<\/p>\n
Roko tablety obsahuj\u00ed loperamid hydrochlorid 2 mg \u2014 agonistu opioidn\u00edch receptor\u016f p\u016fsob\u00edc\u00edho pouze ve st\u0159evn\u00ed st\u011bn\u011b, kter\u00fd zpomaluje st\u0159evn\u00ed motilitu a zm\u00edr\u0148uje akutn\u00ed i chronick\u00fd pr\u016fjem. V\u00fdrobce Cipla doporu\u010duje po\u010d\u00e1te\u010dn\u00ed d\u00e1vku 4 mg, n\u00e1sledovanou 2 mg po ka\u017ed\u00e9 \u0159\u00eddk\u00e9 stolici, maxim\u00e1ln\u011b 16 mg za 24 hodin. Sni\u017euje frekvenci stolice a nutk\u00e1n\u00ed bez centr\u00e1ln\u00edch nervov\u00fdch \u00fa\u010dink\u016f jin\u00fdch opioid\u016f.<\/p>\n<\/div>\n
\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n Roko je antidiarrhoikum obsahuj\u00edc\u00ed loperamid hydrochlorid 2 mg<\/strong>, vyr\u00e1b\u011bn\u00e9 spole\u010dnost\u00ed Cipla Ltd<\/strong> v Indii. Loperamid je syntetick\u00fd agonista opioidn\u00edch receptor\u016f, kter\u00fd p\u016fsob\u00ed specificky ve st\u0159evn\u00ed st\u011bn\u011b, zpomaluje st\u0159evn\u00ed motilitu a sni\u017euje frekvenci stolice. Na rozd\u00edl od star\u0161\u00edch opioid\u016f (kodein, difenoxyl\u00e1t) nem\u00e1 loperamid v terapeutick\u00fdch d\u00e1vk\u00e1ch t\u00e9m\u011b\u0159 \u017e\u00e1dn\u00fd \u00fa\u010dinek na centr\u00e1ln\u00ed nervov\u00fd syst\u00e9m, proto\u017ee je aktivn\u011b vylu\u010dov\u00e1n z mozku P-glykoproteinov\u00fdm transport\u00e9rem hematoencefalick\u00e9 bari\u00e9ry.<\/p>\n Toto farmakologick\u00e9 zam\u011b\u0159en\u00ed \u010din\u00ed p\u0159\u00edpravek Roko jedine\u010dn\u011b vhodn\u00fdm pro kontrolu pr\u016fjmu bez sedace, euforie, respira\u010dn\u00ed deprese nebo potenci\u00e1lu zneu\u017eit\u00ed spojen\u00e9ho s jin\u00fdmi opioidy. Od sv\u00e9ho zaveden\u00ed v 70. letech 20. stolet\u00ed je hlavn\u00edm antidiarrhoikem celosv\u011btov\u011b a je za\u0159azen na Modelov\u00fd seznam z\u00e1kladn\u00edch l\u00e9\u010div WHO.<\/p>\n Loperamid se v\u00e1\u017ee na \u03bc-opioidn\u00ed receptory<\/strong> v myenterick\u00e9m plexu tlust\u00e9ho st\u0159eva \u2014 na s\u00ed\u0165 nervov\u00fdch bun\u011bk, kter\u00e1 reguluje peristaltiku. Vazba inhibuje uvol\u0148ov\u00e1n\u00ed acetylcholinu a prostaglandin\u016f, co\u017e sni\u017euje s\u00edlu a frekvenci st\u0159evn\u00edch kontrakc\u00ed. V\u00fdsledkem je pomalej\u0161\u00ed pr\u016fchod<\/strong>, co\u017e d\u00e1v\u00e1 tlust\u00e9mu st\u0159evu v\u00edce p\u0159\u00edle\u017eitosti k op\u011btovn\u00e9mu vst\u0159eb\u00e1v\u00e1n\u00ed vody a elektrolyt\u016f ze stolice. \u010cist\u00fd objem stolice se sni\u017euje a stolice se st\u00e1v\u00e1 pevn\u011bj\u0161\u00ed.<\/p>\n Loperamid tak\u00e9 sni\u017euje abnorm\u00e1ln\u00ed tonus an\u00e1ln\u00edho sv\u011bra\u010de pozorovan\u00fd u pr\u016fjmu, \u010d\u00edm\u017e zlep\u0161uje kontinenci. V terapeutick\u00fdch d\u00e1vk\u00e1ch nedoch\u00e1z\u00ed k analgetick\u00e9mu ani centr\u00e1ln\u00edmu opioidn\u00edmu \u00fa\u010dinku kv\u016fli P-glykoproteinov\u00e9 bari\u00e9\u0159e na hematoencefalick\u00e9 bari\u00e9\u0159e. To je d\u016fvod, pro\u010d loperamid nen\u00ed ve v\u011bt\u0161in\u011b zem\u00ed klasifikov\u00e1n jako kontrolovan\u00e1 l\u00e1tka.<\/p>\n D\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9 u akutn\u00edho pr\u016fjmu<\/strong>: 4 mg (dv\u011b tablety) zpo\u010d\u00e1tku, n\u00e1sledovan\u00e9 2 mg (jednou tabletou) po ka\u017ed\u00e9 dal\u0161\u00ed \u0159\u00eddk\u00e9 stolici. Maxim\u00e1ln\u011b 16 mg (8 tablet) za 24 hodin. P\u0159eru\u0161te, kdy\u017e stolice zhoustne.<\/p>\n D\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9 u chronick\u00e9ho pr\u016fjmu<\/strong>: 4 mg zpo\u010d\u00e1tku, pot\u00e9 2 mg po ka\u017ed\u00e9 \u0159\u00eddk\u00e9 stolici nebo podle pot\u0159eby. Udr\u017eovac\u00ed d\u00e1vka 2\u201312 mg denn\u011b, upraven\u00e1 podle klinick\u00e9 odpov\u011bdi. Maxim\u00e1ln\u011b 16 mg denn\u011b.<\/p>\n D\u011bti ve v\u011bku 4\u20138 let<\/strong>: 1 mg a\u017e 3kr\u00e1t denn\u011b, maxim\u00e1ln\u011b 2 dny. D\u011bti 9\u201312 let<\/strong>: 2 mg dvakr\u00e1t denn\u011b, maxim\u00e1ln\u011b 5 dn\u00ed. Nepou\u017e\u00edvejte u d\u011bt\u00ed mlad\u0161\u00edch 4 let bez l\u00e9ka\u0159sk\u00e9ho doporu\u010den\u00ed.<\/p>\n D\u016fle\u017eit\u00e9 interakce: ritonavir, chinidin, itrakonazol, ketokonazol<\/strong> \u2014 inhibuj\u00ed metabolismus loperamidu a P-glykoproteinov\u00fd eflux, zvy\u0161uj\u00ed plazmatick\u00e9 hladiny a riziko centr\u00e1ln\u00edch opioidn\u00edch \u00fa\u010dink\u016f a kardiotoxicity; cholestyramin<\/strong> \u2014 v\u00e1\u017ee loperamid ve st\u0159ev\u011b, sni\u017euje absorpci; L\u00e9ky prodlu\u017euj\u00edc\u00ed QT interval<\/strong> (amiodaron, sotalol, makrolidov\u00e1 antibiotika, n\u011bkter\u00e1 antipsychotika) \u2014 aditivn\u00ed riziko arytmie p\u0159i vysok\u00fdch d\u00e1vk\u00e1ch loperamidu; jin\u00e9 opioidy<\/strong> \u2014 teoreticky aditivn\u00ed centr\u00e1ln\u00ed \u00fa\u010dinky p\u0159i velmi vysok\u00fdch d\u00e1vk\u00e1ch.<\/p>\n Skladujte p\u0159i teplot\u011b do 25 \u00b0C v p\u016fvodn\u00edm blistru, chr\u00e1n\u011bno p\u0159ed vlhkost\u00ed. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed. Nepou\u017e\u00edvejte po uplynut\u00ed doby pou\u017eitelnosti.<\/p>\n \u00daleva obvykle nast\u00e1v\u00e1 b\u011bhem 30 minut a\u017e 1 hodiny po prvn\u00ed d\u00e1vce 4 mg. Vrcholn\u00fd \u00fa\u010dinek je za 4\u20135 hodin. V\u011bt\u0161ina epizod akutn\u00edho pr\u016fjmu se vy\u0159e\u0161\u00ed do 24 hodin od zah\u00e1jen\u00ed u\u017e\u00edv\u00e1n\u00ed p\u0159\u00edpravku Roko, chronick\u00fd pr\u016fjem v\u0161ak vy\u017eaduje del\u0161\u00ed kontinu\u00e1ln\u00ed d\u00e1vkov\u00e1n\u00ed p\u0159izp\u016fsoben\u00e9 individu\u00e1ln\u00ed reakci.<\/p>\n Ano \u2014 Roko je \u00fa\u010dinn\u00fd pro symptomatickou \u00falevu p\u0159i cestovatelsk\u00e9m pr\u016fjmu a m\u016f\u017ee b\u00fdt kombinov\u00e1n s vhodnou antibiotickou terapi\u00ed u st\u0159edn\u011b t\u011b\u017ek\u00fdch a\u017e t\u011b\u017ek\u00fdch p\u0159\u00edpad\u016f. Pokud se objev\u00ed krvav\u00e1 stolice, vysok\u00e1 hore\u010dka nebo siln\u00e1 bolest b\u0159icha, vyhledejte l\u00e9ka\u0159skou p\u00e9\u010di nam\u00edsto samol\u00e9\u010dby pouze loperamidem.<\/p>\n P\u0159i chronick\u00fdch stavech jako IBS-D nebo management ileostomie lze loperamid dlouhodob\u011b u\u017e\u00edvat pod l\u00e9ka\u0159sk\u00fdm dohledem v nejni\u017e\u0161\u00ed \u00fa\u010dinn\u00e9 d\u00e1vce. Sledujte z\u00e1cpu a upravte d\u00e1vkov\u00e1n\u00ed podle pot\u0159eby. Dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed v standardn\u00edch d\u00e1vk\u00e1ch nen\u00ed spojeno se z\u00e1vislost\u00ed nebo toleranc\u00ed.<\/p>\n Loperamid se nedoporu\u010duje d\u011btem mlad\u0161\u00edm 2 let kv\u016fli zv\u00fd\u0161en\u00e9mu riziku paralytick\u00e9ho ileu. U d\u011bt\u00ed ve v\u011bku 4\u20138 let lze pod\u00e1vat d\u00e1vky 1 mg po kr\u00e1tkou dobu. V\u017edy se nejprve pora\u010fte s pediatrem a zajist\u011bte dostate\u010dn\u00fd p\u0159\u00edjem tekutin s rehydrata\u010dn\u00edmi solemi, bez ohledu na to, zda se pou\u017e\u00edv\u00e1 Roko.<\/p>\n Loperamid je aktivn\u011b pumpov\u00e1n z mozku P-glykoproteinem na hematoencefalick\u00e9 bari\u00e9\u0159e. P\u0159i terapeutick\u00fdch d\u00e1vk\u00e1ch se prakticky \u017e\u00e1dn\u00fd nedostane k centr\u00e1ln\u00edm opioidn\u00edm receptor\u016fm zodpov\u011bdn\u00fdm za euforii nebo z\u00e1vislost. P\u0159i extr\u00e9mn\u011b vysok\u00fdch d\u00e1vk\u00e1ch (>60 mg) se transport\u00e9r saturuje a mohou se objevit n\u011bkter\u00e9 centr\u00e1ln\u00ed \u00fa\u010dinky \u2014 proto byly v n\u011bkolika zem\u00edch zavedeny limity velikosti balen\u00ed.<\/p>\n Neu\u017e\u00edvejte Roko, pokud m\u00e1te: krvavou stolici, vysokou hore\u010dku (nad 38,5 \u00b0C), silnou bolest b\u0159icha nazna\u010duj\u00edc\u00ed ileus nebo peritonitidu, kolitidu spojenou s antibiotiky nebo aktivn\u00ed vzplanut\u00ed ulcer\u00f3zn\u00ed kolitidy nebo Crohnovy choroby. V t\u011bchto situac\u00edch m\u016f\u017ee zpomalen\u00ed motility zhor\u0161it z\u00e1kladn\u00ed stav.<\/p>\n M\u00edrn\u00e9 p\u0159ed\u00e1vkov\u00e1n\u00ed (a\u017e 16 mg nad denn\u00ed limit) obvykle zp\u016fsob\u00ed pouze silnou z\u00e1cpu nebo bolesti b\u0159icha. Velk\u00e1 p\u0159ed\u00e1vkov\u00e1n\u00ed (nad 60 mg za den) mohou zp\u016fsobit srde\u010dn\u00ed arytmii a vy\u017eaduj\u00ed neodkladnou l\u00e9ka\u0159skou p\u00e9\u010di \u2014 monitorov\u00e1n\u00ed EKG a podp\u016frnou p\u00e9\u010di. V p\u0159\u00edpad\u011b pochybnost\u00ed zavolejte na toxikologick\u00e9 informa\u010dn\u00ed st\u0159edisko nebo vyhledejte pohotovostn\u00ed p\u00e9\u010di.<\/p>\n <\/p>\n Dal\u0161\u00ed produkty v Obecn\u00e9 zdrav\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n Roko obsahuje loperamid hydrochlorid<\/span><\/p>","protected":false},"featured_media":54847,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3812],"product_tag":[3813],"class_list":{"0":"post-54846","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-trapped-wind-relief","9":"product_tag-loperamide-hydrochloride","11":"first","12":"instock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/54846","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=54846"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/54847"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=54846"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=54846"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=54846"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=54846"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Co je Roko?<\/h2>\n
Pou\u017eit\u00ed p\u0159\u00edpravku Roko<\/h2>\n
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Jak Roko funguje<\/h2>\n
D\u00e1vkov\u00e1n\u00ed a pod\u00e1n\u00ed<\/h2>\n
Jak pou\u017e\u00edvat Roko<\/h2>\n
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Vedlej\u0161\u00ed \u00fa\u010dinky Roko<\/h2>\n
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Opat\u0159en\u00ed a varov\u00e1n\u00ed<\/h2>\n
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Interakce s l\u00e9\u010divy<\/h2>\n
Skladov\u00e1n\u00ed<\/h2>\n
\u010casto kladen\u00e9 dotazy<\/h2>\n
Jak rychle Roko zab\u00edr\u00e1?<\/h3>\n
Mohu u\u017e\u00edvat Roko p\u0159i cestovatelsk\u00e9m pr\u016fjmu?<\/h3>\n
Je Roko bezpe\u010dn\u00fd pro dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed?<\/h3>\n
Mohu podat Roko sv\u00e9mu d\u00edt\u011bti?<\/h3>\n
Pro\u010d loperamid nen\u00ed n\u00e1vykov\u00fd?<\/h3>\n
Kdy bych NEM\u011aL u\u017e\u00edvat Roko?<\/h3>\n
Co m\u00e1m d\u011blat, kdy\u017e jsem n\u00e1hodou u\u017eil p\u0159\u00edli\u0161 mnoho?<\/h3>\n
Souvisej\u00edc\u00ed alternativy<\/h3>\n
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\u2705 \u00daleva od p\u0159\u00edznak\u016f pr\u016fjmu
\n\u2705 Normalizuje funkci st\u0159ev
\n\u2705 Zm\u00edr\u0148uje p\u0159idru\u017een\u00e9 p\u0159\u00edznaky
\n\u2705 Rychl\u00fd a \u00fa\u010dinn\u00fd
\n\u2705 Zlep\u0161en\u00e1 kvalita \u017eivota<\/h5>\n