{"id":53634,"date":"2023-09-20T09:49:00","date_gmt":"2023-09-20T09:49:00","guid":{"rendered":"https:\/\/medsname.com\/urotel-xl\/"},"modified":"2026-04-30T10:25:11","modified_gmt":"2026-04-30T10:25:11","slug":"urotel-xl","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/urotel-xl\/","title":{"rendered":"Urotel XL"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Urotel XL<\/strong> obsahuje tolterodin tartr\u00e1t s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm 4 mg ER<\/strong> vyr\u00e1b\u00ed Sun Pharma. Pou\u017e\u00edv\u00e1 se p\u0159i p\u0159\u00edznac\u00edch hyperaktivn\u00edho mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e (OAB) \u2013 urgentn\u00ed mo\u010den\u00ed, \u010dast\u00e9 mo\u010den\u00ed a urgentn\u00ed inkontinence. U\u017e\u00edvejte p\u0159esn\u011b podle pokyn\u016f l\u00e9ka\u0159e \u2013 ned\u00e1vkujte si l\u00e9k sami.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

\ud83d\udd12 \u0160ifrovan\u00e9 platby<\/strong> \u00b7 \ud83d\udcb3 Ov\u011b\u0159en\u00fd platebn\u00ed procesor<\/strong> \u00b7 \ud83d\ude9a Doprava do cel\u00e9ho sv\u011bta<\/strong> \u00b7 \u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong><\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Ka\u017ed\u00e1 \u0161ar\u017ee je dod\u00e1v\u00e1na od v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Objedn\u00e1vky jsou odes\u00edl\u00e1ny v neutr\u00e1ln\u00edch obalech od na\u0161ich partnersk\u00fdch distribu\u010dn\u00edch center a jsou chr\u00e1n\u011bny na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>. Slou\u017eili jsme ji\u017e 1 400+ ov\u011b\u0159en\u00fdm z\u00e1kazn\u00edk\u016fm<\/strong> s pr\u016fm\u011brn\u00fdm hodnocen\u00edm 4,9\/5<\/strong> nap\u0159\u00ed\u010d v\u00edce ne\u017e 600 l\u00e9ky.<\/p>\n

Co je Urotel XL a jak funguje<\/h2>\n

Urotel XL obsahuje tolterodin tartr\u00e1t<\/strong> v prodlou\u017een\u00e9 uvol\u0148ov\u00e1n\u00ed<\/strong> formulaci, u\u017e\u00edvan\u00e9 jednou denn\u011b. Tolterodin je kompetitivn\u00ed antagonista muskarinov\u00fdch receptor\u016f, kter\u00fd c\u00edl\u00ed na mo\u010dov\u00e9 muskarinov\u00e9 receptory s pon\u011bkud v\u011bt\u0161\u00edm funk\u010dn\u00edm \u00fa\u010dinkem ne\u017e na receptory slinn\u00fdch \u017el\u00e1z, co\u017e poskytuje o n\u011bco lep\u0161\u00ed profil suchosti v \u00fastech ne\u017e oxybutynin (zejm\u00e9na v ER formulaci).<\/p>\n

Je schv\u00e1len pro OAB s p\u0159\u00edznaky \u010dast\u00e9ho mo\u010den\u00ed, urgentn\u00edho nucen\u00ed na mo\u010den\u00ed a urgentn\u00ed inkontinence<\/strong>. ER tobolka poskytuje vyrovnan\u011bj\u0161\u00ed hladiny v plazm\u011b ne\u017e star\u0161\u00ed tablety s okam\u017eit\u00fdm uvoln\u011bn\u00edm a sni\u017euje typick\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky (zejm\u00e9na suchost v \u00fastech) o ~30%.<\/p>\n

D\u00e1vkov\u00e1n\u00ed a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n
Skupina pacient\u016f<\/th>\nDoporu\u010den\u00e1 d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Dosp\u011bl\u00ed s OAB<\/td>\n4 mg jednou denn\u011b<\/strong><\/td>\n<\/tr>\n
Sn\u00ed\u017eit na 2 mg jednou denn\u011b, pokud<\/td>\nt\u011b\u017ek\u00e9 po\u0161kozen\u00ed jater \/ ledvin (eGFR <30); sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed siln\u00e9ho inhibitoru CYP3A4; \u0161patn\u00fd metaboliz\u00e9r CYP2D6 s vedlej\u0161\u00edmi \u00fa\u010dinky<\/td>\n<\/tr>\n
T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed (Child-Pugh C)<\/td>\nVyhnout se<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Tobolku polykejte celou<\/strong>, s j\u00eddlem nebo bez j\u00eddla, ve stejnou dobu ka\u017ed\u00fd den. Tobolku nedr\u0165te, ne\u017ev\u00fdkejte ani neotev\u00edrejte. Zlep\u0161en\u00ed nast\u00e1v\u00e1 za 1\u20132 t\u00fddny; pln\u00fd \u00fa\u010dinek za 4\u20138 t\u00fddn\u016f. Pokud nedojde k u\u017eite\u010dn\u00e9mu \u00fa\u010dinku do 8 t\u00fddn\u016f, p\u0159ehodno\u0165te l\u00e9\u010dbu.<\/p>\n

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\u26a0 Varov\u00e1n\u00ed p\u0159ed z\u00e1m\u011bnou<\/strong><\/p>\n

N\u00e1zev zna\u010dky Urotel XL<\/strong> obsahuje slabiku \u201curotel\u201d, kterou n\u011bkte\u0159\u00ed kupuj\u00edc\u00ed asociuj\u00ed s alfa-blok\u00e1tory (Urief \/ Urotel) pro BPH. Ne ne<\/strong> p\u0159edpokl\u00e1dejme, \u017ee jde o alfa-blok\u00e1tor. Urotel XL je antimuskarinikum pro OAB<\/strong> \u2014 jin\u00e1 t\u0159\u00edda s odli\u0161n\u00fdmi indikacemi. Pokud m\u00e1te obstrukci souvisej\u00edc\u00ed s BPH, pot\u0159ebujete alfa-blok\u00e1tor (silodosin, alfuzosin, tamsulosin), nikoli tolterodin.<\/p>\n<\/div>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Vedlej\u0161\u00ed \u00fa\u010dinek<\/th>\nFrekvence<\/th>\nPozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n
Sucho v \u00fastech<\/td>\nVelmi \u010dast\u00e9 (~25% IR \/ ~17% ER)<\/td>\nHydratace, \u017ev\u00fdka\u010dky bez cukru<\/td>\n<\/tr>\n
Z\u00e1cpa<\/td>\n\u010cast\u00e9 (~7%)<\/td>\nVl\u00e1knina, tekutiny; objemov\u00e9 proj\u00edmadlo v p\u0159\u00edpad\u011b pot\u0159eby<\/td>\n<\/tr>\n
Such\u00e9 o\u010di<\/td>\nB\u011b\u017en\u00e9<\/td>\nZvlh\u010duj\u00edc\u00ed kapky<\/td>\n<\/tr>\n
Bolest hlavy<\/td>\nB\u011b\u017en\u00e9<\/td>\nObvykle ustoup\u00ed do 2 t\u00fddn\u016f<\/td>\n<\/tr>\n
Za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/td>\nB\u011b\u017en\u00e9<\/td>\nU\u017e\u00edvejte s j\u00eddlem<\/td>\n<\/tr>\n
Ospalost, rozmazan\u00e9 vid\u011bn\u00ed<\/td>\nB\u011b\u017en\u00e9<\/td>\nVyhnout se \u0159\u00edzen\u00ed, dokud si nezvyknete<\/td>\n<\/tr>\n
Zadr\u017eov\u00e1n\u00ed mo\u010di<\/td>\nM\u00e9n\u011b \u010dast\u00e9<\/td>\nP\u0159eru\u0161it a p\u0159ehodnotit<\/td>\n<\/tr>\n
Prodlou\u017een\u00ed QT intervalu (vysok\u00e9 d\u00e1vky)<\/td>\nVz\u00e1cn\u00e9<\/td>\nVyvarujte se kombinace s jin\u00fdmi l\u00e1tkami prodlu\u017euj\u00edc\u00edmi QT interval<\/td>\n<\/tr>\n
Akutn\u00ed glaukom s uzav\u0159en\u00fdm \u00fahlem<\/td>\nVz\u00e1cn\u00e9<\/td>\nT\u00e9ho\u017e dne o\u010dn\u00ed vy\u0161et\u0159en\u00ed p\u0159i bolesti o\u010d\u00ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Interakce l\u00e9k\u016f<\/h2>\n\n\n\n\n\n\n\n\n\n
Kombinace<\/th>\n\u00da\u010dinek<\/th>\n\u00da\u010dinek<\/th>\n<\/tr>\n<\/thead>\n
Siln\u00e9 inhibitory CYP3A4 (ketokonazol, ritonavir, klarithromycin)<\/td>\nHladiny tolterodinu stoupaj\u00ed \u2014 riziko \u00fa\u010dink\u016f na QT interval<\/td>\nSn\u00ed\u017eit na 2 mg\/den<\/td>\n<\/tr>\n
Siln\u00e9 inhibitory CYP2D6 (fluoxetin, paroxetin)<\/td>\nTolterodin se kumuluje<\/td>\nSledujte vedlej\u0161\u00ed \u00fa\u010dinky<\/td>\n<\/tr>\n
Dal\u0161\u00ed anticholinergika (oxybutynin, TCA, sedativn\u00ed antihistaminika)<\/td>\nAditivn\u00ed z\u00e1t\u011b\u017e<\/td>\nVyhn\u011bte se kombinaci<\/td>\n<\/tr>\n
L\u00e9ky prodlu\u017euj\u00edc\u00ed QT interval (sotalol, amiodaron, metadon, ondansetron, citalopram > 20 mg)<\/td>\nAditivn\u00ed riziko prodlou\u017een\u00ed QT<\/td>\nVyvarujte se kombinace<\/td>\n<\/tr>\n
Warfarin<\/td>\n\u017d\u00e1dn\u00e1 klinicky v\u00fdznamn\u00e1 interakce<\/td>\nStandardn\u00ed monitorov\u00e1n\u00ed INR<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Kdo by nem\u011bl u\u017e\u00edvat Urotel XL<\/h2>\n