{"id":55536,"date":"2024-02-07T00:02:44","date_gmt":"2024-02-07T00:02:44","guid":{"rendered":"https:\/\/medsname.com\/aprezo\/"},"modified":"2026-04-30T10:24:47","modified_gmt":"2026-04-30T10:24:47","slug":"aprezo","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/aprezo\/","title":{"rendered":"Aprezo"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Aprezo?<\/h3>\n<p style=\"margin:0;\"><strong>Aprezo<\/strong> je peror\u00e1ln\u00ed <strong>apremilast 30 mg<\/strong> tableta \u2014 <strong>inhibitor PDE4<\/strong> pou\u017e\u00edvan\u00e1 k l\u00e9\u010db\u011b <strong>st\u0159edn\u011b t\u011b\u017ek\u00e1 a\u017e t\u011b\u017ek\u00e1 plo\u0161n\u00e1 psori\u00e1za<\/strong>, <strong>aktivn\u00ed psoriatick\u00e1 artritida<\/strong>, a <strong>or\u00e1ln\u00ed v\u0159edy u Beh\u00e7etovy choroby<\/strong>. Je to <strong>prvn\u00ed volba peror\u00e1ln\u00ed syst\u00e9mov\u00e9 l\u00e9\u010dby<\/strong> pro pacienty, kte\u0159\u00ed nemohou nebo necht\u011bj\u00ed u\u017e\u00edvat methotrex\u00e1t, cyklosporin nebo biologika. Standardn\u00ed udr\u017eovac\u00ed d\u00e1vka je <strong>30 mg dvakr\u00e1t denn\u011b<\/strong> po 5denn\u00ed titraci. Klinicky ekvivalentn\u00ed p\u0159\u00edpravku Otezla od Amgenu <strong>Otezla<sup>\u00ae<\/sup><\/strong>.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<p><strong>Aprezo<\/strong> je peror\u00e1ln\u00ed tableta od Glenmarku <strong>apremilast 30 mg<\/strong> tableta \u2014 imunomodul\u00e1tor, kter\u00fd p\u0159edstavoval skute\u010dn\u00fd pokrok v l\u00e9\u010db\u011b psori\u00e1zy p\u0159i schv\u00e1len\u00ed FDA v roce 2014. Apremilast je <strong>inhibitor fosfodiester\u00e1zy 4 (PDE4)<\/strong> kter\u00fd p\u016fsob\u00ed v\u00fdhradn\u011b intracelul\u00e1rn\u011b na signalizaci imunitn\u00edch bun\u011bk, bez imunosuprese, nutnosti laboratorn\u00edho monitorov\u00e1n\u00ed nebo injek\u010dn\u00edch aplikac\u00ed, jako je tomu u metotrex\u00e1tu nebo biologick\u00fdch l\u00e9\u010div.<\/p>\n<p>Aprezo obsahuje stejnou \u00fa\u010dinnou l\u00e1tku ve stejn\u00e9 koncentraci jako origin\u00e1ln\u00ed p\u0159\u00edpravek od spole\u010dnosti Amgen <strong>Otezla<sup>\u00ae<\/sup><\/strong> a pat\u0159\u00ed mezi nej\u010dast\u011bji p\u0159edepisovan\u00e9 peror\u00e1ln\u00ed syst\u00e9mov\u00e9 l\u00e9ky na psori\u00e1zu na sv\u011bt\u011b. M\u00e1 p\u0159\u00edzniv\u00fd bezpe\u010dnostn\u00ed profil vhodn\u00fd pro dlouhodob\u00e9 ambulantn\u00ed u\u017e\u00edv\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">Co je Aprezo?<\/h2>\n<p>Aprezo je p\u0159edpisov\u00fd <strong>peror\u00e1ln\u00ed imunomodul\u00e1tor<\/strong> kter\u00fd selektivn\u011b inhibuje PDE4 v imunitn\u00edch a z\u00e1n\u011btliv\u00fdch bu\u0148k\u00e1ch. T\u00edm zvy\u0161uje intracelul\u00e1rn\u00ed cyklick\u00fd AMP a posouv\u00e1 rovnov\u00e1hu cytokin\u016f od proz\u00e1n\u011btliv\u00fdch sign\u00e1l\u016f (TNF-\u03b1, IL-23, IL-17, IFN-\u03b3) sm\u011brem k protiz\u00e1n\u011btliv\u00fdm (IL-10).<\/p>\n<p>Aprezo je indikov\u00e1n k l\u00e9\u010db\u011b:<\/p>\n<ul>\n<li><strong>St\u0159edn\u011b t\u011b\u017ek\u00e9 a\u017e t\u011b\u017ek\u00e9 lo\u017eiskov\u00e9 psori\u00e1zy<\/strong> \u2014 u dosp\u011bl\u00fdch, u nich\u017e je vhodn\u00e1 fototerapie nebo jin\u00e1 syst\u00e9mov\u00e1 terapie<\/li>\n<li><strong>Aktivn\u00ed psoriatick\u00e9 artritidy<\/strong> \u2014 samostatn\u011b nebo v kombinaci s DMARDs, jako je metotrex\u00e1t<\/li>\n<li><strong>Or\u00e1ln\u00edch v\u0159ed\u016f spojen\u00fdch s Beh\u00e7etovou chorobou<\/strong> \u2014 indikace schv\u00e1len\u00e1 FDA od roku 2019<\/li>\n<li><strong>Psori\u00e1zy vlasov\u00e9 poko\u017eky a neht\u016f<\/strong> \u2014 \u010dasto zvl\u00e1\u0161t\u011b citliv\u00e9 na apremilast<\/li>\n<li><strong>Psori\u00e1za dlan\u00ed a plosek a genit\u00e1ln\u00ed psori\u00e1za<\/strong> \u2014 kde lok\u00e1ln\u00ed terapie nen\u00ed dostate\u010dn\u00e1<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Jak funguje Aprezo?<\/h2>\n<p>Mechanismus \u00fa\u010dinku apremilastu se li\u0161\u00ed od jin\u00fdch syst\u00e9mov\u00fdch l\u00e9\u010div psori\u00e1zy:<\/p>\n<ul>\n<li><strong>Inhibuje PDE4<\/strong> uvnit\u0159 imunitn\u00edch bun\u011bk \u2014 PDE4 je enzym, kter\u00fd norm\u00e1ln\u011b rozkl\u00e1d\u00e1 intracelul\u00e1rn\u00ed cAMP<\/li>\n<li>Vy\u0161\u0161\u00ed hladina cAMP <strong>aktivuje protein kin\u00e1zu A<\/strong> a <strong>potla\u010duje transkrip\u010dn\u00ed faktor NF-\u03baB<\/strong><\/li>\n<li>N\u00e1sledn\u00fd \u00fa\u010dinek: <strong>sn\u00ed\u017een\u00e1 produkce TNF-\u03b1, IL-23, IL-17, IL-8 a IFN-\u03b3<\/strong>, s <strong>zv\u00fd\u0161enou hladinou IL-10<\/strong><\/li>\n<li>\u017d\u00e1dn\u00e9 p\u0159\u00edm\u00e9 imunosuprese \u2014 pacienti nejsou imunokompromitovan\u00ed a nepot\u0159ebuj\u00ed rutinn\u00ed screening infekc\u00ed jako u biologik<\/li>\n<li>Klinick\u00fd \u00fa\u010dinek je postupn\u00fd \u2014 v\u011bt\u0161ina pacient\u016f pozoruje v\u00fdznamn\u00e9 zlep\u0161en\u00ed psori\u00e1zy do <strong>16 t\u00fddn\u016f<\/strong>; n\u011bkte\u0159\u00ed d\u0159\u00edve<\/li>\n<\/ul>\n<p>Proto\u017ee l\u00e9k nezasahuje pouze jednu cytokinovou dr\u00e1hu, ale moduluje cel\u00e9 sign\u00e1ln\u00ed prost\u0159ed\u00ed v\u00fd\u0161e v kask\u00e1d\u011b, jeho \u00fa\u010dinnost je m\u00edrn\u011bj\u0161\u00ed ne\u017e u biologik TNF nebo IL-17, ale bezpe\u010dnostn\u00ed profil je \u0161ir\u0161\u00ed \u2014 co\u017e je zvl\u00e1\u0161t\u011b atraktivn\u00ed pro pacienty, kte\u0159\u00ed nesn\u00e1\u0161ej\u00ed biologika nebo cht\u011bj\u00ed vyhnout injekc\u00edm.<\/p>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed a pod\u00e1n\u00ed p\u0159\u00edpravku Aprezo<\/h2>\n<p>Apremilast vyu\u017e\u00edv\u00e1 <strong>5denn\u00ed titraci<\/strong> ke sn\u00ed\u017een\u00ed po\u010d\u00e1te\u010dn\u00edch gastrointestin\u00e1ln\u00edch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f.<\/p>\n<table>\n<thead>\n<tr>\n<th>Den<\/th>\n<th>R\u00e1no<\/th>\n<th>Ve\u010der<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>1<\/td>\n<td>10 mg<\/td>\n<td>\u2014<\/td>\n<\/tr>\n<tr>\n<td>2<\/td>\n<td>10 mg<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>3<\/td>\n<td>10 mg<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>4<\/td>\n<td>20 mg<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>5<\/td>\n<td>20 mg<\/td>\n<td>30 mg<\/td>\n<\/tr>\n<tr>\n<td>6 d\u00e1le<\/td>\n<td><strong>30 mg<\/strong><\/td>\n<td><strong>30 mg<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Pozn\u00e1mka:<\/strong> titira\u010dn\u00ed balen\u00ed obvykle obsahuje tablety 10 mg a 20 mg pro dny 1\u20135. Tableta 30 mg (Aprezo) je udr\u017eovac\u00ed d\u00e1vka od 6. dne.<\/p>\n<table>\n<thead>\n<tr>\n<th>Sc\u00e9n\u00e1\u0159<\/th>\n<th>D\u00e1vka<\/th>\n<th>Pozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Plo\u0161kov\u00e1 psori\u00e1za \/ psoriatick\u00e1 artritida (udr\u017eovac\u00ed l\u00e9\u010dba)<\/strong><\/td>\n<td>30 mg dvakr\u00e1t denn\u011b<\/td>\n<td>Pokra\u010dovat neomezen\u011b, dokud je \u00fa\u010dinn\u00e9<\/td>\n<\/tr>\n<tr>\n<td><strong>Beh\u00e7etovy or\u00e1ln\u00ed v\u0159edy<\/strong><\/td>\n<td>30 mg dvakr\u00e1t denn\u011b<\/td>\n<td>Podobn\u00e1 titrace<\/td>\n<\/tr>\n<tr>\n<td><strong>T\u011b\u017ek\u00e9 ren\u00e1ln\u00ed posti\u017een\u00ed (CrCl &lt;30 ml\/min)<\/strong><\/td>\n<td>30 mg jednou denn\u011b (pouze r\u00e1no)<\/td>\n<td>Sni\u017ete udr\u017eovac\u00ed d\u00e1vku na polovinu; titrace vyu\u017e\u00edv\u00e1 pouze rann\u00ed d\u00e1vky<\/td>\n<\/tr>\n<tr>\n<td><strong>Porucha funkce jater<\/strong><\/td>\n<td>Standardn\u00ed d\u00e1vka<\/td>\n<td>Nen\u00ed t\u0159eba \u00fapravy<\/td>\n<\/tr>\n<tr>\n<td><strong>T\u011bhotenstv\u00ed<\/strong><\/td>\n<td>Vyhnout se<\/td>\n<td>Kontraindikov\u00e1no<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">Jak spr\u00e1vn\u011b u\u017e\u00edvat Aprezo<\/h3>\n<ul>\n<li>Tabletu spolkn\u011bte celou s vodou; lze u\u017e\u00edvat s j\u00eddlem i bez j\u00eddla<\/li>\n<li>U\u017e\u00edvejte p\u0159ibli\u017en\u011b ve stejnou dobu ka\u017ed\u00fd den (r\u00e1no a ve\u010der, asi 12 hodin od sebe)<\/li>\n<li>Dokon\u010dete celou 5denn\u00ed titraci, i kdy\u017e sn\u00e1\u0161\u00edte po\u010d\u00e1te\u010dn\u00ed d\u00e1vky dob\u0159e \u2014 titra\u010dn\u00ed sch\u00e9ma v\u00fdznamn\u011b sni\u017euje gastrointestin\u00e1ln\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/li>\n<li>Pokud je nevolnost nebo pr\u016fjem p\u0159i udr\u017eovac\u00ed d\u00e1vce obt\u011b\u017euj\u00edc\u00ed, u\u017e\u00edvejte s j\u00eddlem m\u00edsto vysazen\u00ed<\/li>\n<li>Po\u010dkejte <strong>alespo\u0148 16 t\u00fddn\u016f<\/strong> p\u0159ed posouzen\u00edm \u00fa\u010dinnosti \u2014 v\u011bt\u0161ina pacient\u016f, kte\u0159\u00ed budou reagovat, tak u\u010din\u00ed do t\u00e9to doby<\/li>\n<li>Monitorujte hmotnost m\u011bs\u00ed\u010dn\u011b \u2014 ne\u00famysln\u00fd \u00fabytek hmotnosti se vyskytuje u men\u0161iny pacient\u016f<\/li>\n<li>Aktivn\u011b sledujte n\u00e1ladu \u2014 byly hl\u00e1\u0161eny nov\u00e9 nebo zhor\u0161uj\u00edc\u00ed se deprese<\/li>\n<li>Nep\u0159est\u00e1vejte n\u00e1hle bez l\u00e9ka\u0159sk\u00e9 konzultace \u2014 psori\u00e1za se m\u016f\u017ee zhor\u0161it<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky p\u0159\u00edpravku Aprezo<\/h2>\n<table>\n<thead>\n<tr>\n<th>Z\u00e1va\u017enost<\/th>\n<th>Vedlej\u0161\u00ed \u00fa\u010dinek<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>B\u011b\u017en\u00e9 (\u22651 z 10)<\/strong><\/td>\n<td>Pr\u016fjem, nevolnost, bolest hlavy (zejm\u00e9na 1.\u20134. t\u00fdden)<\/td>\n<\/tr>\n<tr>\n<td><strong>B\u011b\u017en\u00e9 (\u22651 ze 100)<\/strong><\/td>\n<td>Bolest b\u0159icha, zvracen\u00ed, infekce horn\u00edch cest d\u00fdchac\u00edch, \u00fanava, \u00fabytek hmotnosti (\u22655 % t\u011blesn\u00e9 hmotnosti u ~10 % u\u017eivatel\u016f)<\/td>\n<\/tr>\n<tr>\n<td><strong>M\u00e9n\u011b \u010dast\u00e9<\/strong><\/td>\n<td>Zm\u011bny n\u00e1lady \/ deprese, migr\u00e9na, nespavost, hypersenzitivn\u00ed reakce<\/td>\n<\/tr>\n<tr>\n<td><strong>Vz\u00e1cn\u00e9<\/strong><\/td>\n<td>Z\u00e1va\u017en\u00fd pr\u016fjem vy\u017eaduj\u00edc\u00ed hospitalizaci, v\u00fdrazn\u00fd \u00fabytek hmotnosti, sebevra\u017eedn\u00e9 my\u0161lenky, angioed\u00e9m<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Gastrointestin\u00e1ln\u00ed vedlej\u0161\u00ed \u00fa\u010dinky jsou obvykle samovoln\u011b ustupuj\u00edc\u00ed<\/strong> \u2014 v\u011bt\u0161ina odezn\u00ed b\u011bhem prvn\u00edch 2\u20134 t\u00fddn\u016f, jak si t\u011blo zvyk\u00e1. P\u0159etrv\u00e1vaj\u00edc\u00ed z\u00e1va\u017en\u00fd pr\u016fjem by m\u011bl v\u00e9st k p\u0159ehodnocen\u00ed l\u00e9\u010dby.<\/p>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>Riziko deprese.<\/strong> U n\u011bkter\u00fdch pacient\u016f byly hl\u00e1\u0161eny nov\u00e9 nebo zhor\u0161uj\u00edc\u00ed se deprese, sebevra\u017eedn\u00e9 my\u0161lenky nebo sebevra\u017eda. Sledujte n\u00e1ladu; jak\u00e9koli zm\u011bny neprodlen\u011b nahlaste<\/li>\n<li><strong>\u00dabytek hmotnosti.<\/strong> 10 % pacient\u016f ztrat\u00ed \u22655 % t\u011blesn\u00e9 hmotnosti. Monitorujte hmotnost m\u011bs\u00ed\u010dn\u011b \u2014 pokud dojde k v\u00fdrazn\u00e9mu ne\u00famysln\u00e9mu \u00fabytku, zva\u017ete sn\u00ed\u017een\u00ed d\u00e1vky nebo ukon\u010den\u00ed l\u00e9\u010dby<\/li>\n<li><strong>Pr\u016fjem a nevolnost.<\/strong> Nej\u010dast\u011bj\u0161\u00ed v prvn\u00edch 2\u20134 t\u00fddnech \u2014 5denn\u00ed titra\u010dn\u00ed sch\u00e9ma v\u00fdrazn\u011b sni\u017euje z\u00e1va\u017enost<\/li>\n<li><strong>T\u011bhotenstv\u00ed.<\/strong> Teratogenn\u00ed v pokusech na zv\u00ed\u0159atech \u2014 vyvarujte se u\u017e\u00edv\u00e1n\u00ed. Pou\u017e\u00edvejte spolehlivou antikoncepci b\u011bhem u\u017e\u00edv\u00e1n\u00ed a 30 dn\u00ed po ukon\u010den\u00ed<\/li>\n<li><strong>Kojen\u00ed.<\/strong> Nedoporu\u010duje se<\/li>\n<li><strong>Alkohol.<\/strong> \u017d\u00e1dn\u00e1 p\u0159\u00edm\u00e1 interakce, ale zhor\u0161uje gastrointestin\u00e1ln\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky v prvn\u00edch t\u00fddnech<\/li>\n<li><strong>O\u010dkov\u00e1n\u00ed.<\/strong> \u017div\u00e9 vakc\u00edny jsou p\u0159i u\u017e\u00edv\u00e1n\u00ed apremilastu (na rozd\u00edl od biologik) povoleny, proto\u017ee apremilast nepotla\u010duje imunitu<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace \u2014 Kdo by NEM\u011aL u\u017e\u00edvat Aprezo<\/h2>\n<ul>\n<li>T\u011bhotenstv\u00ed<\/li>\n<li>Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na apremilast nebo jakoukoli pomocnou l\u00e1tku<\/li>\n<li>Aktivn\u00ed t\u011b\u017ek\u00e1 deprese se sebevra\u017eedn\u00fdmi sklony (pe\u010dliv\u011b zva\u017ete)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table>\n<thead>\n<tr>\n<th>L\u00e9\u010divo \/ T\u0159\u00edda<\/th>\n<th>Interakce<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Siln\u00e9 induktory CYP3A4 (rifampicin, fenytoin, karbamazepin, fenobarbital, t\u0159ezalka te\u010dkovan\u00e1)<\/strong><\/td>\n<td><strong>Vyvarujte se kombinace<\/strong> \u2014 m\u016f\u017ee sn\u00ed\u017eit hladinu apremilastu o 72 % a ztratit \u00fa\u010dinnost<\/td>\n<\/tr>\n<tr>\n<td><strong>Inhibitory CYP3A4 (ketokonazol, ritonavir, klarithromycin)<\/strong><\/td>\n<td>M\u00edrn\u00e9 zv\u00fd\u0161en\u00ed hladin apremilastu \u2014 obvykle klinicky zvl\u00e1dnuteln\u00e9<\/td>\n<\/tr>\n<tr>\n<td><strong>Methotrex\u00e1t<\/strong><\/td>\n<td>\u010casto p\u0159edepisov\u00e1no sou\u010dasn\u011b u psoriatick\u00e9 artritidy \u2014 \u017e\u00e1dn\u00e1 ne\u017e\u00e1douc\u00ed farmakokinetick\u00e1 interakce<\/td>\n<\/tr>\n<tr>\n<td><strong>Biologick\u00e9 l\u00e9ky (inhibitory TNF, IL-17, IL-23)<\/strong><\/td>\n<td>Obvykle se pou\u017e\u00edvaj\u00ed postupn\u011b sp\u00ed\u0161e ne\u017e v kombinaci \u2014 \u00fadaje o spole\u010dn\u00e9m p\u0159edepisov\u00e1n\u00ed jsou omezen\u00e9<\/td>\n<\/tr>\n<tr>\n<td><strong>Alkohol<\/strong><\/td>\n<td>Zhor\u0161uje gastrointestin\u00e1ln\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky na za\u010d\u00e1tku; st\u0159edn\u011b pozd\u011bji<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Pokyny k uchov\u00e1v\u00e1n\u00ed<\/h2>\n<ul>\n<li>Nepou\u017eit\u00e9 tobolky zlikvidujte prost\u0159ednictv\u00edm l\u00e9k\u00e1rensk\u00e9ho zp\u011btn\u00e9ho odb\u011bru, je-li k dispozici<\/li>\n<li>Uchov\u00e1vejte v p\u016fvodn\u00edm blistrov\u00e9m obalu<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed<\/li>\n<li>Nepou\u017e\u00edvejte po uplynut\u00ed data expirace<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/dapsone\/\" rel=\"noopener\">Dapson<\/a> \u2014 alternativn\u00ed peror\u00e1ln\u00ed imunomodul\u00e1tor pro vybran\u00e1 z\u00e1n\u011btliv\u00e1 ko\u017en\u00ed onemocn\u011bn\u00ed<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/eczema-psoriasis-treatment\/\" rel=\"noopener\">Prohl\u00e9dn\u011bte v\u0161echny l\u00e9\u010debn\u00e9 p\u0159\u00edpravky na ekz\u00e9my a psori\u00e1zu \u2192<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">K \u010demu se Aprezo pou\u017e\u00edv\u00e1?<\/h3>\n<p>Aprezo (apremilast) l\u00e9\u010d\u00ed <strong>st\u0159edn\u011b t\u011b\u017ekou a\u017e t\u011b\u017ekou plakovou psori\u00e1zu, aktivn\u00ed psoriatickou artritidu a or\u00e1ln\u00ed v\u0159edy u Beh\u00e7etovy choroby<\/strong>. \u010casto se p\u0159edepisuje pacient\u016fm, kte\u0159\u00ed nemohou nebo d\u00e1vaj\u00ed p\u0159ednost tomu nepou\u017e\u00edvat biologick\u00e9 injekce nebo metotrex\u00e1t.<\/p>\n<h3 class=\"wp-block-heading\">Jak rychle Aprezo \u00fa\u010dinkuje?<\/h3>\n<p>Prvn\u00ed zlep\u0161en\u00ed za 4\u20136 t\u00fddn\u016f; v\u00fdznamn\u00e1 odpov\u011b\u010f obvykle do <strong>16 t\u00fddn\u016f<\/strong>. Kloubn\u00ed p\u0159\u00edznaky u psoriatick\u00e9 artritidy mohou reagovat rychleji ne\u017e ko\u017en\u00ed l\u00e9ze.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d existuje titra\u010dn\u00ed balen\u00ed?<\/h3>\n<p>Postupn\u00e9 zvy\u0161ov\u00e1n\u00ed d\u00e1vky b\u011bhem 5 dn\u016f z 10 mg na udr\u017eovac\u00ed d\u00e1vku 30 mg dvakr\u00e1t denn\u011b v\u00fdrazn\u011b sni\u017euje po\u010d\u00e1te\u010dn\u00ed nevolnost, pr\u016fjem a bolesti hlavy. Nikdy nevynech\u00e1vejte titraci \u2014 za\u010d\u00e1tek p\u0159\u00edmo na 30 mg dvakr\u00e1t denn\u011b je mnohem m\u00e9n\u011b snesiteln\u00fd.<\/p>\n<h3 class=\"wp-block-heading\">Je Aprezo biologick\u00fd l\u00e9k?<\/h3>\n<p><strong>Ne<\/strong> \u2014 apremilast je mal\u00e1 molekula <strong>peror\u00e1ln\u00ed<\/strong> l\u00e9ku, nikoli biologikum. Nevy\u017eaduje injekce, infuze, skladov\u00e1n\u00ed v chladn\u00e9m \u0159et\u011bzci ani p\u0159edl\u00e9\u010debn\u00e9 vy\u0161et\u0159en\u00ed na tuberkul\u00f3zu\/hepatitidu. To je jedna z jeho hlavn\u00edch praktick\u00fdch v\u00fdhod.<\/p>\n<h3 class=\"wp-block-heading\">Sn\u00ed\u017e\u00edm na Aprezo v\u00e1hu?<\/h3>\n<p>P\u0159ibli\u017en\u011b 10 % u\u017eivatel\u016f zhubne \u22655 % t\u011blesn\u00e9 hmotnosti. U pacient\u016f s nadv\u00e1hou to m\u016f\u017ee b\u00fdt v\u00edtan\u00e9, ale jak\u00fdkoli v\u00fdznamn\u00fd ne\u00famysln\u00fd \u00fabytek v\u00e1hy byste m\u011bli probrat s l\u00e9ka\u0159em. Hmotnost kontrolujte m\u011bs\u00ed\u010dn\u011b.<\/p>\n<h3 class=\"wp-block-heading\">Mohu p\u00edt alkohol p\u0159i u\u017e\u00edv\u00e1n\u00ed Aprezo?<\/h3>\n<p>M\u00edrn\u00e1 konzumace je p\u0159ijateln\u00e1. Nadm\u011brn\u00e9 pit\u00ed m\u016f\u017ee zhor\u0161it gastrointestin\u00e1ln\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky, zejm\u00e9na v prvn\u00edch t\u00fddnech.<\/p>\n<h3 class=\"wp-block-heading\">Mohu ot\u011bhotn\u011bt p\u0159i u\u017e\u00edv\u00e1n\u00ed Aprezo?<\/h3>\n<p><strong>Ne<\/strong> \u2014 apremilast je v t\u011bhotenstv\u00ed kontraindikov\u00e1n. Pou\u017e\u00edvejte spolehlivou antikoncepci b\u011bhem l\u00e9\u010dby a alespo\u0148 30 dn\u00ed po jej\u00edm ukon\u010den\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Mohu kombinovat Aprezo s methotrex\u00e1tem?<\/h3>\n<p>Ano \u2014 tato kombinace je b\u011b\u017en\u00e1 u psoriatick\u00e9 artritidy a je dob\u0159e sn\u00e1\u0161ena. \u017d\u00e1dn\u00e1 nep\u0159\u00edzniv\u00e1 farmakokinetick\u00e1 interakce.<\/p>\n<h3 class=\"wp-block-heading\">Ovliv\u0148uje Aprezo imunitn\u00ed syst\u00e9m?<\/h3>\n<p>Na rozd\u00edl od biologik apremilast nezp\u016fsobuje imunosupresi. Rutinn\u00ed vy\u0161et\u0159en\u00ed na tuberkul\u00f3zu nebo hepatitidu nen\u00ed nutn\u00e9 a \u017eiv\u00e9 vakc\u00edny jsou povoleny.<\/p>\n<h3 class=\"wp-block-heading\">Co d\u011blat, kdy\u017e Aprezo nezab\u00edr\u00e1 po 16 t\u00fddnech?<\/h3>\n<p>\u00da\u010dinnost je m\u00edrn\u011bj\u0161\u00ed ne\u017e u biologik. Pokud je odpov\u011b\u010f nedostate\u010dn\u00e1, v\u00e1\u0161 dermatolog nebo revmatolog m\u016f\u017ee p\u0159ej\u00edt na biologikum (adalimumab, sekukinumab, ixekizumab, guselkumab) nebo na tradi\u010dn\u00ed syst\u00e9mov\u00e9 l\u00e9ky (methotrex\u00e1t, cyklosporin).<\/p>\n<p><!-- medsbase-faq-h3-converted --><\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/inderal\/\">Inderal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lipaglyn\/\">Lipaglyn<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/triohale-rotacaps\/\">Triohale Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/seroflo-rotacaps\/\">Seroflo Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/amlip\/\">Amlip<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Sni\u017euje p\u0159\u00edznaky psori\u00e1zy<br \/>\n\u2705 Kontroluje psoriatickou artritidu<br \/>\n\u2705 Minimalizuje z\u00e1n\u011bt k\u016f\u017ee<br \/>\n\u2705 Zm\u00edr\u0148uje bolesti kloub\u016f<br \/>\n\u2705 Zlep\u0161uje \u010distotu pleti<\/p>\n<p>Aprezo obsahuje Apremilast.<\/p>","protected":false},"featured_media":55537,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3942],"product_tag":[3943,3944,5765,5767,5766,5761,5762,5763,5764],"class_list":{"0":"post-55536","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-eczema-psoriasis-treatment","9":"product_tag-apremilast","10":"product_tag-aprezo","11":"product_tag-behcet-disease","12":"product_tag-glenmark","13":"product_tag-immunomodulator","14":"product_tag-otezla-generic","15":"product_tag-pde4-inhibitor","16":"product_tag-plaque-psoriasis","17":"product_tag-psoriatic-arthritis","19":"first","20":"instock","21":"shipping-taxable","22":"purchasable","23":"product-type-variable","24":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/55536","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=55536"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/55537"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=55536"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=55536"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=55536"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=55536"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}