{"id":55183,"date":"2024-01-10T09:33:08","date_gmt":"2024-01-10T09:33:08","guid":{"rendered":"https:\/\/medsname.com\/nizonide\/"},"modified":"2026-04-30T10:24:50","modified_gmt":"2026-04-30T10:24:50","slug":"nizonide","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/nizonide\/","title":{"rendered":"Nizonide"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Nizonide?<\/h3>\n

Nizonide je zna\u010dka spole\u010dnosti Cipla pro nitazoxanid<\/strong> (200 \/ 500 mg) \u2014 \u0161irokospektr\u00e1ln\u00ed antiprotozo\u00e1ln\u00ed a antivirotikum. Prvn\u00ed volba pro potvrzen\u00e9 infekce Giardia lamblia<\/em> a Cryptosporidium parvum<\/em> (jedin\u00e9 indikace schv\u00e1len\u00e9 FDA) a u\u017eite\u010dn\u00fd p\u0159i am\u00e9b\u00f3ze a vybran\u00fdch virov\u00fdch pr\u016fjmech. Standardn\u00ed d\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9 je 500 mg dvakr\u00e1t denn\u011b po dobu 3 dn\u016f, u\u017e\u00edvan\u00e9 s j\u00eddlem.<\/p>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase?<\/strong> Dod\u00e1v\u00e1no od v\u00fdrobce certifikovan\u00e9ho WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Doprava po cel\u00e9m sv\u011bt\u011b \u00b7 1 400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

K \u010demu se Nizonide pou\u017e\u00edv\u00e1<\/h2>\n

Nizonide je thiazolidov\u00e9 antiprotozoikum vyr\u00e1b\u011bn\u00e9 spole\u010dnost\u00ed Cipla. \u00da\u010dinn\u00e1 l\u00e1tka nitazoxanid m\u00e1 unik\u00e1tn\u011b \u0161irok\u00e9 spektrum \u00fa\u010dinku proti intracelul\u00e1rn\u00edm a lumin\u00e1ln\u00edm prvok\u016fm, n\u011bkter\u00fdm helmint\u016fm, anaerobn\u00edm bakteri\u00edm a \u0159ad\u011b RNA vir\u016f. V praxi cestovatelsk\u00fdch pr\u016fjm\u016f a tropick\u00e9 medic\u00edny se nej\u010dast\u011bji pou\u017e\u00edv\u00e1 pro:<\/p>\n

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  • Giardi\u00f3za<\/strong> \u2014 prvn\u00ed volba v mnoha zem\u00edch; alternativa k metronidazolu a tinidazolu. L\u00e9pe sn\u00e1\u0161en (\u017e\u00e1dn\u00e1 disulfiramov\u00e1 reakce s alkoholem) a krat\u0161\u00ed 3denn\u00ed l\u00e9\u010dba.<\/li>\n
  • Kryptosporidi\u00f3za<\/strong> \u2014 l\u00e9k schv\u00e1len\u00fd FDA pro tuto infekci u imunokompetentn\u00edch dosp\u011bl\u00fdch a d\u011bt\u00ed. U t\u011b\u017ek\u00e9 kryptosporidi\u00f3zy spojen\u00e9 s HIV\/AIDS je odpov\u011b\u010f \u010d\u00e1ste\u010dn\u00e1 \u2014 obnoven\u00ed po\u010dtu CD4 pomoc\u00ed ART je kl\u00ed\u010dov\u00fdm z\u00e1sahem. pouze<\/em> L\u00e9k schv\u00e1len\u00fd FDA pro tuto infekci u imunokompetentn\u00edch dosp\u011bl\u00fdch a d\u011bt\u00ed. U t\u011b\u017ek\u00e9 kryptosporidi\u00f3zy spojen\u00e9 s HIV\/AIDS je odpov\u011b\u010f \u010d\u00e1ste\u010dn\u00e1 \u2014 obnova po\u010dtu CD4 pomoc\u00ed ART je kl\u00ed\u010dovou intervenc\u00ed.<\/li>\n
  • (st\u0159evn\u00ed, off-label) \u2014 dobr\u00e1 \u00fa\u010dinnost proti<\/strong> (st\u0159evn\u00ed, off-label) \u2014 dobr\u00e1 aktivita proti ; metronidazol nebo tinidazol z\u016fst\u00e1vaj\u00ed preferovanou volbou pro invazivn\u00ed onemocn\u011bn\u00ed.<\/em>; metronidazol nebo tinidazol z\u016fst\u00e1vaj\u00ed preferovan\u00fdmi l\u00e1tkami pro invazivn\u00ed formu onemocn\u011bn\u00ed.<\/li>\n
  • Blastocystis hominis<\/strong> \u2014 Cyclospora<\/em>, Isospora<\/em>, ve vybran\u00fdch kontextech.<\/em> Helminti.<\/li>\n
  • Hymenolepis nana<\/strong> (mimo indikaci) \u2014 (trpasli\u010d\u00ed tasemnice),<\/em> ; albendazol\/mebendazol z\u016fst\u00e1vaj\u00ed preferovanou prvn\u00ed volbou., Ascaris lumbricoides<\/em>, Trichuris trichiura<\/em>; albendazole\/mebendazole z\u016fst\u00e1vaj\u00ed preferovanou prvn\u00ed lini\u00ed.<\/li>\n
  • Virov\u00e1 gastroenteritida<\/strong> \u2014 klinick\u00e9 studie prokazuj\u00ed m\u00edrn\u00e9 zkr\u00e1cen\u00ed d\u00e9lky p\u0159\u00edznak\u016f u rotavirov\u00fdch a norovirov\u00fdch pr\u016fjm\u016f (Rossignol JAMA 2009; Rossignol Lancet 2006). Nen\u00ed standardn\u00ed l\u00e9\u010dba; zva\u017ete u t\u011b\u017ek\u00fdch nebo protrahovan\u00fdch virov\u00fdch onemocn\u011bn\u00ed.<\/li>\n
  • Recidivuj\u00edc\u00ed Clostridioides difficile<\/em><\/strong> infekce (off-label salvage) \u2014 pouze mal\u00e9 kazuistiky; vankomycin a fidaxomicin z\u016fst\u00e1vaj\u00ed prvn\u00ed volbou.<\/li>\n<\/ul>\n

    Jak Nizonide funguje<\/h2>\n

    Nitazoxanid je profarmakon rychle hydrolyzovan\u00fd na sv\u016fj aktivn\u00ed metabolit tizoxanid ve st\u0159ev\u011b a j\u00e1trech. Mechanismus je unik\u00e1tn\u00ed mezi antiinfektivy: inhibuje pyruv\u00e1t:ferredoxin oxidoredukt\u00e1zu (PFOR) enzym<\/strong> nezbytn\u00fd pro anaerobn\u00ed energetick\u00fd metabolismus u protozo\u00ed, anaerobn\u00edch bakteri\u00ed a n\u011bkter\u00fdch helmint\u016f. Proto\u017ee sav\u010d\u00ed bu\u0148ky vyu\u017e\u00edvaj\u00ed aerobn\u00ed mitochondri\u00e1ln\u00ed metabolismus, je l\u00e9\u010divo selektivn\u011b toxick\u00e9 pro patogeny. Antivirov\u00fd \u00fa\u010dinek proti rotavir\u016fm, norovir\u016fm, ch\u0159ipce a hepatitid\u011b B\/C je zprost\u0159edkov\u00e1n r\u016fzn\u00fdmi mechanismy v\u010detn\u011b interference s maturac\u00ed virov\u00fdch protein\u016f.<\/p>\n

    D\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n
    Indikace<\/th>\nD\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9<\/th>\nPediatrie (1\u201311 let)<\/th>\nD\u00e9lka<\/th>\n<\/tr>\n
    Giardi\u00f3za<\/td>\n500 mg 2\u00d7 denn\u011b<\/td>\n1\u20133 roky: 100 mg 2\u00d7 denn\u011b \u00b7 4\u201311 let: 200 mg 2\u00d7 denn\u011b<\/td>\n3 dny<\/td>\n<\/tr>\n
    Kryptosporidi\u00f3za (imunokompetentn\u00ed pacienti)<\/td>\n500 mg 2\u00d7 denn\u011b<\/td>\n100 \/ 200 mg 2\u00d7 denn\u011b podle v\u011bkov\u00e9 skupiny<\/td>\n3 dny<\/td>\n<\/tr>\n
    Kryptosporidi\u00f3za (HIV\/CD4 < 200)<\/td>\n500\u20131000 mg 2\u00d7 denn\u011b<\/td>\nOdborn\u00e9 doporu\u010den\u00ed<\/td>\nMinim\u00e1ln\u011b 14 dn\u00ed<\/td>\n<\/tr>\n
    Am\u00e9b\u00f3za (mimo schv\u00e1len\u00e9 indikace)<\/td>\n500 mg 2\u00d7 denn\u011b<\/td>\nPodle v\u011bkov\u00e9 skupiny<\/td>\n3 dny<\/td>\n<\/tr>\n
    Virov\u00e1 gastroenteritida (mimo schv\u00e1len\u00e9 indikace)<\/td>\n500 mg 2\u00d7 denn\u011b<\/td>\nPodle v\u011bkov\u00e9 skupiny<\/td>\n3 dny<\/td>\n<\/tr>\n<\/table>\n
    \u2705 U\u017e\u00edvejte s j\u00eddlem<\/strong>
    Nitazoxanid je \u0161patn\u011b rozpustn\u00fd ve vod\u011b. U\u017e\u00edv\u00e1n\u00ed ka\u017ed\u00e9 d\u00e1vky s j\u00eddlem<\/strong> zvy\u0161uje AUC p\u0159ibli\u017en\u011b 2\u20133\u00d7 oproti nala\u010dno. Dodr\u017eov\u00e1n\u00ed tohoto pravidla je nejv\u00fdznamn\u011bj\u0161\u00edm prediktorem \u00fasp\u011bchu l\u00e9\u010dby \u2013 ne\u00fasp\u011b\u0161n\u00e9 l\u00e9\u010debn\u00e9 cykly jsou nej\u010dast\u011bji zp\u016fsobeny nedostate\u010dnou absorpc\u00ed, nikoli nedostate\u010dn\u00fdm d\u00e1vkov\u00e1n\u00edm.<\/div>\n

    Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n