{"id":52613,"date":"2023-09-20T09:35:47","date_gmt":"2023-09-20T09:35:47","guid":{"rendered":"https:\/\/medsname.com\/mikacin-injection\/"},"modified":"2026-05-19T05:01:18","modified_gmt":"2026-05-19T05:01:18","slug":"mikacin-injection","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/mikacin-injection\/","title":{"rendered":"Mikacin Injection"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Mikacin Injection?<\/h3>\n

Mikacin Injection je amikacin IV \/ IM injekce (Aristo)<\/strong> \u2014 aminoglykosidov\u00e9 antibiotikum pro t\u011b\u017ek\u00e9 gramnegativn\u00ed sepse, pseudomon\u00e1dov\u00e9 pneumonie a komplikovan\u00e9 UTI. Pouze pro nemocni\u010dn\u00ed pou\u017eit\u00ed s povinn\u00fdm terapeutick\u00fdm monitorov\u00e1n\u00edm l\u00e9ku. \u010cern\u00e1 sk\u0159\u00ed\u0148ka: nefrotoxicita, ototoxicita, neuromuskul\u00e1rn\u00ed blok\u00e1da.<\/p>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase?<\/strong> Dod\u00e1v\u00e1no od v\u00fdrobce certifikovan\u00e9ho WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Doprava po cel\u00e9m sv\u011bt\u011b \u00b7 1 400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Jak funguje injekce Mikacin<\/h2>\n

Injekce Mikacin obsahuje amikacin<\/strong>, aminoglykosidov\u00e9 antibiotikum, kter\u00e9 se v\u00e1\u017ee na 30S ribozom\u00e1ln\u00ed podjednotku, zp\u016fsobuje chybn\u00e9 \u010dten\u00ed mRNA kodon\u016f a inhibuje bakteri\u00e1ln\u00ed synt\u00e9zu protein\u016f. Je baktericidn\u00ed s koncentra\u010dn\u011b z\u00e1visl\u00fdm \u00fa\u010dinkem a dlouh\u00fdm postantibiotick\u00fdm efektem \u2014 podporuje jednodenn\u00ed pod\u00e1v\u00e1n\u00ed ve zv\u011bt\u0161en\u00fdch intervalech pro v\u011bt\u0161inu indikac\u00ed. Spektrum: aerobn\u00ed gramnegativn\u00ed ty\u010dinky (Pseudomonas aeruginosa, Klebsiella, Enterobacter, Serratia, Acinetobacter, Proteus, Citrobacter) a synergick\u00fd \u00fa\u010dinek s l\u00e1tkami p\u016fsob\u00edc\u00edmi na bun\u011b\u010dnou st\u011bnu proti Enterococcus a viridans streptokok\u016fm. Aktivita proti atypick\u00fdm mykobakteri\u00edm (M. tuberculosis kmeny MDR, M. abscessus). \u017d\u00e1dn\u00e1 aktivita proti anaerob\u016fm nebo v\u011bt\u0161in\u011b grampozitivn\u00edch bakteri\u00ed jako monoterapie.<\/p>\n

Indikace & d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n\n
D\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9 \u2014 IM \/ IV<\/caption>\n
Indikace<\/th>\nD\u00e1vka<\/th>\nD\u00e9lka<\/th>\n<\/tr>\n<\/thead>\n
T\u011b\u017ek\u00e1 gramnegativn\u00ed sepse (pyelonefritida, intraabdomin\u00e1ln\u00ed \u2014 kombinace)<\/td>\n15 mg\/kg jednou denn\u011b (zv\u011bt\u0161en\u00fd interval) NEBO 7,5 mg\/kg ka\u017ed\u00fdch 12 h<\/td>\n5\u20137 dn\u00ed, pot\u00e9 deeskalace<\/td>\n<\/tr>\n
Pseudomonas pneumonia (kombinace s cefepimem \/ piperacilin-tazobaktamem)<\/td>\n15 mg\/kg jednou denn\u011b<\/td>\n5\u201314 dn\u00ed<\/td>\n<\/tr>\n
Komplikovan\u00e1 infekce mo\u010dov\u00fdch cest \/ spojen\u00e1 s kat\u00e9trem<\/td>\n15 mg\/kg jednou denn\u011b<\/td>\n5\u20137 dn\u00ed<\/td>\n<\/tr>\n
Endokarditida (kombinace, alternativn\u00ed gentamicin)<\/td>\nSch\u00e9ma MDR-TB (speci\u00e1ln\u00ed pou\u017eit\u00ed)<\/td>\n4\u20136 t\u00fddn\u016f<\/td>\n<\/tr>\n
Podle sch\u00e9matu<\/td>\n15 mg\/kg jednou denn\u011b<\/td>\n15 mg\/kg t\u0159ikr\u00e1t t\u00fddn\u011b<\/td>\n<\/tr>\n
\u00daprava d\u00e1vkov\u00e1n\u00ed:<\/td>\npou\u017eijte ide\u00e1ln\u00ed t\u011blesnou hmotnost (nebo upravenou hmotnost, pokud je ob\u00e9zn\u00ed). Sni\u017ete d\u00e1vku \/ prodlu\u017ete interval p\u0159i ren\u00e1ln\u00edm selh\u00e1n\u00ed na z\u00e1klad\u011b clearance kreatininu. Terapeutick\u00e9 sledov\u00e1n\u00ed l\u00e9k\u016f je povinn\u00e9 \u2014 c\u00edlov\u00fd vrchol 50\u201360 mg\/l (prodlou\u017een\u00fd interval) a c\u00edlov\u00fd pokles < 1 mg\/l pro v\u011bt\u0161inu indikac\u00ed.<\/td>\nKonzultujte specialistu<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u26a0 \u010cern\u00e1 sk\u0159\u00ed\u0148ka: nefrotoxicita, ototoxicita, neuromuskul\u00e1rn\u00ed blok\u00e1da<\/strong> Aminoglykosidy zp\u016fsobuj\u00ed d\u00e1vkov\u011b a \u010dasov\u011b z\u00e1visl\u00e9.<\/p>\n

nefrotoxicitu<\/strong><\/p>\n
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Aminoglycosides cause dose- and duration-related nephrotoxicity<\/strong> (15\u201325 % l\u00e9\u010den\u00fdch pacient\u016f) a ototoxicita<\/strong> \u2014 jak vestibul\u00e1rn\u00ed (rovnov\u00e1ha\/z\u00e1vrat\u011b), tak kochle\u00e1rn\u00ed (ztr\u00e1ta sluchu ve vysok\u00fdch frekvenc\u00edch). Ztr\u00e1ta sluchu m\u016f\u017ee b\u00fdt trval\u00e1; vestibul\u00e1rn\u00ed po\u0161kozen\u00ed \u010dasto tak\u00e9. Rizikov\u00e9 faktory: pokro\u010dil\u00fd v\u011bk, z\u00e1kladn\u00ed ren\u00e1ln\u00ed posti\u017een\u00ed, dehydratace, sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed kli\u010dkov\u00fdch diuretik\/vancomycinu\/cisplatiny\/amfotericinu\/NSAID\/kontrastn\u00edch l\u00e1tek, prodlou\u017een\u00e9 l\u00e9\u010debn\u00e9 k\u00fary (> 7 dn\u00ed). Aminoglykosidy tak\u00e9 zesiluj\u00ed neuromuskul\u00e1rn\u00ed blok\u00e1du<\/strong> \u2014 opatrnost u myasthenia gravis a b\u011bhem anestezie. Mutace mitochondri\u00e1ln\u00ed DNA m.1555A>G p\u0159edpov\u00edd\u00e1 z\u00e1va\u017enou rychle nastupuj\u00edc\u00ed ztr\u00e1tu sluchu i po jedn\u00e9 d\u00e1vce; genetick\u00fd screening se st\u00e1le v\u00edce doporu\u010duje tam, kde je dostupn\u00fd rychl\u00fd test.<\/p>\n<\/div>\n<\/div>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n