{"id":52709,"date":"2023-09-20T09:36:48","date_gmt":"2023-09-20T09:36:48","guid":{"rendered":"https:\/\/medsname.com\/zospar\/"},"modified":"2026-04-30T10:18:09","modified_gmt":"2026-04-30T10:18:09","slug":"zospar","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/zospar\/","title":{"rendered":"Zospar"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Zospar?<\/h3>\n

Zospar je tableta sparfloxacinu (200 mg, FDC)<\/strong> \u2014 fluorochinolon t\u0159et\u00ed generace se \u0161ir\u0161\u00edm spektrem \u00fa\u010dinku na Gram-pozitivn\u00ed bakterie. Pou\u017e\u00edv\u00e1 se u komunitn\u00ed pneumonie, sinusitidy a bronchitidy. Vy\u0161\u0161\u00ed riziko fotosenzitivity a prodlou\u017een\u00ed QT intervalu ne\u017e u jin\u00fdch fluorochinolon\u016f.<\/p>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase?<\/strong> Dod\u00e1v\u00e1no od v\u00fdrobce certifikovan\u00e9ho WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Doprava po cel\u00e9m sv\u011bt\u011b \u00b7 1 400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Jak Zospar funguje<\/h2>\n

Zospar obsahuje Sparfloxacin<\/strong>, fluorochinolonov\u00e9 antibiotikum, kter\u00e9 inhibuje bakteri\u00e1ln\u00ed DNA gyr\u00e1zu (topoizomer\u00e1zu II) a topoizomer\u00e1zu IV \u2014 enzymy zodpov\u011bdn\u00e9 za superhelik\u00e1ln\u00ed strukturu a dekatenaci bakteri\u00e1ln\u00ed DNA b\u011bhem replikace. Bez funk\u010dn\u00ed gyr\u00e1zy\/topoizomer\u00e1zy se bakteri\u00e1ln\u00ed chromozom fragmentuje a bu\u0148ka hyne. Fluorochinolony jsou baktericidn\u00ed a vykazuj\u00ed koncentra\u010dn\u011b z\u00e1visl\u00e9 \u00fa\u010dinky s dlouh\u00fdm postantibiotick\u00fdm efektem, co\u017e umo\u017e\u0148uje pod\u00e1v\u00e1n\u00ed jednou denn\u011b u mnoha indikac\u00ed.<\/p>\n

Sparfloxacin je fluorochinolon t\u0159et\u00ed generace se \u0161ir\u0161\u00edm spektrem \u00fa\u010dinku na Gram-pozitivn\u00ed a atypick\u00e9 bakterie. V porovn\u00e1n\u00ed s jin\u00fdmi fluorochinolony nese vy\u0161\u0161\u00ed riziko fotosenzitivity a prodlou\u017een\u00ed QT intervalu, co\u017e omezuje jeho modern\u00ed pou\u017eit\u00ed.<\/p>\n

Indikace & d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n
D\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9<\/caption>\n
Indikace<\/th>\nD\u00e1vka<\/th>\nD\u00e9lka<\/th>\n<\/tr>\n<\/thead>\n
Komunitn\u00ed pneumonie<\/td>\n400 mg \u00favodn\u00ed d\u00e1vka, pot\u00e9 200 mg denn\u011b<\/td>\n10 dn\u00ed<\/td>\n<\/tr>\n
Akutn\u00ed exacerbace chronick\u00e9 bronchitidy<\/td>\n400 mg \u00favodn\u00ed d\u00e1vka, pot\u00e9 200 mg denn\u011b<\/td>\n5 dn\u00ed<\/td>\n<\/tr>\n
Sinusitida<\/td>\n400 mg \u00favodn\u00ed d\u00e1vka, pot\u00e9 200 mg denn\u011b<\/td>\n10 dn\u00ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00daprava d\u00e1vkov\u00e1n\u00ed p\u0159i ren\u00e1ln\u00edm posti\u017een\u00ed:<\/strong> v\u0161echny fluorochinolony krom\u011b moxifloxacinu vy\u017eaduj\u00ed \u00fapravu d\u00e1vky p\u0159i CrCl pod 50. Moxifloxacin se metabolizuje v j\u00e1trech a nevy\u017eaduje ren\u00e1ln\u00ed \u00fapravu.<\/p>\n

\u26a0 FDA black-box: tendinopatie, perifern\u00ed neuropatie, CNS \u00fa\u010dinky, aort\u00e1ln\u00ed komplikace<\/strong><\/p>\n
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Fluorochinolony nesou varov\u00e1n\u00ed FDA v \u010dern\u00e9m r\u00e1me\u010dku pro: tendinitidu a rupturu \u0161lachy<\/strong> (nej\u010dast\u011bji Achillovy \u0161lachy; riziko se zvy\u0161uje s v\u011bkem > 60 let, u\u017e\u00edv\u00e1n\u00edm kortikosteroid\u016f, transplantac\u00ed org\u00e1n\u016f); perifern\u00ed neuropatii<\/strong> (m\u016f\u017ee b\u00fdt trval\u00e1 \u2013 p\u0159eru\u0161te l\u00e9\u010dbu p\u0159i prvn\u00edch p\u0159\u00edznac\u00edch); \u00fa\u010dinky na centr\u00e1ln\u00ed nervov\u00fd syst\u00e9m<\/strong> (\u00fazkost, zmatenost, halucinace, z\u00e1chvaty); a aort\u00e1ln\u00ed aneurysma\/disekce<\/strong> (relativn\u00ed riziko ~2,0, zejm\u00e9na u star\u0161\u00edch dosp\u011bl\u00fdch s hypertenz\u00ed, ateroskler\u00f3zou nebo zn\u00e1m\u00fdm aneurysmatem). P\u0159ezkum FDA z roku 2016 dosp\u011bl k z\u00e1v\u011bru, \u017ee u nekomplikovan\u00fdch infekc\u00ed mo\u010dov\u00fdch cest, sinusitidy a akutn\u00ed bronchitidy mohou p\u0159eva\u017eovat rizika nad p\u0159\u00ednosy \u2013 fluorochinolony vyhra\u010fte pro indikace bez alternativ. P\u0159eru\u0161te pod\u00e1v\u00e1n\u00ed l\u00e9ku p\u0159i prvn\u00edch zn\u00e1mk\u00e1ch bolesti \u0161lach, parest\u00e9zie nebo neuropsychiatrick\u00fdch zm\u011bn.<\/p>\n<\/div>\n<\/div>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n