{"id":54784,"date":"2023-09-20T10:03:49","date_gmt":"2023-09-20T10:03:49","guid":{"rendered":"https:\/\/medsname.com\/acigene\/"},"modified":"2026-05-01T10:49:12","modified_gmt":"2026-05-01T10:49:12","slug":"acigene","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/acigene\/","title":{"rendered":"Acigene"},"content":{"rendered":"

<\/p>\n

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Acigene?<\/h3>\n

Acigene<\/strong> je \u017ev\u00fdkac\u00ed antacidum kombinuj\u00edc\u00ed hydroxid hlinit\u00fd + hydroxid ho\u0159e\u010dnat\u00fd + simetikon + k\u0159emi\u010ditan hlinito-ho\u0159e\u010dnat\u00fd<\/strong>, vyr\u00e1b\u011bn\u00e9 spole\u010dnost\u00ed Cipla. Dod\u00e1v\u00e1 se ve form\u011b \u017ev\u00fdkac\u00edch tablet s m\u00e1tovou nebo pomeran\u010dovou p\u0159\u00edchut\u00ed a p\u016fsob\u00ed p\u0159\u00edmou neutralizac\u00ed ji\u017e vylou\u010den\u00e9 \u017ealude\u010dn\u00ed kyseliny<\/strong> (chemick\u00e1 neutralizace HCl), fyzick\u00fdm pokryt\u00edm<\/strong> \u017ealude\u010dn\u00ed a j\u00edcnov\u00e9 sliznice (Mg-Al-silik\u00e1tov\u00fd j\u00edl), a sn\u00ed\u017een\u00ed mno\u017estv\u00ed plynu v \u017ealudku<\/strong> (simethikon uvol\u0148uje zachycen\u00e9 plynov\u00e9 bubliny). \u00da\u010dinek nastupuje b\u011bhem n\u011bkolika minut<\/strong> \u2014 rychleji ne\u017e jak\u00fdkoli p\u0159edpisov\u00fd l\u00e9k na kyselost. Doba \u00fa\u010dinku je kr\u00e1tk\u00e1<\/strong> (30\u201360 minut), proto jsou antacida nejvhodn\u011bj\u0161\u00ed pro ob\u010dasn\u00e9 nebo pr\u016flomov\u00e9 p\u0159\u00edznaky, nikoli jako n\u00e1hrada PPI nebo H2<\/sub> antagonist\u016f p\u0159i chronick\u00fdch onemocn\u011bn\u00edch. Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9:<\/strong> 1\u20132 \u017ev\u00fdkac\u00ed tablety a\u017e \u010dty\u0159ikr\u00e1t denn\u011b po j\u00eddle a p\u0159ed span\u00edm, podle pot\u0159eby. U\u017e\u00edvejte s odstupem nejm\u00e9n\u011b 2 hodin od jin\u00fdch peror\u00e1ln\u00edch l\u00e9k\u016f (antacidum v\u00e1\u017ee mnoho l\u00e9\u010div a sni\u017euje jejich vst\u0159eb\u00e1v\u00e1n\u00ed). P\u0159i chronick\u00e9m onemocn\u011bn\u00ed ledvin se vyvarujte dlouhodob\u00e9ho ka\u017edodenn\u00edho u\u017e\u00edv\u00e1n\u00ed.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Co je Acigene<\/h2>\n

Acigene je \u017ev\u00fdkac\u00ed antacidn\u00ed tableta od spole\u010dnosti Cipla (m\u00e1ta nebo pomeran\u010dov\u00e1 p\u0159\u00edchu\u0165), kter\u00e1 kombinuje \u010dty\u0159i funk\u010dn\u00ed slo\u017eky v jedn\u00e9 tablet\u011b:<\/p>\n

    \n
  • Hydroxid hlinit\u00fd<\/strong> \u2014 alkalick\u00e1 s\u016fl, kter\u00e1 neutralizuje HCl v \u017ealudku, s m\u00edrn\u00fdm z\u00e1cpov\u00fdm \u00fa\u010dinkem<\/li>\n
  • Hydroxid ho\u0159e\u010dnat\u00fd<\/strong> \u2014 rychleji p\u016fsob\u00edc\u00ed alkalick\u00e1 s\u016fl s m\u00edrn\u00fdm proj\u00edmav\u00fdm \u00fa\u010dinkem \u2014 vyva\u017euje z\u00e1cpov\u00fd \u00fa\u010dinek hlin\u00edku, tak\u017ee se st\u0159evn\u00ed n\u00e1vyky nem\u011bn\u00ed<\/li>\n
  • Simethikon<\/strong> \u2014 inertn\u00ed silikonov\u00fd polymer, kter\u00fd odstra\u0148uje zachycen\u00e9 bublinky plynu ve st\u0159evech, \u010d\u00edm\u017e sni\u017euje nad\u00fdm\u00e1n\u00ed a plynatost<\/li>\n
  • Magnesium aluminium silicate<\/strong> \u2014 j\u00edlovit\u00fd miner\u00e1l, kter\u00fd fyzicky pokr\u00fdv\u00e1 \u017ealude\u010dn\u00ed a j\u00edcnovou sliznici, vytv\u00e1\u0159ej\u00edc do\u010dasnou ochrannou vrstvu<\/li>\n<\/ul>\n

    Kombinace je navr\u017eena tak, aby v jedn\u00e9 tablet\u011b \u0159e\u0161ila t\u0159i slo\u017eky p\u0159\u00edznak\u016f p\u0159ekyselen\u00ed: nadbytek kyseliny, nadm\u011brn\u00e9 mno\u017estv\u00ed plynu a nedostate\u010dnou ochranu sliznice.<\/p>\n

    Jak Acigene funguje<\/h2>\n

    Mechanismus je \u010dist\u011b chemick\u00fd a fyzik\u00e1ln\u00ed<\/strong>, nikoli farmakologick\u00fd ve smyslu vazby na receptory:<\/p>\n

      \n
    • Neutralizace:<\/strong> Al(OH)3<\/sub> + 3 HCl \u2192 AlCl3<\/sub> + 3 H2<\/sub>O. Mg(OH)2<\/sub> + 2 HCl \u2192 MgCl2<\/sub> + 2 H2<\/sub>O. Ka\u017ed\u00e1 molekula antacida neutralizuje 2\u20133 molekuly \u017ealude\u010dn\u00ed kyseliny; pufrovac\u00ed kapacita jedn\u00e9 \u017ev\u00fdkac\u00ed tablety je v rozmez\u00ed 10\u201315 mEq HCl.<\/li>\n
    • Fyzik\u00e1ln\u00ed obalov\u00e1n\u00ed:<\/strong> Ho\u0159e\u010dnato-hlinit\u00fd k\u0159emi\u010ditan je j\u00edlovit\u00fd miner\u00e1l, kter\u00fd ve vod\u011b bobtn\u00e1 a vytv\u00e1\u0159\u00ed visk\u00f3zn\u00ed gel. P\u0159i \u017ev\u00fdk\u00e1n\u00ed a polyk\u00e1n\u00ed tablety gel pokryje v\u00fdstelku j\u00edcnu a \u017ealudku, \u010d\u00edm\u017e vytvo\u0159\u00ed do\u010dasnou mechanickou bari\u00e9ru.<\/li>\n
    • Odstra\u0148ov\u00e1n\u00ed p\u011bny:<\/strong> Simeticon sni\u017euje povrchov\u00e9 nap\u011bt\u00ed mal\u00fdch plynov\u00fdch bublin zachycen\u00fdch ve st\u0159evech, co\u017e umo\u017e\u0148uje jejich slou\u010den\u00ed do v\u011bt\u0161\u00edch bublin, kter\u00e9 jsou n\u00e1sledn\u011b vylou\u010deny. T\u00edm se ulev\u00ed od nad\u00fdm\u00e1n\u00ed a plynatosti.<\/li>\n<\/ul>\n

      N\u00e1stup \u00fa\u010dinku je do 5\u201315 minut<\/strong> \u2014 hydroxid ho\u0159e\u010dnat\u00fd p\u016fsob\u00ed b\u011bhem minut; hydroxid hlinit\u00fd je pomalej\u0161\u00ed, ale \u00fa\u010dinek je d\u00e9le trvaj\u00edc\u00ed. Celkov\u00e1 doba \u00fa\u010dinku je 30\u201360 minut, v\u00fdjime\u010dn\u011b a\u017e 90 minut p\u0159i u\u017eit\u00ed po j\u00eddle (potrava v \u017ealudku prodlu\u017euje \u00fa\u010dinek). L\u00e9k neovliv\u0148uje budouc\u00ed sekreci kyseliny, proto jsou antacida vhodn\u00e1 sp\u00ed\u0161e pro ob\u010dasn\u00e9 nebo pr\u016flomov\u00e9 p\u0159\u00edznaky ne\u017e jako dlouhodob\u00e1 terapie chronick\u00e9ho GERD.<\/p>\n

      Indikace \u2014 K \u010demu se Acigene pou\u017e\u00edv\u00e1<\/h2>\n

      1. Ob\u010dasn\u00e9 p\u00e1len\u00ed \u017e\u00e1hy a kysel\u00e1 dyspepsie<\/h3>\n

      Klasick\u00e1 indikace antacid. \u00da\u010dinn\u00e1 a rychl\u00e1 pomoc p\u0159i p\u00e1len\u00ed \u017e\u00e1hy po j\u00eddle, zejm\u00e9na po konzumaci zn\u00e1m\u00fdch spou\u0161t\u011b\u010d\u016f. Antacida nejsou vhodn\u00e1 pro dlouhodob\u00e9 denn\u00ed u\u017e\u00edv\u00e1n\u00ed \u2013 pro tento typ p\u0159\u00edznak\u016f je vhodn\u011bj\u0161\u00ed H2<\/sub> blok\u00e1tor nebo PPI.<\/p>\n

      2. Pr\u016flomov\u00e9 p\u0159\u00edznaky b\u011bhem u\u017e\u00edv\u00e1n\u00ed PPI nebo H2<\/sub>-antagonisty<\/h3>\n

      Zat\u00edmco PPI pot\u0159ebuje 3\u20135 dn\u00ed k dosa\u017een\u00ed pln\u00e9ho \u00fa\u010dinku, antacida tuto mezeru vypln\u00ed. P\u0159i chronick\u00e9 supresi kyseliny jsou antacida u\u017eite\u010dn\u00e1 pro ob\u010dasn\u00e9 pr\u016flomov\u00e9 p\u0159\u00edznaky.<\/p>\n

      3. Funk\u010dn\u00ed dyspepsie \u2013 pot\u00ed\u017ee souvisej\u00edc\u00ed s j\u00eddlem<\/h3>\n

      Pro pot\u00ed\u017ee souvisej\u00edc\u00ed s j\u00eddlem, nad\u00fdm\u00e1n\u00ed a pocit plnosti po j\u00eddle je kombinace simetikonu a ochrann\u00e9ho \u00fa\u010dinku na sliznici \u00fa\u010dinn\u011bj\u0161\u00ed ne\u017e \u010dist\u011b neutraliza\u010dn\u00ed antacida.<\/p>\n

      4. T\u011bhotensk\u00e9 p\u00e1len\u00ed \u017e\u00e1hy (po \u00faprav\u011b \u017eivotn\u00edho stylu)<\/h3>\n

      Antacida jsou prvn\u00ed volbou pro p\u00e1len\u00ed \u017e\u00e1hy v t\u011bhotenstv\u00ed po \u00faprav\u011b \u017eivotn\u00edho stylu (zv\u00fd\u0161en\u00ed hlavy postele, men\u0161\u00ed porce j\u00eddel, vyh\u00fdb\u00e1n\u00ed se pozdn\u00edm ve\u010de\u0159\u00edm). V t\u011bhotenstv\u00ed se vyhn\u011bte antacid\u016fm s obsahem jedl\u00e9 sody (nadbytek sod\u00edku); up\u0159ednost\u0148uj\u00ed se kombinace hlin\u00edku a ho\u0159\u010d\u00edku jako Acigene.<\/p>\n

      5. Nad\u00fdm\u00e1n\u00ed \/ plynatost<\/h3>\n

      Simetikonov\u00e1 slo\u017eka \u00fa\u010dinn\u011b zm\u00edr\u0148uje p\u0159\u00edznaky nad\u00fdm\u00e1n\u00ed a plynatosti zp\u016fsoben\u00e9 spolykan\u00fdm vzduchem nebo nad\u00fdmav\u00fdmi potravinami.<\/p>\n

      D\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n
      Pacient<\/th>\nD\u00e1vka<\/th>\nPozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n
      Dosp\u011bl\u00ed \u2013 standardn\u00ed d\u00e1vkov\u00e1n\u00ed<\/td>\n1\u20132 \u017ev\u00fdkac\u00ed tablety, d\u016fkladn\u011b roz\u017ev\u00fdkan\u00e9, a\u017e \u010dty\u0159ikr\u00e1t denn\u011b po j\u00eddle a p\u0159ed span\u00edm podle pot\u0159eby<\/td>\nkr\u00e1tkodob\u00e9 u\u017e\u00edv\u00e1n\u00ed (1\u20132 t\u00fddny)<\/td>\n<\/tr>\n
      Maxim\u00e1ln\u00ed denn\u00ed d\u00e1vka<\/td>\nObecn\u011b 8 tablet za 24 hodin<\/td>\nnep\u0159ekra\u010dujte bez l\u00e9ka\u0159sk\u00e9ho doporu\u010den\u00ed<\/td>\n<\/tr>\n
      Doba bez l\u00e9ka\u0159sk\u00e9 kontroly<\/td>\nA\u017e 2 t\u00fddny pravideln\u00e9ho u\u017e\u00edv\u00e1n\u00ed<\/td>\np\u0159etrv\u00e1vaj\u00edc\u00ed p\u0159\u00edznaky vy\u017eaduj\u00ed vy\u0161et\u0159en\u00ed<\/td>\n<\/tr>\n
      D\u011bti 6\u201312 let<\/td>\nPolovi\u010dn\u00ed d\u00e1vka pro dosp\u011bl\u00e9, pod dohledem pediatra<\/td>\npouze kr\u00e1tkodob\u00e9 u\u017e\u00edv\u00e1n\u00ed<\/td>\n<\/tr>\n
      D\u011bti < 6 let<\/td>\nNedoporu\u010duje se \u2013 pouze po konzultaci s odborn\u00edkem<\/td>\nobavy z obsahu hlin\u00edku<\/td>\n<\/tr>\n
      Porucha funkce ledvin (CrCl < 30 ml\/min)<\/td>\nVyhn\u011bte se dlouhodob\u00e9mu denn\u00edmu u\u017e\u00edv\u00e1n\u00ed \u2014 hromad\u011bn\u00ed hlin\u00edku a ho\u0159\u010d\u00edku<\/td>\npou\u017eijte alternativu s v\u00e1penat\u00fdm uhli\u010ditanem<\/td>\n<\/tr>\n
      T\u011bhotenstv\u00ed<\/td>\nStandardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9<\/td>\nkr\u00e1tkodob\u00e9 u\u017e\u00edv\u00e1n\u00ed; vyhn\u011bte se alternativ\u00e1m s hydrogenuhli\u010ditanem sodn\u00fdm<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      Tabletu d\u016fkladn\u011b roz\u017ev\u00fdkejte<\/strong> \u2014 nepolykejte ji celou. U\u017eit\u00ed s mal\u00fdm mno\u017estv\u00edm vody po roz\u017ev\u00fdk\u00e1n\u00ed pom\u00e1h\u00e1 slo\u017ece s obalem z ho\u0159e\u010dnato-hlinit\u00e9ho k\u0159emi\u010ditanu dos\u00e1hnout j\u00edcnu. Nejvhodn\u011bj\u0161\u00ed je u\u017e\u00edvat po j\u00eddle a p\u0159ed span\u00edm, kdy je reflux nejpravd\u011bpodobn\u011bj\u0161\u00ed.<\/p>\n

      KRITICK\u00c9: Pravidlo na\u010dasov\u00e1n\u00ed l\u00e9ku<\/h2>\n
      Acigene sni\u017euje vst\u0159eb\u00e1v\u00e1n\u00ed mnoha dal\u0161\u00edch peror\u00e1ln\u00edch l\u00e9k\u016f.<\/strong> Podobn\u011b jako sukralf\u00e1t, antacida v\u00e1\u017eou molekuly l\u00e9k\u016f ve st\u0159ev\u011b chelatac\u00ed nebo zv\u00fd\u0161en\u00edm lok\u00e1ln\u00edho pH a sn\u00ed\u017een\u00edm rozpou\u0161t\u011bn\u00ed. Mezi l\u00e9ky, jejich\u017e vst\u0159eb\u00e1v\u00e1n\u00ed je sn\u00ed\u017eeno, pat\u0159\u00ed: tetracykliny (doxycyklin), fluorochinolony (ciprofloxacin, levofloxacin), dopl\u0148ky \u017eeleza, levothyroxin, ketokonazol, itrakonazol, bisfosfon\u00e1ty, mykofenol\u00e1t, atazanavir, rilpivirin, digoxin, fenytoin<\/strong>, a mnoho dal\u0161\u00edch. V\u0161echny ostatn\u00ed peror\u00e1ln\u00ed l\u00e9ky u\u017e\u00edvejte nejm\u00e9n\u011b 2 hodiny p\u0159ed nebo 4 hodiny po Acigene.<\/strong> To je obzvl\u00e1\u0161t\u011b d\u016fle\u017eit\u00e9 u substitu\u010dn\u00ed terapie \u0161t\u00edtn\u00e9 \u017el\u00e1zy, antibiotik a antiretrovirov\u00fdch l\u00e9k\u016f na HIV, kde sn\u00ed\u017een\u00e9 vst\u0159eb\u00e1v\u00e1n\u00ed m\u016f\u017ee m\u00edt v\u00e1\u017en\u00e9 klinick\u00e9 d\u016fsledky.<\/div>\n

      Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n

      \u010cast\u00e9 (1\u20135 %):<\/strong><\/p>\n