{"id":53524,"date":"2023-09-20T09:47:35","date_gmt":"2023-09-20T09:47:35","guid":{"rendered":"https:\/\/medsname.com\/temoside\/"},"modified":"2026-04-30T16:30:25","modified_gmt":"2026-04-30T16:30:25","slug":"temoside","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/temoside\/","title":{"rendered":"Temoside"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">Rychl\u00e1 odpov\u011b\u010f<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Temoside<\/strong> \u2014 temozolomid 20\/100\/250 mg (Sun Pharma). Peror\u00e1ln\u00ed DNA-alkyluj\u00edc\u00ed l\u00e1tka \u2014 prvn\u00ed volba chemoterapie pro glioblastom multiforme (s n\u00e1slednou radioterapi\u00ed a adjuvantn\u00ed l\u00e9\u010dbou), anaplastick\u00fd astrocytom, melanom (mimo indikaci\/historick\u00e9 pou\u017eit\u00ed). Pronik\u00e1 hematoencefalickou bari\u00e9rou.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/li>\n<li>Diskr\u00e9tn\u00ed balen\u00ed v oby\u010dejn\u00e9 ob\u00e1lce<\/li>\n<li>Dod\u00e1n\u00ed po cel\u00e9m sv\u011bt\u011b<\/li>\n<li>Hodnoceno v\u00edce ne\u017e 1 400 z\u00e1kazn\u00edky (<a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">\u010d\u00edst recenze<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Z\u00e1ruka op\u011btovn\u00e9ho zasl\u00e1n\u00ed:<\/strong> pokud va\u0161e objedn\u00e1vka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f od odesl\u00e1n\u00ed, za\u0161leme ji znovu bez dal\u0161\u00edch n\u00e1klad\u016f. <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">P\u0159e\u010d\u00edst podm\u00ednky<\/a>.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Temoside je expedov\u00e1n od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v neutr\u00e1ln\u00edm balen\u00ed, fakturace prob\u00edh\u00e1 p\u0159es regulovan\u00e9ho platebn\u00edho procesora (na v\u00fdpisu z karty se zobraz\u00ed regulovan\u00fd platebn\u00ed procesor \u2014 nikdy MedsBase nebo n\u00e1zev l\u00e9ku). Ka\u017ed\u00e1 objedn\u00e1vka je kryta na\u0161\u00ed 20-pracovn\u00ed denn\u00ed z\u00e1rukou na p\u0159eposl\u00e1n\u00ed.<\/p>\n<div class=\"medsbase-specialist-strip\" style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0;\"><strong>\u26a0\ufe0f Specializovan\u00e1 onkologick\u00e1 l\u00e9\u010dba pod dohledem l\u00e9ka\u0159e<\/strong> \u2014 tento l\u00e9k je zahajov\u00e1n, monitorov\u00e1n a ukon\u010dov\u00e1n onkologem nebo hematologem. D\u00e1vkov\u00e1n\u00ed z\u00e1vis\u00ed na typu n\u00e1doru, stadiu, t\u011blesn\u00e9m povrchu, funkci org\u00e1n\u016f a sou\u010dasn\u00e9 terapii. Samol\u00e9\u010dba nen\u00ed vhodn\u00e1; n\u00ed\u017ee uveden\u00e9 informace jsou vzd\u011bl\u00e1vac\u00ed a podporuj\u00ed informovan\u00e9 rozhovory s va\u0161\u00edm specialistou.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Myelosuprese + profylaxe PCP<\/strong><br \/>Kumulativn\u00ed myelosuprese (zejm\u00e9na trombocytopenie a lymfopenie). Povinn\u00fd t\u00fddenn\u00ed krevn\u00ed obraz. Lymfopenie spolu s prob\u00edhaj\u00edc\u00ed radioterapi\u00ed zvy\u0161uje riziko infekce \u2014 doporu\u010duje se profylaxe Pneumocystis jirovecii pneumonie (PCP) (kotrimoxazol nebo atovakvon) b\u011bhem f\u00e1ze chemoradioterapie.<\/div>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Standardn\u00ed sch\u00e9ma?<\/h3>\n<p>Stupp\u016fv protokol: 75 mg\/m\u00b2\/den b\u011bhem 6 t\u00fddn\u016f radioterapie, pot\u00e9 4t\u00fddenn\u00ed pauza, n\u00e1sledn\u011b adjuvantn\u00ed l\u00e9\u010dba 150-200 mg\/m\u00b2 \u00d7 5 dn\u00ed ka\u017ed\u00fdch 28 dn\u00ed po dobu 6 cykl\u016f. Nov\u011bj\u0161\u00ed sch\u00e9mata (prodlou\u017een\u00e1 adjuvantn\u00ed l\u00e9\u010dba, d\u00e1vkov\u00e1n\u00ed s vy\u0161\u0161\u00ed intenzitou) se pou\u017e\u00edvaj\u00ed u vybran\u00fdch p\u0159\u00edpad\u016f.<\/p>\n<h3>U\u017e\u00edvat s j\u00eddlem?<\/h3>\n<p>Nala\u010dno (1 hodinu p\u0159ed j\u00eddlem nebo 2 hodiny po j\u00eddle) ve stejnou denn\u00ed dobu. Profylaxe antiemetiky (antagonist\u00e9 5-HT3) je standardem.<\/p>\n<h3>\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky?<\/h3>\n<p>Nevolnost\/zvracen\u00ed (kontrolovan\u00e9 antiemetiky), \u00fanava, lymfopenie, trombocytopenie, bolest hlavy, alopecie (p\u0159i radioterapii), z\u00e1cpa.<\/p>\n<h3>Stav metylace MGMT?<\/h3>\n<p>Metylace promotoru MGMT p\u0159edpov\u00edd\u00e1 v\u011bt\u0161\u00ed benefit z temozolomidu. Testovat u v\u0161ech nov\u011b diagnostikovan\u00fdch glioblastom\u016f. U metylovan\u00fdch n\u00e1dor\u016f je medi\u00e1n p\u0159e\u017eit\u00ed ~22 m\u011bs\u00edc\u016f p\u0159i Stuppov\u011b re\u017eimu vs ~12 m\u011bs\u00edc\u016f u nemetylovan\u00fdch.<\/p>\n<h3>Profylaxe PCP \u2014 pro\u010d?<\/h3>\n<p>Dlouhodob\u00e1 lymfopenie spolu s prob\u00edhaj\u00edc\u00ed radioterapi\u00ed vytv\u00e1\u0159\u00ed riziko oportunn\u00ed infekce, zejm\u00e9na Pneumocystis jirovecii pneumonie. Kotrimoxazol 480 mg t\u0159ikr\u00e1t t\u00fddn\u011b b\u011bhem f\u00e1ze chemoradioterapie je standardem.<\/p>\n<h3>T\u011bhotenstv\u00ed?<\/h3>\n<p>Siln\u011b kontraindikov\u00e1no \u2014 teratogenn\u00ed. Efektivn\u00ed antikoncepce b\u011bhem a nejm\u00e9n\u011b 6 m\u011bs\u00edc\u016f po l\u00e9\u010db\u011b pro oba partnery.<\/p>\n<h3>Interakce l\u00e9k\u016f?<\/h3>\n<p>M\u00e1lo v\u00fdznamn\u00fdch. Valpro\u00e1t m\u016f\u017ee m\u00edrn\u011b ovliv\u0148ovat hladiny. Antiemetika (granisetron, ondansetron) se rutinn\u011b pou\u017e\u00edvaj\u00ed.<\/p>\n<h3>Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Vynechat vynechanou d\u00e1vku; pokra\u010dovat v norm\u00e1ln\u00edm sch\u00e9matu n\u00e1sleduj\u00edc\u00ed den. Informovat onkologick\u00fd t\u00fdm.<\/p>\n<h3>Dlouhodob\u00e9 komplikace?<\/h3>\n<p>Kumulativn\u00ed myelosuprese a mal\u00e9 riziko sekund\u00e1rn\u00ed malignity (myelodysplazie, AML) po letech kumulativn\u00ed terapie.<\/p>\n<h3>Co druh\u00e1 linie?<\/h3>\n<p>P\u0159i progresi glioblastomu jsou mo\u017enost\u00ed bevacizumab, lomustin, re-irradiace nebo klinick\u00e9 studie. Neexistuje standardn\u00ed l\u00e9\u010dba druh\u00e9 linie \u2014 v\u0161echna rozhodnut\u00ed veden\u00e1 specialistou.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Dal\u0161\u00ed l\u00e9ky na rakovinu<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/xeloda\/\">Xeloda<\/a> \u2014 kapecitabin 500 mg \u2014 peror\u00e1ln\u00ed profarmakon 5-FU pro karcinom prsu\/kolorekta\/\u017ealudku<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/altraz\/\">Altraz<\/a> \u2014 anastrozol 1 mg \u2014 inhibitor aromat\u00e1zy pro postmenopauz\u00e1ln\u00ed karcinom prsu<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/xbira\/\">Xbira<\/a> \u2014 abirateron 250 mg \u2014 inhibitor CYP17 pro metastatick\u00fd karcinom prostaty<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zoldria\/\">Zoldria<\/a> \u2014 kyselina zoledronov\u00e1 IV \u2014 pro kostn\u00ed metast\u00e1zy a hyperkalc\u00e9mii<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/actorise\/\">Actorise<\/a> \u2014 darbepoetin alfa \u2014 pro an\u00e9mii vyvolanou chemoterapi\u00ed<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> L\u00e9\u010dba rakoviny je vysoce individualizovan\u00e1. Konkr\u00e9tn\u00ed l\u00e9k, d\u00e1vkov\u00e1n\u00ed, re\u017eim, monitorov\u00e1n\u00ed a podp\u016frn\u00e1 p\u00e9\u010de mus\u00ed b\u00fdt stanoveny kvalifikovan\u00fdm onkologem nebo hematologem na z\u00e1klad\u011b biologie n\u00e1doru, stadia onemocn\u011bn\u00ed, p\u0159idru\u017een\u00fdch chorob a c\u00edl\u016f l\u00e9\u010dby. Tyto informace jsou vzd\u011bl\u00e1vac\u00edho charakteru; nenahrazuj\u00ed odborn\u00e9 l\u00e9ka\u0159sk\u00e9 poradenstv\u00ed.<\/div>","protected":false},"excerpt":{"rendered":"<p>Temoside (Temozolomid 20\/100\/250 mg) \u2014 Sun Pharma peror\u00e1ln\u00ed DNA-alkyluj\u00edc\u00ed l\u00e1tka pro glioblastom a anaplastick\u00fd astrocytom. Stupp\u016fv protokol s n\u00e1slednou radioterapi\u00ed a adjuvantn\u00ed l\u00e9\u010dbou.<\/p>","protected":false},"featured_media":53525,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[],"class_list":{"0":"post-53524","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","10":"first","11":"outofstock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/53524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=53524"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/53525"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=53524"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=53524"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=53524"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=53524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}