{"id":52373,"date":"2023-09-20T09:32:21","date_gmt":"2023-09-20T09:32:21","guid":{"rendered":"https:\/\/medsname.com\/augmentin\/"},"modified":"2026-04-30T10:25:15","modified_gmt":"2026-04-30T10:25:15","slug":"augmentin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/augmentin\/","title":{"rendered":"Augmentin"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Augmentin?<\/h3>\n

Augmentin je p\u0159\u00edpravek spole\u010dnosti GSK amoxicilin 250 mg + kyselina klavulanov\u00e1 125 mg<\/strong> tableta \u2014 beta-laktamov\u00e9 antibiotikum kombinovan\u00e9 s inhibitorem beta-laktam\u00e1zy, kter\u00e9 obnovuje \u00fa\u010dinnost proti mnoha rezistentn\u00edm bakteri\u00edm. Indikov\u00e1no pro vybran\u00e9 infekce d\u00fdchac\u00edch cest, u\u0161\u00ed, nosu a krku, mo\u010dov\u00fdch cest, k\u016f\u017ee a kousn\u00fdch ran. Standardn\u00ed d\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9 je jedna tableta 375 mg t\u0159ikr\u00e1t denn\u011b po dobu 5\u20137 dn\u00ed; komplikovan\u00e9 infekce mohou vy\u017eadovat p\u0159\u00edpravky 625 mg nebo 1 g.<\/p>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase?<\/strong> Dod\u00e1v\u00e1no od v\u00fdrobce certifikovan\u00e9ho WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Doprava po cel\u00e9m sv\u011bt\u011b \u00b7 1 400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

\u26a0\ufe0f Varov\u00e1n\u00ed p\u0159ed cholestatickou hepatitidou<\/strong>
Co-amoxiclav m\u00e1 nejvy\u0161\u0161\u00ed hl\u00e1\u0161enou m\u00edru l\u00e9ky vyvolan\u00e9 cholestatick\u00e9 hepatitidy ze v\u0161ech peror\u00e1ln\u00edch antibiotik \u2014 p\u0159ibli\u017en\u011b 1 z 2 500 a\u017e 1 z 6 000 l\u00e9\u010debn\u00fdch cykl\u016f. N\u00e1stup je charakteristicky opo\u017ed\u011bn\u00fd (obvykle 1\u20136 t\u00fddn\u016f po ukon\u010den\u00ed l\u00e9\u010dby)<\/strong>, se \u017eloutenkou, tmavou mo\u010d\u00ed, sv\u011btlou stolic\u00ed a sv\u011bd\u011bn\u00edm. P\u0159edchoz\u00ed epizoda \u017eloutenky spojen\u00e9 s co-amoxiclavem je absolutn\u00ed celo\u017eivotn\u00ed kontraindikac\u00ed<\/strong> \u2014 riziko recidivy p\u0159i op\u011btovn\u00e9m vystaven\u00ed je velmi vysok\u00e9. Riziko je vy\u0161\u0161\u00ed u star\u0161\u00edch mu\u017e\u016f a p\u0159i prodlou\u017een\u00fdch l\u00e9\u010debn\u00fdch cyklech.<\/div>\n

K \u010demu se Augmentin pou\u017e\u00edv\u00e1<\/h2>\n

Augmentin kombinuje amoxicilin (\u0161irokospektr\u00e9 aminopenicilin) s kyselinou klavulanovou (nevratn\u00fd inhibitor beta-laktam\u00e1zy). Tato kombinace zachov\u00e1v\u00e1 grampozitivn\u00ed a vybran\u00e9 gramnegativn\u00ed p\u016fsoben\u00ed amoxicilinu a nav\u00edc p\u0159id\u00e1v\u00e1 \u00fa\u010dinnost proti kmen\u016fm produkuj\u00edc\u00edm beta-laktam\u00e1zu, jako jsou Staphylococcus aureus<\/em> (pouze methicilin-senzitivn\u00ed), Haemophilus influenzae<\/em>, Moraxella catarrhalis<\/em>, Klebsiella<\/em>, anaeroby v\u010detn\u011b Bacteroides fragilis<\/em>, a mnoho Escherichia coli<\/em>. B\u011b\u017en\u00e9 indikace:<\/p>\n

    \n
  • Akutn\u00ed bakteri\u00e1ln\u00ed sinusitida<\/strong> \u2014 preferovan\u00fd p\u0159i t\u011b\u017ek\u00fdch p\u0159\u00edznac\u00edch, p\u0159etrv\u00e1vaj\u00edc\u00edch > 10 dn\u00ed, nebo zhor\u0161uj\u00edc\u00edch se po po\u010d\u00e1te\u010dn\u00edm zlep\u0161en\u00ed.<\/li>\n
  • Akutn\u00ed z\u00e1n\u011bt st\u0159edn\u00edho ucha<\/strong> \u2014 jako druh\u00e1 volba po samotn\u00e9m amoxicilinu nebo jako prvn\u00ed volba, pokud se o\u010dek\u00e1v\u00e1 vysok\u00e1 prevalence beta-laktam\u00e1z.<\/li>\n
  • Komunitn\u00ed pneumonie (CAP)<\/strong> \u2014 obvykle v kombinaci s makrolidem pro pokryt\u00ed atypick\u00fdch patogen\u016f.<\/li>\n
  • Akutn\u00ed exacerbace CHOPN<\/strong> s hnisav\u00fdm sputem a zv\u00fd\u0161enou du\u0161nost\u00ed.<\/li>\n
  • Komplikovan\u00e9 infekce mo\u010dov\u00fdch cest \/ pyelonefritida<\/strong> ve vybran\u00fdch p\u0159\u00edpadech, s ohledem na m\u00edstn\u00ed rezistenci a kultivaci.<\/li>\n
  • Infekce k\u016f\u017ee a m\u011bkk\u00fdch tk\u00e1n\u00ed<\/strong> v\u010detn\u011b profylaxe po pokous\u00e1n\u00ed zv\u00ed\u0159etem nebo \u010dlov\u011bkem (pokr\u00fdv\u00e1 Pasteurella multocida<\/em>, Eikenella corrodens<\/em>, or\u00e1ln\u00ed anaeroby).<\/li>\n
  • Vybran\u00e9 bakteri\u00e1ln\u00ed GI infekce<\/strong> v kontextu cestovatele \u2014 nen\u00ed prvn\u00ed volbou pro b\u011b\u017en\u00e9 cestovatelsk\u00e9 pr\u016fjmy (preferuje se azithromycin nebo fluorochinolon), ale u\u017eite\u010dn\u00e9 pro zdokumentovan\u00e9 citliv\u00e9 patogeny.<\/li>\n
  • Zubn\u00ed absces \/ odontogenn\u00ed infekce<\/strong> kdy\u017e monoterapie penicilinem-V je nedostate\u010dn\u00e1.<\/li>\n<\/ul>\n
    \ud83d\udca1 Nen\u00ed prvn\u00ed volbou pro cestovatelsk\u00e9 pr\u016fjmy<\/strong>
    V\u011bt\u0161ina bakteri\u00e1ln\u00edch cestovatelsk\u00fdch pr\u016fjm\u016f je zp\u016fsobena enterotoxigenn\u00edmi E. coli<\/em>, Campylobacter, Shigella nebo Salmonella. Jednor\u00e1zov\u00e1 d\u00e1vka azithromycinu 1 g<\/strong> je preferov\u00e1na pro ji\u017en\u00ed \/ jihov\u00fdchodn\u00ed Asii (vysok\u00e1 rezistence Campylobacter na fluorochinolony) a jinde je preferov\u00e1n 1\u20133 denn\u00ed kurz fluorochinolon\u016f (ciprofloxacin, levofloxacin). Co-amoxiclav m\u00e1 roli u vybran\u00fdch citliv\u00fdch infekc\u00ed, ale nem\u011bl by b\u00fdt empirickou volbou pro cestovatelsk\u00e9 pr\u016fjmy.<\/div>\n

    Jak Augmentin funguje<\/h2>\n

    Amoxicilin<\/strong> v\u00e1\u017ee se na penicilin-v\u00e1zaj\u00edc\u00ed proteiny (PBPs) v bakteri\u00e1ln\u00ed bun\u011b\u010dn\u00e9 st\u011bn\u011b, naru\u0161uje p\u0159\u00ed\u010dn\u00e9 vazby peptidoglykanu a spou\u0161t\u00ed bun\u011b\u010dnou l\u00fdzu \u2014 baktericidn\u00ed \u00fa\u010dinek. Clavulanic acid<\/strong> m\u00e1 minim\u00e1ln\u00ed antibakteri\u00e1ln\u00ed aktivitu s\u00e1m o sob\u011b; je to \u201csubstr\u00e1t sebevra\u017edy\u201d, kter\u00fd nevratn\u011b v\u00e1\u017ee bakteri\u00e1ln\u00ed beta-laktam\u00e1zov\u00e9 enzymy, \u010d\u00edm\u017e br\u00e1n\u00ed jejich hydrol\u00fdze beta-laktamov\u00e9ho kruhu amoxicilinu. Pom\u011br 4:1 amoxicilinu ke klavulan\u00e1tu v tablet\u011b 375 mg (250 mg + 125 mg) je p\u016fvodn\u00ed formulace GSK; modern\u00ed tablety s vy\u0161\u0161\u00ed d\u00e1vkou (625 mg, 1 g) pou\u017e\u00edvaj\u00ed pom\u011br 7:1 nebo vy\u0161\u0161\u00ed, aby sn\u00ed\u017eily GI ne\u017e\u00e1douc\u00ed \u00fa\u010dinky klavulan\u00e1tu p\u0159i zachov\u00e1n\u00ed pokryt\u00ed beta-laktam\u00e1zami.<\/p>\n

    D\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
    Indikace<\/th>\nD\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9<\/th>\nD\u00e9lka<\/th>\n<\/tr>\n
    Akutn\u00ed sinusitida\/otitida<\/td>\n375 mg 3\u00d7 denn\u011b nebo 625 mg 2\u00d7 denn\u011b<\/td>\n5\u20137 dn\u00ed<\/td>\n<\/tr>\n
    Komunitn\u00ed pneumonie<\/td>\n625 mg nebo 1 g 3\u00d7 denn\u011b + makrolid<\/td>\n5\u20137 dn\u00ed<\/td>\n<\/tr>\n
    Komplikovan\u00e1 infekce mo\u010dov\u00fdch cest<\/td>\n625 mg 2\u00d7 nebo 3\u00d7 denn\u011b<\/td>\n7\u201314 dn\u00ed<\/td>\n<\/tr>\n
    Ko\u017en\u00ed\/kousnut\u00ed r\u00e1ny<\/td>\n375 mg 3\u00d7 denn\u011b nebo 625 mg 2\u00d7 denn\u011b<\/td>\n5\u201310 dn\u00ed<\/td>\n<\/tr>\n
    Zubn\u00ed absces<\/td>\n375 mg 3\u00d7 denn\u011b<\/td>\n5 dn\u00ed<\/td>\n<\/tr>\n
    Ren\u00e1ln\u00ed insuficience (CrCl 10\u201330)<\/td>\n375 mg 2\u00d7 denn\u011b<\/td>\nDle indikace<\/td>\n<\/tr>\n
    Ren\u00e1ln\u00ed insuficience (CrCl < 10)<\/td>\n375 mg 1\u00d7 denn\u011b<\/td>\nDle indikace<\/td>\n<\/tr>\n<\/table>\n
    \u2705 U\u017e\u00edvejte s j\u00eddlem<\/strong>
    U\u017e\u00edvejte ka\u017edou tabletu na za\u010d\u00e1tku j\u00eddla. Potrava v\u00fdznamn\u011b neovliv\u0148uje vst\u0159eb\u00e1v\u00e1n\u00ed amoxicilinu, ale v\u00fdrazn\u011b sni\u017euje gastrointestin\u00e1ln\u00ed pot\u00ed\u017ee (nevolnost, pr\u016fjem) zp\u016fsoben\u00e9 klavulan\u00e1tem.<\/div>\n

    Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n