{"id":52342,"date":"2023-09-20T09:32:16","date_gmt":"2023-09-20T09:32:16","guid":{"rendered":"https:\/\/medsname.com\/azeetop\/"},"modified":"2026-04-30T10:11:34","modified_gmt":"2026-04-30T10:11:34","slug":"azeetop","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/azeetop\/","title":{"rendered":"Azeetop"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Azeetop?<\/h3>\n

Azeetop je tableta azithromycinu (250 mg \/ 500 mg, Mankind)<\/strong> \u2014 makrolidov\u00e9 antibiotikum. Standardn\u00ed re\u017eim: 500 mg prvn\u00ed den, pot\u00e9 250 mg denn\u011b (5denn\u00ed kurz) nebo 500 mg jednou denn\u011b po dobu 3 dn\u016f. U\u017e\u00edvejte s j\u00eddlem nebo nala\u010dno. Vyvarujte se pod\u00e1v\u00e1n\u00ed pacient\u016fm s vrozen\u00fdm dlouh\u00fdm QT intervalem nebo po ned\u00e1vn\u00e9m akutn\u00edm koron\u00e1rn\u00edm syndromu.<\/p>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase?<\/strong> Dod\u00e1v\u00e1no od v\u00fdrobce certifikovan\u00e9ho WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Doprava po cel\u00e9m sv\u011bt\u011b \u00b7 1 400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Objedn\u00e1v\u00e1n\u00ed z MedsBase v\u00e1m zaji\u0161\u0165uje dod\u00e1vky od v\u00fdrobce certifikovan\u00e9ho WHO-GMP, diskr\u00e9tn\u00ed balen\u00ed v oby\u010dejn\u00e9 ob\u00e1lce, celosv\u011btovou dopravu a hodnocen\u00ed 4,9\u2605 od v\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch z\u00e1kazn\u00edk\u016f. Platby kartou jsou sm\u011brov\u00e1ny p\u0159es regulovan\u00fd krypto-on-ramp \u2014 popis na v\u00fdpisu z va\u0161eho bankovn\u00edho \u00fa\u010dtu bude obsahovat jm\u00e9no procesoru (regulovan\u00e9ho procesoru plateb kartou), nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku. Ka\u017ed\u00e1 z\u00e1silka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>.<\/p>\n

Jak Azeetop funguje<\/h2>\n

Azeetop obsahuje Azithromycin<\/strong>, azithromycin, makrolidov\u00e9 antibiotikum, kter\u00e9 se v\u00e1\u017ee na 50S podjednotku bakteri\u00e1ln\u00ed ribozom\u00e1ln\u00ed podjednotky a blokuje prodlu\u017eov\u00e1n\u00ed peptidov\u00e9ho \u0159et\u011bzce, \u010d\u00edm\u017e zastavuje bakteri\u00e1ln\u00ed synt\u00e9zu b\u00edlkovin. Makrolidy jsou ve standardn\u00edch d\u00e1vk\u00e1ch bakteriostatick\u00e9, ale ve vy\u0161\u0161\u00edch koncentrac\u00edch baktericidn\u00ed proti citliv\u00fdm organism\u016fm. Spektrum zahrnuje druhy Streptococcus (v\u010detn\u011b n\u011bkter\u00fdch penicilin-rezistentn\u00edch pneumokok\u016f), Mycoplasma pneumoniae, Chlamydia trachomatis a pneumoniae, Legionella, Bordetella a Helicobacter pylori. \u00da\u010dinnost proti stafylokok\u016fm je nejist\u00e1 kv\u016fli roz\u0161\u00ed\u0159en\u00e9 rezistenci na makrolidy a v\u011bt\u0161ina Enterobacteriaceae je p\u0159irozen\u011b rezistentn\u00ed.<\/p>\n

Azithromycin je nej\u010dast\u011bji pou\u017e\u00edvan\u00fd makrolid d\u00edky sv\u00e9mu prodlou\u017een\u00e9mu polo\u010dasu (~68 hodin intracelul\u00e1rn\u011b), jednoduch\u00e9mu d\u00e1vkovac\u00edmu sch\u00e9matu a ni\u017e\u0161\u00ed inhibici CYP3A4 ve srovn\u00e1n\u00ed s erytromycinem nebo klarithromycinem.<\/p>\n

Indikace & d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
D\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9<\/caption>\n
Indikace<\/th>\nD\u00e1vka<\/th>\nD\u00e9lka<\/th>\n<\/tr>\n<\/thead>\n
Akutn\u00ed bakteri\u00e1ln\u00ed sinusitida \/ m\u00edrn\u00e1 komunitn\u00ed pneumonie<\/td>\n500 mg prvn\u00ed den, pot\u00e9 250 mg denn\u011b \u2014 celkem 5 dn\u00ed<\/td>\n5 dn\u00ed<\/td>\n<\/tr>\n
Akutn\u00ed bakteri\u00e1ln\u00ed sinusitida (alternativn\u00ed re\u017eim)<\/td>\n500 mg jednou denn\u011b<\/td>\n3 dny<\/td>\n<\/tr>\n
Streptokokov\u00e1 faryngitida (p\u0159i alergii na penicilin)<\/td>\n500 mg prvn\u00ed den, pot\u00e9 250 mg denn\u011b<\/td>\n5 dn\u00ed<\/td>\n<\/tr>\n
Nekomplikovan\u00e1 chlamydiov\u00e1 uretritida\/cervicitida<\/td>\n1 g jednor\u00e1zov\u00e1 d\u00e1vka<\/td>\nJednor\u00e1zov\u00e1 d\u00e1vka<\/td>\n<\/tr>\n
Nekomplikovan\u00e1 kapavka (v kombinaci s ceftriaxonem)<\/td>\n1 g jednor\u00e1zov\u00e1 d\u00e1vka<\/td>\nJednor\u00e1zov\u00e1 d\u00e1vka<\/td>\n<\/tr>\n
Mycoplasma genitalium (roz\u0161\u00ed\u0159en\u00fd re\u017eim)<\/td>\n500 mg prvn\u00ed den, pot\u00e9 250 mg denn\u011b<\/td>\n5 dn\u00ed<\/td>\n<\/tr>\n
Pr\u016fjem cestovatel\u016f (v rozvojov\u00fdch zem\u00edch)<\/td>\n500 mg\u20131 g denn\u011b<\/td>\n3 dny<\/td>\n<\/tr>\n
\u010cern\u00fd ka\u0161el (pertuse)<\/td>\n500 mg prvn\u00ed den, pot\u00e9 250 mg denn\u011b<\/td>\n5 dn\u00ed<\/td>\n<\/tr>\n
Profylaxe MAC u HIV (CD4 < 50)<\/td>\n1,2 g jednou t\u00fddn\u011b<\/td>\nA\u017e do CD4 > 100 trvale<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\u26a0 Prodlou\u017een\u00ed QT intervalu \u2014 varov\u00e1n\u00ed t\u0159\u00eddy<\/strong><\/p>\n
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V\u0161echna makrolidov\u00e1 antibiotika mohou prodlou\u017eit QT interval a vyvolat torsade de pointes \u2014 zejm\u00e9na u pacient\u016f s vrozen\u00fdm dlouh\u00fdm QT intervalem, poruchou elektrolyt\u016f (n\u00edzk\u00e9 K+ \/ Mg2+), bradykardi\u00ed, sou\u010dasn\u00fdm u\u017e\u00edv\u00e1n\u00edm l\u00e9k\u016f prodlu\u017euj\u00edc\u00edch QT interval (azoly, fluorochinolony, citalopram, ondansetron, n\u011bkter\u00e1 antipsychotika, n\u011bkter\u00e1 antiarytmika) nebo v\u00fdznamn\u00fdm srde\u010dn\u00edm onemocn\u011bn\u00edm. Azithromycin obdr\u017eel v roce 2013 aktualizaci \u010dern\u00e9ho r\u00e1me\u010dku FDA pot\u00e9, co observa\u010dn\u00ed data spojila jeho u\u017e\u00edv\u00e1n\u00ed s mal\u00fdm absolutn\u00edm zv\u00fd\u0161en\u00edm kardiovaskul\u00e1rn\u00ed mortality u pacient\u016f se zv\u00fd\u0161en\u00fdm kardiovaskul\u00e1rn\u00edm rizikem. Pacienti se stabiln\u00edm kardiovaskul\u00e1rn\u00edm onemocn\u011bn\u00edm mohou obvykle makrolidy u\u017e\u00edvat bezpe\u010dn\u011b; vysoce rizikov\u00ed pacienti \u2014 zn\u00e1m\u00fd dlouh\u00fd QT interval, ned\u00e1vn\u00fd infarkt myokardu, pokro\u010dil\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed \u2014 mohou pot\u0159ebovat alternativn\u00ed t\u0159\u00eddu l\u00e9k\u016f.<\/p>\n<\/div>\n<\/div>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n