{"id":55590,"date":"2024-02-07T05:32:09","date_gmt":"2024-02-07T05:32:09","guid":{"rendered":"https:\/\/medsname.com\/atomoxet\/"},"modified":"2026-04-30T10:24:46","modified_gmt":"2026-04-30T10:24:46","slug":"atomoxet","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/atomoxet\/","title":{"rendered":"Atomoxet"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Atomoxet (Atomoxetin 10 \/ 18 \/ 25 \/ 40 \/ 60 \/ 80 mg) je selektivn\u00ed inhibitor zp\u011btn\u00e9ho vychyt\u00e1v\u00e1n\u00ed noradrenalinu pro ADHD u d\u011bt\u00ed, dosp\u00edvaj\u00edc\u00edch a dosp\u011bl\u00fdch. Nestimula\u010dn\u00ed p\u0159\u00edpravek \u2014 \u017e\u00e1dn\u00fd potenci\u00e1l zneu\u017eit\u00ed, nen\u00ed na seznamu kontrolovan\u00fdch l\u00e1tek. U\u017eite\u010dn\u00fd, kdy\u017e jsou stimulanty nevhodn\u00e9, ne\u00fa\u010dinn\u00e9 nebo kontraindikovan\u00e9.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Atomoxet na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Atomoxet a jak funguje<\/h2>\n

Atomoxet je tobolka s obsahem 10 \/ 18 \/ 25 \/ 40 \/ 60 \/ 80 mg atomoxetinu dod\u00e1van\u00e1 spole\u010dnost\u00ed Intas. Atomoxetin selektivn\u011b inhibuje transport\u00e9r pro zp\u011btn\u00e9 vychyt\u00e1v\u00e1n\u00ed noradrenalinu (NET), \u010d\u00edm\u017e zvy\u0161uje synaptickou hladinu noradrenalinu a \u2014 nep\u0159\u00edmo prost\u0159ednictv\u00edm kortik\u00e1ln\u00ed interakce NA-DA \u2014 dopaminu v \u010deln\u00edm kortexu, ani\u017e by ovliv\u0148oval striat\u00e1ln\u00ed dopamin. To je pr\u00e1v\u011b to, co odli\u0161uje atomoxetin od stimulant\u016f: \u017e\u00e1dn\u00e1 euforie, \u017e\u00e1dn\u00fd potenci\u00e1l zneu\u017eit\u00ed, nen\u00ed na seznamu kontrolovan\u00fdch l\u00e1tek.<\/p>\n

\nPomal\u00fd n\u00e1stup \u00fa\u010dinku \u2013 nejedn\u00e1 se o l\u00e9k s okam\u017eit\u00fdm \u00fa\u010dinkem<\/strong><\/p>\n

Stimulanty za\u010d\u00ednaj\u00ed p\u016fsobit b\u011bhem 30\u201360 minut po prvn\u00ed d\u00e1vce. Atomoxetin vy\u017eaduje 2\u20134 t\u00fddny pro po\u010d\u00e1te\u010dn\u00ed odpov\u011b\u010f a 8\u201312 t\u00fddn\u016f pro pln\u00fd \u00fa\u010dinek. Pacienti (a rodi\u010de) o\u010dek\u00e1vaj\u00edc\u00ed okam\u017eitou zm\u011bnu jako u stimulant\u016f budou zklam\u00e1ni a l\u00e9\u010dbu ukon\u010d\u00ed. Nastavte spr\u00e1vn\u00e1 o\u010dek\u00e1v\u00e1n\u00ed ji\u017e p\u0159i zah\u00e1jen\u00ed terapie.<\/p>\n<\/div>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n
Pacient<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
D\u011bti a dosp\u00edvaj\u00edc\u00ed \u2264 70 kg<\/td>\n0,5 mg\/kg\/den \u00d7 3 dny<\/td>\n1,2 mg\/kg\/den<\/td>\n1,4 mg\/kg nebo 100 mg<\/td>\n<\/tr>\n
D\u011bti a dosp\u00edvaj\u00edc\u00ed > 70 kg<\/td>\n40 mg 1\u00d7 denn\u011b \u00d7 3 dny<\/td>\n80 mg 1\u00d7 denn\u011b<\/td>\n100 mg 1\u00d7 denn\u011b<\/td>\n<\/tr>\n
Dosp\u011bl\u00ed<\/td>\n40 mg 1\u00d7 denn\u011b \u00d7 7 dn\u00ed<\/td>\n80 mg 1\u00d7 denn\u011b<\/td>\n100 mg<\/td>\n<\/tr>\n
Siln\u00fd inhibitor CYP2D6 \/ slab\u00fd metaboliz\u00e9r<\/td>\n0,5 mg\/kg nebo 40 mg<\/td>\n0,5 \u00d7 norm\u00e1ln\u00ed c\u00edlov\u00e9 d\u00e1vkov\u00e1n\u00ed<\/td>\ndle sn\u00e1\u0161enlivosti<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Lze pod\u00e1vat jednou denn\u011b r\u00e1no nebo rozd\u011blit na dv\u011b d\u00e1vky (r\u00e1no + pozdn\u00ed odpoledne \u2014 ve\u010der se vyvarujte kv\u016fli nespavosti).<\/p>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\n\u010cern\u00e9 varov\u00e1n\u00ed ohledn\u011b sebevra\u017eednosti (u d\u011bt\u00ed)<\/strong><\/p>\n

Atomoxetin nese \u010dern\u00e9 varov\u00e1n\u00ed FDA pro zv\u00fd\u0161en\u00e9 riziko sebevra\u017eedn\u00fdch my\u0161lenek u d\u011bt\u00ed a dosp\u00edvaj\u00edc\u00edch, zejm\u00e9na v prvn\u00edm m\u011bs\u00edci a p\u0159i zm\u011bn\u00e1ch d\u00e1vkov\u00e1n\u00ed. Pe\u010dliv\u011b sledujte zm\u011bny chov\u00e1n\u00ed u d\u011btsk\u00fdch pacient\u016f p\u0159i zah\u00e1jen\u00ed l\u00e9\u010dby.<\/p>\n<\/div>\n

\nHepatotoxicita \u2014 vz\u00e1cn\u00e1<\/strong><\/p>\n

Byly hl\u00e1\u0161eny vz\u00e1cn\u00e9 p\u0159\u00edpady z\u00e1va\u017en\u00e9ho po\u0161kozen\u00ed jater. Okam\u017eit\u011b p\u0159eru\u0161te l\u00e9\u010dbu, pokud se objev\u00ed \u017eloutenka, tmav\u00e1 mo\u010d, bolest v prav\u00e9m pod\u017eeb\u0159\u00ed, \u00fanava nebo nevysv\u011btliteln\u00e1 nevolnost. Po prok\u00e1zan\u00e9m po\u0161kozen\u00ed jater l\u00e9\u010dbu neobnovujte.<\/p>\n<\/div>\n

\nKardiovaskul\u00e1rn\u00ed<\/strong><\/p>\n

Atomoxetin zp\u016fsobuje m\u00edrn\u00e9 pr\u016fm\u011brn\u00e9 zv\u00fd\u0161en\u00ed krevn\u00edho tlaku (+2 mmHg) a srde\u010dn\u00ed frekvence (+5 tep\u016f\/min). U dosp\u011bl\u00fdch jsou ob\u010das pozorov\u00e1ny v\u011bt\u0161\u00ed vzestupy. Kontrolujte krevn\u00ed tlak a srde\u010dn\u00ed frekvenci na za\u010d\u00e1tku, p\u0159i ka\u017ed\u00e9 zm\u011bn\u011b d\u00e1vky a p\u0159i kontroln\u00edch vy\u0161et\u0159en\u00edch. Vyvarujte se pou\u017eit\u00ed u z\u00e1va\u017en\u00fdch struktur\u00e1ln\u00edch abnormalit srdce, t\u011b\u017ek\u00fdch kardiovaskul\u00e1rn\u00edch onemocn\u011bn\u00ed nebo feochromocytomu.<\/p>\n<\/div>\n

\nR\u016fst (u d\u011bt\u00ed)<\/strong><\/p>\n

U d\u011bt\u00ed u\u017e\u00edvaj\u00edc\u00edch atomoxetin byly hl\u00e1\u0161eny m\u00edrn\u00e9 sn\u00ed\u017een\u00ed r\u016fstov\u00e9 rychlosti \u2014 obvykle se \u010dasem vyrovnaj\u00ed. Pravideln\u011b zaznamen\u00e1vejte v\u00fd\u0161ku a hmotnost p\u0159i ka\u017ed\u00e9 n\u00e1v\u0161t\u011bv\u011b.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n