{"id":55366,"date":"2024-01-31T17:18:38","date_gmt":"2024-01-31T17:18:38","guid":{"rendered":"https:\/\/medsname.com\/hyloric\/"},"modified":"2026-04-30T10:24:48","modified_gmt":"2026-04-30T10:24:48","slug":"hyloric","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/hyloric\/","title":{"rendered":"Hyloric"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Hyloric?<\/h3>\n<p style=\"margin:0;\"><strong>Hyloric<\/strong> je <strong>allopurinol 300 mg<\/strong>, inhibitor xanthinoxid\u00e1zy, kter\u00fd sni\u017euje hladinu kyseliny mo\u010dov\u00e9 v krvi, aby p\u0159edch\u00e1zel dnav\u00fdm z\u00e1chvat\u016fm, tof\u016fm a mo\u010dov\u00fdm kam\u00ednk\u016fm. D\u00e1vkov\u00e1n\u00ed za\u010d\u00edn\u00e1 na 100 mg denn\u011b a postupn\u011b se upravuje sm\u011brem k 300\u2013600 mg na z\u00e1klad\u011b hladiny mo\u010doviny v s\u00e9ru. Paradoxn\u00ed vzplanut\u00ed jsou b\u011b\u017en\u00e9 v prvn\u00edch 3\u20136 m\u011bs\u00edc\u00edch l\u00e9\u010dby \u2014 to je o\u010dek\u00e1van\u00e9 a nen\u00ed d\u016fvodem k ukon\u010den\u00ed l\u00e9\u010dby.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<p><strong>Hyloric<\/strong> je \u0161iroce p\u0159edepisovan\u00fd <strong>allopurinol 300 mg tableta<\/strong> pou\u017e\u00edv\u00e1 se ke sn\u00ed\u017een\u00ed hladiny kyseliny mo\u010dov\u00e9 u lid\u00ed s <strong>chronickou dnou, opakuj\u00edc\u00edmi se ledvinov\u00fdmi kameny a p\u0159i ur\u010dit\u00fdch typech l\u00e9\u010dby rakoviny<\/strong>. Vyrobeno se stejnou farmaceutickou kvalitou jako mezin\u00e1rodn\u00ed zna\u010dky, nap\u0159\u00edklad <strong>Zyloric<\/strong>, ka\u017ed\u00e1 tableta Hyloric obsahuje klinicky ov\u011b\u0159en\u00fd inhibitor xanthinoxid\u00e1zy allopurinol.<\/p>\n<p>Na rozd\u00edl od rychle p\u016fsob\u00edc\u00edch l\u00e9k\u016f proti bolesti je Hyloric <strong>dlouhodob\u00fdm preventivn\u00edm l\u00e9kem<\/strong> \u2014 neulevuje od aktivn\u00edho z\u00e1chvatu dny, ale p\u0159i ka\u017edodenn\u00edm u\u017e\u00edv\u00e1n\u00ed postupn\u011b sni\u017euje mno\u017estv\u00ed kyseliny mo\u010dov\u00e9 v krvi, rozpou\u0161t\u00ed krystalick\u00e9 usazeniny a p\u0159edch\u00e1z\u00ed budouc\u00edm z\u00e1chvat\u016fm. V\u011bt\u0161ina pacient\u016f za\u010dne pozorovat m\u00e9n\u011b z\u00e1chvat\u016f b\u011bhem 3\u20136 m\u011bs\u00edc\u016f pravideln\u00e9 l\u00e9\u010dby.<\/p>\n<h2 class=\"wp-block-heading\">Co je Hyloric?<\/h2>\n<p>Hyloric je indick\u00fd obchodn\u00ed n\u00e1zev pro <strong>allopurinol<\/strong>, jeden z nejstar\u0161\u00edch a nejv\u00edce studovan\u00fdch l\u00e9k\u016f na sn\u00ed\u017een\u00ed hladiny ur\u00e1t\u016f v medic\u00edn\u011b. Allopurinol je v klinick\u00e9m pou\u017eit\u00ed nep\u0159etr\u017eit\u011b od roku 1966 a je l\u00e9kem prvn\u00ed volby doporu\u010dovan\u00fdm Americkou vysokou \u0161kolou revmatologie, EULAR a Britskou spole\u010dnost\u00ed pro revmatologii pro chronickou terapii sni\u017euj\u00edc\u00ed hladinu ur\u00e1t\u016f.<\/p>\n<p>Hyloric je nej\u010dast\u011bji p\u0159edepisov\u00e1n pro:<\/p>\n<ul>\n<li><strong>Chronickou dnu<\/strong> \u2014 k prevenci opakovan\u00fdch z\u00e1chvat\u016f sn\u00ed\u017een\u00edm s\u00e9rov\u00fdch ur\u00e1t\u016f<\/li>\n<li><strong>Asymptomatickou hyperurik\u00e9mii<\/strong> kdy\u017e jsou hladiny kyseliny mo\u010dov\u00e9 velmi vysok\u00e9 (\u22659 mg\/dL \/ 0,54 mmol\/L) s rizikov\u00fdmi faktory<\/li>\n<li><strong>Tof\u00f3zn\u00ed dnu<\/strong> \u2014 k rozpu\u0161t\u011bn\u00ed viditeln\u00fdch usazenin ur\u00e1t\u016f (tof\u016f) v u\u0161\u00edch, prstech, prstech u nohou a loktech<\/li>\n<li><strong>Mo\u010dov\u00e9 kameny z kyseliny mo\u010dov\u00e9<\/strong> a opakuj\u00edc\u00ed se \u0161\u0165avelanov\u00e9 kameny s vysokou hladinou mo\u010dov\u00fdch ur\u00e1t\u016f<\/li>\n<li><strong>Prevenci syndromu l\u00fdzy n\u00e1doru<\/strong> b\u011bhem chemoterapie hematologick\u00fdch n\u00e1dor\u016f<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Jak Hyloric funguje?<\/h2>\n<p>Kyselina mo\u010dov\u00e1 je kone\u010dn\u00fdm produktem metabolismu purin\u016f. U lid\u00ed s dnou t\u011blo bu\u010f produkuje p\u0159\u00edli\u0161 mnoho kyseliny mo\u010dov\u00e9, nebo ji odstra\u0148uje p\u0159\u00edli\u0161 pomalu \u2013 co\u017e vede k p\u0159esycen\u00e9 krvi a jehli\u010dkovit\u00fdm krystal\u016fm mononatrium ur\u00e1tu, kter\u00e9 se ukl\u00e1daj\u00ed v kloubech, \u0161lach\u00e1ch a ledvin\u00e1ch.<\/p>\n<ul>\n<li>Puriny z potravy a obnovy bun\u011bk jsou p\u0159em\u011bn\u011bny na <strong>hypoxantin<\/strong>, pot\u00e9 na <strong>xantin<\/strong>, pot\u00e9 na <strong>kyselinu mo\u010dovou<\/strong><\/li>\n<li>Posledn\u00ed dva kroky jsou katalyzov\u00e1ny enzymem <strong>xanthinoxid\u00e1za<\/strong><\/li>\n<li><strong>Allopurinol a jeho aktivn\u00ed metabolit oxypurinol blokuj\u00ed xanthinoxid\u00e1zu<\/strong>, \u010d\u00edm\u017e sni\u017euj\u00ed produkci kyseliny mo\u010dov\u00e9 v p\u0159edchoz\u00edch kroc\u00edch<\/li>\n<li>Hladina s\u00e9rov\u00e9ho ur\u00e1tu kles\u00e1, st\u00e1vaj\u00edc\u00ed krystaly se pomalu rozpou\u0161t\u011bj\u00ed a budouc\u00ed tvorba krystal\u016f je prevenov\u00e1na<\/li>\n<\/ul>\n<p>\u00dapln\u00fd preventivn\u00ed \u00fa\u010dinek vy\u017eaduje \u010das \u2014 obvykle <strong>2\u20136 m\u011bs\u00edc\u016f<\/strong> na odstran\u011bn\u00ed nahromad\u011bn\u00fdch krystalick\u00fdch usazenin \u2014 proto je d\u016fsledn\u00e9 denn\u00ed d\u00e1vkov\u00e1n\u00ed nezbytn\u00e9, i kdy\u017e se c\u00edt\u00edte dob\u0159e.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>Prevence dnav\u00fdch z\u00e1chvat\u016f<\/strong> u pacient\u016f se dv\u011bma nebo v\u00edce z\u00e1chvaty ro\u010dn\u011b, tofy nebo ur\u00e1tovou nefropati\u00ed<\/li>\n<li><strong>Rozpu\u0161t\u011bn\u00ed tof\u00f3zn\u00edch depozit<\/strong> u dlouhodob\u00e9 dny<\/li>\n<li><strong>Sn\u00ed\u017een\u00ed hladiny s\u00e9rov\u00e9ho ur\u00e1tu<\/strong> na c\u00edlov\u00e9 hodnoty (&lt;6 mg\/dL pro v\u011bt\u0161inu pacient\u016f, &lt;5 mg\/dL pro tof\u00f3zn\u00ed dnu)<\/li>\n<li><strong>Prevence recidivuj\u00edc\u00edch mo\u010dov\u00fdch kamen\u016f z kyseliny mo\u010dov\u00e9<\/strong><\/li>\n<li><strong>Prevence \u0161\u0165avelanov\u00fdch kamen\u016f<\/strong> u pacient\u016f s hyperurikosuri\u00ed<\/li>\n<li><strong>Prevence syndromu n\u00e1dorov\u00e9ho rozpadu<\/strong> p\u0159ed chemoterapi\u00ed u leuk\u00e9mie, lymfomu nebo jin\u00fdch malignit s vysokou bun\u011b\u010dnou obnovou<\/li>\n<li><strong>Hyperurik\u00e9mie<\/strong> spojen\u00e9 s cytotoxickou terapi\u00ed, hematologick\u00fdmi stavy nebo n\u011bkter\u00fdmi d\u011bdi\u010dn\u00fdmi enzymov\u00fdmi poruchami<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed a pod\u00e1n\u00ed p\u0159\u00edpravku Hyloric<\/h2>\n<p>D\u00e1vkov\u00e1n\u00ed je individualizov\u00e1no na z\u00e1klad\u011b funkce ledvin a c\u00edlov\u00e9 hladiny s\u00e9rov\u00e9ho ur\u00e1tu. L\u00e9\u010dba obvykle za\u010d\u00edn\u00e1 <strong>n\u00edzkou po\u010d\u00e1te\u010dn\u00ed d\u00e1vkou, aby se sn\u00ed\u017eilo riziko paradoxn\u00edho vzplanut\u00ed dny<\/strong> p\u0159i zm\u011bn\u00e1ch hladin ur\u00e1tu.<\/p>\n<table>\n<thead>\n<tr>\n<th>Indikace \/ Pacient<\/th>\n<th>Po\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\n<th>Obvykl\u00e1 udr\u017eovac\u00ed l\u00e9\u010dba<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Chronick\u00e1 dna (po\u010d\u00e1te\u010dn\u00ed f\u00e1ze)<\/strong><\/td>\n<td>100 mg jednou denn\u011b<\/td>\n<td>Zvy\u0161ovat d\u00e1vku o 100 mg ka\u017ed\u00e9 2\u20135 t\u00fddny, dokud nen\u00ed dosa\u017eeno c\u00edlov\u00e9 hladiny ur\u00e1t\u016f<\/td>\n<\/tr>\n<tr>\n<td><strong>Chronick\u00e1 dna (udr\u017eovac\u00ed l\u00e9\u010dba)<\/strong><\/td>\n<td>\u2014<\/td>\n<td>300\u2013600 mg denn\u011b (max. 900 mg v rozd\u011blen\u00fdch d\u00e1vk\u00e1ch)<\/td>\n<\/tr>\n<tr>\n<td><strong>Tof\u00f3zn\u00ed dnu<\/strong><\/td>\n<td>100 mg jednou denn\u011b<\/td>\n<td>Upravit podle hladiny ur\u00e1t\u016f &lt;5 mg\/dL; obvykle 400\u2013600 mg denn\u011b<\/td>\n<\/tr>\n<tr>\n<td><strong>Mo\u010dov\u00e9 kameny (kyselina mo\u010dov\u00e1)<\/strong><\/td>\n<td>200\u2013300 mg denn\u011b<\/td>\n<td>Upravit podle 24hodinov\u00e9 exkrece ur\u00e1t\u016f v mo\u010di<\/td>\n<\/tr>\n<tr>\n<td><strong>Prevence n\u00e1dorov\u00e9ho l\u00fdzov\u00e9ho syndromu<\/strong><\/td>\n<td>600\u2013800 mg denn\u011b<\/td>\n<td>Zah\u00e1jit 1\u20132 dny p\u0159ed chemoterapi\u00ed, l\u00e9\u010dba trv\u00e1 3\u20137 dn\u00ed<\/td>\n<\/tr>\n<tr>\n<td><strong>eGFR 30\u201359 ml\/min<\/strong><\/td>\n<td>50\u2013100 mg jednou denn\u011b<\/td>\n<td>Titrujte pomalu za pe\u010dliv\u00e9ho sledov\u00e1n\u00ed<\/td>\n<\/tr>\n<tr>\n<td><strong>eGFR &lt;30 ml\/min<\/strong><\/td>\n<td>50 mg obden<\/td>\n<td>Doporu\u010duje se odborn\u00fd dohled<\/td>\n<\/tr>\n<tr>\n<td><strong>Senio\u0159i (65+)<\/strong><\/td>\n<td>100 mg denn\u011b<\/td>\n<td>Pou\u017eijte nejni\u017e\u0161\u00ed d\u00e1vku udr\u017euj\u00edc\u00ed c\u00edlovou hladinu ur\u00e1t\u016f<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">Jak spr\u00e1vn\u011b u\u017e\u00edvat Hyloric<\/h3>\n<ul>\n<li>U\u017e\u00edvejte Hyloric <strong>jednou denn\u011b, nejl\u00e9pe s j\u00eddlem<\/strong>, aby se sn\u00ed\u017eilo riziko \u017ealude\u010dn\u00edch pot\u00ed\u017e\u00ed<\/li>\n<li>D\u00e1vky nad 300 mg by m\u011bly b\u00fdt obecn\u011b <strong>rozd\u011bleny do dvou nebo t\u0159\u00ed d\u00e1vek<\/strong> b\u011bhem dne<\/li>\n<li>Pijte alespo\u0148 <strong>2 litry vody denn\u011b<\/strong> \u2014 dobr\u00e1 hydratace chr\u00e1n\u00ed ledviny, proto\u017ee se mobilizuje kyselina mo\u010dov\u00e1<\/li>\n<li>U\u017e\u00edvejte Hyloric p\u0159ibli\u017en\u011b ve <strong>stejnou dobu ka\u017ed\u00fd den<\/strong> pro udr\u017een\u00ed stabiln\u00ed hladiny v krvi<\/li>\n<li>Nep\u0159est\u00e1vejte <strong>ne<\/strong> u\u017e\u00edvat Hyloric p\u0159i dnav\u00e9m z\u00e1chvatu \u2014 p\u0159eru\u0161en\u00ed a op\u011btovn\u00e9 zah\u00e1jen\u00ed m\u016f\u017ee vyvolat nov\u00fd z\u00e1chvat. Pokra\u010dujte v u\u017e\u00edv\u00e1n\u00ed Hyloricu a l\u00e9\u010dte z\u00e1chvat kr\u00e1tkodob\u00fdm u\u017e\u00edv\u00e1n\u00edm NSAID, kolchicinu nebo kortikosteroid\u016f podle p\u0159edpisu<\/li>\n<li>Pokud je d\u00e1vka vynech\u00e1na a je to do 12 hodin, u\u017eijte ji co nejd\u0159\u00edve, jak si vzpomenete. Jinak ji vynechejte \u2014 neduplikujte d\u00e1vku<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky p\u0159\u00edpravku Hyloric<\/h2>\n<p>V\u011bt\u0161ina pacient\u016f p\u0159\u00edpravek Hyloric sn\u00e1\u0161\u00ed velmi dob\u0159e, zvl\u00e1\u0161t\u011b kdy\u017e se za\u010d\u00edn\u00e1 s n\u00edzkou d\u00e1vkou a postupn\u011b se zvy\u0161uje. Vedlej\u0161\u00ed \u00fa\u010dinky se obvykle objevuj\u00ed v prvn\u00edch n\u011bkolika m\u011bs\u00edc\u00edch.<\/p>\n<table>\n<thead>\n<tr>\n<th>Z\u00e1va\u017enost<\/th>\n<th>Vedlej\u0161\u00ed \u00fa\u010dinek<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>\u010cast\u00e9 (\u22651 ze 100)<\/strong><\/td>\n<td>Paradoxn\u00ed vzplanut\u00ed dny v prvn\u00edch 2\u20133 m\u011bs\u00edc\u00edch, vyr\u00e1\u017eka, nevolnost, pr\u016fjem, bolest hlavy, ospalost<\/td>\n<\/tr>\n<tr>\n<td><strong>M\u00e9n\u011b \u010dast\u00e9<\/strong><\/td>\n<td>Zv\u00fd\u0161en\u00e9 jatern\u00ed enzymy, hore\u010dka, bolest kloub\u016f, m\u00edrn\u00e1 an\u00e9mie<\/td>\n<\/tr>\n<tr>\n<td><strong>Vz\u00e1cn\u00e9, ale z\u00e1va\u017en\u00e9<\/strong><\/td>\n<td>Z\u00e1va\u017en\u00e9 ko\u017en\u00ed reakce (Stevens-Johnson\u016fv syndrom, toxick\u00e1 epiderm\u00e1ln\u00ed nekrol\u00fdza), syndrom p\u0159ecitliv\u011blosti na alopurinol (DRESS), akutn\u00ed po\u0161kozen\u00ed ledvin, aplastick\u00e1 an\u00e9mie, hepatitida<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Okam\u017eit\u011b p\u0159esta\u0148te u\u017e\u00edvat p\u0159\u00edpravek Hyloric a vyhledejte neodkladnou l\u00e9ka\u0159skou pomoc<\/strong> pokud se u v\u00e1s objev\u00ed jak\u00e1koliv vyr\u00e1\u017eka, puch\u00fd\u0159e, v\u0159edy v \u00fastech, hore\u010dka, otok obli\u010deje nebo ze\u017eloutnut\u00ed o\u010d\u00ed\/k\u016f\u017ee. Tyto p\u0159\u00edznaky mohou b\u00fdt \u010dasn\u00fdmi zn\u00e1mkami z\u00e1va\u017en\u00e9 p\u0159ecitliv\u011blosti, kter\u00e1 je <strong>\u017eivot ohro\u017euj\u00edc\u00ed, pokud se l\u00e9k nad\u00e1le u\u017e\u00edv\u00e1<\/strong>.<\/p>\n<h2 class=\"wp-block-heading\">Paradoxn\u00ed vzplanut\u00ed \u2013 co o\u010dek\u00e1vat v prvn\u00edch m\u011bs\u00edc\u00edch<\/h2>\n<p>Kdy\u017e hladina kyseliny mo\u010dov\u00e9 za\u010dne klesat, rozpou\u0161t\u00ed se st\u00e1vaj\u00edc\u00ed krystalick\u00e9 usazeniny \u2013 a tento proces s\u00e1m m\u016f\u017ee vyvolat vzplanut\u00ed dny. Tomu se \u0159\u00edk\u00e1 <strong>\u201cmobiliza\u010dn\u00ed vzplanut\u00ed\u201d<\/strong> a nen\u00ed to <strong>zn\u00e1mka toho, \u017ee l\u00e9k nefunguje<\/strong>. Doporu\u010den\u00ed sm\u011brnic <strong>profylaxe vzplanut\u00ed dny<\/strong> \u2014 n\u00edzk\u00e1 d\u00e1vka kolchicinu, NSAID nebo prednisolonu \u2014 b\u011bhem prvn\u00edch 3\u20136 m\u011bs\u00edc\u016f terapie sni\u017euj\u00edc\u00ed hladinu ur\u00e1t\u016f. V\u017edy pokra\u010dujte v u\u017e\u00edv\u00e1n\u00ed p\u0159\u00edpravku Hyloric i b\u011bhem vzplanut\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>genetick\u00e9 testov\u00e1n\u00ed HLA-B*5801<\/strong> se doporu\u010duje pacient\u016fm \u010d\u00ednsk\u00e9ho, thajsk\u00e9ho, korejsk\u00e9ho nebo jin\u00e9ho jihov\u00fdchodn\u00edho asijsk\u00e9ho p\u016fvodu p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby p\u0159\u00edpravkem Hyloric, proto\u017ee maj\u00ed vy\u0161\u0161\u00ed riziko z\u00e1va\u017en\u00fdch ko\u017en\u00edch reakc\u00ed<\/li>\n<li><strong>Porucha funkce ledvin<\/strong> \u2014 sn\u00ed\u017eit po\u010d\u00e1te\u010dn\u00ed d\u00e1vku a titrovat pomalu; oxypurinol je vylu\u010dov\u00e1n ledvinami<\/li>\n<li><strong>Onemocn\u011bn\u00ed jater<\/strong> \u2014 monitorovat jatern\u00ed enzymy; sn\u00ed\u017eit d\u00e1vku p\u0159i v\u00fdrazn\u00e9 abnormalit\u011b<\/li>\n<li><strong>Akutn\u00ed z\u00e1chvat dny<\/strong> \u2014 neza\u010d\u00ednejte s p\u0159\u00edpravkem Hyloric b\u011bhem aktivn\u00edho vzplanut\u00ed; po\u010dkejte, a\u017e z\u00e1n\u011bt ustoup\u00ed (pokud ji\u017e nejste na terapii zavedeni)<\/li>\n<li><strong>Kardiovaskul\u00e1rn\u00ed riziko<\/strong> \u2014 pozorov\u00e1na m\u00edrn\u00e1 redukce rizika; alopurinol je preferov\u00e1n p\u0159ed febuxostatem u pacient\u016f se zaveden\u00fdm kardiovaskul\u00e1rn\u00edm onemocn\u011bn\u00edm<\/li>\n<li>Alkohol (zejm\u00e9na pivo a destil\u00e1ty) zvy\u0161uje hladinu kyseliny mo\u010dov\u00e9; omezen\u00ed p\u0159\u00edjmu zvy\u0161uje \u00fa\u010dinnost p\u0159\u00edpravku Hyloric<\/li>\n<li>Vyhn\u011bte se n\u00e1hl\u00fdm zm\u011bn\u00e1m v p\u0159\u00edjmu potravin bohat\u00fdch na puriny (\u010derven\u00e9 maso, vnit\u0159nosti, kor\u00fd\u0161i, n\u00e1poje s vysok\u00fdm obsahem frukt\u00f3zy) bez l\u00e9ka\u0159sk\u00e9ho doporu\u010den\u00ed<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace \u2014 Kdo by NEM\u011aL u\u017e\u00edvat Hyloric<\/h2>\n<ul>\n<li>Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na alopurinol<\/li>\n<li>P\u0159edchoz\u00ed syndrom p\u0159ecitliv\u011blosti na alopurinol (DRESS, SJS nebo TEN)<\/li>\n<li>Aktivn\u00ed, t\u011b\u017ek\u00e9 selh\u00e1n\u00ed jater nebo ledvin bez odborn\u00e9ho dohledu<\/li>\n<li>T\u011bhotenstv\u00ed (kategorie B3) \u2014 pouze pokud p\u0159\u00ednos p\u0159ev\u00e1\u017e\u00ed riziko<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table>\n<thead>\n<tr>\n<th>L\u00e9k<\/th>\n<th>Interakce<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Azathioprin, 6-merkaptopurin<\/strong><\/td>\n<td>Alopurinol blokuje metabolismus \u2014 <strong>\u017eivot ohro\u017euj\u00edc\u00ed toxicita kostn\u00ed d\u0159en\u011b<\/strong>. D\u00e1vka azathioprinu\/6-MP mus\u00ed b\u00fdt sn\u00ed\u017eena o 75 %, pokud je spole\u010dn\u00e1 administrace nevyhnuteln\u00e1<\/td>\n<\/tr>\n<tr>\n<td><strong>Warfarin<\/strong><\/td>\n<td>M\u016f\u017ee zv\u00fd\u0161it INR a riziko krv\u00e1cen\u00ed \u2014 monitorujte \u010dast\u011bji p\u0159i zah\u00e1jen\u00ed nebo ukon\u010den\u00ed l\u00e9\u010dby<\/td>\n<\/tr>\n<tr>\n<td><strong>Amoxicilin a ampicilin<\/strong><\/td>\n<td>Vy\u0161\u0161\u00ed v\u00fdskyt ko\u017en\u00ed vyr\u00e1\u017eky p\u0159i kombinaci<\/td>\n<\/tr>\n<tr>\n<td><strong>Thiazidov\u00e1 diuretika, kli\u010dkov\u00e1 diuretika<\/strong><\/td>\n<td>Zvy\u0161uj\u00ed hladinu kyseliny mo\u010dov\u00e9 a sni\u017euj\u00ed \u00fa\u010dinnost allopurinolu; mohou tak\u00e9 zv\u00fd\u0161it riziko vyr\u00e1\u017eky<\/td>\n<\/tr>\n<tr>\n<td><strong>ACE inhibitory<\/strong><\/td>\n<td>Zv\u00fd\u0161en\u00e9 riziko p\u0159ecitliv\u011blosti, zejm\u00e9na p\u0159i ren\u00e1ln\u00ed insuficienci<\/td>\n<\/tr>\n<tr>\n<td><strong>Cyklosporin<\/strong><\/td>\n<td>Zv\u00fd\u0161en\u00e9 hladiny cyklosporinu \u2014 pe\u010dliv\u011b monitorujte<\/td>\n<\/tr>\n<tr>\n<td><strong>Theofylin<\/strong><\/td>\n<td>Allopurinol m\u016f\u017ee ve vysok\u00fdch d\u00e1vk\u00e1ch zv\u00fd\u0161it hladiny theofylinu<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Monitorov\u00e1n\u00ed p\u0159i u\u017e\u00edv\u00e1n\u00ed Hyloric<\/h2>\n<ul>\n<li><strong>S\u00e9rov\u00e1 hladina kyseliny mo\u010dov\u00e9<\/strong> ka\u017ed\u00e9 2\u20134 t\u00fddny b\u011bhem titrace d\u00e1vky, pot\u00e9 ka\u017ed\u00fdch 6\u201312 m\u011bs\u00edc\u016f po stabilizaci<\/li>\n<li><strong>C\u00edlov\u00e1 hodnota:<\/strong> &lt;6 mg\/dL (&lt;0,36 mmol\/L) u v\u011bt\u0161iny pacient\u016f; &lt;5 mg\/dL u tof\u00f3zn\u00ed dny<\/li>\n<li><strong>Funkce ledvin (eGFR a kreatinin)<\/strong> na za\u010d\u00e1tku a ka\u017ed\u00fdch 6\u201312 m\u011bs\u00edc\u016f<\/li>\n<li><strong>Jatern\u00ed enzymy (ALT, AST)<\/strong> na za\u010d\u00e1tku a pravideln\u011b b\u011bhem l\u00e9\u010dby<\/li>\n<li><strong>Kompletn\u00ed krevn\u00ed obraz<\/strong> p\u0159i jak\u00e9mkoli neobvykl\u00e9m krv\u00e1cen\u00ed, \u00fanav\u011b nebo opakovan\u00fdch infekc\u00edch<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Pokyny k uchov\u00e1v\u00e1n\u00ed<\/h2>\n<ul>\n<li>Skladujte p\u0159i teplot\u011b do 25 \u00b0C na such\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9 p\u0159ed p\u0159\u00edm\u00fdm sv\u011btlem<\/li>\n<li>Ponechte v p\u016fvodn\u00edm blistru a\u017e do pou\u017eit\u00ed<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed<\/li>\n<li>Nepou\u017e\u00edvejte po uplynut\u00ed uveden\u00e9ho data expirace<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed produkty na MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/meftal\/\" rel=\"noopener\">Meftal (Mefenamov\u00e1 kyselina)<\/a> \u2014 NSAID \u010dasto pou\u017e\u00edvan\u00e9 k l\u00e9\u010db\u011b akutn\u00edch z\u00e1chvat\u016f dny<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/heart-blood-pressure\/\" rel=\"noopener\">L\u00e9ky na srdce a krevn\u00ed tlak<\/a> \u2014 dna \u010dasto koexistuje s hypertenz\u00ed<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Jak rychle Hyloric sni\u017euje hladinu kyseliny mo\u010dov\u00e9?<\/h3>\n<p>Hladina s\u00e9rov\u00e9ho ur\u00e1tu obvykle za\u010dne klesat b\u011bhem 1\u20132 t\u00fddn\u016f, nov\u00e9ho ust\u00e1len\u00e9ho stavu dos\u00e1hne za 4\u20136 t\u00fddn\u016f. \u00dapln\u00e9 rozpu\u0161t\u011bn\u00ed st\u00e1vaj\u00edc\u00edch krystalick\u00fdch usazenin m\u016f\u017ee trvat 6\u201312 m\u011bs\u00edc\u016f d\u016fsledn\u00e9 terapie.<\/p>\n<h3 class=\"wp-block-heading\">Mohu u\u017e\u00edvat Hyloric b\u011bhem z\u00e1chvatu dny?<\/h3>\n<p>Pokud ji\u017e Hyloric pravideln\u011b u\u017e\u00edv\u00e1te, <strong>nep\u0159est\u00e1vejte<\/strong> \u2014 pokra\u010dujte v u\u017e\u00edv\u00e1n\u00ed a z\u00e1chvat l\u00e9\u010dte kr\u00e1tkodob\u00fdm u\u017e\u00edv\u00e1n\u00edm NSAID, kolchicinu nebo kortikosteroidu. Pokud Hyloric je\u0161t\u011b neu\u017e\u00edv\u00e1te, v\u011bt\u0161ina specialist\u016f doporu\u010duje po\u010dkat, a\u017e z\u00e1chvat odezn\u00ed, ne\u017e s l\u00e9\u010dbou za\u010dnete.<\/p>\n<h3 class=\"wp-block-heading\">Mus\u00edm Hyloric u\u017e\u00edvat nav\u017edy?<\/h3>\n<p>U v\u011bt\u0161iny pacient\u016f s chronickou dnou ano \u2014 l\u00e9\u010dba sni\u017euj\u00edc\u00ed hladinu ur\u00e1t\u016f je dlouhodob\u00e1. Po vysazen\u00ed Hyloricu hladina ur\u00e1t\u016f obvykle b\u011bhem t\u00fddn\u016f stoupne zp\u011bt na p\u016fvodn\u00ed hodnotu a z\u00e1chvaty dny se vr\u00e1t\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Mohu p\u00edt alkohol p\u0159i u\u017e\u00edv\u00e1n\u00ed Hyloricu?<\/h3>\n<p>Alkohol, zejm\u00e9na pivo a tvrd\u00fd alkohol, zvy\u0161uje hladinu kyseliny mo\u010dov\u00e9 a vyvol\u00e1v\u00e1 dnav\u00e9 z\u00e1chvaty. M\u00edrn\u00e1 konzumace v\u00edna je obvykle tolerov\u00e1na. \u00dapln\u00e1 abstinence nen\u00ed nutn\u00e1, ale omezen\u00ed alkoholu v\u00fdrazn\u011b zvy\u0161uje \u00fa\u010dinnost p\u0159\u00edpravku Hyloric.<\/p>\n<h3 class=\"wp-block-heading\">Je Hyloric to sam\u00e9 co Zyloric?<\/h3>\n<p>Oba obsahuj\u00ed stejnou \u00fa\u010dinnou l\u00e1tku \u2014 alopurinol \u2014 ve stejn\u00e9 d\u00e1vce 300 mg. Hyloric je indick\u00fd generick\u00fd p\u0159\u00edpravek; Zyloric je mezin\u00e1rodn\u00ed zna\u010dka. Klinick\u00e1 \u00fa\u010dinnost je identick\u00e1.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d se m\u00e9 dnav\u00e9 z\u00e1chvaty zhor\u0161ily od doby, kdy u\u017e\u00edv\u00e1m Hyloric?<\/h3>\n<p>Jde o tzv. \u201cparadoxn\u00ed vzplanut\u00ed\u201d \u2014 b\u011b\u017en\u00e9 v prvn\u00edch 2\u20133 m\u011bs\u00edc\u00edch. Pokles hladiny kyseliny mo\u010dov\u00e9 uvol\u0148uje star\u00e9 krystalick\u00e9 usazeniny, co\u017e m\u016f\u017ee vyvolat z\u00e1chvaty. Nen\u00ed to zn\u00e1mka ne\u00fa\u010dinnosti \u2014 pokra\u010dujte v u\u017e\u00edv\u00e1n\u00ed Hyloricu a pora\u010fte se s l\u00e9ka\u0159em o profylaxi z\u00e1chvat\u016f pomoc\u00ed n\u00edzk\u00fdch d\u00e1vek kolchicinu nebo NSAID.<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017ee Hyloric po\u0161kodit m\u00e9 ledviny?<\/h3>\n<p>Dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed Hyloricu v odpov\u00eddaj\u00edc\u00edch d\u00e1vk\u00e1ch ve skute\u010dnosti <strong>chr\u00e1n\u00ed funkci ledvin<\/strong> u pacient\u016f s hyperurik\u00e9mi\u00ed. Vz\u00e1cn\u011b v\u0161ak mohou nastat z\u00e1va\u017en\u00e9 hypersenzitivn\u00ed reakce vedouc\u00ed k akutn\u00edmu po\u0161kozen\u00ed ledvin. Funkce ledvin by m\u011bla b\u00fdt vy\u0161et\u0159ena p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby a pravideln\u011b monitorov\u00e1na.<\/p>\n<h3 class=\"wp-block-heading\">Jak\u00fdm potravin\u00e1m bych se m\u011bl vyhnout p\u0159i u\u017e\u00edv\u00e1n\u00ed Hyloricu?<\/h3>\n<p>Potraviny s vysok\u00fdm obsahem purin\u016f zahrnuj\u00ed vnit\u0159nosti (j\u00e1tra, ledviny), kor\u00fd\u0161e, sardinky, an\u010dovi\u010dky a n\u00e1poje s vysok\u00fdm obsahem frukt\u00f3zy. Nemus\u00edte je zcela vylou\u010dit, ale omezte jejich konzumaci. Ml\u00e9\u010dn\u00e9 v\u00fdrobky a rostlinn\u00e9 b\u00edlkoviny jsou spojeny s <em>ni\u017e\u0161\u00edm<\/em> rizikem dny.<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017ee se Hyloric pou\u017e\u00edvat p\u0159i ledvinov\u00fdch kamenech?<\/h3>\n<p>Ano \u2014 pou\u017e\u00edv\u00e1 se k prevenci opakovan\u00fdch ur\u00e1tov\u00fdch kamen\u016f a \u0161\u0165avelanov\u00fdch kamen\u016f u lid\u00ed s vysokou hladinou ur\u00e1t\u016f v mo\u010di. Obvykle se kombinuje s alkalizac\u00ed mo\u010di a zv\u00fd\u0161en\u00fdm p\u0159\u00edjmem tekutin.<\/p>\n<h3 class=\"wp-block-heading\">Kdy zaznamen\u00e1m m\u00e9n\u011b z\u00e1chvat\u016f dny?<\/h3>\n<p>V\u011bt\u0161ina pacient\u016f pozoruje v\u00fdrazn\u00e9 sn\u00ed\u017een\u00ed frekvence vzplanut\u00ed ji\u017e <strong>b\u011bhem 3\u20136 m\u011bs\u00edc\u016f<\/strong> po dosa\u017een\u00ed c\u00edlov\u00e9 hladiny ur\u00e1t\u016f. Tofy obvykle vy\u017eaduj\u00ed 12\u201324 m\u011bs\u00edc\u016f soustavn\u00e9 l\u00e9\u010dby, aby se viditeln\u011b zmen\u0161ily.<\/p>\n<p><!-- medsbase-faq-h3-converted --><\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lispro\/\">Lispro<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/rosuline\/\">Rosuline<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/okacet\/\">Okacet<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tiova-inhaler\/\">Tiova Inhaler<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/domin-injection\/\">Domin Injection<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Sni\u017euje hladinu kyseliny mo\u010dov\u00e9<br \/>\n\u2705 Prevence dnav\u00fdch z\u00e1chvat\u016f<br \/>\n\u2705 Zm\u00edr\u0148uje bolesti kloub\u016f<br \/>\n\u2705 Sni\u017euje otoky<br \/>\n\u2705 Zlep\u0161uje pohyblivost<\/p>\n<p>Hyloric obsahuje Allopurinol.<\/p>","protected":false},"featured_media":55367,"comment_status":"closed","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3920],"product_tag":[3921,3922],"class_list":{"0":"post-55366","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-gout-treatment","9":"product_tag-allopurinol","10":"product_tag-hyloric","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/55366","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=55366"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/55367"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=55366"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=55366"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=55366"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=55366"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}