{"id":53639,"date":"2023-09-20T09:49:00","date_gmt":"2023-09-20T09:49:00","guid":{"rendered":"https:\/\/medsname.com\/silofast\/"},"modified":"2026-04-30T10:25:11","modified_gmt":"2026-04-30T10:25:11","slug":"silofast","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/silofast\/","title":{"rendered":"Silofast"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Silofast<\/strong> obsahuje silodosin 4 mg \/ 8 mg<\/strong> v\u00fdrobce Cipla Inc. Pou\u017e\u00edv\u00e1 se k l\u00e9\u010db\u011b p\u0159\u00edznak\u016f zv\u011bt\u0161en\u00e9 prostaty (benign\u00ed hyperplazie prostaty, BPH) u mu\u017e\u016f. U\u017e\u00edvejte p\u0159esn\u011b podle pokyn\u016f l\u00e9ka\u0159e \u2014 ned\u00e1vkujte si l\u00e9k sami.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

\ud83d\udd12 \u0160ifrovan\u00e9 platby<\/strong> \u00b7 \ud83d\udcb3 Ov\u011b\u0159en\u00fd platebn\u00ed procesor<\/strong> \u00b7 \ud83d\ude9a Doprava do cel\u00e9ho sv\u011bta<\/strong> \u00b7 \u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong><\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Ka\u017ed\u00e1 \u0161ar\u017ee je dod\u00e1v\u00e1na od v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Objedn\u00e1vky jsou odes\u00edl\u00e1ny v neutr\u00e1ln\u00edch obalech od na\u0161ich partnersk\u00fdch distribu\u010dn\u00edch center a jsou chr\u00e1n\u011bny na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>. Slou\u017eili jsme ji\u017e 1 400+ ov\u011b\u0159en\u00fdm z\u00e1kazn\u00edk\u016fm<\/strong> s pr\u016fm\u011brn\u00fdm hodnocen\u00edm 4,9\/5<\/strong> nap\u0159\u00ed\u010d v\u00edce ne\u017e 600 l\u00e9ky.<\/p>\n

Co je Silofast a jak funguje<\/h2>\n

Silofast obsahuje silodosin<\/strong>, uroselectivn\u00ed antagonista alfa-1A adrenoreceptoru<\/strong>. Hladk\u00e1 svalovina prostaty, prostatick\u00e9 uretry a hrdla mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e je bohat\u00e1 na alfa-1A receptory; jejich blok\u00e1dou doch\u00e1z\u00ed k uvoln\u011bn\u00ed t\u00e9to svaloviny a zlep\u0161en\u00ed toku mo\u010di. Proto\u017ee je silodosin >100kr\u00e1t selektivn\u011bj\u0161\u00ed pro alfa-1A ne\u017e pro alfa-1B receptory, jsou \u00fa\u010dinky na krevn\u00ed tlak men\u0161\u00ed ne\u017e u neselektivn\u00edch alfa-blok\u00e1tor\u016f, jako je terazosin nebo doxazosin.<\/p>\n

Silofast je indikov\u00e1n k \u00falev\u011b p\u0159i p\u0159\u00edznac\u00edch doln\u00edch mo\u010dov\u00fdch cest (LUTS) zp\u016fsoben\u00fdch benign\u00ed hyperplazi\u00ed prostaty<\/strong> \u2014 slab\u00fd proud mo\u010di, obt\u00ed\u017en\u00e9 zah\u00e1jen\u00ed mo\u010den\u00ed, p\u0159eru\u0161ovan\u00e9 mo\u010den\u00ed, pocit ne\u00fapln\u00e9ho vypr\u00e1zdn\u011bn\u00ed, \u010dast\u00e9 mo\u010den\u00ed, urgentn\u00ed nucen\u00ed na mo\u010den\u00ed a nykturii \u2014 u dosp\u011bl\u00fdch mu\u017e\u016f. L\u00e9k ne<\/strong> nezmen\u0161uje prostatu; je-li zmen\u0161en\u00ed pot\u0159ebn\u00e9 (velk\u00e1 \u017el\u00e1za, vysok\u00e9 PSA, opakovan\u00e1 retence mo\u010di), p\u0159id\u00e1v\u00e1 se inhibitor 5-alfa-redukt\u00e1zy, jako je dutasterid nebo finasterid.<\/p>\n

D\u00e1vkov\u00e1n\u00ed a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Skupina pacient\u016f<\/th>\nDoporu\u010den\u00e1 d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Dosp\u011bl\u00ed mu\u017ei s BPH (norm\u00e1ln\u00ed ren\u00e1ln\u00ed funkce)<\/td>\n8 mg jednou denn\u011b<\/strong> s j\u00eddlem<\/td>\n<\/tr>\n
M\u00edrn\u00e9 ren\u00e1ln\u00ed po\u0161kozen\u00ed (eGFR 50\u201380)<\/td>\n8 mg jednou denn\u011b \u2014 obvykle dob\u0159e sn\u00e1\u0161eno<\/td>\n<\/tr>\n
St\u0159edn\u011b t\u011b\u017ek\u00e9 po\u0161kozen\u00ed ledvin (eGFR 30\u201350)<\/td>\nZa\u010dn\u011bte s 4 mg<\/strong> jednou denn\u011b; po 1 t\u00fddnu lze d\u00e1vku zv\u00fd\u0161it na 8 mg, pokud je dob\u0159e sn\u00e1\u0161eno<\/td>\n<\/tr>\n
T\u011b\u017ek\u00e9 ren\u00e1ln\u00ed posti\u017een\u00ed (eGFR <30)<\/td>\nVyhnout se<\/td>\n<\/tr>\n
T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed (Child-Pugh C)<\/td>\nVyhnout se<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

U\u017e\u00edvejte s j\u00eddlem v\u017edy ve stejnou denn\u00ed dobu<\/strong> \u2014 j\u00eddlo zlep\u0161uje sn\u00e1\u0161enlivost a zaji\u0161\u0165uje p\u0159edv\u00eddateln\u011bj\u0161\u00ed hladinu v plazm\u011b. Polykejte cel\u00e9; nedr\u0165te. \u00daleva od p\u0159\u00edznak\u016f nastupuje rychle (b\u011bhem dn\u016f u pr\u016ftoku mo\u010di), ale pln\u00fd \u00fa\u010dinek se projev\u00ed za 2\u20134 t\u00fddny. Pokud d\u00e1vku vynech\u00e1te, pokra\u010dujte dal\u0161\u00ed pl\u00e1novanou d\u00e1vkou \u2014 neduplikujte.<\/p>\n

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\u26a0 P\u0159ed o\u010dn\u00ed operac\u00ed informujte chirurga, \u017ee u\u017e\u00edv\u00e1te silodosin<\/strong><\/p>\n

Silodosin (a dal\u0161\u00ed alfa-blok\u00e1tory) m\u016f\u017ee zp\u016fsobit Syndrom ochabl\u00e9 duhovky b\u011bhem operace (IFIS)<\/strong> p\u0159i operaci \u0161ed\u00e9ho z\u00e1kalu nebo glaukomu komplikace. P\u0159i pl\u00e1novan\u00e9 operaci mus\u00ed b\u00fdt oftalmolog p\u0159edem informov\u00e1n. Nep\u0159eru\u0161ujte l\u00e9\u010dbu sami; chirurgick\u00fd t\u00fdm se p\u0159izp\u016fsob\u00ed.<\/p>\n<\/div>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n
Vedlej\u0161\u00ed \u00fa\u010dinek<\/th>\nFrekvence<\/th>\n\u00da\u010dinek<\/th>\n<\/tr>\n<\/thead>\n
Retrogr\u00e1dn\u00ed ejakulace<\/strong> (such\u00fd orgasmus)<\/td>\nVelmi \u010dast\u00e9 (~28 %)<\/td>\nPo vysazen\u00ed reverzibiln\u00ed; ne\u0161kodn\u00e9, ale proberte s partnerem\/pl\u00e1ny na po\u010det\u00ed<\/td>\n<\/tr>\n
Z\u00e1vra\u0165 p\u0159i postaven\u00ed (ortostatick\u00e1 hypotenze)<\/td>\n\u010cast\u00e9 (~3 %)<\/td>\nVst\u00e1vejte pomalu; hlavn\u011b po prvn\u00edch 1\u20132 d\u00e1vk\u00e1ch<\/td>\n<\/tr>\n
Bolest hlavy<\/td>\nB\u011b\u017en\u00e9<\/td>\nObvykle ustoup\u00ed do t\u00fddne<\/td>\n<\/tr>\n
Nosn\u00ed nepr\u016fchodnost \/ r\u00fdma<\/td>\nB\u011b\u017en\u00e9<\/td>\nSymptomatick\u00e1 l\u00e9\u010dba; antihistaminika jsou vhodn\u00e1<\/td>\n<\/tr>\n
Pr\u016fjem, nevolnost<\/td>\nM\u00e9n\u011b \u010dast\u00e9<\/td>\nU\u017e\u00edvejte s j\u00eddlem; nahlaste, pokud p\u0159etrv\u00e1v\u00e1<\/td>\n<\/tr>\n
Sn\u00ed\u017een\u00e9 libido \/ erektiln\u00ed dysfunkce<\/td>\nM\u00e9n\u011b \u010dast\u00e9<\/td>\nProberte s p\u0159edepisuj\u00edc\u00edm l\u00e9ka\u0159em<\/td>\n<\/tr>\n
Mdloby (synkopa)<\/td>\nVz\u00e1cn\u00e9<\/td>\nP\u0159esta\u0148te u\u017e\u00edvat a vyhledejte l\u00e9ka\u0159skou pomoc<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Interakce l\u00e9k\u016f<\/h2>\n\n\n\n\n\n\n\n\n\n\n
Kombinace<\/th>\n\u00da\u010dinek<\/th>\n\u00da\u010dinek<\/th>\n<\/tr>\n<\/thead>\n
Siln\u00e9 inhibitory CYP3A4 (ketokonazol, itrakonazol, ritonavir, klarithromycin)<\/td>\nV\u00fdrazn\u00e9 zv\u00fd\u0161en\u00ed hladiny silodosinu \u2192 hypotenze<\/td>\nVyvarujte se kombinace<\/strong><\/td>\n<\/tr>\n
Jin\u00e9 alfa-blok\u00e1tory (terazosin, doxazosin, tamsulosin, alfuzosin)<\/td>\nAditivn\u00ed hypotenze<\/td>\nNekombinujte<\/td>\n<\/tr>\n
PDE-5 inhibitory (sildenafil, tadalafil, vardenafil)<\/td>\nAditivn\u00ed hypotenze; tadalafil 5 mg denn\u011b pro BPH\/ED je nejv\u00edce prozkouman\u00e1 kombinace<\/td>\nNejprve stabilizovat na silodosinu; PDE-5 zav\u00e1d\u011bt opatrn\u011b<\/td>\n<\/tr>\n
Antihypertenziva<\/td>\nAditivn\u00ed sn\u00ed\u017een\u00ed krevn\u00edho tlaku<\/td>\nMonitorujte; mo\u017en\u00e1 hypotenze po prvn\u00ed d\u00e1vce<\/td>\n<\/tr>\n
Inhibitory P-gp (cyklosporin)<\/td>\nM\u00edrn\u00e9 zv\u00fd\u0161en\u00ed hladin silodosinu<\/td>\nSledujte<\/td>\n<\/tr>\n
Diuretika, alkohol<\/td>\nZhor\u0161uje ortostatick\u00e9 p\u0159\u00edznaky<\/td>\nOpatrnost; zejm\u00e9na u star\u0161\u00edch pacient\u016f<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Kdo by nem\u011bl u\u017e\u00edvat Silofast<\/h2>\n