{"id":53283,"date":"2023-09-20T09:44:28","date_gmt":"2023-09-20T09:44:28","guid":{"rendered":"https:\/\/medsname.com\/diane-35\/"},"modified":"2026-04-30T10:09:45","modified_gmt":"2026-04-30T10:09:45","slug":"diane-35","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/diane-35\/","title":{"rendered":"Diane 35"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Diane 35?<\/h3>\n

Diane 35 je kombinovan\u00e1 peror\u00e1ln\u00ed antikoncepce obsahuj\u00edc\u00ed cyproteron acet\u00e1t 2 mg + ethinylestradiol 35 mcg, vyr\u00e1b\u011bn\u00e1 spole\u010dnost\u00ed Bayer. Schv\u00e1lena pro st\u0159edn\u011b t\u011b\u017ek\u00e9 a\u017e t\u011b\u017ek\u00e9 akn\u00e9 a androgen-dependentn\u00ed hirsutismus u \u017een, kter\u00e9 nereagovaly na lok\u00e1ln\u00ed terapii nebo peror\u00e1ln\u00ed antibiotika; poskytuje spolehlivou antikoncepci b\u011bhem u\u017e\u00edv\u00e1n\u00ed. U\u017e\u00edv\u00e1 se jednou denn\u011b po dobu 21 dn\u016f, n\u00e1sleduje 7denn\u00ed p\u0159est\u00e1vka bez tablet.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
\n\u26a0\ufe0f D\u016fle\u017eit\u00e9 \u2014 Riziko VTE je vy\u0161\u0161\u00ed ne\u017e u v\u011bt\u0161iny kombinovan\u00fdch peror\u00e1ln\u00edch kontraceptiv.<\/strong> Diane 35 nese riziko \u017eiln\u00ed tromboembolie (VTE) p\u0159ibli\u017en\u011b 1,5\u20132\u00d7 vy\u0161\u0161\u00ed ne\u017e u kombinovan\u00fdch peror\u00e1ln\u00edch kontraceptiv s n\u00edzkou d\u00e1vkou levonorgestrelu (~9\u201315 p\u0159\u00edpad\u016f na 10 000 \u017een-rok\u016f vs 5\u20137 u levonorgestrelu). Je schv\u00e1lena speci\u00e1ln\u011b pro akn\u00e9\/hirsutismus, nikoli jako antikoncepce prvn\u00ed volby. Okam\u017eit\u011b p\u0159eru\u0161te u\u017e\u00edv\u00e1n\u00ed a vyhledejte neodkladn\u00e9 vy\u0161et\u0159en\u00ed p\u0159i nevysv\u011btliteln\u00e9 bolesti nebo otoku l\u00fdtka, n\u00e1hl\u00e9 bolesti na hrudi nebo du\u0161nosti, n\u00e1hl\u00e9 siln\u00e9 bolesti hlavy, n\u00e1hl\u00fdch zm\u011bn\u00e1ch vid\u011bn\u00ed nebo fok\u00e1ln\u00edch neurologick\u00fdch p\u0159\u00edznac\u00edch. P\u0159eru\u0161te u\u017e\u00edv\u00e1n\u00ed 4 t\u00fddny p\u0159ed v\u011bt\u0161\u00ed operac\u00ed a b\u011bhem dlouhodob\u00e9 imobilizace.\n<\/div>\n

Jak Diane 35 funguje<\/h2>\n

Diane 35 kombinuje dva mechanismy. Acet\u00e1t cyproteronu<\/strong> je siln\u00fd antiandrogen, kter\u00fd sout\u011b\u017e\u00ed s testosteronem a dihydrotestosteronem (DHT) na androgenn\u00edm receptoru v k\u016f\u017ei a vlasov\u00fdch folikulech, sni\u017euje produkci ko\u017en\u00edho mazu a zpomaluje r\u016fst vlas\u016f na androgenn\u011b z\u00e1visl\u00fdch oblastech. Ethinylestradiol<\/strong> je syntetick\u00fd estrogen, kter\u00fd potla\u010duje ovulaci, zvy\u0161uje globulin v\u00e1zaj\u00edc\u00ed pohlavn\u00ed hormony (SHBG), sni\u017euje cirkuluj\u00edc\u00ed voln\u00fd testosteron a poskytuje kontrolu cyklu.<\/p>\n

Kombinace poskytuje antikoncep\u010dn\u00ed \u00fa\u010dinnost srovnatelnou s jin\u00fdmi COC (Pearl Index ~0,7 p\u0159i dokonal\u00e9m u\u017e\u00edv\u00e1n\u00ed, ~7 p\u0159i typick\u00e9m u\u017e\u00edv\u00e1n\u00ed), zat\u00edmco antiandrogenn\u00ed \u00fa\u010dinek zlep\u0161uje st\u0159edn\u011b t\u011b\u017ek\u00e9 a\u017e t\u011b\u017ek\u00e9 akn\u00e9 u 60\u201370 % \u017een b\u011bhem 3\u20136 m\u011bs\u00edc\u016f a sni\u017euje sk\u00f3re hirsutismu u 60\u201370 % \u017een.<\/p>\n

Indikace<\/h2>\n

Akn\u00e9 \/ hirsutismus.<\/p>\n

It is sometimes prescribed off-label for polycystic ovary syndrome (PCOS) presenting with acne or hirsutism, and as anti-androgen therapy in transgender women under specialist supervision.<\/p>\n

D\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nD\u00e1vkovac\u00ed sch\u00e9ma<\/th>\nD\u00e9lka l\u00e9\u010dby<\/th>\n<\/tr>\n<\/thead>\n
Acne \/ hirsutism<\/td>\n1 tableta denn\u011b po dobu 21 dn\u00ed, pot\u00e9 7denn\u00ed p\u0159est\u00e1vka bez tablet<\/td>\nPokra\u010dujte alespo\u0148 3\u20134 cykly po vymizen\u00ed p\u0159\u00edznak\u016f; kontrola za 6 m\u011bs\u00edc\u016f<\/td>\n<\/tr>\n
Za\u010d\u00e1tek prvn\u00edho cyklu (bez p\u0159edchoz\u00ed hormon\u00e1ln\u00ed antikoncepce)<\/td>\nZa\u010dn\u011bte 1. den menstrua\u010dn\u00edho krv\u00e1cen\u00ed; okam\u017eit\u00e1 antikoncep\u010dn\u00ed ochrana<\/td>\nNep\u0159etr\u017eit\u011b jako v\u00fd\u0161e<\/td>\n<\/tr>\n
P\u0159echod z jin\u00e9 kombinovan\u00e9 hormon\u00e1ln\u00ed antikoncepce (COC)<\/td>\nZa\u010dn\u011bte den po posledn\u00ed aktivn\u00ed tablet\u011b p\u0159edchoz\u00ed COC; bez p\u0159est\u00e1vky<\/td>\nNep\u0159etr\u017eit\u011b<\/td>\n<\/tr>\n
Vynechan\u00e1 tableta (<12 hodin zpo\u017ed\u011bn\u00ed)<\/td>\nVezm\u011bte ihned; dal\u0161\u00ed tabletu v obvyklou dobu; ochrana zachov\u00e1na<\/td>\n\u017d\u00e1dn\u00e1 dal\u0161\u00ed opat\u0159en\u00ed<\/td>\n<\/tr>\n
Vynechan\u00e1 tableta (>12 hodin zpo\u017ed\u011bn\u00ed)<\/td>\nVezm\u011bte ihned, vezm\u011bte dal\u0161\u00ed tabletu v obvyklou dobu, pou\u017eijte bari\u00e9rovou metodu 7 dn\u00ed<\/td>\nPokud jsou vynech\u00e1ny 3 a v\u00edce tablet v 1. t\u00fddnu, zva\u017ete nouzovou antikoncepci<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Dlouhodob\u00e9 nep\u0159etr\u017eit\u00e9 u\u017e\u00edv\u00e1n\u00ed p\u0159esahuj\u00edc\u00ed 24\u201336 m\u011bs\u00edc\u016f bez p\u0159\u00edznakov\u00e9ho p\u0159\u00ednosu se obecn\u011b nedoporu\u010duje vzhledem k kumulativn\u00ed expozici VTE; m\u011bly by b\u00fdt zv\u00e1\u017eeny alternativn\u00ed antiandrogenn\u00ed strategie (spironolakton, isotretinoin, finasterid pro hirsutismus).<\/p>\n

Kontraindikace<\/h2>\n