{"id":55431,"date":"2024-02-06T23:57:47","date_gmt":"2024-02-06T23:57:47","guid":{"rendered":"https:\/\/medsname.com\/sulpitac\/"},"modified":"2026-04-30T10:24:48","modified_gmt":"2026-04-30T10:24:48","slug":"sulpitac","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/sulpitac\/","title":{"rendered":"Sulpitac"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Sulpitac (Amisulpride 50 \/ 100 \/ 200 \/ 400 mg) je atypick\u00fd antipsychotikum ze skupiny benzamid\u016f ur\u010den\u00e9 k l\u00e9\u010db\u011b schizofrenie. Dvoj\u00ed mechanismus \u00fa\u010dinku v z\u00e1vislosti na d\u00e1vce \u2014 n\u00edzk\u00e9 d\u00e1vky (50\u2013300 mg) l\u00e9\u010d\u00ed negativn\u00ed p\u0159\u00edznaky; vy\u0161\u0161\u00ed d\u00e1vky (400\u20131200 mg) l\u00e9\u010d\u00ed pozitivn\u00ed p\u0159\u00edznaky. Vylu\u010dov\u00e1n p\u0159ev\u00e1\u017en\u011b ledvinami. Dostupn\u00e9 v Evrop\u011b a Asii; neschv\u00e1leno FDA.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Sulpitac na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Sulpitac a jak funguje<\/h2>\n

Sulpitac je tableta amisulpridu dod\u00e1van\u00e1 spole\u010dnost\u00ed Sun Pharma. Dostupn\u00e9 s\u00edly: 50 \/ 100 \/ 200 \/ 400 mg<\/strong>. Amisulprid je atypick\u00fd benzamid se selektivn\u00edm antagonismem D2\/D3 \u2014 bez v\u00fdznamn\u00e9ho \u00fa\u010dinku na receptory 5-HT2A, H1, M1 nebo \u03b1-adrenergn\u00ed. Unik\u00e1tn\u00ed vlastnost\u00ed je d\u00e1vkov\u011b z\u00e1visl\u00fd \u00fa\u010dinek na dopamin: p\u0159i n\u00edzk\u00fdch d\u00e1vk\u00e1ch (50\u2013300 mg) preferen\u010dn\u011b blokuje presynaptick\u00e9 D2 autoreceptory, co\u017e zvy\u0161uje uvol\u0148ov\u00e1n\u00ed dopaminu v prefront\u00e1ln\u00ed k\u016f\u0159e (l\u00e9\u010d\u00ed negativn\u00ed p\u0159\u00edznaky); p\u0159i vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch (400\u20131200 mg) blokuje postsynaptick\u00e9 D2 receptory (l\u00e9\u010d\u00ed pozitivn\u00ed p\u0159\u00edznaky).<\/p>\n

Schv\u00e1leno v Evrop\u011b a Asii pro schizofrenii; neschv\u00e1leno FDA (peror\u00e1ln\u00ed forma). Intraven\u00f3zn\u00ed forma je schv\u00e1lena FDA pro poopera\u010dn\u00ed nevolnost\/zvracen\u00ed pod jinou obchodn\u00ed zna\u010dkou (Barhemsys), ale peror\u00e1ln\u00ed forma nen\u00ed v USA dostupn\u00e1.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
P\u0159ev\u00e1\u017en\u011b negativn\u00ed p\u0159\u00edznaky<\/td>\n50 mg 1\u00d7 denn\u011b<\/td>\n50\u2013300 mg\/den<\/td>\n300 mg<\/td>\n<\/tr>\n
P\u0159ev\u00e1\u017en\u011b pozitivn\u00ed p\u0159\u00edznaky<\/td>\n200 mg 2\u00d7 denn\u011b<\/td>\n400\u2013800 mg\/den<\/td>\n1200 mg<\/td>\n<\/tr>\n
Sm\u00ed\u0161en\u00e1 prezentace<\/td>\n200 mg 2\u00d7 denn\u011b<\/td>\n400\u2013800 mg\/den<\/td>\n1200 mg<\/td>\n<\/tr>\n
Ren\u00e1ln\u00ed insuficience (CrCl 30\u201360)<\/td>\npolovi\u010dn\u00ed d\u00e1vka<\/td>\n\u2014<\/td>\n\u2014<\/td>\n<\/tr>\n
Ren\u00e1ln\u00ed insuficience (CrCl 10\u201330)<\/td>\njedna t\u0159etina norm\u00e1ln\u00ed d\u00e1vky<\/td>\n\u2014<\/td>\n\u2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nFDA black-box \u2014 psych\u00f3za spojen\u00e1 s demenc\u00ed<\/strong><\/p>\n

V\u0161echna atypick\u00e1 antipsychotika nesou varov\u00e1n\u00ed FDA black-box pro zv\u00fd\u0161enou mortalitu (p\u0159edev\u0161\u00edm kardiovaskul\u00e1rn\u00ed a infek\u010dn\u00ed) p\u0159i pou\u017eit\u00ed k l\u00e9\u010db\u011b behavior\u00e1ln\u00edch poruch u star\u0161\u00edch dosp\u011bl\u00fdch s demenc\u00ed. Atypick\u00e1 antipsychotika nejsou schv\u00e1lena pro psych\u00f3zu nebo agitovanost spojenou s demenc\u00ed<\/strong>. Pou\u017eit\u00ed u t\u00e9to populace je off-label, posledn\u00ed mo\u017enost\u00ed, \u010dasov\u011b omezen\u00e9 a vy\u017eaduje explicitn\u00ed rozhovor o rizic\u00edch a p\u0159\u00ednosech.<\/p>\n<\/div>\n

\nProdlou\u017een\u00ed QT intervalu<\/strong><\/p>\n

Amisulprid zp\u016fsobuje d\u00e1vkov\u011b z\u00e1visl\u00e9 prodlou\u017een\u00ed QT intervalu \u2014 v\u00fdznamn\u00e9 p\u0159i vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch. Doporu\u010duje se p\u0159edl\u00e9\u010debn\u00e9 EKG. Vyvarujte se u zn\u00e1m\u00e9ho dlouh\u00e9ho QT intervalu, hypokal\u00e9mie\/hypomagnez\u00e9mie, ned\u00e1vn\u00e9ho IM, nekompenzovan\u00e9ho srde\u010dn\u00edho selh\u00e1n\u00ed a sou\u010dasn\u00e9 terapie prodlu\u017euj\u00edc\u00ed QT interval.<\/p>\n<\/div>\n

\nHyperprolaktin\u00e9mie<\/strong><\/p>\n

Amisulprid v\u00fdrazn\u011b zvy\u0161uje prolaktin \u2014 srovnateln\u011b s risperidonem. Stejn\u00e9 n\u00e1sledn\u00e9 \u00fa\u010dinky: amenorea, galaktorea, sexu\u00e1ln\u00ed dysfunkce, urychlen\u00e1 osteopor\u00f3za. P\u0159i p\u0159\u00edznac\u00edch p\u0159ejd\u011bte na aripiprazol.<\/p>\n<\/div>\n

\nEPS \u2014 z\u00e1visl\u00e9 na d\u00e1vce<\/strong><\/p>\n

EPS prudce stoup\u00e1 nad 800 mg\/den.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n