\u00e9 dotazy t\u00fdkaj\u00edc\u00ed se jak\u00e9hokoli onemocn\u011bn\u00ed nebo l\u00e9ku. Na\u0161\u00edm c\u00edlem je podporovat, nikoli nahrazovat, vztah mezi l\u00e9ka\u0159em a pacientem.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/neurobion-forte-rf-injection\/\">Neurobion Forte RF Injekce (Methylkobalamin + B6 + B3) \u2014 Oprava nerv\u016f<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/bonair-inhaler\/\">Bonair Inhaler<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/budecort-respules\/\">Budecort Respules<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zosert\/\">Zosert<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lidogab-gel\/\">Lidogab Gel<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 L\u00e9\u010d\u00ed hepatitidu C<br \/>\n\u2705 Vysok\u00e1 \u00fasp\u011b\u0161nost<br \/>\n\u2705 Zkracuje dobu l\u00e9\u010dby<br \/>\n\u2705 Sni\u017euje riziko po\u0161kozen\u00ed jater<br \/>\n\u2705 Zlep\u0161uje funkci jater<\/p>\n<p>Hepcinat LP obsahuje Ledipasvir + Sofosbuvir.<\/p>","protected":false},"featured_media":52252,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3334],"product_tag":[3478,3479,3480],"class_list":{"0":"post-52251","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hepatitis-medication","9":"product_tag-hepcinat-lp","10":"product_tag-ledipasvir","11":"product_tag-sofosbuvir","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/52251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=52251"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/52252"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=52251"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=52251"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=52251"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=52251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}