{"id":53570,"date":"2023-09-20T09:48:04","date_gmt":"2023-09-20T09:48:04","guid":{"rendered":"https:\/\/medsname.com\/xeloda\/"},"modified":"2026-04-30T16:30:25","modified_gmt":"2026-04-30T16:30:25","slug":"xeloda","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/xeloda\/","title":{"rendered":"Xeloda"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">Rychl\u00e1 odpov\u011b\u010f<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Xeloda<\/strong> \u2014 capecitabine 500 mg (Roche). Or\u00e1ln\u00ed prodrug 5-fluorouracilu (5-FU) \u2014 pro adjuvantn\u00ed a metastatick\u00fd kolorekt\u00e1ln\u00ed karcinom, karcinom prsu, karcinom \u017ealudku a karcinom pankreatu. Obch\u00e1z\u00ed pot\u0159ebu intraven\u00f3zn\u00edho pod\u00e1n\u00ed. Dvakr\u00e1t denn\u011b or\u00e1ln\u00ed re\u017eim.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/li>\n<li>Diskr\u00e9tn\u00ed balen\u00ed v oby\u010dejn\u00e9 ob\u00e1lce<\/li>\n<li>Dod\u00e1n\u00ed po cel\u00e9m sv\u011bt\u011b<\/li>\n<li>Hodnoceno v\u00edce ne\u017e 1 400 z\u00e1kazn\u00edky (<a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">\u010d\u00edst recenze<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Z\u00e1ruka op\u011btovn\u00e9ho zasl\u00e1n\u00ed:<\/strong> pokud va\u0161e objedn\u00e1vka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f od odesl\u00e1n\u00ed, za\u0161leme ji znovu bez dal\u0161\u00edch n\u00e1klad\u016f. <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">P\u0159e\u010d\u00edst podm\u00ednky<\/a>.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Xeloda je expedov\u00e1na od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v neutr\u00e1ln\u00edm balen\u00ed, fakturov\u00e1no p\u0159es regulovan\u00e9ho platebn\u00edho procesora (na v\u00fdpisu z karty bude uveden regulovan\u00fd platebn\u00ed procesor \u2014 nikdy MedsBase nebo n\u00e1zev l\u00e9ku). Ka\u017ed\u00e1 objedn\u00e1vka zahrnuje na\u0161e 20-pracovn\u00ed-dn\u016f Reshipment Assurance.<\/p>\n<div class=\"medsbase-specialist-strip\" style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0;\"><strong>\u26a0\ufe0f Specializovan\u00e1 onkologick\u00e1 l\u00e9\u010dba pod dohledem l\u00e9ka\u0159e<\/strong> \u2014 tento l\u00e9k je zahajov\u00e1n, monitorov\u00e1n a ukon\u010dov\u00e1n onkologem nebo hematologem. D\u00e1vkov\u00e1n\u00ed z\u00e1vis\u00ed na typu n\u00e1doru, stadiu, t\u011blesn\u00e9m povrchu, funkci org\u00e1n\u016f a sou\u010dasn\u00e9 terapii. Samol\u00e9\u010dba nen\u00ed vhodn\u00e1; n\u00ed\u017ee uveden\u00e9 informace jsou vzd\u011bl\u00e1vac\u00ed a podporuj\u00ed informovan\u00e9 rozhovory s va\u0161\u00edm specialistou.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Syndrom rukou a nohou (palmoplant\u00e1rn\u00ed erytrodysestezie)<\/strong><br \/>B\u011b\u017en\u00fd (30-60 %) a d\u00e1vkov\u011b limituj\u00edc\u00ed. P\u0159\u00edznaky: brn\u011bn\u00ed, zarudnut\u00ed, bolestiv\u00e9 praskliny, olupov\u00e1n\u00ed na dlan\u00edch\/plosk\u00e1ch. Stupe\u0148 2+ vy\u017eaduje p\u0159eru\u0161en\u00ed d\u00e1vkov\u00e1n\u00ed + sn\u00ed\u017een\u00ed d\u00e1vky. Profylaxe: emoliencia, rukavice pro dom\u00e1c\u00ed pr\u00e1ce, vyh\u00fdbat se vystaven\u00ed teplu, kr\u00e9my s obsahem mo\u010doviny, vitamin B6 s neprok\u00e1zan\u00fdm p\u0159\u00ednosem. P\u0159ehodnocovat ka\u017ed\u00fd cyklus.<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>DPYD genotypov\u00e9 testov\u00e1n\u00ed doporu\u010deno<\/strong><br \/>Deficit dihydropyrimidin dehydrogen\u00e1zy (DPD) zp\u016fsobuje z\u00e1va\u017enou, n\u011bkdy fat\u00e1ln\u00ed toxicitu \u2014 neutropenie, mukozitida, pr\u016fjem, neuropatie. N\u011bkter\u00e9 sm\u011brnice nyn\u00ed doporu\u010duj\u00ed DPYD genotypov\u00e9 testov\u00e1n\u00ed p\u0159ed zah\u00e1jen\u00edm jak\u00e9koli l\u00e9\u010dby 5-FU nebo kapecitabinem k identifikaci \u010d\u00e1ste\u010dn\u00e9ho\/\u00fapln\u00e9ho deficitu. Pokud je DPD deficitn\u00ed, je nutn\u00e1 redukce d\u00e1vky nebo alternativn\u00ed terapie.<\/div>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Jak se u\u017e\u00edv\u00e1?<\/h3>\n<p>1250 mg\/m\u00b2 dvakr\u00e1t denn\u011b po dobu 14 dn\u016f, n\u00e1sledov\u00e1no 7denn\u00ed pauzou (3t\u00fddenn\u00ed cyklus). N\u011bkter\u00e9 re\u017eimy pou\u017e\u00edvaj\u00ed 1000 mg\/m\u00b2 BID \u00d7 14 dn\u016f. V\u017edy p\u0159edeps\u00e1no specialistou podle t\u011blesn\u00e9ho povrchu.<\/p>\n<h3>S j\u00eddlem nebo bez?<\/h3>\n<p>Do 30 minut po j\u00eddle \u2014 zlep\u0161uje sn\u00e1\u0161enlivost a standardizuje absorpci.<\/p>\n<h3>\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky?<\/h3>\n<p>Syndrom rukou a nohou (velmi \u010dast\u00fd), pr\u016fjem, nevolnost, \u00fanava, mukozitida, hyperbilirubinemie, m\u00edrn\u00e1 neutropenie. Z\u00e1va\u017en\u00e9 u pacient\u016f s deficitem DPD.<\/p>\n<h3>Interakce l\u00e9k\u016f?<\/h3>\n<p>Warfarin: kapecitabin v\u00fdrazn\u011b zvy\u0161uje INR \u2014 \u010dast\u00e9 monitorov\u00e1n\u00ed nebo p\u0159echod na LMWH. Fenytoin: zv\u00fd\u0161en\u00e9 hladiny. Kyselina listov\u00e1: m\u016f\u017ee zv\u00fd\u0161it toxicitu u n\u011bkter\u00fdch re\u017eim\u016f. Substr\u00e1ty CYP2C9: variabiln\u00ed interakce.<\/p>\n<h3>Kontraindikace?<\/h3>\n<p>T\u011b\u017ek\u00e9 ren\u00e1ln\u00ed posti\u017een\u00ed (CrCl &lt;30), t\u011b\u017ek\u00fd deficit DPD, t\u011bhotenstv\u00ed, kojen\u00ed. Opatrnost u st\u0159edn\u011b t\u011b\u017ek\u00e9ho ren\u00e1ln\u00edho posti\u017een\u00ed (sn\u00ed\u017eit d\u00e1vku o 25%).<\/p>\n<h3>Co d\u011blat, pokud se objev\u00ed syndrom ruka-noha?<\/h3>\n<p>Stupe\u0148 1 (m\u00edrn\u00e9 zarudnut\u00ed\/dysestezie): pokra\u010dovat v lok\u00e1ln\u00ed p\u00e9\u010di. Stupe\u0148 2 (bolestiv\u00e9, omezuj\u00edc\u00ed funkci): p\u0159eru\u0161it do n\u00e1vratu na stupe\u0148 1, sn\u00ed\u017eit d\u00e1vku o 25%. Stupe\u0148 3 (t\u011b\u017ek\u00e9): p\u0159eru\u0161it, sn\u00ed\u017eit o 50% p\u0159i obnoven\u00ed.<\/p>\n<h3>T\u011bhotenstv\u00ed?<\/h3>\n<p>Siln\u011b kontraindikov\u00e1no \u2014 teratogenn\u00ed. Efektivn\u00ed antikoncepce b\u011bhem a alespo\u0148 6 m\u011bs\u00edc\u016f po l\u00e9\u010db\u011b.<\/p>\n<h3>Monitorov\u00e1n\u00ed funkce ledvin?<\/h3>\n<p>Z\u00e1kladn\u00ed vy\u0161et\u0159en\u00ed funkce ledvin p\u0159ed l\u00e9\u010dbou a p\u0159ed ka\u017ed\u00fdm cyklem. \u00daprava d\u00e1vky pro CrCl 30-50 ml\/min. Vyhnout se p\u0159i CrCl &lt;30.<\/p>\n<h3>Ve srovn\u00e1n\u00ed s IV 5-FU?<\/h3>\n<p>Srovnateln\u00e1 nebo lep\u0161\u00ed \u00fa\u010dinnost ve v\u011bt\u0161in\u011b p\u0159\u00edpad\u016f (studie X-ACT u kolorekt\u00e1ln\u00edho karcinomu). Peror\u00e1ln\u00ed pod\u00e1n\u00ed je mnohem pohodln\u011bj\u0161\u00ed a vyh\u00fdb\u00e1 se komplikac\u00edm s centr\u00e1ln\u00edm kat\u00e9trem.<\/p>\n<h3>Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Vynechejte vynechanou d\u00e1vku, pokud je zpo\u017ed\u011bn\u00ed v\u00edce ne\u017e 6 hodin. Neduplikujte d\u00e1vku. Proberte s onkologick\u00fdm t\u00fdmem, pokud vynech\u00e1te v\u00edce d\u00e1vek.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Dal\u0161\u00ed l\u00e9ky na rakovinu<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/xeloda\/\">Xeloda<\/a> \u2014 kapecitabin 500 mg \u2014 peror\u00e1ln\u00ed profarmakon 5-FU pro karcinom prsu\/kolorekta\/\u017ealudku<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/altraz\/\">Altraz<\/a> \u2014 anastrozol 1 mg \u2014 inhibitor aromat\u00e1zy pro postmenopauz\u00e1ln\u00ed karcinom prsu<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/xbira\/\">Xbira<\/a> \u2014 abirateron 250 mg \u2014 inhibitor CYP17 pro metastatick\u00fd karcinom prostaty<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zoldria\/\">Zoldria<\/a> \u2014 kyselina zoledronov\u00e1 IV \u2014 pro kostn\u00ed metast\u00e1zy a hyperkalc\u00e9mii<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/actorise\/\">Actorise<\/a> \u2014 darbepoetin alfa \u2014 pro an\u00e9mii vyvolanou chemoterapi\u00ed<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> L\u00e9\u010dba rakoviny je vysoce individualizovan\u00e1. Konkr\u00e9tn\u00ed l\u00e9k, d\u00e1vkov\u00e1n\u00ed, re\u017eim, monitorov\u00e1n\u00ed a podp\u016frn\u00e1 p\u00e9\u010de mus\u00ed b\u00fdt stanoveny kvalifikovan\u00fdm onkologem nebo hematologem na z\u00e1klad\u011b biologie n\u00e1doru, stadia onemocn\u011bn\u00ed, p\u0159idru\u017een\u00fdch chorob a c\u00edl\u016f l\u00e9\u010dby. Tyto informace jsou vzd\u011bl\u00e1vac\u00edho charakteru; nenahrazuj\u00ed odborn\u00e9 l\u00e9ka\u0159sk\u00e9 poradenstv\u00ed.<\/div>","protected":false},"excerpt":{"rendered":"<p>Xeloda (Capecitabine 500 mg) \u2014 Roche or\u00e1ln\u00ed prodrug 5-FU pro karcinom prsu, kolorekt\u00e1ln\u00ed karcinom, karcinom \u017ealudku a karcinom pankreatu. Dvakr\u00e1t denn\u011b v cyklech 14 dn\u00ed u\u017e\u00edv\u00e1n\u00ed\/7 dn\u00ed pauza s managementem syndromu ruka-noha.<\/p>","protected":false},"featured_media":53571,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[],"class_list":{"0":"post-53570","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","10":"first","11":"outofstock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/53570","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=53570"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/53571"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=53570"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=53570"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=53570"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=53570"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}