{"id":55548,"date":"2024-02-07T05:29:26","date_gmt":"2024-02-07T05:29:26","guid":{"rendered":"https:\/\/medsname.com\/arizole\/"},"modified":"2026-04-30T10:24:46","modified_gmt":"2026-04-30T10:24:46","slug":"arizole","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/arizole\/","title":{"rendered":"Arizole"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Arizole (Aripiprazol 5 \/ 10 \/ 15 \/ 20 \/ 30 mg) je atypick\u00e9 antipsychotikum s unik\u00e1tn\u00edm mechanismem parci\u00e1ln\u00ed agonie D2 receptor\u016f. Pou\u017e\u00edv\u00e1 se p\u0159i schizofrenii, bipol\u00e1rn\u00ed m\u00e1nii a udr\u017eovac\u00ed l\u00e9\u010db\u011b, jako dopln\u011bk u MDD a p\u0159i podr\u00e1\u017ed\u011bnosti u autismu. Metabolicky nej\u0161etrn\u011bj\u0161\u00ed z atypik \u2014 minim\u00e1ln\u00ed p\u0159\u00edr\u016fstek hmotnosti, minim\u00e1ln\u00ed sedace.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Arizole na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Arizole a jak funguje<\/h2>\n

Arizole jsou tablety aripiprazolu dod\u00e1van\u00e9 spole\u010dnost\u00ed Sun Pharma. Dostupn\u00e9 s\u00edly: 5 \/ 10 \/ 15 \/ 20 \/ 30 mg<\/strong>. Aripiprazol se mechanisticky li\u0161\u00ed od ostatn\u00edch atypick\u00fdch antipsychotik: p\u016fsob\u00ed jako parci\u00e1ln\u00ed agonista<\/strong> na dopaminov\u00fdch D2 a serotoninov\u00fdch 5-HT1A receptorech a jako pln\u00fd antagonista na 5-HT2A receptorech. Parci\u00e1ln\u011b agonistick\u00fd profil znamen\u00e1, \u017ee funguje jako antagonista tam, kde je dopaminergn\u00ed aktivita vysok\u00e1 (l\u00e9\u010d\u00ed pozitivn\u00ed p\u0159\u00edznaky schizofrenie) a jako slab\u00fd agonista tam, kde je dopaminergn\u00ed aktivita n\u00edzk\u00e1 (uchov\u00e1v\u00e1 kognitivn\u00ed funkce, sni\u017euje riziko motorick\u00fdch vedlej\u0161\u00edch \u00fa\u010dink\u016f a hyperprolaktin\u00e9mie).<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Schizofrenie (dosp\u011bl\u00ed)<\/td>\n10\u201315 mg 1\u00d7 denn\u011b<\/td>\n10\u201330 mg 1\u00d7 denn\u011b<\/td>\n30 mg<\/td>\n<\/tr>\n
Schizofrenie (dosp\u00edvaj\u00edc\u00ed \u2265 13 let)<\/td>\n2 mg 1\u00d7 denn\u011b \u00d7 2 dny \u2192 5 mg \u00d7 2 dny \u2192 10 mg<\/td>\n10 mg 1\u00d7 denn\u011b<\/td>\n30 mg<\/td>\n<\/tr>\n
Bipol\u00e1rn\u00ed m\u00e1nie (dosp\u011bl\u00ed)<\/td>\n15 mg 1\u00d7 denn\u011b<\/td>\n15\u201330 mg 1\u00d7 denn\u011b<\/td>\n30 mg<\/td>\n<\/tr>\n
Deprese jako dopln\u011bk (s antidepresivy)<\/td>\n2\u20135 mg 1\u00d7 denn\u011b<\/td>\n5\u201310 mg 1\u00d7 denn\u011b<\/td>\n15 mg<\/td>\n<\/tr>\n
Podr\u00e1\u017ed\u011bnost p\u0159i autismu (\u2265 6 let)<\/td>\n2 mg 1\u00d7 denn\u011b<\/td>\n5\u201310 mg 1\u00d7 denn\u011b (d\u00e1vkov\u00e1n\u00ed podle hmotnosti)<\/td>\n15 mg<\/td>\n<\/tr>\n
Tourett\u016fv syndrom (\u2265 6 let)<\/td>\n2 mg 1\u00d7 denn\u011b<\/td>\n5\u201320 mg 1\u00d7 denn\u011b<\/td>\n20 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Jedna denn\u00ed d\u00e1vka, s j\u00eddlem nebo bez. U pacient\u016f citliv\u00fdch na akatizii titrujte pomalu.<\/p>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nFDA black-box \u2014 psych\u00f3za spojen\u00e1 s demenc\u00ed<\/strong><\/p>\n

V\u0161echna atypick\u00e1 antipsychotika nesou varov\u00e1n\u00ed FDA black-box pro zv\u00fd\u0161enou mortalitu (p\u0159edev\u0161\u00edm kardiovaskul\u00e1rn\u00ed a infek\u010dn\u00ed) p\u0159i pou\u017eit\u00ed k l\u00e9\u010db\u011b behavior\u00e1ln\u00edch poruch u star\u0161\u00edch dosp\u011bl\u00fdch s demenc\u00ed. Atypick\u00e1 antipsychotika nejsou schv\u00e1lena pro psych\u00f3zu nebo agitovanost spojenou s demenc\u00ed<\/strong>. Pou\u017eit\u00ed u t\u00e9to populace je off-label, posledn\u00ed mo\u017enost\u00ed, \u010dasov\u011b omezen\u00e9 a vy\u017eaduje explicitn\u00ed rozhovor o rizic\u00edch a p\u0159\u00ednosech.<\/p>\n<\/div>\n

\nAkatizie je dominantn\u00edm vedlej\u0161\u00edm \u00fa\u010dinkem<\/strong><\/p>\n

Aripiprazol zp\u016fsobuje m\u00e9n\u011b p\u0159\u00edr\u016fstku hmotnosti, m\u00e9n\u011b sedace a m\u00e9n\u011b zv\u00fd\u0161en\u00ed prolaktinu ne\u017e jin\u00e1 atypick\u00e1 antipsychotika \u2014 ale v\u00edce akatizie<\/strong> (vnit\u0159n\u00ed neklid, \u010dasto popisovan\u00fd jako \u201cnutk\u00e1n\u00ed h\u00fdbat se\u201d, \u201clezen\u00ed po k\u016f\u017ei\u201d nebo \u201cneschopnost sed\u011bt v klidu\u201d). Akatizie je nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dinou vysazen\u00ed aripiprazolu. \u0158e\u0161\u00ed se sn\u00ed\u017een\u00edm d\u00e1vky, propranololem 20\u201380 mg\/den nebo p\u0159echodem na jin\u00fd l\u00e9k.<\/p>\n<\/div>\n

\nImpulzivn\u00ed poruchy chov\u00e1n\u00ed (vz\u00e1cn\u00e9)<\/strong><\/p>\n

U aripiprazolu byly hl\u00e1\u0161eny patologick\u00e9 hr\u00e1\u010dstv\u00ed, hypersexualita, nutkav\u00e9 nakupov\u00e1n\u00ed a z\u00e1chvatovit\u00e9 p\u0159ej\u00edd\u00e1n\u00ed \u2014 zp\u016fsoben\u00e9 parci\u00e1ln\u00edm agonismem D2\/D3. Po vysazen\u00ed ust\u00e1v\u00e1. Explicitn\u011b se ptejte p\u0159i kontrol\u00e1ch.<\/p>\n<\/div>\n

\n\u010cern\u00e9 varov\u00e1n\u00ed ohledn\u011b sebevra\u017eednosti (u pacient\u016f do 25 let p\u0159i adjuvantn\u00ed l\u00e9\u010db\u011b MDD)<\/strong><\/p>\n

P\u0159i pou\u017eit\u00ed jako dopln\u011bk k antidepresiv\u016fm plat\u00ed varov\u00e1n\u00ed ohledn\u011b zv\u00fd\u0161en\u00e9ho rizika sebevra\u017eednosti u pacient\u016f do 25 let.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n