{"id":52853,"date":"2023-09-20T09:39:08","date_gmt":"2023-09-20T09:39:08","guid":{"rendered":"https:\/\/medsname.com\/misoprost\/"},"modified":"2026-04-30T16:30:23","modified_gmt":"2026-04-30T16:30:23","slug":"misoprost","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/misoprost\/","title":{"rendered":"Misoprost"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">Rychl\u00e1 odpov\u011b\u010f<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Misoprost<\/strong> \u2014 misoprostol 200 mcg (Cipla). Syntetick\u00fd analog prostaglandinu E1 pou\u017e\u00edvan\u00fd pro l\u00e9ka\u0159sk\u00fd potrat (s mifepristonem), prevenci \u017ealude\u010dn\u00edch v\u0159ed\u016f vyvolan\u00fdch NSAID, profylaxi poporodn\u00edho krv\u00e1cen\u00ed, vyvol\u00e1n\u00ed porodu a zvl\u00e1d\u00e1n\u00ed zme\u0161kan\u00e9ho\/ne\u00fapln\u00e9ho potratu. V\u00edce cest pod\u00e1n\u00ed (or\u00e1ln\u00ed, sublingv\u00e1ln\u00ed, vagin\u00e1ln\u00ed, rekt\u00e1ln\u00ed) \u2014 r\u016fzn\u00e9 cesty poskytuj\u00ed r\u016fzn\u00e9 farmakokinetick\u00e9 vlastnosti.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/li>\n<li>Diskr\u00e9tn\u00ed balen\u00ed v oby\u010dejn\u00e9 ob\u00e1lce<\/li>\n<li>Dod\u00e1n\u00ed po cel\u00e9m sv\u011bt\u011b<\/li>\n<li>Hodnoceno v\u00edce ne\u017e 1 400 z\u00e1kazn\u00edky (<a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">\u010d\u00edst recenze<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Z\u00e1ruka op\u011btovn\u00e9ho zasl\u00e1n\u00ed:<\/strong> pokud va\u0161e objedn\u00e1vka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f od odesl\u00e1n\u00ed, za\u0161leme ji znovu bez dal\u0161\u00edch n\u00e1klad\u016f. <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">P\u0159e\u010d\u00edst podm\u00ednky<\/a>.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Misoprost je dod\u00e1v\u00e1n od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v neutr\u00e1ln\u00edm balen\u00ed, fakturov\u00e1n prost\u0159ednictv\u00edm regulovan\u00e9ho platebn\u00edho procesoru (na v\u00fdpisu z karty je uveden regulovan\u00fd platebn\u00ed procesor \u2014 nikdy MedsBase nebo n\u00e1zev l\u00e9ku). Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed 20-pracovn\u00ed-denn\u00ed z\u00e1rukou na p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Kontraindikace v t\u011bhotenstv\u00ed p\u0159i pou\u017eit\u00ed jako profylaxe v\u0159ed\u016f<\/strong><br \/>Misoprostol je teratogenn\u00ed a abortivn\u00ed. NIKDY nepou\u017e\u00edvejte k profylaxi v\u0159ed\u016f vyvolan\u00fdch NSAID v t\u011bhotenstv\u00ed nebo u \u017een, kter\u00e9 by mohly ot\u011bhotn\u011bt bez \u00fa\u010dinn\u00e9 antikoncepce. P\u0159i pou\u017eit\u00ed v t\u011bhotenstv\u00ed je pou\u017eit\u00ed z\u00e1m\u011brn\u00e9 (pro l\u00e9ka\u0159sk\u00fd potrat, zvl\u00e1d\u00e1n\u00ed zme\u0161kan\u00e9ho potratu, vyvol\u00e1n\u00ed porodu nebo poporodn\u00ed krv\u00e1cen\u00ed) a pod dohledem.<\/div>\n<h2>Indikace &amp; d\u00e1vkov\u00e1n\u00ed podle cesty pod\u00e1n\u00ed<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:12px 0;\">\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;border:1px solid #ddd;\">Indikace<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;\">D\u00e1vka &amp; cesta pod\u00e1n\u00ed<\/th>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">L\u00e9ka\u0159sk\u00fd potrat \u22649 t\u00fddn\u016f (s mifepristonem 200 mg, 24-48 hodin pot\u00e9)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">800 mcg buk\u00e1ln\u00ed\/vagin\u00e1ln\u00ed\/sublingv\u00e1ln\u00ed; opakovat po 4 hodin\u00e1ch, pokud nedojde k vypuzen\u00ed<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Zme\u0161kan\u00fd\/ne\u00fapln\u00fd potrat (a\u017e do 13 t\u00fddn\u016f)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">800 mcg vagin\u00e1ln\u011b nebo 600 mcg sublingv\u00e1ln\u011b; opakovat po 24-48 hodin\u00e1ch, pokud je t\u0159eba<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Profylaxe poporodn\u00edho krv\u00e1cen\u00ed (3. doba porodn\u00ed) tam, kde nen\u00ed k dispozici oxytocin<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">600 mcg sublingv\u00e1ln\u011b po porodu (doporu\u010den\u00ed WHO)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">L\u00e9\u010dba poporodn\u00edho krv\u00e1cen\u00ed (oxytocin prvn\u00ed volba, misoprostol druh\u00e1)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">800 mcg sublingv\u00e1ln\u011b jednor\u00e1zov\u011b<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Profylaxe v\u0159ed\u016f vyvolan\u00fdch NSAID<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">200 mcg peror\u00e1ln\u011b 2\u20134\u00d7 denn\u011b s j\u00eddlem<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">P\u0159\u00edprava d\u011blo\u017en\u00edho hrdla p\u0159ed kyret\u00e1\u017e\u00ed, zaveden\u00edm IUD nebo hysteroskopi\u00ed<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">400 mcg vagin\u00e1ln\u011b\/sublingu\u00e1ln\u011b 3\u201312 hodin p\u0159ed v\u00fdkonem<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Vyvol\u00e1n\u00ed porodu (donosl\u00e9 t\u011bhotenstv\u00ed, \u017eivotaschopn\u00fd plod)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">25 mcg vagin\u00e1ln\u011b ka\u017ed\u00e9 4 hodiny, max. 6 d\u00e1vek (pouze pod odborn\u00fdm porodnick\u00fdm dohledem)<\/td>\n<\/tr>\n<\/table>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Nouzov\u00e1 situace<\/strong><br \/>Siln\u00e9 krv\u00e1cen\u00ed (pros\u00e1knut\u00ed 2 velk\u00fdch vlo\u017eek\/hodinu po dobu 2+ po sob\u011b jdouc\u00edch hodin), p\u0159etrv\u00e1vaj\u00edc\u00ed siln\u00e1 bolest b\u0159icha, hore\u010dka &gt;38\u00b0C trvaj\u00edc\u00ed d\u00e9le ne\u017e 24 hodin, zn\u00e1mky sepse nebo ne\u00fasp\u011b\u0161n\u00e9 vypuzen\u00ed po kompletn\u00edm medikament\u00f3zn\u00edm potratov\u00e9m re\u017eimu vy\u017eaduj\u00ed neodkladn\u00e9 osobn\u00ed vy\u0161et\u0159en\u00ed. Misoprostol m\u016f\u017ee zp\u016fsobit rupturu d\u011blohy v pozdn\u00edm t\u011bhotenstv\u00ed nebo u \u017een s p\u0159edchoz\u00edm c\u00edsa\u0159sk\u00fdm \u0159ezem \u2013 v t\u011bchto situac\u00edch nikdy nepou\u017e\u00edvejte bez odborn\u00e9ho dohledu.<\/div>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Jak misoprostol funguje?<\/h3>\n<p>V\u00e1\u017ee se na receptory prostaglandinu E1 v hladk\u00e9m svalstvu d\u011blohy (zp\u016fsobuje kontrakce a zm\u011bk\u010den\u00ed d\u011blo\u017en\u00edho hrdla) a v pariet\u00e1ln\u00edch bu\u0148k\u00e1ch \u017ealudku (potla\u010duje tvorbu kyselin a zvy\u0161uje produkci hlenu). Stejn\u00fd mechanismus vysv\u011btluje \u0161irok\u00e9 spektrum indikac\u00ed.<\/p>\n<h3>Pro\u010d existuje tolik zp\u016fsob\u016f pod\u00e1n\u00ed?<\/h3>\n<p>R\u016fzn\u00e9 zp\u016fsoby pod\u00e1n\u00ed maj\u00ed r\u016fzn\u00e9 farmakokinetick\u00e9 vlastnosti. Sublingu\u00e1ln\u00ed pod\u00e1n\u00ed m\u00e1 nejrychlej\u0161\u00ed n\u00e1stup a nejvy\u0161\u0161\u00ed vrcholovou koncentraci; vagin\u00e1ln\u00ed pod\u00e1n\u00ed poskytuje nejd\u00e9le trvaj\u00edc\u00ed hladiny; peror\u00e1ln\u00ed pod\u00e1n\u00ed se nejrychleji vst\u0159eb\u00e1v\u00e1, ale p\u016fsob\u00ed nejkrat\u0161\u00ed dobu; buk\u00e1ln\u00ed pod\u00e1n\u00ed je mezistupe\u0148. Volba z\u00e1vis\u00ed na indikaci a klinick\u00e9m kontextu.<\/p>\n<h3>Vedlej\u0161\u00ed \u00fa\u010dinky?<\/h3>\n<p>K\u0159e\u010de, krv\u00e1cen\u00ed (z\u00e1m\u011brn\u00e9 v porodnick\u00fdch indikac\u00edch), nevolnost, zvracen\u00ed, pr\u016fjem, hore\u010dka (\u010dasto z\u00e1visl\u00e9 na d\u00e1vce a samovoln\u011b ustupuj\u00edc\u00ed), t\u0159esavka. Siln\u00e9 krv\u00e1cen\u00ed nebo sepse vy\u017eaduj\u00ed neodkladn\u00e9 vy\u0161et\u0159en\u00ed.<\/p>\n<h3>Co kdy\u017e ne\u00fa\u010dinkuje?<\/h3>\n<p>P\u0159i medikament\u00f3zn\u00edm potratu doch\u00e1z\u00ed k \u00fapln\u00e9mu vypuzen\u00ed v ~95 % p\u0159\u00edpad\u016f p\u0159i standardn\u00edm re\u017eimu. P\u0159i ne\u00fapln\u00e9m vypuzen\u00ed se pod\u00e1vaj\u00ed opakovan\u00e9 d\u00e1vky; p\u0159i p\u0159etrv\u00e1vaj\u00edc\u00ed ne\u00faplnosti je nutn\u00fd chirurgick\u00fd z\u00e1krok. V\u017edy n\u00e1sledujte pokyny p\u0159edepisuj\u00edc\u00edho l\u00e9ka\u0159e.<\/p>\n<h3>Mohou ji u\u017e\u00edvat mu\u017ei?<\/h3>\n<p>Misoprostol se u mu\u017e\u016f nepou\u017e\u00edv\u00e1. Tato molekula nem\u00e1 v\u00fdznamn\u00e9 indikace mimo porodnictv\u00ed a gastroenterologii.<\/p>\n<h3>Skladov\u00e1n\u00ed?<\/h3>\n<p>Pod 25\u00b0C, na such\u00e9m m\u00edst\u011b. Misoprostol se rychle rozkl\u00e1d\u00e1 vlhkost\u00ed \u2014 tablety uchov\u00e1vejte v p\u016fvodn\u00edm blistru a\u017e do pou\u017eit\u00ed.<\/p>\n<h3>Interakce l\u00e9k\u016f?<\/h3>\n<p>Antacida obsahuj\u00edc\u00ed ho\u0159\u010d\u00edk zhor\u0161uj\u00ed pr\u016fjem vyvolan\u00fd misoprostolem. Jinak m\u00e1 l\u00e9k m\u00e1lo v\u00fdznamn\u00fdch interakc\u00ed s jin\u00fdmi l\u00e9\u010divy.<\/p>\n<h3>Mifepriston nen\u00ed k dispozici \u2014 lze pou\u017e\u00edt samotn\u00fd misoprostol?<\/h3>\n<p>Re\u017eimy pouze s misoprostolem jsou uzn\u00e1vanou alternativou, ale maj\u00ed o n\u011bco vy\u0161\u0161\u00ed m\u00edru ne\u00fasp\u011bchu ne\u017e kombinovan\u00e1 l\u00e9\u010dba. B\u011b\u017en\u00fd protokol: 800 mcg sublingu\u00e1ln\u011b nebo vagin\u00e1ln\u011b, opakovan\u011b ka\u017ed\u00e9 3-4 hodiny a\u017e do 3 d\u00e1vek. WHO tento re\u017eim podporuje tam, kde nen\u00ed k dispozici mifepriston.<\/p>\n<h3>A co profylaxe v\u0159ed\u016f, kdy\u017e jsou k dispozici modern\u00ed PPI?<\/h3>\n<p>Modern\u00ed inhibitory protonov\u00e9 pumpy (omeprazol, pantoprazol) jsou obecn\u011b l\u00e9pe sn\u00e1\u0161eny a stejn\u011b \u00fa\u010dinn\u00e9 p\u0159i profylaxi NSAID-v\u0159ed\u016f. Misoprostol se nyn\u00ed pou\u017e\u00edv\u00e1 hlavn\u011b v porodnictv\u00ed a jako alternativa, kdy\u017e jsou PPI kontraindikov\u00e1ny nebo nedostupn\u00e9.<\/p>\n<h3>Je to v m\u00e9 zemi leg\u00e1ln\u00ed?<\/h3>\n<p>Misoprostol je ve v\u011bt\u0161in\u011b zem\u00ed leg\u00e1ln\u00ed pro profylaxi v\u0159ed\u016f a porodnick\u00e9 indikace. Pou\u017eit\u00ed pro l\u00e9ka\u0159sk\u00e9 ukon\u010den\u00ed t\u011bhotenstv\u00ed je v mnoha jurisdikc\u00edch p\u0159\u00edsn\u011b regulov\u00e1no. M\u00edstn\u00ed z\u00e1kony se v\u00fdrazn\u011b li\u0161\u00ed. Tyto informace slou\u017e\u00ed pouze pro l\u00e9ka\u0159sk\u00e9 vzd\u011bl\u00e1v\u00e1n\u00ed \u2014 dodr\u017eujte m\u00edstn\u00ed p\u0159edpisy.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Dal\u0161\u00ed l\u00e9ky pro zdrav\u00ed \u017een<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/mifepristone\/\">Mifepriston<\/a> \u2013 antiprogesteron \u2013 v kombinaci s misoprostolem pro l\u00e9ka\u0159sk\u00fd potrat<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/naturogest\/\">Naturogest<\/a> \u2013 p\u0159\u00edrodn\u00ed mikronizovan\u00fd progesteron \u2013 pro lute\u00e1ln\u00ed podporu p\u0159i IVF, prevenci potratu<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/meprate\/\">Meprate<\/a> \u2014 medroxyprogesteron 10 mg \u2014 pro regulaci cyklu, vyvol\u00e1n\u00ed menstrua\u010dn\u00edho krv\u00e1cen\u00ed<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/cabgolin\/\">Cabgolin<\/a> \u2014 kabergolin \u2014 pro potla\u010den\u00ed laktace<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/pan\/\">Pan<\/a> \u2014 pantoprazol 40 mg \u2014 modern\u00ed alternativa k prevenci v\u0159ed\u016f p\u0159i u\u017e\u00edv\u00e1n\u00ed NSAID<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro informaci a nenahrazuje l\u00e9ka\u0159skou p\u00e9\u010di kvalifikovan\u00e9ho odborn\u00edka. Proberte jak\u00e9koli nov\u00e9 l\u00e9ky se sv\u00fdm l\u00e9ka\u0159em nebo l\u00e9k\u00e1rn\u00edkem.<\/div>","protected":false},"excerpt":{"rendered":"<p>Misoprost (Misoprostol 200 mcg) \u2014 Prostaglandin E1 analog od Cipla. V\u00edce\u010detn\u00e9 porodnick\u00e9 pou\u017eit\u00ed (medikament\u00f3zn\u00ed potrat s mifepristonem, zvl\u00e1d\u00e1n\u00ed potratu, poporodn\u00ed krv\u00e1cen\u00ed), plus profylaxe NSAID-v\u0159ed\u016f.<\/p>","protected":false},"featured_media":52854,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3530,3141,3502],"product_tag":[3531,3532],"class_list":{"0":"post-52853","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-alternative-contraceptives","7":"product_cat-category-overview","8":"product_cat-womens-health","9":"product_tag-misoprost","10":"product_tag-misoprostol","12":"first","13":"outofstock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/52853","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=52853"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/52854"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=52853"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=52853"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=52853"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=52853"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}