{"id":53310,"date":"2023-09-20T09:44:53","date_gmt":"2023-09-20T09:44:53","guid":{"rendered":"https:\/\/medsname.com\/honvan\/"},"modified":"2026-04-30T16:30:24","modified_gmt":"2026-04-30T16:30:24","slug":"honvan","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/honvan\/","title":{"rendered":"Honvan"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">Rychl\u00e1 odpov\u011b\u010f<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Honvan<\/strong> \u2014 Fosfestrol tetrasodn\u00fd 120 mg (Asta Medica). Difosf\u00e1t diethylstilbestrolu \u2014 vysok\u00e1 d\u00e1vka estrogenu pro pokro\u010dilou metastatickou rakovinu prostaty. Largely nahrazen agonisty LHRH; z\u016fst\u00e1v\u00e1 v prost\u0159ed\u00edch s omezen\u00fdmi zdroji nebo v paliativn\u00ed p\u00e9\u010di.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/li>\n<li>Diskr\u00e9tn\u00ed balen\u00ed v oby\u010dejn\u00e9 ob\u00e1lce<\/li>\n<li>Dod\u00e1n\u00ed po cel\u00e9m sv\u011bt\u011b<\/li>\n<li>Hodnoceno v\u00edce ne\u017e 1 400 z\u00e1kazn\u00edky (<a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">\u010d\u00edst recenze<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Z\u00e1ruka op\u011btovn\u00e9ho zasl\u00e1n\u00ed:<\/strong> pokud va\u0161e objedn\u00e1vka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f od odesl\u00e1n\u00ed, za\u0161leme ji znovu bez dal\u0161\u00edch n\u00e1klad\u016f. <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">P\u0159e\u010d\u00edst podm\u00ednky<\/a>.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Honvan je expedov\u00e1n od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v neutr\u00e1ln\u00edm balen\u00ed, fakturace prob\u00edh\u00e1 p\u0159es regulovan\u00e9ho platebn\u00edho procesora (na v\u00fdpisu z \u00fa\u010dtu se zobraz\u00ed regulovan\u00fd platebn\u00ed procesor \u2014 nikdy MedsBase nebo n\u00e1zev l\u00e9ku). Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed 20pracovnodenn\u00ed z\u00e1rukou na p\u0159eposl\u00e1n\u00ed.<\/p>\n<div class=\"medsbase-specialist-strip\" style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0;\"><strong>\u26a0\ufe0f Specializovan\u00e1 onkologick\u00e1 l\u00e9\u010dba pod dohledem l\u00e9ka\u0159e<\/strong> \u2014 tento l\u00e9k je zahajov\u00e1n, monitorov\u00e1n a ukon\u010dov\u00e1n onkologem nebo hematologem. D\u00e1vkov\u00e1n\u00ed z\u00e1vis\u00ed na typu n\u00e1doru, stadiu, t\u011blesn\u00e9m povrchu, funkci org\u00e1n\u016f a sou\u010dasn\u00e9 terapii. Samol\u00e9\u010dba nen\u00ed vhodn\u00e1; n\u00ed\u017ee uveden\u00e9 informace jsou vzd\u011bl\u00e1vac\u00ed a podporuj\u00ed informovan\u00e9 rozhovory s va\u0161\u00edm specialistou.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Vysok\u00e9 kardiovaskul\u00e1rn\u00ed riziko<\/strong><br \/>Fosfestrol nese v\u00fdznamn\u00e9 kardiovaskul\u00e1rn\u00ed riziko \u2014 hlubok\u00e1 \u017eiln\u00ed tromb\u00f3za, plicn\u00ed embolie, infarkt myokardu, c\u00e9vn\u00ed mozkov\u00e1 p\u0159\u00edhoda, zadr\u017eov\u00e1n\u00ed tekutin. Pou\u017e\u00edvejte pouze tehdy, kdy\u017e modern\u00ed alternativy (agonist\u00e9 LHRH, abirateron, enzalutamid) nejsou dostupn\u00e9 nebo vhodn\u00e9. Povinn\u00e1 konzultace tromboprofylaxe s kardiologem.<\/div>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Kdy se to pou\u017e\u00edv\u00e1?<\/h3>\n<p>Diethylstilbestrol difosf\u00e1t \u2014 vysokod\u00e1vkovan\u00fd estrogen pro pokro\u010dilou metastatickou rakovinu prostaty. V\u011bt\u0161inou nahrazen agonisty LHRH; z\u016fst\u00e1v\u00e1 v omezen\u00fdch zdroj\u00edch nebo paliativn\u00ed p\u00e9\u010di.<\/p>\n<h3>Na kter\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky si d\u00e1t pozor?<\/h3>\n<p>N\u00e1valy horka, gynekomastie, \u00fanava, sexu\u00e1ln\u00ed dysfunkce (typick\u00e9 pro t\u0159\u00eddu antiandrogen\u016f). Monitorov\u00e1n\u00ed specifick\u00e9 pro tento l\u00e9k je uvedeno v bezpe\u010dnostn\u00edch upozorn\u011bn\u00edch v\u00fd\u0161e.<\/p>\n<h3>Interakce l\u00e9k\u016f?<\/h3>\n<p>Li\u0161\u00ed se podle molekuly \u2014 abirateron je substr\u00e1t CYP3A4; bicalutamid je substr\u00e1t CYP3A4. V\u017edy sd\u011blte v\u0161echny u\u017e\u00edvan\u00e9 l\u00e9ky. Siln\u00e9 inhibitory\/induktory CYP3A4 v\u00fdznamn\u011b ovliv\u0148uj\u00ed hladiny l\u00e9ku.<\/p>\n<h3>Kdy by m\u011bl b\u00fdt vysazen?<\/h3>\n<p>P\u0159i progresi onemocn\u011bn\u00ed, intolerovateln\u00e9 toxicit\u011b nebo \u00fasp\u011b\u0161n\u00e9 odpov\u011bdi s pl\u00e1novanou p\u0159est\u00e1vkou v l\u00e9\u010db\u011b. V\u017edy rozhodne specialista \u2014 n\u00e1hl\u00e9 vysazen\u00ed m\u016f\u017ee v\u00e9st k p\u0159echodn\u00e9mu vzestupu PSA (abstinen\u010dn\u00ed reakce), co\u017e obvykle nen\u00ed d\u016fvodem k obav\u00e1m.<\/p>\n<h3>Monitorov\u00e1n\u00ed PSA?<\/h3>\n<p>PSA ka\u017ed\u00e9 1-3 m\u011bs\u00edce b\u011bhem l\u00e9\u010dby. Vzestup PSA p\u0159i kastraci nazna\u010duje kastra\u010dn\u00ed rezistenci \u2014 m\u016f\u017ee b\u00fdt nutn\u00fd p\u0159echod na l\u00e9ky druh\u00e9 linie (abirateron, enzalutamid, docetaxel).<\/p>\n<h3>Kombinovan\u00e1 androgenn\u00ed blok\u00e1da?<\/h3>\n<p>LHRH agonista (goserelin, leuprolid) + bikalutamid je b\u011b\u017en\u00e1 kombinace. Maxim\u00e1ln\u00ed androgenn\u00ed blok\u00e1da m\u00e1 m\u00edrn\u00fd p\u0159e\u017eitkov\u00fd benefit oproti samotn\u00e9mu LHRH.<\/p>\n<h3>Zdrav\u00ed kost\u00ed?<\/h3>\n<p>Dlouhodob\u00e1 androgenn\u00ed deprivace urychluje \u00fabytek kostn\u00ed hmoty. P\u0159i osteopenii\/osteopor\u00f3ze p\u0159idejte bisfosfon\u00e1t (zoledron\u00e1t) nebo denosumab. Suplementace v\u00e1pn\u00edkem a vitaminem D.<\/p>\n<h3>T\u011bhotenstv\u00ed?<\/h3>\n<p>Antiandrogeny jsou teratogenn\u00ed \u2014 partne\u0159i mus\u00ed b\u011bhem terapie pou\u017e\u00edvat \u00fa\u010dinnou antikoncepci. Nejv\u00fdznamn\u011bj\u0161\u00ed pro mlad\u0161\u00ed mu\u017ee s lokalizovan\u00fdm onemocn\u011bn\u00edm.<\/p>\n<h3>Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Vezm\u011bte, kdy\u017e si vzpomenete ten sam\u00fd den; jinak vynechejte. Specialista m\u016f\u017ee m\u00edt specifick\u00e9 pokyny pro vynechan\u00e9 d\u00e1vky v z\u00e1vislosti na re\u017eimu.<\/p>\n<h3>Kardiovaskul\u00e1rn\u00ed monitorov\u00e1n\u00ed?<\/h3>\n<p>Povinn\u00e9 u fosfestrolu; doporu\u010deno u abirateronu (TK, retence tekutin, elektrolyty); rutinn\u00ed u bikalutamidu (ob\u010dasn\u00e1 kardiovaskul\u00e1rn\u00ed kontrola).<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Dal\u0161\u00ed rakovina a antiandrogenn\u00ed terapie<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/calutide\/\">Calutide<\/a> \u2014 bikalutamid 50 mg \u2014 alternativn\u00ed zna\u010dka antiandrogenu<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/xbira\/\">Xbira<\/a> \u2014 abirateron 250 mg \u2014 inhibitor CYP17 pro mCRPC<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/honvan\/\">Honvan<\/a> \u2014 fosfestrol 120 mg \u2014 difosf\u00e1t diethylstilbestrolu<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/estramustine\/\">Estramustin<\/a> \u2014 estramustin fosf\u00e1t \u2014 alkyla\u010dn\u00ed \u010dinidlo pro hormon\u00e1ln\u011b refraktern\u00ed onemocn\u011bn\u00ed<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zoldria\/\">Zoldria<\/a> \u2014 zoledronov\u00e1 kyselina IV pro kostn\u00ed metast\u00e1zy<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> L\u00e9\u010dba rakoviny je vysoce individualizovan\u00e1. Konkr\u00e9tn\u00ed l\u00e9k, d\u00e1vkov\u00e1n\u00ed, re\u017eim, monitorov\u00e1n\u00ed a podp\u016frn\u00e1 p\u00e9\u010de mus\u00ed b\u00fdt stanoveny kvalifikovan\u00fdm onkologem nebo hematologem na z\u00e1klad\u011b biologie n\u00e1doru, stadia onemocn\u011bn\u00ed, p\u0159idru\u017een\u00fdch chorob a c\u00edl\u016f l\u00e9\u010dby. Tyto informace jsou vzd\u011bl\u00e1vac\u00edho charakteru; nenahrazuj\u00ed odborn\u00e9 l\u00e9ka\u0159sk\u00e9 poradenstv\u00ed.<\/div>","protected":false},"excerpt":{"rendered":"<p>Honvan (Fosfestrol 120 mg) \u2014 vysok\u00e1 d\u00e1vka difosf\u00e1tu diethylstilbestrolu, estrogenu pro pokro\u010dilou metastatickou rakovinu prostaty. V\u00fdznamn\u00e9 kardiovaskul\u00e1rn\u00ed a trombotick\u00e9 riziko.<\/p>","protected":false},"featured_media":53311,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[],"class_list":{"0":"post-53310","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","10":"first","11":"outofstock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/53310","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=53310"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/53311"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=53310"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=53310"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=53310"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=53310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}