{"id":52872,"date":"2023-09-20T09:39:35","date_gmt":"2023-09-20T09:39:35","guid":{"rendered":"https:\/\/medsname.com\/doxinate\/"},"modified":"2026-04-30T10:25:14","modified_gmt":"2026-04-30T10:25:14","slug":"doxinate","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/doxinate\/","title":{"rendered":"Doxinate"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Doxinate?<\/h3>\n<p style=\"margin:0;\"><strong>Doxinate<\/strong> je tableta s pevnou d\u00e1vkou <strong>doxylamin sukcin\u00e1t 10 mg + pyridoxin (vitamin B6) 10 mg<\/strong> \u2014 schv\u00e1len\u00e1 ACOG a FDA jako <strong>prvn\u00ed volba farmakoterapie pro nevolnost a zvracen\u00ed v t\u011bhotenstv\u00ed (NVP)<\/strong>. Kombinace je tak\u00e9 prod\u00e1v\u00e1na pod n\u00e1zvy Diclegis (US) a Cariban (EU). Doxylamin je sedativn\u00ed H1-antihistaminikum; pyridoxin sni\u017euje nevolnost mechanismy, kter\u00e9 nejsou je\u0161t\u011b pln\u011b objasn\u011bny. Standardn\u00ed re\u017eim: <strong>2 tablety p\u0159ed span\u00edm<\/strong>, s p\u0159id\u00e1n\u00edm 1 d\u00e1vky r\u00e1no + 1 odpoledne, pokud p\u0159\u00edznaky p\u0159etrv\u00e1vaj\u00ed. N\u00e1stup \u00fa\u010dinku za 4\u20136 hodin, proto ve\u010dern\u00ed d\u00e1vka c\u00edl\u00ed na rann\u00ed nevolnost. V\u00fdrobce certifikovan\u00fd WHO-GMP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2714 <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong> \u2714 Diskr\u00e9tn\u00ed balen\u00ed \u2714 Celosv\u011btov\u00e1 doprava \u2714 <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">Ov\u011b\u0159en\u00e9 recenze z\u00e1kazn\u00edk\u016f (1 400+ z\u00e1kazn\u00edk\u016f)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>\ud83d\udca1 Prvn\u00ed volba pro NVP dle ACOG (2024) a FDA.<\/strong> Pyridoxine-doxylamin m\u00e1 nejsiln\u011bj\u0161\u00ed v\u011bdeckou podklad ze v\u0161ech antiemetik v t\u011bhotenstv\u00ed. FDA kategorie byla v roce 2013 zv\u00fd\u0161ena na A po metaanal\u00fdze v\u00edce ne\u017e 200 000 expozic, kter\u00e1 neprok\u00e1zala teratogenn\u00ed \u00fa\u010dinky. NICE 2024 jej uv\u00e1d\u00ed jako l\u00e9k prvn\u00ed volby pro nevolnost a zvracen\u00ed v t\u011bhotenstv\u00ed (NVP) po nefarmakologick\u00fdch opat\u0159en\u00edch. V prvn\u00edm trimestru je up\u0159ednost\u0148ov\u00e1n p\u0159ed metoclopramidem, ondansetronem a prochlorperazinem.<\/div>\n<h3 class=\"wp-block-heading\">Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Doxinate je dod\u00e1v\u00e1n z <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 pokud nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, z\u00e1silku zdarma p\u0159epos\u00edl\u00e1me. Jde o jedinou kombinaci antiemetik s statusem FDA kategorie A v t\u011bhotenstv\u00ed a je doporu\u010dov\u00e1na jako prvn\u00ed volba organizacemi ACOG, NICE a SOGC pro nevolnost a zvracen\u00ed v t\u011bhotenstv\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">Mechanismus \u00fa\u010dinku<\/h2>\n<p>Doxylamin je antihistaminikum prvn\u00ed generace ze skupiny ethanolamin\u016f s v\u00fdrazn\u00fdm pr\u016fnikem do CNS; blok\u00e1da H1 receptor\u016f ve vestibul\u00e1rn\u00edch j\u00e1drech mozkov\u00e9ho kmene a v chemorecep\u010dn\u00ed spou\u0161t\u011bc\u00ed z\u00f3n\u011b (CTZ) vyvol\u00e1v\u00e1 antiemetick\u00fd \u00fa\u010dinek, doprov\u00e1zen\u00fd sedac\u00ed a anticholinergn\u00ed aktivitou charakteristickou pro tuto t\u0159\u00eddu antihistaminik. Pyridoxin (vitamin B6) je kofaktorem pro v\u00edce ne\u017e 100 enzym\u016f v\u010detn\u011b dekarboxyl\u00e1zy DOPA a glutam\u00e1tdekarboxyl\u00e1zy; p\u0159esn\u00fd mechanismus antiemetick\u00e9ho \u00fa\u010dinku v t\u011bhotenstv\u00ed nen\u00ed jasn\u00fd, ale randomizovan\u00e1 studie (Sahakian 1991) prok\u00e1zala nez\u00e1visl\u00fd \u00fa\u010dinek p\u0159i d\u00e1vce 30 mg\/den a kombinovan\u00fd p\u0159\u00edpravek je \u00fa\u010dinn\u011bj\u0161\u00ed ne\u017e ka\u017ed\u00e1 slo\u017eka samostatn\u011b.<\/p>\n<h2 class=\"wp-block-heading\">Indikace<\/h2>\n<ul>\n<li>Nevolnost a zvracen\u00ed v t\u011bhotenstv\u00ed (NVP) v\u010detn\u011b hyperemesis gravidarum (\u00favodn\u00ed terapie)<\/li>\n<li>Nespavost v t\u011bhotenstv\u00ed (mimo indikaci, n\u00edzk\u00e1 \u00farove\u0148 d\u016fkaz\u016f)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed \u2014 standardn\u00ed re\u017eim pro NVP<\/h2>\n<p>Den 1: 2 tablety p\u0159ed span\u00edm. Den 2: 1 r\u00e1no + 2 p\u0159ed span\u00edm, pokud p\u0159\u00edznaky p\u0159etrv\u00e1vaj\u00ed. Den 3+: 1 r\u00e1no + 1 odpoledne + 2 p\u0159ed span\u00edm (maxim\u00e1ln\u011b 4 tablety\/den). Jednotliv\u00e9 d\u00e1vky jsou nedostate\u010dn\u00e9, proto\u017ee ust\u00e1len\u00e9ho stavu je dosa\u017eeno za 2\u20133 dny. Pokra\u010dujte do stabilizace p\u0159\u00edznak\u016f, pot\u00e9 d\u00e1vky postupn\u011b sni\u017eujte b\u011bhem t\u00fddne.<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li>Ospalost (velmi \u010dast\u00e1 \u2014 ve\u010dern\u00ed d\u00e1vkov\u00e1n\u00ed tento \u00fa\u010dinek zm\u00edr\u0148uje)<\/li>\n<li>Sucho v \u00fastech, rozmazan\u00e9 vid\u011bn\u00ed, obt\u00ed\u017ee s mo\u010den\u00edm (anticholinergn\u00ed \u00fa\u010dinky)<\/li>\n<li>Z\u00e1cpa<\/li>\n<li>Z\u00e1vrat\u011b, bolesti hlavy<\/li>\n<li>Ko\u017en\u00ed alergick\u00e9 reakce (vz\u00e1cn\u00e9)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce l\u00e9k\u016f<\/h2>\n<ul>\n<li>Jin\u00e1 depresiva CNS (alkohol, opioidy, benzodiazepiny): aditivn\u00ed sedace \u2014 v t\u011bhotenstv\u00ed se alkoholu zcela vyhn\u011bte.<\/li>\n<li>Jin\u00e9 anticholinergika: aditivn\u00ed sucho v \u00fastech, z\u00e1cpa, retence mo\u010di.<\/li>\n<li>Inhibitory MAO: kombinaci se vyhn\u011bte.<\/li>\n<li>Levodopa: pyridoxin zvy\u0161uje perifern\u00ed konverzi; v\u00fdznamn\u00e9 pouze bez karbidopy.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Kdy v t\u011bhotenstv\u00ed mohu u\u017e\u00edvat Doxinate?<\/h3>\n<p>Lze jej za\u010d\u00edt u\u017e\u00edvat ji\u017e p\u0159i prvn\u00edch p\u0159\u00edznac\u00edch nevolnosti a zvracen\u00ed v t\u011bhotenstv\u00ed (NVP) \u2014 obvykle v 6. t\u00fddnu t\u011bhotenstv\u00ed. Pokra\u010dujte tak dlouho, dokud p\u0159\u00edznaky p\u0159etrv\u00e1vaj\u00ed, obvykle vrchol\u00ed v 9.\u201312. t\u00fddnu a ustupuj\u00ed do 16.\u201320. t\u00fddne.<\/p>\n<h3 class=\"wp-block-heading\">Ubl\u00ed\u017e\u00ed to d\u00edt\u011bti?<\/h3>\n<p>Neexistuj\u00ed d\u016fkazy o teratogenn\u00edm \u00fa\u010dinku. FDA v roce 2013 po rozs\u00e1l\u00e9 metaanal\u00fdze &gt; 200 000 expozic zm\u011bnila kategorii na A. Pou\u017e\u00edv\u00e1 se od 50. let 20. stolet\u00ed u milion\u016f t\u011bhotenstv\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d dv\u011b tablety p\u0159ed span\u00edm?<\/h3>\n<p>Vrcholn\u00fd antiemetick\u00fd \u00fa\u010dinek nast\u00e1v\u00e1 4\u20136 hodin po d\u00e1vce. V\u011bt\u0161\u00ed d\u00e1vka p\u0159ed span\u00edm c\u00edl\u00ed na rann\u00ed nevolnost, kdy jsou p\u0159\u00edznaky obvykle nejhor\u0161\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Bude m\u011b to b\u011bhem dne ospal\u00e1?<\/h3>\n<p>Mo\u017en\u00e1. V\u011bt\u0161\u00ed d\u00e1vka p\u0159ed span\u00edm minimalizuje denn\u00ed ospalost, ale rann\u00ed a odpoledn\u00ed d\u00e1vky st\u00e1le mohou zp\u016fsobit ospalost. Ne\u0159i\u010fte, dokud nev\u00edte, jak na v\u00e1s l\u00e9k p\u016fsob\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Mohu to u\u017e\u00edvat s ondansetronem?<\/h3>\n<p>Ano, toto je uzn\u00e1van\u00fd krok, pokud samotn\u00fd pyridoxin-doxylamin nesta\u010d\u00ed. ACOG \u0159ad\u00ed ondansetron jako druhou volbu u NVP (po 10. t\u00fddnu) kv\u016fli mal\u00e9mu riziku roz\u0161t\u011bpu patra p\u0159i \u010dasn\u00e9m u\u017e\u00edv\u00e1n\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Kdy bych se m\u011bla za\u010d\u00edt ob\u00e1vat?<\/h3>\n<p>Siln\u00e9 zvracen\u00ed (&gt; 3\u00d7 denn\u011b), neschopnost p\u0159ij\u00edmat tekutiny, \u00fabytek hmotnosti &gt; 5 % p\u0159ed t\u011bhotensk\u00e9 hmotnosti, ketony v mo\u010di nebo zn\u00e1mky dehydratace vy\u017eaduj\u00ed neodkladnou gynekologickou kontrolu \u2014 m\u016f\u017ee se jednat o hyperemesis gravidarum a m\u016f\u017ee b\u00fdt nutn\u00e1 hospitalizace.<\/p>\n<h3 class=\"wp-block-heading\">Stoj\u00ed za to vyzkou\u0161et nejprve mo\u017enosti bez l\u00e9k\u016f?<\/h3>\n<p>Ano. Doporu\u010duje se za\u010d\u00edt mal\u00fdmi \u010dast\u00fdmi j\u00eddly, z\u00e1zvorem, akupresurou (n\u00e1ramky P6), vyh\u00fdb\u00e1n\u00ed se spou\u0161t\u011b\u010d\u016fm (pachy, tu\u010dn\u00e1 j\u00eddla) a monoterapi\u00ed vitaminem B6 (10\u201325 mg t\u0159ikr\u00e1t denn\u011b), co\u017e \u010dasto pom\u00e1h\u00e1 p\u0159i m\u00edrn\u00fdch p\u0159\u00edznac\u00edch t\u011bhotensk\u00e9 nevolnosti.<\/p>\n<h3 class=\"wp-block-heading\">Mus\u00edm p\u0159estat, pokud se m\u00e9 p\u0159\u00edznaky zlep\u0161\u00ed?<\/h3>\n<p>M\u016f\u017eete d\u00e1vkov\u00e1n\u00ed postupn\u011b sni\u017eovat, ne\u017e p\u0159estat n\u00e1hle \u2014 mnoho \u017een zjist\u00ed, \u017ee \u00fapln\u00e9 vysazen\u00ed m\u016f\u017ee v\u00e9st k n\u00e1vratu p\u0159\u00edznak\u016f. Sni\u017eujte d\u00e1vku o jednu tabletu ka\u017ed\u00fdch 1\u20132 dny, jak to sn\u00e1\u0161\u00edte.<\/p>\n<h3 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h3>\n<p>Pod 30 \u00b0C chra\u0148te p\u0159ed vlhkost\u00ed. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Vezm\u011bte si l\u00e9k, kdy\u017e si vzpomenete, pokud to nen\u00ed bl\u00edzko dal\u0161\u00ed pl\u00e1novan\u00e9 d\u00e1vky. Ned\u00e1vejte dvojn\u00e1sobnou d\u00e1vku \u2014 to jen zv\u00fd\u0161\u00ed ospalost.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Dal\u0161\u00ed l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/dompewal-tablet\/\">Dompewal \u2014 Domperidon (alternativa pro nevolnost mimo t\u011bhotenstv\u00ed)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/reglan\/\">Reglan \u2014 Metoklopramid (druh\u00e1 volba v t\u011bhotenstv\u00ed)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/stemetil\/\">Stemetil \u2014 Prochlorperazin (t\u0159et\u00ed volba v t\u011bhotenstv\u00ed)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zofer\/\">Zofer \u2014 Ondansetron (NVP druh\u00e1 volba po 10. t\u00fddnu)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/folvite\/\">Folvite \u2014 Kyselina listov\u00e1 (dopln\u011bk stravy v t\u011bhotenstv\u00ed)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/gastro-health\/\"><strong>Prohl\u00e9dnout v\u0161echny l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed.<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro informa\u010dn\u00ed \u00fa\u010dely a nenahrazuje l\u00e9ka\u0159skou pomoc kvalifikovan\u00e9ho zdravotnick\u00e9ho pracovn\u00edka. NVP, kter\u00e9 br\u00e1n\u00ed p\u0159\u00edjmu tekutin, zp\u016fsobuje ztr\u00e1tu hmotnosti &gt; 5 % nebo prokazuje ketonurii, je hyperemesis gravidarum a vy\u017eaduje gynekologick\u00e9 vy\u0161et\u0159en\u00ed.<\/div>","protected":false},"excerpt":{"rendered":"<p>Doxinate (Doxylamin 10 mg + Vitamin B6 10 mg) \u2014 prvn\u00ed volba farmakologick\u00e9 terapie pro nevolnost a zvracen\u00ed v t\u011bhotenstv\u00ed (NVP) dle ACOG\/NICE\/SOGC. FDA kategorie t\u011bhotenstv\u00ed A.<\/p>","protected":false},"featured_media":52873,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3541,3141,3542,3342,3543],"product_tag":[3544,3545,3546],"class_list":{"0":"post-52872","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-emetic","7":"product_cat-category-overview","8":"product_cat-gastro-health","9":"product_cat-general-health","10":"product_cat-nausea-treatment","11":"product_tag-doxinate","12":"product_tag-doxylamine","13":"product_tag-vitamin-b6","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable","20":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/52872","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=52872"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/52873"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=52872"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=52872"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=52872"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=52872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}