{"id":53039,"date":"2023-09-20T09:41:38","date_gmt":"2023-09-20T09:41:38","guid":{"rendered":"https:\/\/medsname.com\/rifagut\/"},"modified":"2026-04-30T10:25:13","modified_gmt":"2026-04-30T10:25:13","slug":"rifagut","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/rifagut\/","title":{"rendered":"Rifagut"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Rifagut?<\/h3>\n<p style=\"margin:0;\"><strong>Rifagut<\/strong> obsahuje <strong>rifaximin<\/strong> (400 mg nebo 550 mg), <strong>st\u0159evn\u011b selektivn\u00ed, neabsorbovan\u00e9 antibiotikum ze skupiny rifamycin\u016f. Proto\u017ee &lt; 0,4% peror\u00e1ln\u00ed d\u00e1vky se vst\u0159eb\u00e1 do krevn\u00edho ob\u011bhu, rifaximin poskytuje vysok\u00e9 antibakteri\u00e1ln\u00ed koncentrace ve st\u0159evn\u00edm lumen s minim\u00e1ln\u00ed syst\u00e9movou expozic\u00ed a velmi m\u00e1lo l\u00e9kov\u00fdmi interakcemi.<\/strong>. \u010cty\u0159i hlavn\u00ed pou\u017eit\u00ed:. <strong>cestovatelsk\u00fd pr\u016fjem<\/strong> (1) <strong>\u2014 200 mg t\u0159ikr\u00e1t denn\u011b po dobu 3 dn\u016f; (2)<\/strong> prevence recidivy hepatick\u00e9 encefalopatie <strong>prevention of recurrent hepatic encephalopathy<\/strong> \u2014 550 mg dvakr\u00e1t denn\u011b; (3) <strong>IBS s pr\u016fjmem (IBS-D) u dosp\u011bl\u00fdch bez z\u00e1cpy<\/strong> \u2014 550 mg t\u0159ikr\u00e1t denn\u011b po dobu 14 dn\u016f, opakovateln\u00e9 a\u017e 2\u00d7; (4) <strong>p\u0159emno\u017een\u00ed bakteri\u00ed v tenk\u00e9m st\u0159ev\u011b (SIBO)<\/strong> \u2014 off-label, ale \u0161iroce pou\u017e\u00edvan\u00e9, 550 mg t\u0159ikr\u00e1t denn\u011b po dobu 14 dn\u016f. Obecn\u011b dob\u0159e sn\u00e1\u0161en\u00e9; nej\u010dast\u011bj\u0161\u00edmi \u00fa\u010dinky jsou m\u00edrn\u00e1 bolest hlavy a nevolnost. Vyvarujte se u\u017e\u00edv\u00e1n\u00ed p\u0159i p\u0159ecitliv\u011blosti na rifamyciny a p\u0159i t\u011b\u017ek\u00e9m po\u0161kozen\u00ed jater.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:16px 20px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\ud83d\udcc5 Pro\u010d objedn\u00e1vat Rifagut od MedsBase?<\/strong> P\u016fvodn\u00ed z\u00e1soby v\u00fdrobce Sun Pharma \u00b7 diskr\u00e9tn\u00ed balen\u00ed \u00b7 celosv\u011btov\u00e1 doprava \u00b7 1 400+ z\u00e1kazn\u00edk\u016f ve v\u00edce ne\u017e 50 zem\u00edch \u00b7 hodnocen\u00ed 4,9\u2605. <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">P\u0159e\u010dt\u011bte si recenze z\u00e1kazn\u00edk\u016f<\/a>.<\/div>\n<h2 class=\"wp-block-heading\">Co je Rifagut?<\/h2>\n<p>Rifagut jsou peror\u00e1ln\u00ed antibiotick\u00e9 tablety obsahuj\u00edc\u00ed <strong>rifaximin<\/strong> (400 mg nebo 550 mg), vyr\u00e1b\u011bn\u00e9 spole\u010dnost\u00ed Sun Pharma. Dod\u00e1v\u00e1 se v balen\u00edch po 10, 30 nebo 60 tablet\u00e1ch. Rifaximin je <strong>polosyntetick\u00fd rifamycin<\/strong> odvozen\u00fd od rifampicinu, upraven\u00fd tak, aby se nevst\u0159eb\u00e1val ze st\u0159eva \u2014 &lt; 0,4% peror\u00e1ln\u00ed d\u00e1vky vstupuje do syst\u00e9mov\u00e9ho ob\u011bhu. To mu d\u00e1v\u00e1 jedine\u010dn\u00fd profil: vysokou antibakteri\u00e1ln\u00ed aktivitu v lumen st\u0159eva, t\u00e9m\u011b\u0159 nulovou syst\u00e9movou expozici, minim\u00e1ln\u00ed interakce s l\u00e9ky a n\u00edzk\u00e9 riziko vzniku rezistence mimo st\u0159evo.<\/p>\n<p>Origin\u00e1ln\u00ed zna\u010dka: <strong>Xifaxan<\/strong> (Salix \/ Bausch Health, US) a <strong>Normix<\/strong> (Alfa Wassermann, EU). Rifaximin se klinicky pou\u017e\u00edv\u00e1 od 80. let 20. stolet\u00ed a je schv\u00e1len FDA pro l\u00e9\u010dbu cestovatelsk\u00e9ho pr\u016fjmu (2004), jatern\u00ed encefalopatie (2010) a IBS-D (2015).<\/p>\n<h2 class=\"wp-block-heading\">K \u010demu se Rifagut pou\u017e\u00edv\u00e1?<\/h2>\n<ul>\n<li><strong>Cestovatelsk\u00fd pr\u016fjem<\/strong> (neinvazivn\u00ed <em>E. coli<\/em> kmeny) \u2014 dosp\u011bl\u00ed a dosp\u00edvaj\u00edc\u00ed ve v\u011bku 12+<\/li>\n<li><strong>Sn\u00ed\u017een\u00ed recidivy manifestn\u00ed jatern\u00ed encefalopatie<\/strong> u pacient\u016f s pokro\u010dil\u00fdm onemocn\u011bn\u00edm jater \u2014 obvykle v kombinaci s laktul\u00f3zou<\/li>\n<li><strong>Syndrom dr\u00e1\u017ediv\u00e9ho tra\u010dn\u00edku s pr\u016fjmem (IBS-D)<\/strong> u nekonstipovan\u00fdch dosp\u011bl\u00fdch \u2014 poskytuje t\u00fddny a\u017e m\u011bs\u00edce \u00falevy od p\u0159\u00edznak\u016f po 14denn\u00edm cyklu; schv\u00e1leno FDA<\/li>\n<li><strong>Bakteri\u00e1ln\u00ed p\u0159er\u016fst\u00e1n\u00ed v tenk\u00e9m st\u0159ev\u011b (SIBO)<\/strong> \u2014 neschv\u00e1len\u00e9 indikace, ale \u0161iroce pou\u017e\u00edvan\u00e9; \u010dasto kombinov\u00e1no s neomycinem u methanem dominantn\u00edho SIBO<\/li>\n<li><strong>Profylaxe spont\u00e1nn\u00ed bakteri\u00e1ln\u00ed peritonitidy<\/strong> u cirh\u00f3zy (neschv\u00e1len\u00e1 indikace)<\/li>\n<li><strong>Divertikulitida<\/strong> a v n\u011bkter\u00fdch p\u0159\u00edpadech pouchitidy po kolektomii (mimo schv\u00e1len\u00e9 indikace)<\/li>\n<\/ul>\n<p>Rifaximin je <strong>ne<\/strong> \u00fa\u010dinn\u00fd proti invazivn\u00edm bakteri\u00e1ln\u00edm infekc\u00edm (<em>Shigella<\/em>, <em>Salmonella<\/em>, <em>Campylobacter<\/em>) zp\u016fsobuj\u00edc\u00edm hore\u010dku a krvav\u00fd pr\u016fjem \u2014 jsou zapot\u0159eb\u00ed syst\u00e9mov\u00e1 antibiotika. Nen\u00ed tak\u00e9 indikov\u00e1n pro <em>C. difficile<\/em> kolitidu.<\/p>\n<h2 class=\"wp-block-heading\">Jak Rifagut funguje?<\/h2>\n<p>Rifaximin inhibuje bakteri\u00e1ln\u00ed DNA-dependentn\u00ed RNA polymer\u00e1zu vazbou na \u03b2-podjednotku, \u010d\u00edm\u017e br\u00e1n\u00ed transkripci \u2014 stejn\u00fd mechanismus jako jeho mate\u0159sk\u00e1 slou\u010denina rifampicin. M\u00e1 \u0161irokospektr\u00e1ln\u00ed \u00fa\u010dinnost proti grampozitivn\u00edm i gramnegativn\u00edm aerobn\u00edm a anaerobn\u00edm bakteri\u00edm.<\/p>\n<p>Kl\u00ed\u010dov\u00fd rozd\u00edl oproti rifampicinu je <strong>farmakokinetick\u00fd<\/strong>:<\/p>\n<ul>\n<li><strong>&lt; 0,4% or\u00e1ln\u00ed biologick\u00e1 dostupnost<\/strong> \u2014 t\u00e9m\u011b\u0159 cel\u00e1 d\u00e1vka z\u016fst\u00e1v\u00e1 v lumen st\u0159eva<\/li>\n<li>Velmi vysok\u00e9 <strong>intralumin\u00e1ln\u00ed koncentrace<\/strong> \u2014 v\u00fdrazn\u011b nad MIC pro v\u011bt\u0161inu relevantn\u00edch patogen\u016f<\/li>\n<li><strong>\u017d\u00e1dn\u00e1 v\u00fdznamn\u00e1 syst\u00e9mov\u00e1 absorpce<\/strong> \u2014 \u017e\u00e1dn\u00fd jatern\u00ed efekt prvn\u00edho pr\u016fchodu, \u017e\u00e1dn\u00e9 vrcholov\u00e9 plazmatick\u00e9 hladiny, \u017e\u00e1dn\u00e1 syst\u00e9mov\u00e1 z\u00e1t\u011b\u017e vedlej\u0161\u00edmi \u00fa\u010dinky<\/li>\n<li><strong>Minim\u00e1ln\u00ed l\u00e9kov\u00e9 interakce<\/strong> \u2014 na rozd\u00edl od rifampicinu (siln\u00e9ho induktoru CYP), rifaximin v\u00fdznamn\u011b neindukuje ani neinhibuje CYP enzymy<\/li>\n<li><strong>N\u00edzk\u00fd tlak na vznik rezistence<\/strong> mimo st\u0159evo \u2014 syst\u00e9mov\u00e9 patogeny nejsou vystaveny<\/li>\n<\/ul>\n<p>U IBS-D a SIBO se p\u0159edpokl\u00e1d\u00e1, \u017ee prosp\u011b\u0161n\u00fd \u00fa\u010dinek rifaximinu spo\u010d\u00edv\u00e1 v <strong>p\u0159etv\u00e1\u0159en\u00ed st\u0159evn\u00edho mikrobiomu<\/strong> \u2014 sn\u00ed\u017een\u00ed bakteri\u00e1ln\u00ed fermentace, tvorby plyn\u016f a dekonjugace \u017elu\u010dov\u00fdch kyselin, kter\u00e9 vyvol\u00e1vaj\u00ed p\u0159\u00edznaky. \u00da\u010dinek na p\u0159\u00edznaky \u010dasto p\u0159etrv\u00e1v\u00e1 t\u00fddny a\u017e m\u011bs\u00edce po ukon\u010den\u00ed 14denn\u00ed l\u00e9\u010dby, co\u017e nazna\u010duje posun sm\u011brem ke stabiln\u011bj\u0161\u00edmu mikrobi\u00e1ln\u00edmu spole\u010denstv\u00ed sp\u00ed\u0161e ne\u017e pouhou eradikaci patogen\u016f.<\/p>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed a pod\u00e1n\u00ed<\/h2>\n<p><strong>Pr\u016fjem cestovatel\u016f (dosp\u011bl\u00ed a d\u011bti 12+):<\/strong> 200 mg t\u0159ikr\u00e1t denn\u011b po dobu 3 dn\u016f.<\/p>\n<p><strong>Prevence recidivuj\u00edc\u00ed jatern\u00ed encefalopatie:<\/strong> 550 mg dvakr\u00e1t denn\u011b (dlouhodob\u011b).<\/p>\n<p><strong>IBS s pr\u016fjmem (IBS-D):<\/strong> 550 mg t\u0159ikr\u00e1t denn\u011b po dobu 14 dn\u016f. \u00daleva obvykle trv\u00e1 t\u00fddny a\u017e m\u011bs\u00edce. P\u0159i n\u00e1vratu p\u0159\u00edznak\u016f jsou povoleny a\u017e 2 opakovan\u00e9 k\u00fary.<\/p>\n<p><strong>SIBO (mimo schv\u00e1len\u00e9 indikace):<\/strong> 550 mg t\u0159ikr\u00e1t denn\u011b po dobu 14 dn\u016f; n\u011bkter\u00e9 protokoly p\u0159id\u00e1vaj\u00ed neomycin 500 mg dvakr\u00e1t denn\u011b u methanem dominantn\u00edho SIBO.<\/p>\n<ul>\n<li>U\u017e\u00edvejte s j\u00eddlem nebo nala\u010dno. Potrava m\u00edrn\u011b zpomaluje vst\u0159eb\u00e1v\u00e1n\u00ed, ale neovliv\u0148uje klinick\u00fd \u00fa\u010dinek (proto\u017ee se t\u00e9m\u011b\u0159 nic nevst\u0159eb\u00e1v\u00e1).<\/li>\n<li>Dokon\u010dete celou k\u00faru, i kdy\u017e se p\u0159\u00edznaky zlep\u0161\u00ed.<\/li>\n<li>Pokud vynech\u00e1te d\u00e1vku, u\u017eijte ji, jakmile si vzpomenete, pokud nen\u00ed bl\u00edzko dal\u0161\u00ed d\u00e1vky; neduplikujte d\u00e1vku.<\/li>\n<li>P\u0159i cestovatelsk\u00e9m pr\u016fjmu, <strong>nepou\u017e\u00edvejte<\/strong> p\u0159i hore\u010dce nebo krvav\u00e9 stolici (to nazna\u010duje invazivn\u00ed infekci vy\u017eaduj\u00edc\u00ed syst\u00e9mov\u00e1 antibiotika).<\/li>\n<li>P\u0159ehodno\u0165te l\u00e9\u010dbu, pokud se p\u0159\u00edznaky nezlep\u0161\u00ed do 24\u201348 hodin u cestovatelsk\u00e9ho pr\u016fjmu nebo do 2 t\u00fddn\u016f u IBS-D.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p>Rifaximin je velmi dob\u0159e sn\u00e1\u0161en, proto\u017ee se t\u00e9m\u017e neabsorbuje do krevn\u00edho ob\u011bhu.<\/p>\n<p><strong>\u010cast\u00e9:<\/strong><\/p>\n<ul>\n<li>Bolest hlavy<\/li>\n<li>M\u00edrn\u00e1 nevolnost, nepohodl\u00ed v b\u0159i\u0161e<\/li>\n<li>Plynatost, nad\u00fdm\u00e1n\u00ed<\/li>\n<li>Z\u00e1vrat\u011b, \u00fanava<\/li>\n<\/ul>\n<p><strong>M\u00e9n\u011b \u010dast\u00e9:<\/strong><\/p>\n<ul>\n<li>Vyr\u00e1\u017eka, sv\u011bd\u011bn\u00ed<\/li>\n<li>Perifern\u00ed ed\u00e9m<\/li>\n<li>Svalov\u00fd k\u0159e\u010d<\/li>\n<li>Vz\u00e1cn\u00e9: <em>Clostridioides difficile<\/em>-asociovan\u00e1 kolitida \u2014 jak\u00e9koli antibiotikum v\u010detn\u011b rifaximinu m\u016f\u017ee naru\u0161it st\u0159evn\u00ed mikrofl\u00f3ru natolik, \u017ee umo\u017en\u00ed <em>C. difficile<\/em> p\u0159emno\u017een\u00ed, a\u010dkoli riziko je ni\u017e\u0161\u00ed ne\u017e u syst\u00e9mov\u00fdch antibiotik<\/li>\n<li>Velmi vz\u00e1cn\u00e9: hypersenzitivn\u00ed reakce (v\u010detn\u011b vz\u00e1cn\u00fdch p\u0159\u00edpad\u016f Stevens-Johnsonova syndromu)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<p>T\u00e9m\u011b\u0159 nulov\u00e1 syst\u00e9mov\u00e1 absorpce rifaximinu znamen\u00e1, \u017ee m\u00e1 m\u00e1lo klinicky v\u00fdznamn\u00fdch l\u00e9kov\u00fdch interakc\u00ed. D\u016fle\u017eit\u00e9 body:<\/p>\n<ul>\n<li><strong>Or\u00e1ln\u00ed antikoncepce<\/strong> \u2014 teoreticky mohou \u0161irokospektr\u00e1ln\u00ed antibiotika sn\u00ed\u017eit \u00fa\u010dinnost naru\u0161en\u00edm enterohepat\u00e1ln\u00edho ob\u011bhu kontracep\u010dn\u00edch estrogen\u016f. Klinick\u00fd v\u00fdznam u rifaximinu je mal\u00fd, ale pou\u017eit\u00ed z\u00e1lo\u017en\u00ed antikoncepce b\u011bhem a 7 dn\u00ed po l\u00e9\u010db\u011b je konzervativn\u00ed p\u0159\u00edstup.<\/li>\n<li><strong>Warfarin<\/strong> \u2014 naru\u0161en\u00ed st\u0159evn\u00ed mikrofl\u00f3ry m\u016f\u017ee zm\u011bnit metabolismus vitaminu K; sledujte INR.<\/li>\n<li><strong>Cyklosporin<\/strong> \u2014 m\u016f\u017ee zv\u00fd\u0161it syst\u00e9mov\u00e9 hladiny rifaximinu (interakce s P-gp). Obvykle to nen\u00ed klinicky v\u00fdznamn\u00e9.<\/li>\n<li>\u017d\u00e1dn\u00e9 v\u00fdznamn\u00e9 interakce s CYP-enzymy \u2014 hlavn\u00ed v\u00fdhoda oproti rifampicinu.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kdo by nem\u011bl u\u017e\u00edvat Rifagut?<\/h2>\n<ul>\n<li>Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na rifaximin, rifamyciny (rifampicin, rifabutin) nebo jakoukoli pomocnou l\u00e1tku<\/li>\n<li>St\u0159evn\u00ed obstrukce<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed (Child-Pugh C) \u2014 vz\u00e1cn\u00e9, ale syst\u00e9mov\u00e1 absorpce se m\u016f\u017ee zv\u00fd\u0161it<\/li>\n<li>Krvav\u00fd pr\u016fjem nebo pr\u016fjem s hore\u010dkou \u2014 tyto p\u0159\u00edznaky nazna\u010duj\u00ed invazivn\u00ed infekci vy\u017eaduj\u00edc\u00ed syst\u00e9mov\u00e1 antibiotika, nikoliv rifaximin<\/li>\n<li>T\u011bhotenstv\u00ed a kojen\u00ed \u2014 omezen\u00e9 \u00fadaje; vyvarujte se, pokud p\u0159\u00ednos nep\u0159ev\u00e1\u017e\u00ed riziko (n\u00edzk\u00e1 syst\u00e9mov\u00e1 absorpce je teoreticky uklid\u0148uj\u00edc\u00ed)<\/li>\n<li>D\u011bti mlad\u0161\u00ed ne\u017e v\u011bk uveden\u00fd v indikaci<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<p>Skladujte Rifagut p\u0159i teplot\u011b do 30\u00b0C na such\u00e9m m\u00edst\u011b, v p\u016fvodn\u00edm blistru. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Je Rifagut stejn\u00fd jako Xifaxan nebo Normix?<\/h3>\n<p>Ano \u2014 Rifagut obsahuje stejnou \u00fa\u010dinnou l\u00e1tku (rifaximin) ve stejn\u00fdch sil\u00e1ch jako Xifaxan (USA; Salix) a Normix (EU; Alfa Wassermann). Regula\u010dn\u00ed org\u00e1ny vy\u017eaduj\u00ed bioekvivalenci.<\/p>\n<h3 class=\"wp-block-heading\">Jak funguje Rifagut u IBS-D, pokud IBS nen\u00ed infekce?<\/h3>\n<p>IBS-D nen\u00ed zp\u016fsoben patogenem, ale u \u010d\u00e1sti pacient\u016f je naru\u0161ena st\u0159evn\u00ed mikrobiota a bakteri\u00e1ln\u00ed p\u0159er\u016fst\u00e1n\u00ed p\u0159isp\u00edv\u00e1 k p\u0159\u00edznak\u016fm. Rifaximin p\u016fsob\u00ed modulac\u00ed st\u0159evn\u00ed fl\u00f3ry \u2014 sni\u017euje fermentuj\u00edc\u00ed bakterie, dekonjugaci \u017elu\u010dov\u00fdch kyselin a slizni\u010dn\u00ed z\u00e1n\u011bt. Efekt \u010dasto p\u0159etrv\u00e1v\u00e1 t\u00fddny a\u017e m\u011bs\u00edce po 14denn\u00edm cyklu, proto protokol umo\u017e\u0148uje 1\u20132 opakovan\u00e9 cykly p\u0159i n\u00e1vratu p\u0159\u00edznak\u016f.<\/p>\n<h3 class=\"wp-block-heading\">Jak dlouho trv\u00e1 \u00faleva po 14denn\u00edm cyklu u IBS-D?<\/h3>\n<p>Ve studii TARGET 3 (kl\u00ed\u010dov\u00e1 studie FDA) byla medi\u00e1nov\u00e1 doba odpov\u011bdi po 14denn\u00edm cyklu 550 mg TID 10\u201318 t\u00fddn\u016f. Mnoho pacient\u016f za\u017e\u00edv\u00e1 del\u0161\u00ed \u00falevu; n\u011bkte\u0159\u00ed reaguj\u00ed na opakovan\u00e9 cykly p\u0159i n\u00e1vratu p\u0159\u00edznak\u016f.<\/p>\n<h3 class=\"wp-block-heading\">Je Rifagut bezpe\u010dn\u00fd \u2014 m\u00e1m obavy z u\u017e\u00edv\u00e1n\u00ed antibiotik?<\/h3>\n<p>Rifaximin je neobvykle bezpe\u010dn\u00e9 antibiotikum, proto\u017ee &lt; 0,4 % se vst\u0159eb\u00e1v\u00e1 do krevn\u00edho ob\u011bhu. Syst\u00e9mov\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky jsou minim\u00e1ln\u00ed; interakce s l\u00e9ky jsou minim\u00e1ln\u00ed; tlak na rezistenci u ne-st\u0159evn\u00edch bakteri\u00ed je minim\u00e1ln\u00ed. Hlavn\u00edm probl\u00e9mem u jak\u00e9hokoli antibiotika je <em>C. difficile<\/em> kolitida, kter\u00e1 je u rifaximinu vz\u00e1cn\u00e1 ve srovn\u00e1n\u00ed se syst\u00e9mov\u00fdmi antibiotiky. P\u0159esto by m\u011bl b\u00fdt rifaximin pou\u017e\u00edv\u00e1n pro spr\u00e1vnou indikaci a dobu trv\u00e1n\u00ed, ne jako obecn\u00fd l\u00e9k.<\/p>\n<h3 class=\"wp-block-heading\">Mohu pou\u017e\u00edt Rifagut na cestovatelsk\u00fd pr\u016fjem \u2014 kdy bych to nem\u011bl?<\/h3>\n<p>Rifaximin funguje u neinvazivn\u00edho <em>E. coli<\/em> cestovatelsk\u00e9ho pr\u016fjmu (nejb\u011b\u017en\u011bj\u0161\u00ed typ). <strong>Nepou\u017e\u00edvejte<\/strong> rifaximin, pokud m\u00e1te hore\u010dku nebo krvavou stolici \u2014 to nazna\u010duje invazivn\u00ed <em>Shigella<\/em>, <em>Salmonella<\/em>, nebo <em>Campylobacter<\/em>, infekci, kter\u00e1 vy\u017eaduje syst\u00e9mov\u00e1 antibiotika, jako je ciprofloxacin nebo azithromycin.<\/p>\n<h3 class=\"wp-block-heading\">Mohu u\u017e\u00edvat Rifagut s probiotiky?<\/h3>\n<p>Ano \u2014 mnoho klinik\u016f kombinuje l\u00e9\u010dbu rifaximinem s probiotiky (zejm\u00e9na v protokolech pro SIBO). Pokud je to mo\u017en\u00e9, odd\u011blte u\u017e\u00edv\u00e1n\u00ed o 2\u20133 hodiny. N\u011bkter\u00e9 d\u016fkazy nazna\u010duj\u00ed, \u017ee kombinace rifaximinu s <em>Saccharomyces boulardii<\/em> nebo v\u00edceskmenn\u00fdm probiotikem m\u016f\u017ee zlep\u0161it v\u00fdsledky.<\/p>\n<h3 class=\"wp-block-heading\">Kde mohu koupit Rifagut online?<\/h3>\n<p>M\u016f\u017eete si objednat Rifagut (400 mg nebo 550 mg) od MedsBase v balen\u00edch po 10, 30 nebo 60 tablet\u00e1ch. Dod\u00e1v\u00e1me po cel\u00e9m sv\u011bt\u011b s diskr\u00e9tn\u00edm balen\u00edm a origin\u00e1ln\u00edmi z\u00e1sobami od v\u00fdrobce Sun Pharma.<\/p>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed l\u00e9ky na IBS a IBD<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/colospa\/\">Colospa \u2014 Mebeverin (antispasmodikum pro IBS)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/mesacol\/\">Mesacol \u2014 Mesalamin (ulcer\u00f3zn\u00ed kolitida)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/asacol\/\">Asacol \u2014 Mesalamin (UC)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/mesacol-od\/\">Mesacol OD \u2014 Mesalamin jednou denn\u011b MMX<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/sazo\/\">Sazo \u2014 Sulfasalazin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/salazar\/\">Salazar \u2014 Sulfasalazin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/irritable-bowel-syndrome-ibs-treatment\/\"><strong>Prohl\u00e9dn\u011bte si v\u0161echny l\u00e9ky na IBS a IBD<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed.<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro informa\u010dn\u00ed \u00fa\u010dely a nenahrazuje l\u00e9ka\u0159skou p\u00e9\u010di kvalifikovan\u00e9ho zdravotnick\u00e9ho pracovn\u00edka. Pr\u016fjem doprov\u00e1zen\u00fd hore\u010dkou, krvav\u00e1 stolice, siln\u00e1 bolest b\u0159icha nebo p\u0159\u00edznaky dehydratace vy\u017eaduj\u00ed neodkladn\u00e9 l\u00e9ka\u0159sk\u00e9 vy\u0161et\u0159en\u00ed \u2014 nikoli samol\u00e9\u010dbu rifaximinem.<\/div>\n<h3 class=\"wp-block-heading\">Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Rifagut je dod\u00e1v\u00e1n z <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 pokud nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me zdarma. Rifaximin je st\u0159evn\u011b selektivn\u00ed neabsorbovateln\u00e9 antibiotikum s minim\u00e1ln\u00ed syst\u00e9movou absorpc\u00ed (&lt; 0,4 %) a je doporu\u010dov\u00e1n pro cestovatelsk\u00fd pr\u016fjem, jatern\u00ed encefalopatii a IBS-D.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>","protected":false},"excerpt":{"rendered":"<h5>\u2705 \u00da\u010dinnost l\u00e9\u010dby IBS-D<br \/>\n\u2705 Zabra\u0148uje recidiv\u011b encefalopatie<br \/>\n\u2705 Zastavuje cestovatelsk\u00fd pr\u016fjem<br \/>\n\u2705 \u00da\u010dinn\u011b c\u00edl\u00ed na st\u0159evn\u00ed bakterie<br \/>\n\u2705 Jednoduch\u00e9 a pohodln\u00e9 pod\u00e1n\u00ed<\/h5>\n<p><span style=\"color: #999999;\">Rifagut obsahuje Rifaximin<\/span><\/p>","protected":false},"featured_media":53040,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3583,3542,3342,3565],"product_tag":[3584,3585],"class_list":{"0":"post-53039","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-diarrhoea-treatment","9":"product_cat-gastro-health","10":"product_cat-general-health","11":"product_cat-irritable-bowel-syndrome-ibs-treatment","12":"product_tag-rifagut","13":"product_tag-rifaximin","15":"first","16":"outofstock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable","20":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/53039","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=53039"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/53040"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=53039"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=53039"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=53039"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=53039"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}