{"id":53597,"date":"2023-09-20T09:48:06","date_gmt":"2023-09-20T09:48:06","guid":{"rendered":"https:\/\/medsname.com\/votrient\/"},"modified":"2026-04-30T10:25:11","modified_gmt":"2026-04-30T10:25:11","slug":"votrient","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/votrient\/","title":{"rendered":"Votrient"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">pazopanib 400 mg<\/h3>\n<p style=\"margin:0;\"><strong>Votrient<\/strong> \u2014 inhibitor tyrosinkin\u00e1zy s v\u00edce c\u00edli (VEGFR-1\/2\/3, PDGFR-\u03b1\/-\u03b2) <strong>pro<\/strong> pokro\u010dil\u00fd karcinom ledvinn\u00fdch bun\u011bk (RCC) <strong>m\u011bkkotk\u00e1\u0148ov\u00fd sarkom<\/strong> a <strong>(po p\u0159edchoz\u00ed chemoterapii). Standardn\u00ed d\u00e1vkov\u00e1n\u00ed:<\/strong> 800 mg jednou denn\u011b nala\u010dno <strong>800 mg once daily on an empty stomach<\/strong> (1 hodinu p\u0159ed j\u00eddlem nebo 2 hodiny po j\u00eddle). <strong>Varov\u00e1n\u00ed p\u0159ed hepatotoxicitou s \u010dernou sk\u0159\u00ed\u0148kou<\/strong> \u2014 z\u00e1va\u017en\u00e9, n\u011bkdy fat\u00e1ln\u00ed po\u0161kozen\u00ed jater. Povinn\u00e9 t\u00fddenn\u00ed testy jatern\u00edch funkc\u00ed (LFT) po prvn\u00edch 9 t\u00fddn\u016f, pot\u00e9 m\u011bs\u00ed\u010dn\u011b. Dal\u0161\u00ed kl\u00ed\u010dov\u00e1 rizika: hypertenze (~40 %), pr\u016fjem, \u00fanava, zm\u011bna barvy vlas\u016f (depigmentace), proteinurie, prodlou\u017een\u00ed QT intervalu, arteri\u00e1ln\u00ed trombotick\u00e9 p\u0159\u00edhody, perforace GIT, porucha hojen\u00ed ran.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Vy\u017eaduje se odborn\u00fd dohled.<\/strong> L\u00e9ky na rakovinu mus\u00ed b\u00fdt p\u0159edeps\u00e1ny o\u0161et\u0159uj\u00edc\u00edm onkologem s potvrzenou diagn\u00f3zou, vstupn\u00edm stagingem a definovan\u00fdm l\u00e9\u010debn\u00fdm pl\u00e1nem. Nikdy neza\u010d\u00ednejte, nep\u0159eru\u0161ujte, nem\u011b\u0148te d\u00e1vkov\u00e1n\u00ed ani neu\u017e\u00edvejte l\u00e9ky na rakovinu mimo onkologick\u00fd l\u00e9\u010debn\u00fd pl\u00e1n. V\u011bt\u0161ina l\u00e9k\u016f na rakovinu vy\u017eaduje pravideln\u00e9 monitorov\u00e1n\u00ed krevn\u00edch test\u016f (krevn\u00ed obraz, jatern\u00ed testy, funkce ledvin), je absolutn\u011b kontraindikov\u00e1na v t\u011bhotenstv\u00ed a m\u00e1 v\u00fdznamn\u00e9 l\u00e9kov\u00e9 interakce.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 \u0160ifrovan\u00e9 platby<\/strong> \u00b7 <strong>\ud83d\udcb3 Ov\u011b\u0159en\u00fd platebn\u00ed procesor<\/strong> \u00b7 <strong>\ud83d\ude9a Doprava do cel\u00e9ho sv\u011bta<\/strong> \u00b7 <strong>\u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">Co je Votrient?<\/h2>\n<p>Votrient je peror\u00e1ln\u00ed tableta od spole\u010dnosti Novartis obsahuj\u00edc\u00ed <strong>pro<\/strong>. Pazopanib je multi-target inhibitor tyrozinkin\u00e1zy \u00fa\u010dinn\u00fd proti VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-\u03b1, PDGFR-\u03b2, FGFR-1 a KIT. Blokov\u00e1n\u00edm c\u00e9vn\u00edho a r\u016fstov\u00e9ho faktoru inhibuje angiogenezi n\u00e1dor\u016f a r\u016fst vaskul\u00e1rn\u00edch n\u00e1dor\u016f.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>Pokro\u010dil\u00fd ren\u00e1ln\u00ed bun\u011b\u010dn\u00fd karcinom (RCC)<\/strong> \u2014 prvn\u00ed linie a po cytokinov\u00e9 terapii<\/li>\n<li><strong>Pokro\u010dil\u00fd m\u011bkkotk\u00e1\u0148ov\u00fd sarkom (STS)<\/strong> \u2014 po p\u0159edchoz\u00ed chemoterapii (studie PALETTE)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed<\/h2>\n<p>Standardn\u00ed d\u00e1vka: <strong>800 mg jednou denn\u011b (2 \u00d7 400 mg tablety) nala\u010dno<\/strong> \u2014 1 hodinu p\u0159ed j\u00eddlem nebo 2 hodiny po j\u00eddle. Potrava zvy\u0161uje absorpci pazopanibu p\u0159ibli\u017en\u011b 2\u00d7, co\u017e zvy\u0161uje riziko toxicity.<\/p>\n<ol>\n<li><strong>Nala\u010dno \u2014 povinn\u00e9.<\/strong> Nastavte si pravideln\u00fd re\u017eim: d\u00e1vku 1 hodinu p\u0159ed sn\u00eddan\u00ed NEBO 2 hodiny po ve\u010de\u0159i p\u0159ed span\u00edm.<\/li>\n<li>Polykejte tablety cel\u00e9 \u2014 nedr\u0165te, nerozpou\u0161t\u011bjte ani ned\u011blte (v\u00fdznamn\u00e1 zm\u011bna absorpce).<\/li>\n<li><strong>Povinn\u00e9 monitorov\u00e1n\u00ed:<\/strong> Jatern\u00ed testy na za\u010d\u00e1tku, pot\u00e9 <strong>t\u00fddn\u011b po prvn\u00edch 9 t\u00fddn\u016f, pot\u00e9 m\u011bs\u00ed\u010dn\u011b. TK na za\u010d\u00e1tku + ka\u017ed\u00fdch 1\u20132 t\u00fddn\u016f po prvn\u00edch 6 t\u00fddn\u016f, pot\u00e9 m\u011bs\u00ed\u010dn\u011b. EKG (QTc) na za\u010d\u00e1tku + za 4\u20136 t\u00fddn\u016f. Anal\u00fdza mo\u010di na proteinurii m\u011bs\u00ed\u010dn\u011b. Funkce \u0161t\u00edtn\u00e9 \u017el\u00e1zy ka\u017ed\u00e9 3 m\u011bs\u00edce.<\/strong>, \u00dapravy d\u00e1vkov\u00e1n\u00ed: sn\u00ed\u017eit o 200\u2013400 mg p\u0159i toxicit\u011b \u2265 3. stupn\u011b, AST\/ALT &gt; 8\u00d7 ULN, t\u011b\u017ek\u00e9 hypertenzi, t\u011b\u017ek\u00e9 proteinurii nebo prodlou\u017een\u00ed QT intervalu.<\/li>\n<li>P\u0159eru\u0161it pazopanib 7\u201314 dn\u00ed p\u0159ed pl\u00e1novanou operac\u00ed; obnovit za 2\u20134 t\u00fddny po \u00fapln\u00e9m zahojen\u00ed r\u00e1ny.<\/li>\n<li>pr\u016fjem, \u00fanava, nevolnost, sn\u00ed\u017een\u00e1 chu\u0165 k j\u00eddlu, \u00fabytek hmotnosti, zm\u011bna barvy vlas\u016f (depigmentace), hypertenze, syndrom ruka-noha, zm\u011bna chuti, mukozitida.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>\u010cast\u00e9:<\/strong> Hepatotoxicita (BLACK BOX).<\/p>\n<p><strong>D\u016fle\u017eit\u00e9:<\/strong><\/p>\n<ul>\n<li><strong>\u2014 z\u00e1va\u017en\u00e9, n\u011bkdy fat\u00e1ln\u00ed po\u0161kozen\u00ed jater. V\u011bt\u0161ina p\u0159\u00edpad\u016f v prvn\u00edch 4\u20139 t\u00fddnech. Povinn\u00e9 monitorov\u00e1n\u00ed jatern\u00edch funkc\u00ed.<\/strong> Hypertenze (~40 %) \u2014 nov\u011b vznikl\u00e1 nebo zhor\u0161en\u00e1; l\u00e9\u010dit agresivn\u011b.<\/li>\n<li>Prodlu\u017eov\u00e1n\u00ed QT intervalu a torsades<\/li>\n<li>QT prolongation and torsades<\/li>\n<li>Arteri\u00e1ln\u00ed trombotick\u00e9 p\u0159\u00edhody (IM, CMP, TIA)<\/li>\n<li>Krv\u00e1cen\u00ed (epistaxe, GI, intrakrani\u00e1ln\u00ed)<\/li>\n<li>Perforace a fistule GIT<\/li>\n<li>Proteinurie, nefrotick\u00fd syndrom<\/li>\n<li>Hypotyre\u00f3za<\/li>\n<li>Reverzibiln\u00ed syndrom zadn\u00ed leukoencefalopatie (PRES)<\/li>\n<li>Porucha hojen\u00ed ran<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed<\/h2>\n<ul>\n<li><strong>T\u011bhotenstv\u00ed:<\/strong> teratogenn\u00ed. Spolehliv\u00e1 antikoncepce po celou dobu l\u00e9\u010dby + 2 t\u00fddny po.<\/li>\n<li><strong>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed (Child-Pugh C):<\/strong> kontraindikov\u00e1no.<\/li>\n<li><strong>Prodlou\u017een\u00ed QT intervalu, poruchy elektrolyt\u016f:<\/strong> korigovat hypokal\u00e9mii\/hypomagnez\u00e9mii p\u0159ed zah\u00e1jen\u00edm.<\/li>\n<li><strong>Ned\u00e1vn\u00e1 arteri\u00e1ln\u00ed trombotick\u00e1 p\u0159\u00edhoda (&lt; 6 m\u011bs\u00edc\u016f):<\/strong> vyhnout se.<\/li>\n<li><strong>Operace:<\/strong> p\u0159eru\u0161it 7\u201314 dn\u00ed p\u0159ed; obnovit 2\u20134 t\u00fddny po.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombinujte s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">\u00da\u010dinek<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Co d\u011blat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Siln\u00e9 inhibitory CYP3A4 (ketokonazol, ritonavir, klarithromycin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Zv\u00fd\u0161en\u00ed hladin pazopanibu \u2014 toxicita<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sn\u00ed\u017eit d\u00e1vku pazopanibu na 400 mg\/den, pokud nelze zabr\u00e1nit.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Siln\u00ed induktory CYP3A4 (rifampicin, fenytoin, karbamazepin, t\u0159ezalka te\u010dkovan\u00e1)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Ni\u017e\u0161\u00ed hladiny pazopanibu \u2014 selh\u00e1n\u00ed l\u00e9\u010dby<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vylou\u010dit kombinaci.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">PPI (omeprazol, esomeprazol, pantoprazol)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">V\u00fdrazn\u011b sni\u017euj\u00ed vst\u0159eb\u00e1v\u00e1n\u00ed pazopanibu \u2014 riziko selh\u00e1n\u00ed l\u00e9\u010dby<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">P\u0159echod na kr\u00e1tkodob\u011b p\u016fsob\u00edc\u00ed H2-blok\u00e1tor; odd\u011blen\u00e9 d\u00e1vkov\u00e1n\u00ed, pokud je H2-blok\u00e1tor nutn\u00fd.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">L\u00e9ky prodlu\u017euj\u00edc\u00ed QT interval (citalopram, ondansetron, fluorochinolony, metadon)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Prodlou\u017een\u00ed QT intervalu<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vyhn\u011bte se kombinac\u00edm; monitorov\u00e1n\u00ed EKG.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Warfarin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Riziko krv\u00e1cen\u00ed; variabilita INR<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitorujte INR zpo\u010d\u00e1tku t\u00fddn\u011b.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Grapefruitov\u00e1 \u0161\u0165\u00e1va<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Zvy\u0161uje hladiny pazopanibu<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vylou\u010dit kombinaci.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<ul>\n<li>P\u0159i pokojov\u00e9 teplot\u011b, 15\u201325\u00b0C, v p\u016fvodn\u00edm blistru.<\/li>\n<li>Mimo dosah d\u011bt\u00ed, \u017een v reproduk\u010dn\u00edm v\u011bku, dom\u00e1c\u00edch zv\u00ed\u0159at.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/imat\/\"><strong>Imat (imatinib 400 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/imatib\/\"><strong>Imatib (imatinib 100 \/ 400 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/veenat\/\"><strong>Veenat (imatinib 100 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/cs\/anti-cancer-medication\/\">Prohl\u00e9dn\u011bte v\u0161echny protin\u00e1dorov\u00e9 l\u00e9ky \u2192<\/a><\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Pro\u010d mus\u00edm u\u017e\u00edvat Votrient nala\u010dno?<\/h3>\n<p>Potrava (zejm\u00e9na tu\u010dn\u00e1) m\u016f\u017ee <strong>zdvojn\u00e1sobit vst\u0159eb\u00e1v\u00e1n\u00ed pazopanibu<\/strong>, co\u017e zvy\u0161uje hladiny v krvi do toxick\u00e9ho rozmez\u00ed a zvy\u0161uje riziko hepatotoxicity, hypertenze a prodlou\u017een\u00ed QT intervalu. U\u017e\u00edvejte 1 hodinu p\u0159ed j\u00eddlem NEBO 2 hodiny po posledn\u00edm j\u00eddle. V\u011bt\u0161ina pacient\u016f pova\u017euje za nejjednodu\u0161\u0161\u00ed u\u017e\u00edvat pazopanib t\u011bsn\u011b p\u0159ed span\u00edm (za p\u0159edpokladu, \u017ee ve\u010de\u0159e byla dokon\u010dena \u2265 2 hodiny p\u0159edt\u00edm) nebo hned r\u00e1no.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d je Votrient spojov\u00e1n se z\u00e1va\u017enou hepatotoxicitou?<\/h3>\n<p>Pazopanib nese od FDA <strong>\u010dern\u00e9 varov\u00e1n\u00ed pro z\u00e1va\u017en\u00e9, n\u011bkdy fat\u00e1ln\u00ed po\u0161kozen\u00ed jater<\/strong>. V\u011bt\u0161ina p\u0159\u00edpad\u016f se vyskytuje v prvn\u00edch 4\u20139 t\u00fddnech. Povinn\u00e9 monitorov\u00e1n\u00ed: jatern\u00ed testy na za\u010d\u00e1tku, pot\u00e9 <strong>ka\u017ed\u00fd t\u00fdden po dobu prvn\u00edch 9 t\u00fddn\u016f<\/strong>, pot\u00e9 m\u011bs\u00ed\u010dn\u011b. Okam\u017eit\u011b p\u0159eru\u0161te l\u00e9\u010dbu pazopanibem p\u0159i AST\/ALT &gt; 8\u00d7 ULN nebo p\u0159i jak\u00fdchkoli p\u0159\u00edznac\u00edch po\u0161kozen\u00ed jater (\u017eloutenka, tmav\u00e1 mo\u010d, siln\u00e1 \u00fanava).<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d se mi m\u011bn\u00ed barva vlas\u016f p\u0159i u\u017e\u00edv\u00e1n\u00ed Votrientu?<\/h3>\n<p>Pazopanib jako vedlej\u0161\u00ed \u00fa\u010dinek inhibuje tyrozin\u00e1zu (zapojenou do synt\u00e9zy melaninu). Depigmentace vlas\u016f \u2014 \u010dasto dramatick\u00e1, n\u011bkdy vede k ze\u0161ednut\u00ed nebo zb\u011blen\u00ed vlas\u016f b\u011bhem m\u011bs\u00edc\u016f \u2014 je po vysazen\u00ed reverzibiln\u00ed. Postihuje ~40 % pacient\u016f. Jde pouze o kosmetick\u00fd efekt, bez klinick\u00e9ho v\u00fdznamu.<\/p>\n<h3 class=\"wp-block-heading\">Jak se zvl\u00e1d\u00e1 hypertenze?<\/h3>\n<p>Hypertenze vyvolan\u00e1 pazopanibem je mechanistick\u00e1 (inhibice VEGF sni\u017euje synt\u00e9zu oxidu dusnat\u00e9ho). Postihuje ~40 % pacient\u016f, \u010dasto b\u011bhem prvn\u00edch 6 t\u00fddn\u016f. L\u00e9\u010dte agresivn\u011b: ACE inhibitor nebo ARB jako prvn\u00ed volba (ramipril, losartan, kandesartan), p\u0159idejte CCB nebo diuretikum podle pot\u0159eby. Vyvarujte se vysazen\u00ed pazopanibu kv\u016fli hypertenzi, pokud lze TK kontrolovat \u2014 hypertenze toti\u017e koreluje s protin\u00e1dorovou \u00fa\u010dinnost\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d mus\u00edm vysadit Votrient p\u0159ed operac\u00ed?<\/h3>\n<p>Pazopanib naru\u0161uje hojen\u00ed ran (VEGF zprost\u0159edkovan\u00e1 angiogeneze je kl\u00ed\u010dov\u00e1 pro hojen\u00ed ran) a zvy\u0161uje riziko krv\u00e1cen\u00ed. P\u0159eru\u0161te l\u00e9\u010dbu na <strong>7\u201314 dn\u00ed p\u0159ed pl\u00e1novan\u00fdm chirurgick\u00fdm z\u00e1krokem<\/strong>. Obnovte l\u00e9\u010dbu a\u017e po \u00fapln\u00e9m zahojen\u00ed chirurgick\u00e9 r\u00e1ny, obvykle <strong>2\u20134 t\u00fddny po operaci<\/strong>. Informujte v\u0161echny chirurgy a zubn\u00ed l\u00e9ka\u0159e o u\u017e\u00edv\u00e1n\u00ed pazopanibu.<\/p>\n<h3 class=\"wp-block-heading\">Mohu u\u017e\u00edvat PPI spolu s Votrientem?<\/h3>\n<p>PPI (omeprazol, pantoprazol, esomeprazol) zvy\u0161uj\u00ed \u017ealude\u010dn\u00ed pH a v\u00fdrazn\u011b sni\u017euj\u00ed vst\u0159eb\u00e1v\u00e1n\u00ed pazopanibu \u2014 hroz\u00ed selh\u00e1n\u00ed l\u00e9\u010dby. P\u0159echod na kr\u00e1tkodob\u011b p\u016fsob\u00edc\u00ed H2-blok\u00e1tor (famotidin) s odstupem pod\u00e1n\u00ed alespo\u0148 2 hodiny, NEBO u\u017e\u00edvejte antacida pouze p\u0159i p\u0159\u00edznac\u00edch s odstupem alespo\u0148 2 hodiny od pazopanibu.<\/p>\n<h3 class=\"wp-block-heading\">Mohu p\u00edt alkohol p\u0159i u\u017e\u00edv\u00e1n\u00ed Votrientu?<\/h3>\n<p>Omezte alkohol \u2014 jak alkohol, tak pazopanib jsou hepatotoxick\u00e9 a jejich kombinace zvy\u0161uje riziko z\u00e1va\u017en\u00e9ho po\u0161kozen\u00ed jater. P\u0159\u00edle\u017eitostn\u00e9 mal\u00e9 mno\u017estv\u00ed m\u016f\u017ee b\u00fdt tolerov\u00e1no, ale ka\u017edodenn\u00ed nebo nadm\u011brn\u00e9 pit\u00ed by se m\u011blo vyvarovat.<\/p>\n<h3 class=\"wp-block-heading\">Vyl\u00e9\u010d\u00ed Votrient mou rakovinu?<\/h3>\n<p>Pazopanib obvykle nel\u00e9\u010d\u00ed pokro\u010dil\u00fd RCC nebo sarkom, ale dosahuje v\u00fdznamn\u00e9 kontroly onemocn\u011bn\u00ed. U RCC je medi\u00e1n p\u0159e\u017eit\u00ed bez progrese p\u0159i l\u00e9\u010db\u011b pazopanibem v prvn\u00ed linii p\u0159ibli\u017en\u011b 11 m\u011bs\u00edc\u016f (studie COMPARZ). U sarkomu po chemoterapii je prodlou\u017een\u00ed PFS skromn\u011bj\u0161\u00ed. L\u00e9\u010dba pokra\u010duje a\u017e do progrese nebo nep\u0159ijateln\u00e9 toxicity. Nov\u011bj\u0161\u00ed kombinace imunoterapie (pembrolizumab + axitinib, nivolumab + kabozantinib) v\u011bt\u0161inou nahradily monoterapii pazopanibem v prvn\u00ed linii RCC tam, kde jsou dostupn\u00e9.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Ka\u017ed\u00e1 \u0161ar\u017ee je dod\u00e1v\u00e1na od <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Objedn\u00e1vky jsou expedov\u00e1ny v nen\u00e1padn\u00fdch obalech bez loga od na\u0161ich partnersk\u00fdch sklad\u016f a jsou pokryty na\u0161\u00ed <a href=\"\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>: pokud z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, za\u0161leme zdarma n\u00e1hradn\u00ed z\u00e1silku, bez dotaz\u016f.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed protin\u00e1dorov\u00e9 l\u00e9ky<\/h3>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/imatib\/\">Imatib (imatinib 100\/400 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/veenat\/\">Veenat (imatinib 100\/400 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/imat\/\">Imat (imatinib 100\/400 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/riborea\/\">Riborea (ribociclib 200 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/keytruda\/\">Keytruda (pembrolizumab 100 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Inhibuje r\u016fst n\u00e1dorov\u00fdch bun\u011bk<br \/>\n\u2705 L\u00e9\u010d\u00ed pokro\u010dil\u00fd ren\u00e1ln\u00ed karcinom<br \/>\n\u2705 L\u00e9\u010d\u00ed sarkomy m\u011bkk\u00fdch tk\u00e1n\u00ed<br \/>\n\u2705 Zpomaluje progresi n\u00e1doru<br \/>\n\u2705 Pohodlnost peror\u00e1ln\u00edho pod\u00e1v\u00e1n\u00ed<\/p>","protected":false},"featured_media":53598,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[],"class_list":{"0":"post-53597","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/53597","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=53597"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/53598"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=53597"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=53597"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=53597"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=53597"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}