{"id":53011,"date":"2023-09-20T09:41:36","date_gmt":"2023-09-20T09:41:36","guid":{"rendered":"https:\/\/medsname.com\/famocid\/"},"modified":"2026-05-01T10:49:12","modified_gmt":"2026-05-01T10:49:12","slug":"famocid","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/famocid\/","title":{"rendered":"Famocid"},"content":{"rendered":"

<\/p>\n

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Famocid?<\/h3>\n

Famocid<\/strong> je famotidine 20 mg nebo 40 mg tablety<\/strong> od Sun Pharma od v\u00fdrobce certifikovan\u00e9ho WHO-GMP. Famotidin je histaminov\u00fd H2<\/sub> receptorov\u00fd antagonista<\/strong> \u2014 blokuje histaminov\u00fd sign\u00e1l, kter\u00fd stimuluje sekreci \u017ealude\u010dn\u00ed kyseliny. Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9:<\/strong> 20 mg dvakr\u00e1t denn\u011b nebo 40 mg jednou p\u0159ed span\u00edm po dobu a\u017e 8 t\u00fddn\u016f. N\u00e1stup \u00fa\u010dinku je rychlej\u0161\u00ed ne\u017e u PPI<\/strong> (p\u0159ibli\u017en\u011b 30 minut), ale maxim\u00e1ln\u00ed \u00fa\u010dinek na potla\u010den\u00ed kyseliny je men\u0161\u00ed. Famotidin je modern\u00ed bezpe\u010dn\u00e1 n\u00e1hrada za ranitidin<\/strong> \u2014 ranitidin byl v roce 2020 celosv\u011btov\u011b sta\u017een kv\u016fli kontaminaci NDMA a famotidin je H2<\/sub> antagonista, kter\u00fd v\u0161ichni hlavn\u00ed regul\u00e1to\u0159i doporu\u010duj\u00ed jako n\u00e1hradu. U\u017eite\u010dn\u00fd pro pr\u016flomov\u00e9 p\u0159\u00edznaky p\u0159i u\u017e\u00edv\u00e1n\u00ed PPI, p\u0159i ob\u010dasn\u00e9 m\u00edrn\u00e9 GERD, profylaxi v\u0159ed\u016f zp\u016fsoben\u00fdch NSAID a no\u010dn\u00ed pr\u016flomov\u00e9 kyselosti. Tachyfylaxe<\/strong> (ztr\u00e1ta \u00fa\u010dinku) se rozv\u00edj\u00ed po 7\u201314 dnech nep\u0159etr\u017eit\u00e9ho denn\u00edho u\u017e\u00edv\u00e1n\u00ed \u2014 proto je famotidin nejl\u00e9pe u\u017e\u00edvat ob\u010dasn\u011b nebo v kr\u00e1tk\u00fdch k\u00far\u00e1ch, p\u0159i\u010dem\u017e PPI jsou prvn\u00ed volbou pro chronick\u00e1 onemocn\u011bn\u00ed.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Co je Famocid<\/h2>\n

Famocid je zna\u010dka spole\u010dnosti Sun Pharma pro famotidin<\/strong>, antagonista H2<\/sub>-receptor\u016f t\u0159et\u00ed generace. Ka\u017ed\u00e1 tableta obsahuje bu\u010f 20 mg nebo 40 mg famotidinu. Famotidin je nejbezpe\u010dn\u011bj\u0161\u00ed a nejpou\u017e\u00edvan\u011bj\u0161\u00ed antagonista H2<\/sub> na modern\u00edm trhu \u2014 zejm\u00e9na pot\u00e9, co byl ranitidin (Aciloc, Rantac) v roce 2020 sta\u017een z v\u011bt\u0161iny hlavn\u00edch trh\u016f kv\u016fli objeven\u00ed kontaminace N-nitrosodimethylaminem (NDMA, pravd\u011bpodobn\u00fd lidsk\u00fd karcinogen). Dal\u0161\u00edm antagonistou H2<\/sub> , kter\u00fd je st\u00e1le dostupn\u00fd na n\u011bkter\u00fdch trz\u00edch, je cimetidin, ale cimetidin m\u00e1 mnohem v\u011bt\u0161\u00ed z\u00e1t\u011b\u017e l\u00e9kov\u00fdch interakc\u00ed ne\u017e famotidin a dnes se pou\u017e\u00edv\u00e1 jen z\u0159\u00eddka.<\/p>\n

Jak Famocid funguje (mechanismus)<\/h2>\n

Sekrece \u017ealude\u010dn\u00ed kyseliny je \u0159\u00edzena t\u0159emi sign\u00e1ly, kter\u00e9 dosahuj\u00ed pariet\u00e1ln\u00ed bu\u0148ky: acetylcholin<\/strong> (vagov\u00fd nerv), gastrin<\/strong> (G-bu\u0148ky v antru) a histamin<\/strong> (enterochromaffin-like bu\u0148ky). Histaminov\u00fd sign\u00e1l je dominantn\u00ed a p\u016fsob\u00ed p\u0159es H2<\/sub> receptory na bazolater\u00e1ln\u00ed membr\u00e1n\u011b pariet\u00e1ln\u00edch bun\u011bk. Famotidin je kompetitivn\u00ed, reverzibiln\u00ed antagonista tohoto H2<\/sub> receptoru. Blokov\u00e1n\u00edm histaminu vyp\u00edn\u00e1 nejv\u00fdznamn\u011bj\u0161\u00ed jednotliv\u00fd faktor sekrece kyseliny. N\u00e1stup \u00fa\u010dinku je asi 30 minut po peror\u00e1ln\u00edm pod\u00e1n\u00ed, vrchol za 1\u20133 hodiny a trv\u00e1n\u00ed p\u0159ibli\u017en\u011b 10\u201312 hodin \u2014 dostate\u010dn\u011b dlouh\u00e9 na to, aby d\u00e1vkov\u00e1n\u00ed dvakr\u00e1t denn\u011b nebo jednou p\u0159ed span\u00edm pokrylo v\u011bt\u0161inu pacient\u016f.<\/p>\n

Toto je odli\u0161n\u00fd mechanismus od inhibitor\u016f protonov\u00e9 pumpy. PPI p\u016fsob\u00ed d\u00e1le v kask\u00e1d\u011b \u2014 blokuj\u00ed samotnou protonovou pumpu, spole\u010dnou kone\u010dnou cestu. PPI poskytuj\u00ed hlub\u0161\u00ed a del\u0161\u00ed potla\u010den\u00ed kyseliny, ale trv\u00e1 3\u20135 dn\u00ed, ne\u017e dos\u00e1hnou pln\u00e9ho \u00fa\u010dinku. H2<\/sub> antagonist\u00e9 poskytuj\u00ed m\u011bl\u010d\u00ed potla\u010den\u00ed kyseliny, ale \u00fa\u010dinkuj\u00ed do hodiny a zachov\u00e1vaj\u00ed \u010d\u00e1ste\u010dnou sekre\u010dn\u00ed odpov\u011b\u010f na vag\u00e1ln\u00ed stimulaci. Ob\u011b t\u0159\u00eddy lze kombinovat \u2014 PPI r\u00e1no a famotidin p\u0159ed span\u00edm \u2014 pro no\u010dn\u00ed pr\u016flom kyseliny, strategie s rozumnou eviden\u010dn\u00ed podporou u refraktern\u00ed GERD.<\/p>\n

Indikace \u2014 Co Famocid l\u00e9\u010d\u00ed<\/h2>\n

1. M\u00edrn\u00e1 a\u017e st\u0159edn\u011b t\u011b\u017ek\u00e1 GERD \u2014 podle pot\u0159eby nebo kr\u00e1tkodob\u011b<\/h3>\n

Pro ob\u010dasn\u00e9 nebo m\u00edrn\u00e9 refluxn\u00ed p\u0159\u00edznaky \u010dasto posta\u010d\u00ed H2<\/sub> antagonista u\u017e\u00edvan\u00fd podle pot\u0159eby, bez nutnosti dlouhodob\u00e9ho u\u017e\u00edv\u00e1n\u00ed PPI. N\u00e1stup \u00fa\u010dinku do hodiny, vhodn\u00e9 pro p\u0159\u00edznaky po zn\u00e1m\u00e9m spou\u0161t\u011bc\u00edm j\u00eddle.<\/p>\n

2. Pr\u016flomov\u00e9 p\u0159\u00edznaky p\u0159i u\u017e\u00edv\u00e1n\u00ed PPI \u2014 zejm\u00e9na no\u010dn\u00ed<\/h3>\n

N\u011bkte\u0159\u00ed pacienti na adekv\u00e1tn\u00ed terapii PPI st\u00e1le za\u017e\u00edvaj\u00ed no\u010dn\u00ed pr\u016flom kyseliny. P\u0159id\u00e1n\u00ed famotidinu 20\u201340 mg p\u0159ed span\u00edm zlep\u0161uje no\u010dn\u00ed kontrolu pH. Tachyfylaxe znamen\u00e1, \u017ee tato strategie je nejvhodn\u011bj\u0161\u00ed pro ob\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed podle pot\u0159eby.<\/p>\n

3. Peptick\u00e1 v\u0159edov\u00e1 choroba<\/h3>\n

Famotidin hoj\u00ed duoden\u00e1ln\u00ed a \u017ealude\u010dn\u00ed v\u0159edy, a\u010dkoli PPI jsou \u00fa\u010dinn\u011bj\u0161\u00ed. U\u017eite\u010dn\u00e9 tam, kde je PPI \u0161patn\u011b tolerov\u00e1no nebo kontraindikov\u00e1no. Doba hojen\u00ed je 4\u20136 t\u00fddn\u016f pro duoden\u00e1ln\u00ed v\u0159ed, 6\u20138 t\u00fddn\u016f pro \u017ealude\u010dn\u00ed v\u0159ed.<\/p>\n

4. Profylaxe v\u0159ed\u016f spojen\u00fdch s NSAID<\/h3>\n

U pacient\u016f s ni\u017e\u0161\u00edm rizikem na chronick\u00e9 terapii NSAID je dvojit\u00e1 d\u00e1vka famotidinu (40 mg dvakr\u00e1t denn\u011b) alternativou k PPI pro prevenci v\u0159ed\u016f. PPI z\u016fst\u00e1v\u00e1 preferovanou volbou u pacient\u016f s vy\u0161\u0161\u00edm rizikem.<\/p>\n

5. Profylaxe stresov\u00fdch v\u0159ed\u016f (kde PPI nen\u00ed preferov\u00e1no)<\/h3>\n

N\u011bkter\u00e9 ned\u00e1vn\u00e9 postupy na JIP se vr\u00e1tily k H2 antagonist\u016fm pro profylaxi stresov\u00fdch v\u0159ed\u016f kv\u016fli obav\u00e1m z infekc\u00ed souvisej\u00edc\u00edch s PPI2<\/sub> a ventil\u00e1torem asociovan\u00e9 pneumonie. C. difficile<\/em> 6. Zollinger\u016fv-Ellison\u016fv syndrom (vysokod\u00e1vkovan\u00e1 adjuvantn\u00ed terapie).<\/p>\n

Pou\u017e\u00edv\u00e1 se nav\u00edc k vysokod\u00e1vkovan\u00fdm PPI u vybran\u00fdch hypersekre\u010dn\u00edch stav\u016f.<\/h3>\n

7. Profylaxe aspirace p\u0159ed operac\u00ed.<\/p>\n

D\u00e1vka 40 mg noc p\u0159ed a 2 hodiny p\u0159ed indukc\u00ed sni\u017euje objem a kyselost \u017ealude\u010dn\u00edho obsahu (profylaxe Mendelsonova syndromu).<\/h3>\n

20 mg dvakr\u00e1t denn\u011b nebo 40 mg na noc.<\/p>\n

D\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n
Indikace \/ pacient<\/th>\nD\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9<\/th>\nD\u00e9lka l\u00e9\u010dby \/ pozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n
GERD \u2014 m\u00edrn\u00fd a\u017e st\u0159edn\u011b t\u011b\u017ek\u00fd<\/td>\n20 mg twice daily, or 40 mg at bedtime<\/td>\n6\u201312 t\u00fddn\u016f; kontrola<\/td>\n<\/tr>\n
P\u0159i pot\u00ed\u017e\u00edch s refluxem<\/td>\n10\u201320 mg podle pot\u0159eby, max. 40 mg\/24 h<\/td>\npodle pot\u0159eby<\/td>\n<\/tr>\n
Hojen\u00ed duoden\u00e1ln\u00edho v\u0159edu<\/td>\n40 mg p\u0159ed span\u00edm nebo 20 mg dvakr\u00e1t denn\u011b<\/td>\n4\u20136 t\u00fddnech<\/td>\n<\/tr>\n
Hojen\u00ed \u017ealude\u010dn\u00edho v\u0159edu<\/td>\n40 mg p\u0159ed span\u00edm<\/td>\n6\u20138 t\u00fddn\u016f<\/td>\n<\/tr>\n
Profylaxe v\u0159ed\u016f p\u0159i u\u017e\u00edv\u00e1n\u00ed NSAID<\/td>\n20\u201340 mg dvakr\u00e1t denn\u011b<\/td>\npo dobu l\u00e9\u010dby NSAID<\/td>\n<\/tr>\n
Porucha funkce ledvin (CrCl < 50)<\/td>\n20 mg jednou denn\u011b<\/td>\nsn\u00ed\u017eit d\u00e1vku<\/td>\n<\/tr>\n
T\u011b\u017ek\u00e9 ren\u00e1ln\u00ed posti\u017een\u00ed (CrCl < 10)<\/td>\n10 mg jednou denn\u011b nebo 20 mg ka\u017ed\u00fdch 36\u201348 h<\/td>\npod veden\u00edm specialisty<\/td>\n<\/tr>\n
D\u011bti > 1 rok (na p\u0159edpis)<\/td>\n0,5 mg\/kg dvakr\u00e1t denn\u011b (max. 40 mg\/d\u00e1vka)<\/td>\npod dohledem pediatra<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Famotidin lze u\u017e\u00edvat s j\u00eddlem i bez j\u00eddla. N\u00e1stup \u00fa\u010dinku je rychlej\u0161\u00ed nala\u010dno. Vyvarujte se sou\u010dasn\u00e9ho u\u017e\u00edv\u00e1n\u00ed s antacidem (Acigene) \u2014 dodr\u017ete odstup alespo\u0148 1\u20132 hodiny.<\/p>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n

\u010cast\u00e9 (1\u20133 %):<\/strong> bolest hlavy, z\u00e1vrat\u011b, z\u00e1cpa, pr\u016fjem, \u00fanava.<\/p>\n

M\u00e9n\u011b \u010dast\u00e9, ale d\u016fle\u017eit\u00e9:<\/strong><\/p>\n

    \n
  • Zmatenost, neklid, halucinace \u2014 zejm\u00e9na u star\u0161\u00edch pacient\u016f nebo pacient\u016f s ren\u00e1ln\u00edm posti\u017een\u00edm (\u010dast\u011bj\u0161\u00ed p\u0159i vysok\u00fdch d\u00e1vk\u00e1ch)<\/li>\n
  • Bradykardie nebo arytmie (velmi vz\u00e1cn\u00e9; hl\u00e1\u0161eno p\u0159i rychl\u00e9 IV aplikaci)<\/li>\n
  • Trombocytopenie, leukopenie (vz\u00e1cn\u00e9; reverzibiln\u00ed)<\/li>\n
  • Hepatitida, \u017eloutenka (vz\u00e1cn\u00e9; reverzibiln\u00ed po vysazen\u00ed)<\/li>\n
  • Z\u00e1va\u017en\u00e9 p\u0159ecitliv\u011blosti (vyr\u00e1\u017eka, angioed\u00e9m, anafylaxe \u2014 velmi vz\u00e1cn\u00e9)<\/li>\n<\/ul>\n

    Famotidin m\u00e1 mnohem \u010dist\u0161\u00ed profil ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f ne\u017e cimetidin. Na rozd\u00edl od cimetidinu nezp\u016fsobuje gynekomastii, impotenci ani antiandrogenn\u00ed \u00fa\u010dinky.<\/p>\n

    Interakce s l\u00e9\u010divy<\/h2>\n

    Famotidin m\u00e1 mnohem men\u0161\u00ed z\u00e1t\u011b\u017e l\u00e9kov\u00fdch interakc\u00ed ne\u017e cimetidin. Hlavn\u00ed interakce souvisej\u00ed s absorpc\u00ed sp\u00ed\u0161e ne\u017e s enzymatick\u00fdmi mechanismy:<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
    L\u00e9k\/t\u0159\u00edda<\/th>\nInterakce<\/th>\n\u00da\u010dinek<\/th>\n<\/tr>\n<\/thead>\n
    Atazanavir, rilpivirin (HIV)<\/td>\nAbsorpce z\u00e1visl\u00e1 na kyselosti; H\u2082-antagonist\u00e9 sni\u017euj\u00ed hladiny2<\/sub> Odd\u011blit pod\u00e1n\u00ed o 12 hodin; konzultovat specialistu<\/td>\nK absorpci je nutn\u00e1 kyselost; sn\u00ed\u017eena famotidinem<\/td>\n<\/tr>\n
    Itrakonazol, ketokonazol<\/td>\nPokud mo\u017eno kombinaci vyvarovat; zvolit flukonazol<\/td>\nSn\u00ed\u017een\u00e1 kyselost zhor\u0161uje absorpci \u017eeleza<\/td>\n<\/tr>\n
    Dopl\u0148ky \u017eeleza<\/td>\nPou\u017e\u00edt \u017eelezo obohacen\u00e9 vitaminem C, nebo p\u0159ej\u00edt na IV \u017eelezo p\u0159i v\u00fdrazn\u00e9m deficitu<\/td>\nUse vitamin-C-fortified iron, or switch to IV iron if marked deficiency<\/td>\n<\/tr>\n
    Uhli\u010ditan v\u00e1penat\u00fd<\/td>\nSn\u00ed\u017een\u00e1 absorpce z\u00e1visl\u00e1 na kysel\u00e9m prost\u0159ed\u00ed<\/td>\nP\u0159echod na citr\u00e1t v\u00e1penat\u00fd pro l\u00e9\u010dbu osteopor\u00f3zy<\/td>\n<\/tr>\n
    Antacida<\/td>\nM\u016f\u017ee sn\u00ed\u017eit absorpci famotidinu<\/td>\nOdd\u011blte pod\u00e1n\u00ed o 1\u20132 hodiny<\/td>\n<\/tr>\n
    Probenecid<\/td>\nSni\u017euje ren\u00e1ln\u00ed clearance famotidinu<\/td>\nP\u0159i dlouhodob\u00e9m kombinov\u00e1n\u00ed sni\u017ete d\u00e1vku famotidinu<\/td>\n<\/tr>\n
    Tizanidin<\/td>\nFamotidin nem\u00e1 klinicky v\u00fdznamn\u00fd \u00fa\u010dinek (na rozd\u00edl od cimetidinu \u2014 famotidin je bezpe\u010dn\u00fd)<\/td>\nMonitorujte pouze p\u0159i \u00faprav\u011b d\u00e1vkov\u00e1n\u00ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Kontraindikace a upozorn\u011bn\u00ed<\/h2>\n