{"id":53602,"date":"2023-09-20T09:48:34","date_gmt":"2023-09-20T09:48:34","guid":{"rendered":"https:\/\/medsname.com\/pantocid-dsr\/"},"modified":"2026-05-01T10:49:12","modified_gmt":"2026-05-01T10:49:12","slug":"pantocid-dsr","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/pantocid-dsr\/","title":{"rendered":"Pantocid Dsr"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Pantocid DSR?<\/h3>\n

Pantocid DSR<\/strong> je fixn\u00ed kombinace pantoprazol 40 mg + domperidon 30 mg s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm<\/strong> v jedn\u00e9 tobolce, vyr\u00e1b\u011bn\u00e1 spole\u010dnost\u00ed Sun Pharma v z\u00e1vod\u011b certifikovan\u00e9m podle WHO-GMP. Pantoprazolov\u00e1 slo\u017eka sni\u017euje \u017ealude\u010dn\u00ed kyselost (inhibice protonov\u00e9 pumpy); domperidonov\u00e1 slo\u017eka je perifern\u011b p\u016fsob\u00edc\u00ed D2<\/sub> antagonista dopaminov\u00fdch receptor\u016f<\/strong> kter\u00fd zrychluje vyprazd\u0148ov\u00e1n\u00ed \u017ealudku a sni\u017euje regurgitaci. Pou\u017e\u00edv\u00e1 se p\u0159i:<\/strong> GERD s v\u00fdraznou regurgitac\u00ed nebo pocitem plnosti po j\u00eddle, gastropareze (diabetick\u00e9, opioidem indukovan\u00e9, poopera\u010dn\u00ed) a funk\u010dn\u00ed dyspepsii, kde je hlavn\u00edm probl\u00e9mem motilita. Standardn\u00ed d\u00e1vka:<\/strong> jedna tobolka jednou denn\u011b, 30\u201360 minut p\u0159ed sn\u00eddan\u00ed. D\u016fle\u017eit\u00e9 upozorn\u011bn\u00ed na bezpe\u010dnost:<\/strong> domperidon m\u00e1 d\u00e1vkov\u011b z\u00e1visl\u00fd \u00fa\u010dinek na prodlou\u017een\u00ed QT intervalu \u2014 Evropsk\u00e1 agentura pro l\u00e9\u010div\u00e9 p\u0159\u00edpravky omezila dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed na maxim\u00e1ln\u011b 10 mg t\u0159ikr\u00e1t denn\u011b po dobu nejv\u00fd\u0161e 7 dn\u016f. Vyvarujte se u\u017e\u00edv\u00e1n\u00ed u v\u00fdznamn\u00fdch srde\u010dn\u00edch onemocn\u011bn\u00ed, poruch elektrolyt\u016f nebo p\u0159i sou\u010dasn\u00e9m u\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f prodlu\u017euj\u00edc\u00edch QT interval (azolov\u00e1 antimykotika, makrolidov\u00e1 antibiotika, antiarytmika).<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Varov\u00e1n\u00ed ohledn\u011b srde\u010dn\u00ed bezpe\u010dnosti \u2014 domperidon a QT interval.<\/strong> Domperidon, prokinetick\u00e1 slo\u017eka p\u0159\u00edpravku Pantocid DSR, m\u016f\u017ee prodlou\u017eit QT interval a byl spojov\u00e1n se vz\u00e1cn\u00fdmi komorov\u00fdmi arytmiemi a n\u00e1hlou srde\u010dn\u00ed smrt\u00ed, zejm\u00e9na p\u0159i vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch, u star\u0161\u00edch pacient\u016f (> 60 let), u osob s poruchou elektrolyt\u016f (n\u00edzk\u00fd drasl\u00edk, n\u00edzk\u00fd ho\u0159\u010d\u00edk), u srde\u010dn\u00edch onemocn\u011bn\u00ed a p\u0159i kombinaci s dal\u0161\u00edmi l\u00e9ky prodlu\u017euj\u00edc\u00edmi QT interval (azolov\u00e1 antimykotika, makrolidov\u00e1 antibiotika, antiarytmika t\u0159\u00eddy I a III, methadon, n\u011bkter\u00e1 antidepresiva a antipsychotika). Evropsk\u00e1 agentura pro l\u00e9\u010div\u00e9 p\u0159\u00edpravky v roce 2014 omezila domperidon na 10 mg t\u0159ikr\u00e1t denn\u011b po dobu maxim\u00e1ln\u011b 7 dn\u016f<\/strong>; d\u00e1vka 30 mg s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm v Pantocid DSR p\u0159ekra\u010duje toto doporu\u010den\u00ed a nem\u011bla by b\u00fdt pou\u017e\u00edv\u00e1na dlouhodob\u011b, u pacient\u016f star\u0161\u00edch 60 let nebo u kohokoli se srde\u010dn\u00edm onemocn\u011bn\u00edm bez odborn\u00e9ho posouzen\u00ed. Pokud je indikac\u00ed GERD a motilita nen\u00ed hlavn\u00edm probl\u00e9mem, je bezpe\u010dn\u011bj\u0161\u00ed monoterapie \u010dist\u00fdm PPI.<\/strong><\/div>\n

Co je Pantocid DSR<\/h2>\n

Pantocid DSR je kombinovan\u00e1 tobolka s fixn\u00ed d\u00e1vkou od Sun Pharma obsahuj\u00edc\u00ed 40 mg pantoprazolu (inhibitor protonov\u00e9 pumpy ve form\u011b pellet\u016f s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm) a 30 mg domperidonu (perifern\u00ed antagonista dopaminov\u00e9ho receptoru D2<\/sub> ve form\u011b pellet\u016f s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm). Zkratka \u201cDSR\u201d v n\u00e1zvu odr\u00e1\u017e\u00ed technologii modifikovan\u00e9ho uvol\u0148ov\u00e1n\u00ed, kter\u00e1 umo\u017e\u0148uje dod\u00e1vat ob\u011b slo\u017eky z jedn\u00e9 tobolky.<\/p>\n

Jak Pantocid DSR funguje<\/h2>\n

Pantoprazol<\/strong> nevratn\u011b inhibuje protonovou pumpu H+<\/sup>\/K+<\/sup>-ATP\u00e1zy v pariet\u00e1ln\u00edch bu\u0148k\u00e1ch \u017ealudku, \u010d\u00edm\u017e sni\u017euje sekreci kyseliny na 24\u201372 hodin po jedn\u00e9 d\u00e1vce. Domperidon<\/strong> blokuje perifern\u00ed receptory D2<\/sub> v horn\u00ed \u010d\u00e1sti gastrointestin\u00e1ln\u00edho traktu, co\u017e zvy\u0161uje tonus doln\u00edho j\u00edcnov\u00e9ho sv\u011bra\u010de, urychluje vyprazd\u0148ov\u00e1n\u00ed \u017ealudku a sni\u017euje postprandi\u00e1ln\u00ed regurgitaci. Domperidon \u0161patn\u011b pronik\u00e1 hematoencefalickou bari\u00e9rou, tak\u017ee nem\u00e1 centr\u00e1ln\u00ed extrapyramidov\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky jako metoklopramid. Oba mechanismy se dopl\u0148uj\u00ed: pantoprazol sni\u017euje objem a kyselost regurgitovan\u00e9ho obsahu, zat\u00edmco domperidon omezuje samotn\u00fd v\u00fdskyt regurgitace.<\/p>\n

Indikace \u2013 kdy je Pantocid DSR u\u017eite\u010dn\u00fd<\/h2>\n

1. GERD s v\u00fdraznou regurgitac\u00ed nebo pocitem plnosti po j\u00eddle<\/h3>\n

Kdy\u017e p\u00e1len\u00ed \u017e\u00e1hy je dob\u0159e kontrolov\u00e1no PPI, ale p\u0159etrv\u00e1v\u00e1 regurgitace, slin\u011bn\u00ed nebo pocit uv\u00edzl\u00e9ho j\u00eddla na hrudi, p\u0159id\u00e1n\u00ed prokinetika p\u0159in\u00e1\u0161\u00ed klinick\u00fd benefit. Pantocid DSR \u0159e\u0161\u00ed oba probl\u00e9my v jedn\u00e9 tobolce.<\/p>\n

2. Gastropareza<\/h3>\n

Diabetick\u00e1 gastropareza (dlouhodob\u00fd diabetes 1. nebo 2. typu), poopera\u010dn\u00ed gastropareza (po vagotomii nebo fundoplikaci) a opioidem indukovan\u00e1 gastropareza. Domperidon je jedn\u00edm z m\u00e1la prokinetik s rozumnou evidenci \u00fa\u010dinnosti u gastroparezy, a\u010dkoli v\u011bt\u0161ina odborn\u00edk\u016f nyn\u00ed doporu\u010duje ni\u017e\u0161\u00ed d\u00e1vku 10 mg t\u0159ikr\u00e1t denn\u011b maxim\u00e1ln\u011b po dobu 7 dn\u016f.<\/p>\n

3. Funk\u010dn\u00ed dyspepsie \u2013 postprandi\u00e1ln\u00ed distresov\u00fd podtyp<\/h3>\n

U pacient\u016f, jejich\u017e dominantn\u00edm p\u0159\u00edznakem je \u010dasn\u00e1 sytost, pocit plnosti po j\u00eddle nebo nad\u00fdm\u00e1n\u00ed, samotn\u00e9 PPI \u010dasto poskytuje ne\u00faplnou odpov\u011b\u010f. P\u0159id\u00e1n\u00ed prokinetika zlep\u0161uje odpov\u011b\u010f u t\u00e9to podskupiny.<\/p>\n

D\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Pacient<\/th>\nD\u00e1vka<\/th>\nPozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n
Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9<\/td>\nJedna tobolka jednou denn\u011b, 30\u201360 minut p\u0159ed sn\u00eddan\u00ed<\/td>\n4\u20138 t\u00fddn\u016f; p\u0159ehodnotit a sn\u00ed\u017eit d\u00e1vku<\/td>\n<\/tr>\n
T\u011b\u017ek\u00e1 gastropareza (pod dohledem specialisty)<\/td>\nJedna tobolka jednou denn\u011b<\/td>\nP\u0159ehodnocovat ka\u017ed\u00e9 4 t\u00fddny<\/td>\n<\/tr>\n
Porucha funkce jater<\/td>\nOmezit nebo se vyhnout \u2013 nutn\u00e1 konzultace se specialistou<\/td>\nOb\u011b slo\u017eky jsou ovlivn\u011bny<\/td>\n<\/tr>\n
Ren\u00e1ln\u00ed selh\u00e1n\u00ed (CrCl < 30)<\/td>\nVyvarovat se \u2013 riziko kumulace domperidonu<\/td>\nP\u0159echod na \u010dist\u00e9 PPI<\/td>\n<\/tr>\n
V\u011bk > 60<\/td>\nVyhn\u011bte se kombinaci \u2014 zv\u00fd\u0161en\u00e9 riziko prodlou\u017een\u00ed QT intervalu<\/td>\nP\u0159echod na \u010dist\u00e9 PPI<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Polykejte tobolku celou \u2014 nerozlamujte, nedr\u0165te ani ne\u017ev\u00fdkejte. Technologie pelet z\u00e1vis\u00ed na neporu\u0161en\u00e9 struktu\u0159e tobolky pro opo\u017ed\u011bn\u00e9 a prodlou\u017een\u00e9 uvol\u0148ov\u00e1n\u00ed. U\u017e\u00edvejte 30\u201360 minut p\u0159ed sn\u00eddan\u00ed.<\/p>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n

Z pantoprazolov\u00e9 slo\u017eky (1\u201310 %):<\/strong> bolest hlavy, pr\u016fjem, nevolnost, bolesti b\u0159icha, m\u00edrn\u00e1 vyr\u00e1\u017eka. Dlouhodob\u011b: nedostatek12<\/sub> vitaminu B12, nedostatek ho\u0159\u010d\u00edku, zlomeniny, polypy fundick\u00fdch \u017el\u00e1zek.<\/p>\n

Z domperidonov\u00e9 slo\u017eky:<\/strong><\/p>\n