{"id":55235,"date":"2024-01-12T20:18:33","date_gmt":"2024-01-12T20:18:33","guid":{"rendered":"https:\/\/medsname.com\/stemetil\/"},"modified":"2026-04-30T10:24:50","modified_gmt":"2026-04-30T10:24:50","slug":"stemetil","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/stemetil\/","title":{"rendered":"Stemetil"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Stemetil?<\/h3>\n<p style=\"margin:0;\"><strong>Stemetil<\/strong> is prochlorperazine maleate 5 mg &mdash; a phenothiazine first-generation antipsychotic widely used at low doses for <strong>severe nausea and vomiting, vertigo, Meniere&#8217;s disease, and the labyrinthine vertigo<\/strong> of inner-ear dysfunction. It blocks central D2 dopamine receptors in the chemoreceptor trigger zone (antiemetic) and in the labyrinth (anti-vertigo), and to a lesser extent histamine H1 and muscarinic receptors. Standard dose: <strong>5&ndash;10 mg three times daily orally for nausea or vertigo, max 30 mg\/day<\/strong>; bipolar\/schizophrenia at higher doses is rarely used today given atypical antipsychotic alternatives. WHO-GMP certified manufacturer.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2714 <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong> \u2714 Diskr\u00e9tn\u00ed balen\u00ed \u2714 Celosv\u011btov\u00e1 doprava \u2714 <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">Ov\u011b\u0159en\u00e9 recenze z\u00e1kazn\u00edk\u016f (1 400+ z\u00e1kazn\u00edk\u016f)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#9888;&#65039; FGA antipsychotic warnings.<\/strong> Prochlorperazine is a typical (first-generation) antipsychotic and shares the class warnings of acute dystonia, akathisia, parkinsonism, neuroleptic malignant syndrome, and tardive dyskinesia. Risk is dose-and-duration dependent; the antiemetic doses used for nausea\/vertigo are lower than antipsychotic doses but extrapyramidal effects still occur (notably in young men and elderly women). Increased mortality has been observed in elderly dementia patients on antipsychotics &mdash; avoid in this population. Avoid in Parkinson&#8217;s disease.<\/div>\n<h3 class=\"wp-block-heading\">Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Stemetil is supplied from a <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> &mdash; if it does not arrive within 20 business days, we reship at no cost. Stemetil is a long-established antiemetic and vestibular suppressant used worldwide for severe nausea, vertigo, and Meniere&#39;s symptom flares.<\/p>\n<h2 class=\"wp-block-heading\">Mechanismus \u00fa\u010dinku<\/h2>\n<p>Prochlorperazine antagonises central D2 dopamine receptors. In the chemoreceptor trigger zone this produces a strong antiemetic effect (more potent than metoclopramide for severe vomiting). In the inner ear and brainstem vestibular nuclei it suppresses vertigo. H1 antagonism explains the sedation; muscarinic antagonism explains dry mouth. At higher doses it has the typical FGA pharmacology (positive-symptom psychosis suppression).<\/p>\n<h2 class=\"wp-block-heading\">Indikace<\/h2>\n<ul>\n<li>Severe nausea and vomiting (chemo, post-op, migraine, gastroenteritis)<\/li>\n<li>Vertigo (vestibular neuronitis, BPPV with severe symptoms, Meniere&#39;s flare)<\/li>\n<li>Meniere&#8217;s disease symptom relief (combined with diuretic \/ dietary salt restriction)<\/li>\n<li>Labyrinthitis<\/li>\n<li>Schizophrenia (rarely &mdash; superseded by atypicals)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vka<\/h2>\n<p>Adults: 5&ndash;10 mg three times daily orally for nausea\/vertigo. Acute migraine-associated nausea: 5&ndash;10 mg single dose. Meniere&#8217;s: 5 mg three times daily, titrate to symptom control (max 30 mg\/day). Children: avoid &lt; 10 kg. Hepatic impairment: reduce dose. Elderly: start at half-dose &mdash; very high EPS risk.<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li>Common: drowsiness, dry mouth, constipation, blurred vision, postural hypotension<\/li>\n<li>Extrapyramidal: acute dystonia (oculogyric crisis, torticollis), akathisia, parkinsonism, tardive dyskinesia<\/li>\n<li>Hyperprolactinaemia: galactorrhoea, menstrual changes<\/li>\n<li>QT prolongation, torsades de pointes (rare)<\/li>\n<li>Photosensitivity skin rash, cholestatic jaundice (idiosyncratic)<\/li>\n<li>Neuroleptic malignant syndrome (rare, life-threatening)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce l\u00e9k\u016f<\/h2>\n<ul>\n<li>Other dopamine antagonists (metoclopramide, haloperidol, atypicals): additive EPS &mdash; avoid stacking.<\/li>\n<li>QT-prolonging drugs (azithromycin, fluoroquinolones, ondansetron, citalopram, methadone): avoid combination.<\/li>\n<li>CNS depressants (alcohol, opioids, benzodiazepines): additive sedation, hypotension.<\/li>\n<li>Levodopa, dopamine agonists: each blocks the other&#39;s effect &mdash; avoid in Parkinson&#8217;s.<\/li>\n<li>Anticholinergics: additive dry mouth, urinary retention, constipation.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">What is Stemetil mainly used for?<\/h3>\n<p>Severe nausea, vomiting, and vertigo. It is more potent than metoclopramide for severe vomiting and is the standard for vestibular vertigo flares.<\/p>\n<h3 class=\"wp-block-heading\">How quickly will it work?<\/h3>\n<p>Antiemetic effect within 30&ndash;60 minutes orally. The IM and rectal routes (5 mg or 25 mg suppositories) act within 30 minutes when the patient cannot keep tablets down.<\/p>\n<h3 class=\"wp-block-heading\">Is it safe to drive on this?<\/h3>\n<p>Drowsiness is common. Do not drive until you know how it affects you. The first 1&ndash;2 weeks are usually most sedating.<\/p>\n<h3 class=\"wp-block-heading\">Can I take it with my migraine medication?<\/h3>\n<p>Yes &mdash; prochlorperazine is often combined with triptans and analgesics during a migraine attack to control nausea. Avoid with QT-prolonging triptan combinations and tell the prescriber.<\/p>\n<h3 class=\"wp-block-heading\">Is it the same as metoclopramide?<\/h3>\n<p>Both are D2 antagonists. Prochlorperazine is more potent for severe vomiting and is preferred for vertigo. Metoclopramide is more prokinetic. Both share extrapyramidal side-effect risk.<\/p>\n<h3 class=\"wp-block-heading\">Why am I getting muscle spasms?<\/h3>\n<p>Acute dystonia is a recognised early side effect &mdash; uncontrolled muscle pulling in the neck, jaw, eyes, or trunk. Stop the drug and seek medical help. Treated with IV anticholinergic (procyclidine).<\/p>\n<h3 class=\"wp-block-heading\">Can I take it long-term for Meniere&#8217;s?<\/h3>\n<p>Short-to-medium courses for symptom flares are typical. Long-term use (months) raises tardive dyskinesia risk &mdash; specialist ENT\/neurology supervision recommended.<\/p>\n<h3 class=\"wp-block-heading\">Je bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n<p>Category C. Sometimes used for severe hyperemesis gravidarum when first-line fails. Discuss with obstetric prescriber.<\/p>\n<h3 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h3>\n<p>Below 25&deg;C, away from light. Keep out of reach of children.<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Take it as soon as you remember. If close to the next dose, skip it. Do not double up.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Dal\u0161\u00ed l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/dompewal-tablet\/\">Dompewal &mdash; Domperidone<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/reglan\/\">Reglan &mdash; Metoclopramide<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/doxinate\/\">Doxinate &mdash; Doxylamine + B6 (NVP-specific)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zofer\/\">Zofer &mdash; Ondansetron (5-HT3 antiemetic)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/stugeron\/\">Stugeron &mdash; Cinnarizine (vertigo)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/gastro-health\/\"><strong>Prohl\u00e9dnout v\u0161echny l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed.<\/strong> This page is for informational purposes only and does not replace medical advice from a qualified healthcare professional. Persistent vertigo or vomiting needs assessment for vestibular, cardiac, and neurological causes.<\/div>","protected":false},"excerpt":{"rendered":"<p>Stemetil (Prochlorperazine 5 mg) \u2014 phenothiazine antiemetic and vestibular suppressant for severe nausea, vomiting, vertigo, Meniere&#8217;s disease, and migraine-associated vomiting. WHO-GMP certified manufacturer. Worldwide shipping from MedsBase.<\/p>","protected":false},"featured_media":55236,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[3885,3886],"class_list":{"0":"post-55235","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-prochlorperazine-maleate","10":"product_tag-stemetil","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/55235","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=55235"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/55236"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=55235"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=55235"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=55235"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=55235"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}