{"id":55317,"date":"2024-01-30T10:07:16","date_gmt":"2024-01-30T10:07:16","guid":{"rendered":"https:\/\/medsname.com\/agoprex\/"},"modified":"2026-04-30T10:24:49","modified_gmt":"2026-04-30T10:24:49","slug":"agoprex","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/agoprex\/","title":{"rendered":"Agoprex"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Agoprex (Agomelatin 25 mg) je agonista melatoninov\u00fdch receptor\u016f MT1\/MT2 a antagonista 5-HT2C ur\u010den\u00fd k l\u00e9\u010db\u011b t\u011b\u017ek\u00e9 deprese. M\u00e1 odli\u0161n\u00fd profil: nezp\u016fsobuje sexu\u00e1ln\u00ed dysfunkci, nep\u0159ib\u00edr\u00e1n\u00ed na v\u00e1ze ani abstinen\u010dn\u00ed syndrom, ale vy\u017eaduje pravideln\u00e9 monitorov\u00e1n\u00ed jatern\u00edch funkc\u00ed.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Agoprex na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Agoprex a jak funguje<\/h2>\n

Agoprex jsou tablety obsahuj\u00edc\u00ed 25 mg agomelatinu, kter\u00e9 dod\u00e1v\u00e1 Sun Pharma. Agomelatin je mezi antidepresivy mechanisticky unik\u00e1tn\u00ed: p\u016fsob\u00ed jako agonista melatoninov\u00fdch receptor\u016f MT1 a MT2 a antagonista serotoninov\u00fdch receptor\u016f 5-HT2C. Tento dvoj\u00ed mechanismus resynchronizuje naru\u0161en\u00e9 cirkadi\u00e1nn\u00ed rytmy (co\u017e je typick\u00e9 pro t\u011b\u017ekou depresi) a z\u00e1rove\u0148 nep\u0159\u00edmo zvy\u0161uje uvol\u0148ov\u00e1n\u00ed dopaminu a noradrenalinu v prefront\u00e1ln\u00ed k\u016f\u0159e.<\/p>\n

Agomelatin nem\u00e1 aktivitu na SERT, \u017e\u00e1dn\u00e9 anticholinergn\u00ed \u00fa\u010dinky ani histaminergn\u00ed \u00fa\u010dinky \u2013 co\u017e vysv\u011btluje jeho zcela odli\u0161n\u00fd profil ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f oproti SSRI a TCA.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Hlavn\u00ed deprese<\/td>\n25 mg p\u0159ed span\u00edm<\/td>\n25 mg p\u0159ed span\u00edm<\/td>\n50 mg p\u0159ed span\u00edm<\/td>\n<\/tr>\n
Star\u0161\u00ed dosp\u011bl\u00ed \/ jatern\u00ed probl\u00e9my<\/td>\nPouze 25 mg p\u0159ed span\u00edm<\/td>\n\u2014<\/td>\nnezvy\u0161ovat d\u00e1vku<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

V\u017edy se u\u017e\u00edv\u00e1 ve\u010der (vrchol \u00fa\u010dinku za 1 hodinu, polo\u010das rozpadu 1\u20132 hodiny, ale \u00fa\u010dinek na cirkadi\u00e1nn\u00ed rytmus vy\u017eaduje ve\u010dern\u00ed pod\u00e1n\u00ed).<\/p>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nPovinn\u00e9 monitorov\u00e1n\u00ed jatern\u00edch test\u016f<\/strong><\/p>\n

Agomelatine m\u00e1 klinicky v\u00fdznamn\u00fd sign\u00e1l hepatotoxicity \u2014 v\u010detn\u011b vz\u00e1cn\u00fdch p\u0159\u00edpad\u016f fulminantn\u00ed hepatitidy. Povinn\u00e9 jatern\u00ed testy<\/strong> na za\u010d\u00e1tku, pot\u00e9 ve 3., 6., 12. a 24. t\u00fddnu a p\u0159i ka\u017ed\u00e9m zv\u00fd\u0161en\u00ed d\u00e1vky. Okam\u017eit\u011b p\u0159eru\u0161te l\u00e9\u010dbu, pokud AST nebo ALT > 3\u00d7 ULN, nebo pokud \u017eloutenka, tmav\u00e1 mo\u010d, bolest v prav\u00e9m pod\u017eeb\u0159\u00ed nebo \u00fanava nazna\u010duj\u00ed po\u0161kozen\u00ed jater. Kontraindikov\u00e1no u jak\u00e9hokoli p\u0159edexistuj\u00edc\u00edho jatern\u00edho po\u0161kozen\u00ed<\/strong> (Child-Pugh B nebo C), p\u0159i transamin\u00e1z\u00e1ch > 3\u00d7 ULN na za\u010d\u00e1tku a p\u0159i nadm\u011brn\u00e9 konzumaci alkoholu.<\/p>\n<\/div>\n

\nL\u00e9kov\u00e9 interakce \u2014 siln\u00e9 inhibitory CYP1A2<\/strong><\/p>\n

Vyhn\u011bte se sou\u010dasn\u00e9mu u\u017e\u00edv\u00e1n\u00ed fluvoxaminu, ciprofloxacinu, enoxacinu \u2014 tyto l\u00e1tky zvy\u0161uj\u00ed hladinu agomelatinu n\u011bkolikr\u00e1t. Ukon\u010den\u00ed kou\u0159en\u00ed m\u016f\u017ee zv\u00fd\u0161it hladiny (CYP1A2 je indukov\u00e1n kou\u0159en\u00edm).<\/p>\n<\/div>\n

\n\u010cern\u00e9 varov\u00e1n\u00ed ohledn\u011b sebevra\u017eednosti (u osob do 25 let)<\/strong><\/p>\n

V\u0161echna antidepresiva nesou \u010dern\u00e9 varov\u00e1n\u00ed FDA ohledn\u011b zv\u00fd\u0161en\u00e9ho rizika sebevra\u017eedn\u00fdch my\u0161lenek u pacient\u016f mlad\u0161\u00edch 25 let.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n