{"id":52599,"date":"2023-09-20T09:35:17","date_gmt":"2023-09-20T09:35:17","guid":{"rendered":"https:\/\/medsname.com\/martifur\/"},"modified":"2026-04-30T10:18:11","modified_gmt":"2026-04-30T10:18:11","slug":"martifur","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/martifur\/","title":{"rendered":"Martifur"},"content":{"rendered":"

<\/p>\n

\n

\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2013 Co je Martifur?<\/h3>\n

Martifur je nitrofurantoin v modifikovan\u00e9m uvol\u0148ov\u00e1n\u00ed (100 mg, Martin & Brown)<\/strong> \u2014 antibiotikum specificky p\u016fsob\u00edc\u00ed v mo\u010dov\u00fdch cest\u00e1ch pro nekomplikovan\u00e9 infekce doln\u00edch mo\u010dov\u00fdch cest u \u017een (5denn\u00ed l\u00e9\u010dba) a profylaxi recidivuj\u00edc\u00edch UTI (3\u20136 m\u011bs\u00edc\u016f). Nen\u00ed vhodn\u00e9 pro pyelonefritidu nebo jak\u00e9koli neurin\u00e1rn\u00ed infekce. Vyvarujte se pou\u017eit\u00ed p\u0159i CrCl < 45.<\/p>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase?<\/strong> Dod\u00e1v\u00e1no od v\u00fdrobce certifikovan\u00e9ho WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Doprava po cel\u00e9m sv\u011bt\u011b \u00b7 1 400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Jak Martifur funguje<\/h2>\n

Martifur obsahuje nitrofurantoin<\/strong>, antibiotikum specificky p\u016fsob\u00edc\u00ed v mo\u010dov\u00fdch cest\u00e1ch, kter\u00e9 je aktivov\u00e1no bakteri\u00e1ln\u00edmi nitroredukt\u00e1zami v mo\u010di. Aktivn\u00ed meziprodukty po\u0161kozuj\u00ed bakteri\u00e1ln\u00ed ribozomy, DNA a respira\u010dn\u00ed enzymy, co\u017e vede k usmrcen\u00ed bu\u0148ky. Terapeutick\u00e9 koncentrace jsou dosa\u017eeny pouze v mo\u010di \u2014 nitrofurantoin NEN\u00cd vhodn\u00fd pro pyelonefritidu (infekci ledvinov\u00e9ho parenchymu) nebo jak\u00e9koli neurin\u00e1rn\u00ed infekce. Spektrum: v\u011bt\u0161ina uropatogenn\u00edch E. coli, Staphylococcus saprophyticus, Enterococcus faecalis, n\u011bkter\u00e9 kmeny Klebsiella. Rezistence je p\u0159irozen\u011b vz\u00e1cn\u00e1 a vznik\u00e1 pomalu; p\u0159irozen\u00e1 rezistence u Proteus, Serratia, Pseudomonas, Acinetobacter.<\/p>\n

Indikace & d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n
D\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9<\/caption>\n
Indikace<\/th>\nD\u00e1vka<\/th>\nD\u00e9lka<\/th>\n<\/tr>\n<\/thead>\n
Nekomplikovan\u00e9 infekce doln\u00edch mo\u010dov\u00fdch cest u \u017een<\/td>\n100 mg dvakr\u00e1t denn\u011b (modifikovan\u00e9 uvol\u0148ov\u00e1n\u00ed) NEBO 50 mg \u010dty\u0159ikr\u00e1t denn\u011b<\/td>\n5 dn\u00ed (\u017eeny) \/ 7 dn\u00ed (mu\u017ei)<\/td>\n<\/tr>\n
Profylaxe UTI (recidivuj\u00edc\u00ed UTI u negravidn\u00edch \u017een)<\/td>\n50\u2013100 mg p\u0159ed span\u00edm<\/td>\n3\u20136 m\u011bs\u00edc\u016f, pot\u00e9 p\u0159ehodnotit<\/td>\n<\/tr>\n
Asymptomatick\u00e1 bakteriurie v t\u011bhotenstv\u00ed (vyvarovat se na konci t\u011bhotenstv\u00ed)<\/td>\n100 mg dvakr\u00e1t denn\u011b<\/td>\n5\u20137 dn\u00ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Ren\u00e1ln\u00ed hranice:<\/strong> kontraindikov\u00e1no p\u0159i ClCr < 45 ml\/min \u2014 p\u0159i ni\u017e\u0161\u00edch clearencech jsou koncentrace v mo\u010di subterapeutick\u00e9 a hladiny v s\u00e9ru stoupaj\u00ed (riziko toxicity). V\u011bt\u0161ina sou\u010dasn\u00fdch doporu\u010den\u00ed pou\u017e\u00edv\u00e1 60 ml\/min jako opatrn\u011bj\u0161\u00ed hranici u star\u0161\u00edch pacient\u016f.<\/p>\n

U\u017e\u00edvat s j\u00eddlem.<\/strong> J\u00eddlo zvy\u0161uje biologickou dostupnost p\u0159ibli\u017en\u011b o 40 % a sni\u017euje gastrointestin\u00e1ln\u00ed pot\u00ed\u017ee.<\/p>\n

\u26a0 Plicn\u00ed, jatern\u00ed a neurologick\u00e1 toxicita p\u0159i dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed<\/strong><\/p>\n
\n

Dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed nitrofurantoinu (m\u011bs\u00edce a\u017e roky p\u0159i profylaxi) nese mal\u00e9, ale re\u00e1ln\u00e9 riziko chronick\u00e9 interstici\u00e1ln\u00ed pneumonitidy \/ plicn\u00ed fibr\u00f3zy<\/strong> (ka\u0161el, du\u0161nost, \u00fabytek hmotnosti \u2014 ireverzibiln\u00ed, pokud se p\u0159ehl\u00e9dne); chronick\u00e9 aktivn\u00ed hepatitidy<\/strong> (\u010dasto se projevuje autoimunitn\u00edmi rysy); a perifern\u00ed neuropatii<\/strong> (obvykle reverzibiln\u00ed, pokud se zachyt\u00ed v\u010das \u2014 vy\u0161\u0161\u00ed riziko p\u0159i ren\u00e1ln\u00ed insuficienci, diabetu, deficitu B-vitamin\u016f). Pacienti na dlouhodob\u00e9 profylaxi by m\u011bli m\u00edt v\u00fdchoz\u00ed spirometrii, jatern\u00ed testy a klinick\u00e9 neurologick\u00e9 vy\u0161et\u0159en\u00ed v p\u016flro\u010dn\u00edch intervalech. Vyvarovat se u\u017e\u00edv\u00e1n\u00ed ve t\u0159et\u00edm trimestru t\u011bhotenstv\u00ed a u novorozenc\u016f < 1 m\u011bs\u00edc \u2014 riziko hemolytick\u00e9 an\u00e9mie u kojenc\u016f s deficitem G6PD.<\/p>\n<\/div>\n<\/div>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n