{"id":55343,"date":"2024-01-31T08:38:02","date_gmt":"2024-01-31T08:38:02","guid":{"rendered":"https:\/\/medsname.com\/osteofos\/"},"modified":"2026-04-30T10:24:48","modified_gmt":"2026-04-30T10:24:48","slug":"osteofos","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/osteofos\/","title":{"rendered":"Osteofos"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">Rychl\u00e1 odpov\u011b\u010f<\/h3>\n<p><strong>Osteofos (kyselina alendronov\u00e1 (alendron\u00e1t) 70 mg t\u00fddenn\u00ed bisfosfon\u00e1t)<\/strong> je t\u00fddenn\u00ed peror\u00e1ln\u00ed bisfosfon\u00e1t (alendron\u00e1t) pou\u017e\u00edvan\u00fd k l\u00e9\u010db\u011b a prevenci postmenopauz\u00e1ln\u00ed osteopor\u00f3zy, osteopor\u00f3zy u mu\u017e\u016f a glukokortikoidem indukovan\u00e9 osteopor\u00f3zy. Mus\u00ed b\u00fdt u\u017e\u00edv\u00e1n nala\u010dno s p\u0159\u00edsn\u00fdm vzp\u0159\u00edmen\u00fdm postojem po dobu 30\u201360 minut.<\/p>\n<ul style=\"margin-bottom:0;\">\n<li>Alendronov\u00e1 kyselina 70 mg t\u00fddenn\u00ed peror\u00e1ln\u00ed tableta<\/li>\n<li>Indikace: postmenopauz\u00e1ln\u00ed osteopor\u00f3za, osteopor\u00f3za u mu\u017e\u016f, glukokortikoidem indukovan\u00e1 osteopor\u00f3za<\/li>\n<li>KL\u00cd\u010cOV\u00c9 pod\u00e1n\u00ed: nala\u010dno, 200 ml \u010dist\u00e9 vody, vzp\u0159\u00edmen\u00fd postoj 30\u201360 minut<\/li>\n<li>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/li>\n<\/ul>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f6f8;border:1px solid #e0e4e7;padding:12px 16px;margin:18px 0;border-radius:4px;font-size:14px;color:#444;\">\n<strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong> \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\" style=\"color:#2c7cb0;\">1 400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<p style=\"font-size:13px;color:#666;margin:4px 0 18px;\">Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\" style=\"color:#2c7cb0;\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Osteofos je z\u00edsk\u00e1v\u00e1n od v\u00fdrobce certifikovan\u00e9ho WHO-GMP. Ka\u017ed\u00e1 objedn\u00e1vka je odes\u00edl\u00e1na v diskr\u00e9tn\u00edm, nezna\u010den\u00e9m balen\u00ed po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed politikou z\u00e1ruky op\u011btovn\u00e9ho odesl\u00e1n\u00ed. Bezpe\u010dn\u011b pla\u0165te kreditn\u00ed kartou, bankovn\u00edm p\u0159evodem SEPA nebo kryptom\u011bnou. Viz na\u0161e <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">1 400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>.<\/p>\n<h2>Co je Osteofos?<\/h2>\n<p>Osteofos je alendronov\u00e1 kyselina (alendron\u00e1t) \u2014 dus\u00edkat\u00fd bisfosfon\u00e1t, kter\u00fd inhibuje osteoklasty zprost\u0159edkovanou resorpci kosti. V\u00e1\u017ee se na hydroxyapatit v kostn\u00ed matrix; kdy\u017e osteoklasty resorbuj\u00ed kost, p\u0159ij\u00edmaj\u00ed alendron\u00e1t, kter\u00fd n\u00e1sledn\u011b inhibuje farnesyl difosf\u00e1t synt\u00e1zu, naru\u0161uje funkci osteoklast\u016f a spou\u0161t\u00ed apopt\u00f3zu. V\u00fdsledkem je sn\u00ed\u017een\u00e1 resorpce kosti, postupn\u00fd n\u00e1r\u016fst miner\u00e1ln\u00ed hustoty kost\u00ed a sn\u00ed\u017een\u00e9 riziko zlomenin.<\/p>\n<h2>Indikace<\/h2>\n<ul>\n<li><strong>Postmenopauz\u00e1ln\u00ed osteopor\u00f3za<\/strong> \u2014 prvn\u00ed volba peror\u00e1ln\u00ed terapie; kl\u00ed\u010dov\u00e9 studie (FIT, FLEX) prok\u00e1zaly sn\u00ed\u017een\u00ed v\u00fdskytu vertebr\u00e1ln\u00edch, ky\u010deln\u00edch a z\u00e1p\u011bstn\u00edch zlomenin<\/li>\n<li><strong>Osteopor\u00f3za u mu\u017e\u016f<\/strong> s n\u00edzkou kostn\u00ed denzitou (BMD) nebo fragilitn\u00ed zlomeninou<\/li>\n<li><strong>Glukokortikoidy indukovan\u00e1 osteopor\u00f3za<\/strong> \u2014 pacienti dlouhodob\u011b u\u017e\u00edvaj\u00edc\u00ed prednisolon &gt;5 mg\/den po dobu &gt;3 m\u011bs\u00edc\u016f by m\u011bli obvykle dost\u00e1vat profylaktick\u00e9 bisfosfon\u00e1ty<\/li>\n<li><strong>Pagetova choroba kost\u00ed<\/strong><\/li>\n<\/ul>\n<h3>Kritick\u00e1 pravidla pod\u00e1v\u00e1n\u00ed<\/h3>\n<ol>\n<li>U\u017e\u00edvejte JEDNU tabletu 70 mg jednou t\u00fddn\u011b, STEJN\u00dd den v t\u00fddnu, HNED R\u00c1NO po probuzen\u00ed<\/li>\n<li>Zapijte nejm\u00e9n\u011b 200 ml \u010cIST\u00c9 vody (ne miner\u00e1lku, ne d\u017eus, ne k\u00e1vu, ne \u010daj, ne ml\u00e9ko)<\/li>\n<li>Z\u016eSTA\u0147TE VE VZP\u0158\u00cdMEN\u00c9 POLOZE (sezen\u00ed nebo st\u00e1n\u00ed) po dobu nejm\u00e9n\u011b 30 minut (ide\u00e1ln\u011b 1 hodinu)<\/li>\n<li>Nekonzumujte \u017e\u00e1dn\u00e9 j\u00eddlo ani n\u00e1poje krom\u011b \u010dist\u00e9 vody po dobu 30\u201360 minut<\/li>\n<li>NEU\u017d\u00cdVEJTE \u017e\u00e1dn\u00e9 jin\u00e9 peror\u00e1ln\u00ed l\u00e9ky, v\u00e1pn\u00edk, vitamin D ani dopl\u0148ky stravy po dobu nejm\u00e9n\u011b 30\u201360 minut<\/li>\n<\/ol>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Pro\u010d jsou p\u0159\u00edsn\u00e1 pravidla pod\u00e1v\u00e1n\u00ed d\u016fle\u017eit\u00e1<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Bisfosfon\u00e1ty maj\u00ed notoriously n\u00edzkou peror\u00e1ln\u00ed biologickou dostupnost (m\u00e9n\u011b ne\u017e 1%). Jak\u00e9koli j\u00eddlo, jin\u00e9 peror\u00e1ln\u00ed l\u00e9ky nebo n\u00e1poje krom\u011b vody sn\u00ed\u017e\u00ed absorpci t\u00e9m\u011b\u0159 na nulu. Le\u017een\u00ed nebo poloha vle\u017ee b\u011bhem prvn\u00edch 30\u201360 minut zvy\u0161uje riziko retence v j\u00edcnu \u2014 alendron\u00e1t siln\u011b dr\u00e1\u017ed\u00ed sliznici j\u00edcnu a m\u016f\u017ee zp\u016fsobit ezofagitidu, j\u00edcnov\u00e9 v\u0159edy a striktury, zejm\u00e9na u star\u0161\u00edch pacient\u016f s refluxem. Nedodr\u017een\u00ed pravidel pod\u00e1v\u00e1n\u00ed znehodnot\u00ed d\u00e1vku a riskujete po\u0161kozen\u00ed. Pokud nem\u016f\u017eete z\u016fstat ve vzp\u0159\u00edmen\u00e9 poloze 30 minut, alendron\u00e1t pro v\u00e1s nen\u00ed vhodn\u00fd \u2014 zva\u017ete m\u00edsto n\u011bj intraven\u00f3zn\u00ed zoledron\u00e1t jednou ro\u010dn\u011b.<\/p>\n<\/div>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px;text-align:left;\">Indikace<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px;text-align:left;\">D\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Postmenopauz\u00e1ln\u00ed osteopor\u00f3za<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">70 mg jednou t\u00fddn\u011b<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Osteopor\u00f3za u mu\u017e\u016f<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">70 mg jednou t\u00fddn\u011b<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Glukokortikoidem indukovan\u00e1 osteopor\u00f3za (prednisolon &gt;5 mg\/den &gt;3 m\u011bs\u00edce)<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">70 mg jednou t\u00fddn\u011b<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Pagetova choroba<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">40 mg jednou denn\u011b po dobu 6 m\u011bs\u00edc\u016f (specializovan\u00e9 prost\u0159ed\u00ed)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li><strong>Gastrointestin\u00e1ln\u00ed pot\u00ed\u017ee<\/strong> \u2014 ezofagitida, gastritida, dyspepsie, bolesti b\u0159icha (nej\u010dast\u011bj\u0161\u00ed; sn\u00ed\u017een\u00e9 p\u0159\u00edsn\u00fdm pod\u00e1v\u00e1n\u00edm ve vzp\u0159\u00edmen\u00e9 poloze)<\/li>\n<li><strong>Bolesti pohybov\u00e9ho apar\u00e1tu<\/strong> \u2014 m\u00edrn\u00e9 a\u017e st\u0159edn\u011b siln\u00e9 dif\u00fazn\u00ed bolesti kost\u00ed nebo kloub\u016f u n\u011bkter\u00fdch pacient\u016f<\/li>\n<li><strong>Akutn\u00ed f\u00e1ze reakce<\/strong> \u2014 p\u0159\u00edznaky podobn\u00e9 ch\u0159ipce po prvn\u00ed d\u00e1vce, m\u00e9n\u011b \u010dast\u00e9 u t\u00fddenn\u00edho peror\u00e1ln\u00edho pod\u00e1n\u00ed ne\u017e u intraven\u00f3zn\u00edho zoledron\u00e1tu<\/li>\n<li><strong>Hypokalcemie<\/strong> \u2014 pokud byl na za\u010d\u00e1tku nedostate\u010dn\u00fd stav vitaminu D nebo v\u00e1pn\u00edku; nejprve korigujte deficit<\/li>\n<li><strong>Osteonekr\u00f3za \u010delisti (ONJ)<\/strong> \u2014 vz\u00e1cn\u00e1 u peror\u00e1ln\u00edch bisfosfon\u00e1t\u016f; riziko &lt; 1 z 10 000 p\u0159i d\u00e1vkov\u00e1n\u00ed pro osteopor\u00f3zu (mnohem vy\u0161\u0161\u00ed u onkologick\u00fdch intraven\u00f3zn\u00edch d\u00e1vek)<\/li>\n<li><strong>Atypick\u00e1 zlomenina stehenn\u00ed kosti (AFF)<\/strong> \u2014 vz\u00e1cn\u00e9; riziko se zvy\u0161uje s d\u00e9lkou l\u00e9\u010dby &gt;5 let; zva\u017ete p\u0159eru\u0161en\u00ed l\u00e9\u010dby po 5\u20137 letech p\u0159i n\u00edzk\u00e9m riziku zlomenin<\/li>\n<li><strong>Fibrilace s\u00edn\u00ed<\/strong> \u2014 slab\u00fd sign\u00e1l v n\u011bkter\u00fdch studi\u00edch; klinick\u00e1 relevance je p\u0159edm\u011btem diskuse<\/li>\n<\/ul>\n<h2>Interakce l\u00e9k\u016f<\/h2>\n<ul>\n<li><strong>V\u00e1pn\u00edk, ho\u0159\u010d\u00edk, \u017eelezo, antacida, ml\u00e9\u010dn\u00e9 v\u00fdrobky, miner\u00e1ln\u00ed voda<\/strong> \u2014 sni\u017euj\u00ed vst\u0159eb\u00e1v\u00e1n\u00ed; pravidlo 30\u201360 minut nala\u010dno to pokr\u00fdv\u00e1<\/li>\n<li><strong>NSAID<\/strong> \u2014 aditivn\u00ed riziko pro horn\u00ed \u010d\u00e1st tr\u00e1vic\u00edho traktu; pou\u017e\u00edvejte opatrn\u011b spole\u010dn\u011b, zejm\u00e9na p\u0159i sou\u010dasn\u00e9 gastroprotekci<\/li>\n<li><strong>Kyselina acetylsalicylov\u00e1<\/strong> \u2014 m\u00edrn\u00e9 aditivn\u00ed riziko pro tr\u00e1vic\u00ed trakt<\/li>\n<li><strong>Levothyroxin<\/strong> \u2014 oba sout\u011b\u017e\u00ed o okno nala\u010dno; pe\u010dliv\u011b napl\u00e1nujte d\u00e1vkovac\u00ed re\u017eim<\/li>\n<\/ul>\n<h2>Kontraindikace<\/h2>\n<ul>\n<li>Ezofage\u00e1ln\u00ed striktura, achal\u00e1zie nebo jin\u00e1 abnormality j\u00edcnu<\/li>\n<li>Neschopnost st\u00e1t nebo sed\u011bt vzp\u0159\u00edmen\u011b po dobu 30\u201360 minut<\/li>\n<li>T\u011b\u017ek\u00e9 ren\u00e1ln\u00ed posti\u017een\u00ed (eGFR &lt; 35 ml\/min\/1,73 m\u00b2)<sup>2<\/sup>)<\/li>\n<li>Hypokalcemie (nejprve korigovat)<\/li>\n<li>T\u011bhotenstv\u00ed a kojen\u00ed (omezen\u00e1 data; bisfosfon\u00e1ty se kumuluj\u00ed v fet\u00e1ln\u00ed kosti)<\/li>\n<li>T\u011b\u017ek\u00fd nedostatek vitaminu D (nejprve korigovat)<\/li>\n<\/ul>\n<h2>Kontroln\u00ed seznam p\u0159ed l\u00e9\u010dbou<\/h2>\n<ul>\n<li>Potvr\u010fte hladinu 25-OH-D &gt; 30 ng\/ml (nejprve korigujte nedostatek p\u0159\u00edpravkem Calcirol nebo Arachitol)<\/li>\n<li>Potvr\u010fte norm\u00e1ln\u00ed hladinu korigovan\u00e9ho v\u00e1pn\u00edku<\/li>\n<li>Potvr\u010fte eGFR &gt; 35<\/li>\n<li>Zubn\u00ed vy\u0161et\u0159en\u00ed \u2014 \u0159e\u0161te ve\u0161ker\u00e9 aktivn\u00ed zubn\u00ed z\u00e1kroky, zva\u017ete extrakce p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby (sni\u017ete riziko ONJ)<\/li>\n<li>Zhodno\u0165te pl\u00e1n d\u00e9lky l\u00e9\u010dby \u2014 zva\u017ete p\u0159est\u00e1vku v l\u00e9\u010db\u011b po 5\u20137 letech, pokud se riziko zlomenin zlep\u0161ilo<\/li>\n<\/ul>\n<h2>Skladov\u00e1n\u00ed<\/h2>\n<p>Skladujte p\u0159i teplot\u011b pod 25 \u00b0C v p\u016fvodn\u00edm obalu, chra\u0148te p\u0159ed vlhkost\u00ed.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Pro\u010d mus\u00edm z\u016fstat 30 minut ve vzp\u0159\u00edmen\u00e9 poloze?<\/h3>\n<p>Alendron\u00e1t siln\u011b dr\u00e1\u017ed\u00ed sliznici j\u00edcnu. Le\u017een\u00ed zvy\u0161uje riziko zadr\u017een\u00ed tablety v j\u00edcnu, ezofagitidy a striktur. St\u00e1n\u00ed nebo sezen\u00ed ve vzp\u0159\u00edmen\u00e9 poloze umo\u017e\u0148uje gravitaci rychle posunout tabletu dol\u016f. Pravidlo 30 minut je nezbytn\u00e9 \u2013 pokud jej nem\u016f\u017eete dodr\u017eet, alendron\u00e1t pro v\u00e1s nen\u00ed vhodn\u00fd.<\/p>\n<h3>Pro\u010d nala\u010dno?<\/h3>\n<p>Or\u00e1ln\u00ed biologick\u00e1 dostupnost bisfosfon\u00e1t\u016f je m\u00e9n\u011b ne\u017e 1 %. Jak\u00e9koli j\u00eddlo nebo n\u00e1poj krom\u011b vody sn\u00ed\u017e\u00ed vst\u0159eb\u00e1v\u00e1n\u00ed t\u00e9m\u011b\u0159 na nulu, \u010d\u00edm\u017e se d\u00e1vka znehodnot\u00ed. Po u\u017eit\u00ed l\u00e9ku pijte pouze \u010distou vodu po dobu 30\u201360 minut.<\/p>\n<h3>Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Vynechanou d\u00e1vku u\u017eijte n\u00e1sleduj\u00edc\u00ed r\u00e1no za stejn\u00fdch podm\u00ednek a pot\u00e9 pokra\u010dujte ve sv\u00e9m obvykl\u00e9m re\u017eimu. NIKDY neu\u017e\u00edvejte dv\u011b d\u00e1vky ve stejn\u00fd den. Pokud vynech\u00e1te n\u011bkolik d\u00e1vek, jednodu\u0161e za\u010dn\u011bte znovu ve v\u00e1mi zvolen\u00fd den.<\/p>\n<h3>Jak dlouho ho m\u00e1m u\u017e\u00edvat?<\/h3>\n<p>Po\u010d\u00e1te\u010dn\u00ed l\u00e9\u010dba trv\u00e1 5 let u postmenopauz\u00e1ln\u00ed osteopor\u00f3zy s n\u00edzk\u00fdm rizikem zlomenin; 7\u201310 let u vysok\u00e9ho rizika zlomenin. Po 5 letech zhodno\u0165te riziko zlomenin a hustotu kostn\u00ed hmoty (BMD): pokud se riziko zlep\u0161ilo, zva\u017ete \u201cl\u00e9kovou p\u0159est\u00e1vku\u201d na 1\u20132 roky (alendron\u00e1t p\u016fsob\u00ed na kosti je\u0161t\u011b roky po vysazen\u00ed); pokud riziko z\u016fst\u00e1v\u00e1 vysok\u00e9, pokra\u010dujte. Koncept l\u00e9kov\u00e9 p\u0159est\u00e1vky sni\u017euje vz\u00e1cn\u00e1 rizika atypick\u00e9 zlomeniny stehenn\u00ed kosti.<\/p>\n<h3>Co je osteonekr\u00f3za \u010delisti?<\/h3>\n<p>Vz\u00e1cn\u00e1 komplikace, kdy se kost obna\u017e\u00ed skrz d\u00e1se\u0148, nehoj\u00ed se a m\u016f\u017ee doj\u00edt k infekci. Riziko p\u0159i peror\u00e1ln\u00ed l\u00e9\u010db\u011b osteopor\u00f3zy je m\u00e9n\u011b ne\u017e 1 p\u0159\u00edpad na 10 000 pacient\u016f ro\u010dn\u011b. Rizikov\u00e9 faktory: rozs\u00e1hl\u00e9 zubn\u00ed z\u00e1kroky (extrakce, implant\u00e1ty), \u0161patn\u00e1 \u00fastn\u00ed hygiena, u\u017e\u00edv\u00e1n\u00ed glukokortikoid\u016f, kou\u0159en\u00ed. Pokud je to mo\u017en\u00e9, prove\u010fte ve\u0161ker\u00e9 zubn\u00ed z\u00e1kroky P\u0158ED zah\u00e1jen\u00edm u\u017e\u00edv\u00e1n\u00ed alendron\u00e1tu.<\/p>\n<h3>Co je atypick\u00e1 zlomenina stehenn\u00ed kosti?<\/h3>\n<p>Zlomenina subtrochanterick\u00e9 oblasti nebo diaf\u00fdzy femuru s charakteristick\u00fdmi rentgenov\u00fdmi n\u00e1lezy, \u010dasto po minim\u00e1ln\u00edm traumatu, n\u011bkdy p\u0159edch\u00e1zen\u00e1 bolest\u00ed stehna nebo t\u0159\u00edsla. Riziko se zvy\u0161uje p\u0159i l\u00e9\u010db\u011b trvaj\u00edc\u00ed d\u00e9le ne\u017e 5 let. Koncept l\u00e9kov\u00e9 p\u0159est\u00e1vky toto \u0159e\u0161\u00ed. Jak\u00e9koli nov\u00e9 bolesti stehna nebo t\u0159\u00edsla neprodlen\u011b nahlaste.<\/p>\n<h3>Bude fungovat, kdy\u017e ho budu u\u017e\u00edvat s j\u00eddlem?<\/h3>\n<p>Ne \u2013 v podstat\u011b \u017e\u00e1dn\u00fd l\u00e9k nez\u00edsk\u00e1te. Alendron\u00e1t bez p\u0159\u00edsn\u00e9ho dodr\u017eov\u00e1n\u00ed u\u017e\u00edv\u00e1n\u00ed nala\u010dno je zbyte\u010dn\u00fd.<\/p>\n<h3>M\u016f\u017eu u\u017e\u00edvat vitamin D a v\u00e1pn\u00edk s n\u00edm?<\/h3>\n<p>Ano \u2013 ve skute\u010dnosti byste m\u011bli. Ale u\u017e\u00edvejte je v jinou denn\u00ed dobu. Topcal M nebo Cipcal p\u0159i ob\u011bd\u011b a ve\u010de\u0159i; alendron\u00e1t hned r\u00e1no nala\u010dno. V\u00e1pn\u00edk a alendron\u00e1t spole\u010dn\u011b = \u017e\u00e1dn\u00e9 vst\u0159eb\u00e1n\u00ed l\u00e9ku.<\/p>\n<h3>Co m\u00edsto toho nitro\u017eiln\u00ed zoledron\u00e1t?<\/h3>\n<p>Zoledronic acid 5 mg IV jednou ro\u010dn\u011b je v\u00fdbornou alternativou pro pacienty, kte\u0159\u00ed nesn\u00e1\u0161ej\u00ed pravidla peror\u00e1ln\u00edho pod\u00e1v\u00e1n\u00ed, trp\u00ed gastrointestin\u00e1ln\u00edmi vedlej\u0161\u00edmi \u00fa\u010dinky nebo preferuj\u00ed ro\u010dn\u00ed d\u00e1vkov\u00e1n\u00ed. Kompromis: v\u00fdrazn\u011bj\u0161\u00ed akutn\u00ed f\u00e1ze reakce po prvn\u00ed d\u00e1vce (ch\u0159ipkov\u00e9 p\u0159\u00edznaky 24\u201348 hodin) a m\u00edrn\u011b vy\u0161\u0161\u00ed riziko osteonekr\u00f3zy \u010delisti p\u0159i onkologick\u00e9m d\u00e1vkov\u00e1n\u00ed (ni\u017e\u0161\u00ed u osteopor\u00f3zy).<\/p>\n<h3>Je bezpe\u010dn\u00fd pro mu\u017ee?<\/h3>\n<p>Ano \u2014 alendron\u00e1t je schv\u00e1len pro osteopor\u00f3zu u mu\u017e\u016f s n\u00edzkou hustotou kostn\u00ed tk\u00e1n\u011b (BMD) nebo fragilitn\u00ed zlomeninou. D\u00e1vkov\u00e1n\u00ed a pravidla pod\u00e1n\u00ed jsou stejn\u00e9.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Ostatn\u00ed vitam\u00edny a miner\u00e1ly<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/calcirol\/\">Calcirol<\/a> \u2014 cholecalciferol 60 000 IU s\u00e1\u010dek<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/alphadol\/\">Alphadol<\/a> \u2014 alfacalcidol pro deficit souvisej\u00edc\u00ed s chronick\u00fdm onemocn\u011bn\u00edm ledvin (CKD)<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/cipcal\/\">Cipcal<\/a> \u2014 uhli\u010ditan v\u00e1penat\u00fd + multivitaminy<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/topcal-m\/\">Topcal M<\/a> \u2014 v\u00e1pn\u00edk + ho\u0159\u010d\u00edk + vitamin D<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/arachitol-6l-injection\/\">Arachitol 6L Injekce<\/a> \u2014 cholekalciferol IM depot<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/multivite-gold\/\">Multivite Gold<\/a> \u2014 komplexn\u00ed multivitamin<\/li>\n<\/ul>\n<h2>L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:14px;color:#444;\">\nTato str\u00e1nka slou\u017e\u00ed pouze pro vzd\u011bl\u00e1vac\u00ed \u00fa\u010dely a nenahrazuje odbornou l\u00e9ka\u0159skou pomoc. Dopln\u011bn\u00ed vitam\u00edn\u016f a miner\u00e1l\u016f by m\u011blo b\u00fdt ide\u00e1ln\u011b vedeno laboratorn\u00edmi testy, pokud je podez\u0159en\u00ed na nedostatek. Megad\u00e1vky dopl\u0148k\u016f nejsou ne\u0161kodn\u00e9 \u2014 vitamin A je teratogenn\u00ed, vitamin E zvy\u0161uje riziko krv\u00e1cen\u00ed, beta-karoten zvy\u0161uje riziko rakoviny plic u ku\u0159\u00e1k\u016f a vysok\u00e9 d\u00e1vky v\u00e1pn\u00edku maj\u00ed kardiovaskul\u00e1rn\u00ed \u00fa\u010dinky. T\u011bhotn\u00e9 nebo koj\u00edc\u00ed pacientky by m\u011bly dodr\u017eovat doporu\u010den\u00ed pro prenat\u00e1ln\u00ed suplementaci. Pacienti u\u017e\u00edvaj\u00edc\u00ed warfarin mus\u00ed udr\u017eovat stabiln\u00ed p\u0159\u00edjem vitaminu K. Pacienti u\u017e\u00edvaj\u00edc\u00ed levothyroxin, fluorochinolony nebo tetracykliny mus\u00ed odd\u011blit p\u0159\u00edjem \u017eeleza a v\u00e1pn\u00edku o 4 hodiny. V\u017edy informujte sv\u00e9ho l\u00e9ka\u0159e a l\u00e9k\u00e1rn\u00edka o v\u0161ech dopl\u0148c\u00edch stravy.\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 Zvy\u0161uje hustotu kost\u00ed<br \/>\n\u2705 Sni\u017euje riziko zlomenin<br \/>\n\u2705 L\u00e9\u010d\u00ed osteopor\u00f3zu<br \/>\n\u2705 Zabra\u0148uje \u00fabytku kostn\u00ed hmoty<br \/>\n\u2705 Zlep\u0161uje zdrav\u00ed kost\u00ed<\/p>\n<p>Osteofos obsahuje kyselinu alendronovou.<\/p>","protected":false},"featured_media":55344,"comment_status":"closed","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3863],"product_tag":[3914,3915],"class_list":{"0":"post-55343","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-vitamins-and-minerals","9":"product_tag-alendronic-acid","10":"product_tag-osteofos","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/55343","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=55343"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/55344"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=55343"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=55343"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=55343"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=55343"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}